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Targets a number of aging-related mechanisms, and has demonstrated protective effects against several age-related diseases.

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Metformin Benefits

Metformin Benefits

Do More, Age Less

  • Activates longevity pathways
  • May lower risk of colon & pancreatic cancer
  • May reduce risk of cognitive impairment & dementia
  • May reduce risk of macrovascular disease
  • Facilitates weight loss 
  • Reduces chance of diabetes

Metformin has not been approved by the FDA for these uses, but there are multiple studies that have shown these benefits.

See The Longevity Science


Background & History

  • Derived from natural compounds in the French Lilac plant
  • Used successfully for 60+ years with an outstanding safety record
  • Listed on World of Health’s Essential Medicines, a catalog of the most effective, safe & cost-effective therapies for diabetes
  • Used to treat diabetes since the Middle Ages
  • FDA approved to treat diabetes
  • Read more on our Metformin Blog
Metformin Background & History
Aging Pathways

Aging Pathways Impacted

  • Genomic Instability
  • Epigenetic Alteration
  • Deregulated Nutrient Sensing
  • Cellular Senescence
Learn About Aging Pathways

What Our Metformin Users
Are Saying

The process for my Metformin prescription was easy, answering appropriate health questions… AgelessRx has become an import cog in my health endeavors. Their Customer Service is friendly and punctual with any questions.

67 Year Old Male Topeka, KS

This company makes it simple and user friendly to understand the options available and how those options could benefit your life. If you have any questions – they have a great team that is happy to speak to you (and they are super nice)! It is a win win.

35 Year Old Male Holts Summit, MO

AgelessRx provides great service and prices. Their website is very easy to use. I am very happy to have found them and will recommend them to my friends.

52 Year Old Female Virginia Beach, VA

Your individual results might differ from the above testimonials

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$25 / month billed $75 quarterly | shipped quarterly
  • 3-month supply per shipment
  • 1,000mg/day or as prescribed

  • Extended Release (ER) version

  • Lab tested for purity (read more)

  • Free shipping

CODE MET20$20 off first quarter & FREE medical evaluation

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Doctor may recommend
a different dose during medical intake process

You can request daily dose adjustments between refills

You will be automatically billed & sent refills based on your plan

You can pause or cancel at any time before your next shipment

* Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See below for important safety information. Benefits outlined on are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.

101 Video


How often do I take Metformin?

You will take Metformin daily with a meal. To start, you will take ½ or 1 tablet daily and slowly ramp up to the prescribed dose.

Is this safe to take with other prescription medications?

Generally, yes. Metformin is one of the safest prescriptions and commonly prescribed, however, a doctor will review your health history and current medications to see if it is appropriate.

What do I do if I lose my pills?

Contact AgelessRx to order an interim shipment or move up your next refill date.

See all FAQs


Most people start with a small dose to avoid stomach discomfort (½ or 1 tablet per day with food, slowly increasing to what has been prescribed). AgelessRx prescribes the Extended Release (ER) version to reduce stomach discomfort.

Note: Metformin is commonly stopped a week before any surgical procedure or medical diagnostic requiring contrast, such as a CT scan.  If you are unsure, please ask the doctor ordering the test or procedure.

Most Common Metformin Side Effects

  • Gastrointestinal discomfort (diarrhea, nausea, bloating)
    Check out this blog for tips on how to combat Metformin gut woes
  • Reduction of Vitamin B12 levels
    AgelessRx recommends you supplement with Vitamin B12

For a full list of possible side effects, click here.

Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.