Sermorelin Nasal Spray Product Guide

Before you begin

First things first. Get the bottle into the refrigerator as soon as it reaches you, between 36°F and 46°F, away from direct light and heat.

What follows is our official Sermorelin Nasal Spray protocol, in the order you’ll need it. Always follow your personalized plan set by your provider for specific details.

Sermorelin is a growth hormone releasing hormone analog: it’s understood to prompt the pituitary gland to release more of the body’s own growth hormone, which is why timing matters as much as size. The nasal form is taken at night, when the pituitary is most active, and at least 2 hours after your last meal so digestion isn’t competing with absorption. 5x weekly, one spray in each nostril, on the schedule your care team sets.

There is nothing to mix, draw up, or inject: prime, spray, wipe the nozzle, and back in the fridge. What people notice, and how soon, varies a great deal from person to person, and no result is guaranteed. The FDA has not approved or reviewed Sermorelin for safety, efficacy, quality, or for any use, including the AgelessRx compounded product. Read the short safety list below before your first dose.

You’re making a great choice

Feeling uncertain before a first dose is normal. Here’s what the science says Sermorelin may support.

Sleep quality

The body releases most of its growth hormone during deep sleep, and Sermorelin is dosed at night to work with that rhythm.

Recovery

Growth hormone is part of how tissue repairs itself. Some people tell us they bounce back faster, others notice nothing.

Mental clarity

Research has looked at focus, problem solving and memory in older adults taking Sermorelin. Any change may build with use over time.

Needle-free

The nasal form is the same peptide without a syringe or sharps container.

Results vary, and Sermorelin has not been approved by the FDA for these or any uses.

Read first: safety

Most people tolerate Sermorelin Nasal Spray without much trouble, but a few reactions mean you should stop and check in. Keep this short list somewhere you will see it before each dose.

Stop and seek help if you experience:

Shortness of breath or wheezing after a dose.
Swelling around your face, lips, tongue, or throat.
Hives, or a rash spreading across the body.

If symptoms are severe, call emergency services (911). For milder but persistent concerns, contact your care team before your next dose.

This is normal

A brief burning or stinging as you spray is commonly reported, along with a post-nasal trickle, congestion, facial flushing, a mild headache, or some nausea in the first weeks (full list under Side effects below). These are usually mild and settle within a week or two. Aiming away from the center wall of the nose and breathing in gently both help.

Your nightly dose

↑1 + 1

One spray in each nostril, 5x weekly, at night and at least 2 hours after your last meal. That is roughly 200 to 300 mcg per nightly dose. If you’re ever unsure, just ask your care team.

About your shipment

If your order arrives warm

Get your Sermorelin Nasal Spray into the refrigerator as soon as you bring it in. Sermorelin Nasal Spray must sit between 36°F and 46°F; time outside that range may make it ineffective. There isn’t one set number of hours that automatically makes a warm bottle unusable. If you’re unsure, message your care team before using it.

Do not assume a warm delivery is fine

If your box arrived hot, the ice packs were fully melted, or it sat outside for hours, do not use it and do not throw it away. Photograph the box and ice packs, message your care team with roughly how long it sat, and let them decide whether to keep going or replace it.

Storing between doses

Keep the bottle in the fridge between doses, 36°F to 46°F, away from direct light and heat, and never freeze it. Put it back promptly after each dose.

Use it by the date on your storage instructions

A compounded nasal spray carries a beyond use date set by the pharmacy that made it. That date is printed on the storage instructions packed with your prescription, and it is the one to go by. If the date has passed, or you can’t find it, message your care team.

There is nothing to mix

Your Sermorelin Nasal Spray arrives as a ready-to-use liquid in a metered pump bottle: no reconstitution, no syringe in the box. If it looks like a dry powder, or the bottle is cracked or leaking, stop and message your care team.

Dosing

Sermorelin Nasal Spray has one simple routine: one spray in each nostril, 5x weekly. Timing matters as much as the dose itself, so take nightly at least 2 hours after your last meal. Always follow the specific dose your provider prescribed and the directions on your prescription label.

Finding your dose

Read the instructions on your medication label carefully before your first dose, and check again if anything changes.

Step	Dose each night	How often
Weeks 1+	1x spray in each nostril (approximately 200 to 300 mcg per dose)	5x weekly, at night, at least 2 hours after your last meal. The two nights off are yours to place.
If your label differs	Whatever your prescription label says	Your care team’s instructions always come first.

Please don’t go higher than this

More sprays do not necessarily mean better results, and taking more than prescribed can raise growth hormone beyond the intended range. If you feel like the treatment isn’t meeting your goals, contact your care team rather than changing the dose yourself.

Missed a dose?

Take it as soon as you remember that night. If it’s almost time for your next dose, or more than a day has passed, skip the missed dose and resume on schedule. Never double up.

How often, and when

You can choose which two nights you take off. Pick a pattern that’s easy to remember and try to keep it consistent. Take your dose around the same time each night, with one spray in each nostril—never two in one nostril.

Your bottle

The label carries the product name and the bottle volume, 5 mL, not a milligram concentration: your dose is written in sprays, which is what the pump measures accurately. For the exact concentration on your prescription, message your care team.

How often you dose	Sprays each night	Adds up to per week	Your bottle
5x weekly	2, one per nostril	10 sprays	One 5 mL bottle

On the standard routine, one bottle lasts about five weeks. If unopened bottles start piling up, you may want to adjust your refill schedule so they don’t pass their beyond-use date. If a bottle runs out sooner than expected or the pump stops delivering a full spray, message your care team.

Ramp-up timeline

Night 1

Prime the new bottle, then take your first dose.

A brand new bottle has air in the pump, so it’s primed into a tissue first, then one spray in each nostril. A brief burn is commonly reported and isn’t a reason to stop.

Week 1

Settle the routine, five nights on and two off.

Mild side effects are most likely now. Pick your two off nights and keep them in the same place each week.

Weeks 2 to 4

Hold steady, with no changes to the amount.

If early side effects aren’t settling, message your care team.

Ongoing

Maintain and monitor.

Stay on your prescribed routine as benefits take time to build. Not hitting your goals, or restarting after a break? Contact your care team first.

What you’ll need

Set up somewhere clean and well lit, and wash your hands with warm, soapy water before you handle the bottle.

Your Sermorelin Nasal Spray bottle, straight from the fridge
A few clean tissues, for priming and for wiping the nozzle
Your prescription label, to confirm tonight’s dose
A mirror, helpful the first few nights

Take the chill off

A cold spray is more startling than a room-temperature one. Take the bottle out a couple of minutes before dosing, then put it straight back. Don’t warm it under hot water or leave it out.

Prime your spray

A metered pump measures the dose for you, which is why your instruction is written in sprays instead of milliliters. It can’t push medication through a barrel full of air, so a brand new bottle is primed first, about twenty seconds, only when a bottle is new.

Wash your hands

Wash thoroughly with warm, soapy water and dry with a clean towel before you touch the bottle.

Check tonight’s dose

Read the prescription label: sprays per nostril and nights per week.

Gently blow your nose

Clear the passageway of any mucus before you dose, gently.

Shake gently, then take the cap off

Give the bottle a gentle shake, then remove the cap and keep it somewhere clean.

Prime a new bottle into a tissue

Point the nozzle away from your face, into a tissue, and press until an even mist comes out rather than a spit or a dribble, usually a few pumps. Those priming sprays are discarded; they aren’t your dose.

An unprimed pump delivers less than a full dose on the first press.

You do not re-prime every night

Once a bottle is in daily use it stays primed. If it has sat unused a while, or the first press feels like nothing came out, prime into a tissue again.

Using your spray

The goal is to get the mist onto the outer lining of the nose, rather than directly onto the center wall. Take your time the first few nights. The technique gets easy quickly.

Tilt your head slightly forward

Not tipped back. Tipping back is the most common reason a dose ends up as a mouthful of post-nasal drip.

Close one nostril

Press a finger gently against one nostril to close it, and work the other side first.

Insert the nozzle and aim it outward

Insert the tip a quarter to half an inch, aiming towards the back of your head and slightly outward. Avoid the center septum, the thin wall between your nostrils; spraying against it causes irritation and nosebleeds.

Breathe in slowly as you press

Breathing in gently through your nose, press the pump down once, a single firm push, one spray only. A hard sniff pulls the mist down the throat, which is where the burning and drip come from.

Repeat in the other nostril

Swap fingers, close the first nostril, and take your second spray the same way. That’s your full nightly dose.

Do not blow your nose afterwards

Avoid sneezing or blowing your nose for a few minutes after a dose, it clears the medication before it can absorb.

Both nostrils, every night

The dose is simply split across both nostrils, one spray each, every night.

Alternate which side goes first each night (left on odd nights, right on even, or just switch from wherever you finished), since the first side tends to get the more careful technique.
Blocked on one side? Blow your nose gently and try again. If a nostril is too congested or sore to dose into, message your care team.
If you also take another AgelessRx nasal spray, do not stack them into the same nostril back to back. Ask your care team how to space them.

After you spray

Leave your nose alone for a few minutes. A post-nasal trickle is commonly reported and is not a sign the dose was wasted.
Wipe the nozzle with a clean tissue after every dose, then cap it. Do not rinse it or poke anything into it.
Back in the fridge, promptly, at 36°F to 46°F, away from direct light. Leaving it out overnight is the single most common storage slip on a bedtime medication.
Keep it to yourself. Never let anyone else use your Sermorelin Nasal Spray, even within a household.
Log your dose and how you slept, in one line, so the conversation with your provider is easier than remembering six weeks back.

There are no sharps to dispose of. When a bottle is finished or past its beyond use date, discard it with household medicines per local guidance, or ask your pharmacy about take-back options.

Your dosing at a glance

The full Sermorelin Nasal Spray protocol in one view. Your prescription label is always the authority, and your care team can adjust any of this to fit you.

〰Nightly dose: 1x spray in each nostril, 2x sprays in total

◎Priming: a new bottle is primed into a tissue before its first dose, then not again in daily use

♡Frequency: 5x weekly, at night, at least 2 hours after your last meal

≈Never exceed: the number of sprays printed on your prescription label. No self-increases.

⌄Storage: refrigerate at 36°F to 46°F, away from light, never frozen; use by the beyond use date on your storage instructions

Message your care team ›

Signals to adjust your dose

Sermorelin Nasal Spray isn’t something you adjust based on how you feel from night to night.

Tolerating it well and sleeping through? Keep the routine exactly as it is.

Burning more than brief, a sore nose the next day, or a nosebleed? Check your angle, stop dosing that nostril if it bled, and message your care team.

Hives, a spreading rash, wheezing, swelling of the face or throat, or a racing heart? Stop and seek emergency care.

Message your care team ›

Safety and interactions

Do not use Sermorelin Nasal Spray if any apply

Under 30 years of age
Pregnant, breastfeeding, or planning to become pregnant or breastfeed
Active cancer, or any cancer within the last two years
Moderate to severe liver dysfunction
Moderate to severe kidney disease
Untreated hypothyroidism
Untreated hyperglycemia or diabetes

Talk to your provider first if any apply

Hypothyroidism, left untreated: can impair the growth hormone response, so your care team may ask you to show it is treated first.
Hyperglycemia or diabetes, left untreated: Sermorelin may further impair glycemic control, so your care team may ask you to show it is managed before you start.
Pregnancy during treatment. Consult your care team before your next dose if you become pregnant.
A known allergy to Sermorelin or other GHRH analogs.

Drug interactions

Sermorelin nasal spray has no known major drug interactions, but may interact with several classes of medication. Tell your care team everything you take, including supplements.

Glucocorticoids such as prednisone. May blunt growth hormone release; mention any course, including a short one.
Oral estrogens. May increase IGF-1 resistance, the marker a provider watches to judge response.
Insulin or sulfonylureas. May alter glycemic control, especially if already treated for blood sugar.
Somatostatin analogs. May antagonize what Sermorelin is meant to do.
Dopamine antagonists. May disrupt how growth hormone release is regulated.
GABAergic medications. May reduce the pulsatility of growth hormone release.
Beta blockers such as metoprolol or propranolol. May reduce how effective Sermorelin is.
Other secretagogues or peptides. May stack up to unsafe levels of growth hormone, never a do-it-yourself decision. Bring your full medication list, including anything else by nasal spray or injection, to your care team first.

Side effects

What most people notice is local and brief: a burn as the spray goes in, and a trickle down the back of the throat afterwards. Aiming away from the septum and breathing in gently rather than sniffing hard is the best prevention for both.

Common

Burning during administration
Post-nasal drip to the throat
Congestion
Face or neck flushing
Headache
Nausea

Less common

Nosebleed, usually from spraying against the septum
Soreness or irritation inside the nose that lasts beyond the dose

Rare

Allergic reaction, including shortness of breath or swelling around the face, tongue or throat

Side effects are most likely in the first weeks. If mild, keep the routine and let them settle. If they worsen or become severe, stop and contact your provider. For the emergency allergic-reaction signs, see Read first: safety above.

Troubleshooting

My package arrived hot, or I left the bottle out

Refrigerate it right away, don’t throw it away, and message your care team before your next dose (see About your shipment above). If it was a shipment, photograph the box and ice packs and tell them roughly how long it sat, so they can decide whether to keep going or replace it.

My bottle drips instead of spraying, or nothing comes out

Take the cap off, point it into a tissue, and prime it again with a few firm presses, this often fixes a pump that’s sat unused or was never primed. If it still dribbles, don’t poke the nozzle or decant the liquid. Message your care team for a replacement.

It burns or stings every time I spray

A brief burn is a known side effect. Check your technique (see Using your spray above) and try taking the bottle out of the fridge a couple of minutes early. If it’s still more than mild after a couple of weeks, hold your routine and message your care team.

I sneezed, or blew my nose, right after a dose

Don’t re-dose to make up for it. Carry on with your normal schedule the next night, and mention it if it keeps happening.

My nose is blocked with a cold

Blow your nose gently and try again. If a nostril is too blocked or sore to dose into, don’t put both sprays into the clear side. Message your care team and ask whether to skip the dose or pause.

Questions? We’re here

Your care team can help with dosing questions, side effects, a bottle that will not spray, a shipment that arrived warm, or anything that simply does not feel right. Reach out any time before your next dose.

Message your care team ›

Frequently asked questions

How much Sermorelin is in my bottle, and how long will it last?

See Dosing above for the bottle label, the dose-in-sprays explanation, and how long a bottle lasts.

Why at night, and why on an empty stomach?

The pituitary releases most growth hormone during sleep, so dosing at night works with that cycle. Food, and the insulin response that follows, can work against absorption, hence the 2-hour gap.

How long until I notice something?

Sermorelin nudges your own pituitary instead of delivering an effect directly, so nothing happens the way a stimulant does. Sleep is what people most often mention first, sometimes within a few weeks, though that’s anecdotal. Recovery, body composition, or mental clarity would build over months and vary by person, and results aren’t guaranteed. If you’re not hitting your goals, contact your care team.

Can I take it alongside NAD+ nasal spray, other peptides, or a GLP-1?

Ask your care team before you add anything (see Drug interactions above). If prescribed a second nasal spray, don’t take them back to back into the same nostril; ask your care team how to space them. Testosterone, vitamin injections and weight-loss medications aren’t on our interaction list, which isn’t the same as being cleared, so tell your provider about them too.

What is the difference between the nasal spray and the injection?

Same peptide, different route, prescribed separately: the nasal spray is a metered pump, the injection is drawn from a vial and given under the skin on its own titration schedule. Doses, schedules, and storage rules aren’t interchangeable; follow the instructions for the one in front of you.

Who should not use Sermorelin Nasal Spray?

See Safety and interactions above for the full list, including the age-30 minimum, pregnancy and cancer exclusions, and the conditions your care team needs to see treated first. If you have other health conditions or take prescription medications, check with your AgelessRx provider before you start.

Can I travel with Sermorelin Nasal Spray?

Yes, as long as you keep it refrigerated. Use a temperature-controlled storage container to maintain 36°F to 46°F throughout your trip.

References and support

About Sermorelin Nasal Spray ›

Take Sermorelin Nasal Spray at night, on an empty stomach, at least 2 hours after your last meal, 5x weekly, one spray in each nostril.
Prime a new bottle into a tissue before its first dose. Aim away from the center septum, breathe in gently instead of sniffing hard, and avoid blowing your nose for a few minutes afterward.
Missed a dose? See Dosing above: take it that night if you remember in time, otherwise skip it and resume on schedule, without doubling up.
Store the bottle at 36°F to 46°F, away from direct light, and never freeze it. Time outside that range may make it ineffective, so message your care team. The beyond use date is on the storage instructions packed with your prescription.
Questions about your dose, a bottle that will not spray, or restarting after a break? Contact your care team before making any change to your routine.
This guide is not a substitute for personal medical advice. Always consult your provider before changing your dose or routine.

This guide is for general educational purposes and does not replace personalized medical advice. Always follow the instructions from your AgelessRx provider and the dosing on your prescription. If you experience a medical emergency, call 911. The FDA has not approved or reviewed Sermorelin for safety, efficacy, quality, or for any use, including the AgelessRx compounded product. This product is not intended to diagnose, treat, cure, or prevent any disease.