Methylene Blue Product Guide
Backed by over 150 years of scientific literature, Methylene Blue is a powerful antioxidant with diverse longevity potential that may help optimize brain health and cellular energy for better focus, improved memory, and reduced risk of neurodegenerative disease.
Before you get started, read more about important usage information for Methylene Blue.
Quick tips
Here are some simple steps to help you get the most from each dose:
- Take in the morning
- Take after a meal
- Take with a full glass of water
- Drink lots of water throughout the day
- Be mindful of spending time in the sun
- Be sure not to break capsules
Following these steps will ensure that you set the best expectations for yourself before getting started, so you can experience the best possible benefits while minimizing side effects.
Getting started
When you first receive Methylene Blue, ensure proper storage guidelines to maintain the quality of the medication.
Review the titration instructions provided by your prescriber.
Understand Methylene Blue benefits so you know what to expect.
Learn the best strategy for reducing side effects in your first weeks.
Storage
When your prescription arrives, check that the contents are properly sealed and undamaged. Be sure to keep your medication in its original container to maintain the utmost quality.
Store at room temperature (between 68°F and 77°F) and away from direct light, like in your pantry. Avoid storing Methylene Blue in areas with excessive heat or humidity, like your laundry room or utility closet. Always keep Methylene Blue where your children or pets can’t reach it.
Titration instructions
Methylene Blue follows a simple, standardized titration plan that will proceed as follows unless your AgelessRx prescriber tells you otherwise:
| Week | Dose | Frequency |
|---|---|---|
| Weeks 1-2 | 1 capsule (5mg) | 3x per week in the morning |
| Weeks 3-4 | 2 capsules (2x5mg) | 3x per week in the morning |
| Week 5+ | 2 capsules (2x10mg) | 3x per week in the morning |
Methylene Blue may enhance alertness, focus, and mental clarity, all of which can disrupt sleep patterns. As such, you should take Methylene Blue in the morning, or as early in your day as possible, after your first meal of the day. For the best results, take Methylene Blue around the same time each day with a full glass of water.
You will take your prescribed dose three times per week, so be sure to schedule times that work best for you, like Monday/Wednesday/Friday.
For the first 2 weeks, you will start by taking 1 capsule in the morning, on 3 non-consecutive days each week.
For weeks 3-4, you will increase your dose to 2 capsules in the morning, for a total dose of 10mg.
Starting at week 5, the strength of your capsules will double from 5mg to 10mg. You will then take 2x10mg capsules in the morning for the duration of your prescription.
If you miss a dose, simply skip the dose you missed and take your next dose when you normally would. Try to avoid taking Methylene Blue in the afternoon if you missed a morning dose—this may interfere with your sleep. Do not take more than prescribed. Never double up on doses to reconcile a missed dose.
If you feel you’re not meeting your health goals on your prescribed dose, contact your prescriber to see if changing your target dose is right for you.
Methylene Blue benefits
Methylene Blue works by integrating into the mitochondria within our cells, especially damaged mitochondria within the brain. This helps increase ATP production, which is the main source of fuel for our cells, and optimize the electron transport chain. In this way, Methylene Blue may help to:
- Boost mitochondrial energy
- Improve memory & focus
- Clear brain fog
- Enhance cognitive function
- Stifle inflammation
- Minimize oxidative stress
- Reduce the risk of neurodegeneration
The more you take Methylene Blue, the more you’ll notice benefits. For the most optimal benefits of Methylene Blue, it should be taken over an extended period of at least 6-12 months.
Side effects
The most common side effects of Methylene Blue include:
- Blue urine
- Nausea
- Vomiting
- Stomach pain
- Diarrhea
- Loss of appetite
Blue urine is a normal reaction to Methylene Blue and is not cause for concern. If you notice that your urine is blue after taking Methylene Blue, wait until your urine clears before taking another dose. Feces, saliva, and sweat may also be temporarily discolored with a blue tint. Most patients clear the medication from their system within 4-6 hours, or up to 24 hours.
Most side effects are mild and go away on their own within a week or two. Taking Methylene Blue with a full glass of water and a meal may help minimize the chances of side effects.
Some patients may also notice anxiety or insomnia, mild urinary irritation, or hypersensitivity to UV (sun) exposure. To minimize the risk of these side effects, take Methylene Blue in the morning, drink plenty of water, and be mindful when spending time outside, especially during peak sun hours.
Methylene Blue should not be used by those with G6PD sensitivity. Patients who have or are at risk of renal dysfunction should check with their AgelessRx prescriber to see if taking Methylene Blue is safe and appropriate.
If you are currently taking antidepressants like SSRIs or MAOIs, you should not use Methylene Blue. This includes Trazodone, a mild SARI (serotonin antagonist and reuptake inhibitor) that may interact with Methylene Blue.
Please inform your AgelessRx prescriber of all medications you are taking, including supplements and over-the-counter medications. For a full list of Methylene Blue side effects, please review the Mayo Clinic’s Methylene Blue resources.
Important safety information
Methylene Blue should not be used by anyone with a history of G6PD deficiency, or anyone who has or has had renal dysfunction.
Do not use Methylene Blue if you are currently taking a medication that affects serotonin, such as antidepressants like SSRIs and MAOIs, or SARIs like Trazodone.
Do not use Methylene Blue if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed while taking Methylene Blue.
Though rare, allergic reactions to Methylene Blue are still possible. If you notice any shortness of breath or swelling around your face, tongue, or throat after using methylene Blue, stop use and contact emergency services right away.
As with any prescription medication, the dose prescribed is for you and you alone. Do not, under any circumstances, share or allow anyone else to use your Methylene Blue prescription.
FAQs
Can I take Methylene Blue with other medications?
Most medications are safe to use with Methylene Blue, including other AgelessRx products. Do not use Methylene Blue if you are currently taking a medication that affects serotonin, such as antidepressants like SSRIs and MAOIs, or SARIs like Trazodone.
You should always tell your AgelessRx prescriber of all medications you’re taking before getting started with Methylene Blue, especially those for G6PD deficiency or those that affect your serotonin levels.
Your prescriber will only recommend a Methylene Blue prescription if they feel it is safe and appropriate for you. Please review the full list of possible drug interactions with Methylene Blue before requesting a prescription.
Why is my Methylene Blue in capsules, and not a drop bottle?
Methylene Blue capsules allow for simple, precise dosing so you can get consistent results. Our FDA-registered, US-licensed pharmacy partners rigorously test each Methylene Blue prescription for quality and efficacy, while liquid Methylene Blue drops often have questionable purity without sufficient medical oversight. Capsules also remove the risk of teeth or tongue staining and limit the bitter taste of Methylene Blue solution.
Will Methylene Blue capsules stain my teeth?
Nope! Unlike Methylene Blue drops, capsules protect your teeth from discoloration. However, you should still expect the medication to turn your urine blue, which is a known and harmless side effect.
When encapsulated, the Methylene Blue solution doesn’t come into direct contact with your teeth, tongue, cheeks, or any part of your mouth—it’s swallowed whole so it can be more easily absorbed.
But capsules only protect from discoloration if they remain intact. If you break the capsule, the medication will likely stain anything it comes into contact with. Avoid chewing or separating your Methylene Blue capsules.
I broke my Methylene Blue capsules, how do I remove the stain?
If you chewed your capsule and it stained your mouth, tongue, or teeth, try swishing your mouth with lemon juice or vinegar water for 30 seconds, then rinsing. Repeat this step several times if necessary. You should also stay hydrated and drink as much water as possible.
If Methylene Blue stains your skin or clothes, try scrubbing with the same lemon juice or vinegar water solution, or using a full-strength, skin-safe detergent. You can remove Methylene Blue from objects or surfaces with most commercial stain removers.
Please note that there is no reliable method to reduce the appearance of blue urine after taking Methylene Blue. In most cases, urine will not clear until 2-6 hours after your last dose, or up to 24 hours.