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Low Dose Naltrexone

  • Pill

A common treatment for recovery, low doses of Naltrexone may also help reduce inflammation, lower fatigue, increase endorphin levels, and improve immunity.

Starting at $35

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LDN Benefits


Do more, age less

  • Modulates the immune system
  • Increases endorphin levels up to 3x
  • Lowers markers of inflammation in the body
  • May reduce fatigue
  • Clinical evidence in reducing chronic pain
  • Encourages weight loss

Low Dose Naltrexone has not been approved by the FDA for these uses, but there are multiple studies that have shown these benefits.

See the Longevity Science


Background and history

  • Prescribed for 40+ years with outstanding safety record
  • FDA approved to treat opiate dependencies and obesity
  • Dosages below 10mg/day are considered “Low Dose Naltrexone” (LDN)—4.5mg/day is the most common
  • Exhibits novel and paradoxical effects for a variety of conditions
  • Used to treat autoimmune diseases and viral infections since 1985
  • Explore which starting dose is right for you
  • Read more on our LDN Blog or What is LDN?
LDN Background and History
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Aging pathways impacted

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What our LDN users are saying

Great company. Answered all my questions and product was delivered on time!

42 Year Old FemaleCastle Pines, CO

This company is amazing! From first consult to me receiving the medication was EXTREMELY quick and painless. The customer service is top notch and answer immediately and are extremely friendly. I would highly recommend this company they are extremely professional, quick, and courteous.

27 Year Old MalePeabody, MA

AgelessRx is great. Fast, and simple! My meds came in the mail and they keep in touch with me to make sure everything is good. Hassle free experience.

55 Year Old MaleLas Vegas, NV
LDN Research Trust 2023 Member

Your individual results might differ from the above testimonials

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Quarterly Monthly
Quarterly 1.5mg Protocol
$35 / month billed $105 quarterly | free shipping
  • 1.5mg strength capsules

  • Standard titration process

  • Ramp up to 4.5mg daily dose or as prescribed

  • 3-month supply

CODE LDN20$20 off first quarter & FREE medical evaluation

Quarterly 0.5mg Protocol
$35 / month billed $105 quarterly | free shipping
  • 0.5mg strength capsules

  • Slower titration process

  • Ramp up to 4.5mg daily dose or as prescribed

  • 3-month supply

CODE LDN20$20 off first quarter & FREE medical evaluation

Monthly 1.5mg Protocol
$45 / month billed monthly | free shipping
  • 1.5mg strength capsules
  • Standard titration process
  • Ramp up to 4.5mg daily dose or as prescribed
  • 1-month supply

Doctor may recommend
a different dose during medical intake process

You can request daily dose adjustments between refills

You will be automatically billed & sent refills based on your plan

You can pause or cancel at any time before your next shipment

* Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See below for important safety information. Benefits outlined on are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.

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How often do I take Low Dose Naltrexone – LDN?

You will always take your LDN dose every night before bedtime (between 9pm and 2am). To start, you will take 1 capsule (0.5mg or 1.5mg), and slowly ramp up to the target dose (3.0mg or 4.5mg).

How can I monitor my response to LDN?

In the short term, patients report an improvement or reduction of symptoms related to inflammation and rampant oxidative stress, such as joint pain, back pain, fatigue, weight gain, and more.

What form of LDN will I receive?

AgelessRx provides LDN in capsule form with sucrose as the standard filler.

If you are taking LDN for the first time, you will start out with a lower dose (0.5mg or 1.5mg) and slowly work up to the prescribed dose (3.0mg or 4.5mg) over a 20-day to 3-month period, depending on your titration schedule.

See all FAQs

Important safety information and common side effects

When starting LDN, you may experience mild to moderate levels of the below-listed side effects during the first 3 to 5 days. These typically diminish on their own as your body adjusts to the medication, usually by the fifth day.

If you are on thyroid medication, you may need to monitor your thyroid levels more closely as you start LDN. IF you develop symptoms of hyperthyroidism while taking LDN, such as heart racing, increased anxiety, restlessness, or trouble sleeping, please stop LDN and talk to the prescriber for your thyroid medication.

Note: You MUST stop taking LDN at least 48 hours before any surgical or diagnostic procedure requiring sedation. If you’re scheduled for a procedure and not sure whether you should stop taking LDN, please ask the doctor ordering the test or procedure. Additionally, you CANNOT resume LDN until at least 48 hours after you have finished any prescribed medication for the procedure.

Most common LDN side effects

  • Vivid dreams
  • Mild anxiety
  • Insomnia
  • Headache

For a full list of possible side effects, click here.

Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.