2 Weeks
B12 is getting into cells and rewiring the way genes are expressed, influencing cellular metabolism, energy production, and repair.5
Energy & Fatigue
B12 Injection Rx
Boost energy, improve focus, and fight fatigue with one of the most efficient ways to restore B12 levels that naturally decline with age, delivering more reliable results than supplements.
Starting at
$65
/mo
- One-Time, Monthly, and 3-mo plans
- Starting price applies to 3-mo plan
- Unlimited provider messaging
- Pause or cancel anytime
93% saw noticeable benefits by 3rd check-in
Supports memory, focus, and long-term brain health² ⁴
Bypass digestion for 3–10x absorption than supplements¹² ¹³
HSA / FSA
Ongoing, expert support
Free, discreet shipping
100% online
Frequently asked questions
Why should I choose B12 Injection over an OTC supplement?
Injections have better bioavailability than oral supplements as they bypass the digestive system completely, providing a direct supply of B12 into the bloodstream to fuel your body. Oral supplements might work for some, however, as we age, our ability to absorb orally delivered B12 often decreases.
How much B12 is administered per injection?
The solution contains 1000mcg of B12 per ml/cc.
How often do I administer B12 Injections?
Start by injecting 1ml/cc per injection once per week. If you feel you’re not getting your expected results, please contact your provider.
What are the benefits of regular B12 shots?
B12 shots may help support more than just daily energy levels. Maintaining healthy B12 levels may also support cognitive function, vision health, and lower risk for age-related conditions like osteoporosis, macular degeneration, and cardiovascular disease. B12 shots also may help promote better sleep alongside healthier skin and nails.
Usage Instructions
View all FAQs
B12 Injections are self-injected 1-2 times per week, with or without food, according to your provider-guided titration schedule. If prescribed, a US-licensed medical provider will provide a tailored dosage schedule and specific treatment instructions with your care plan.
Important safety information and common side effects
The most common side effect of B12 Injections is irritation at the injection site. If this occurs, consider changing placement on the body or use injections less often.
For a complete list of possible side effects, click here.
Do not use B12 Injections if you are currently pregnant, breastfeeding, or plan to become pregnant or breastfeed.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality.
How B12 Injections work differently
The body becomes less efficient with time at absorbing B12 from food and supplements, making it harder to keep optimal levels for energy, mental clarity, and recovery.1 3 4 7
Standard supplements can lose most of their B12 during digestion. Injections may bypass the digestive system for 3–10x greater absorption, potentially helping more B12 reach the body directly.12 13
Absorption of B12 comparing injections vs. supplements.12 13
3-10x
How B12 shots work
2 Months
As tissue regeneration and recovery improves, users may notice improved energy, strength, and endurance.1
3 Months
As brain cell signaling improves, users may experience improved mood, sharper clarity, and less fatigue.2 9
6 Months
Continued B12 optimization supports healthy nerve function, supporting memory, focus, and more restorative sleep.2 10 11
1 Year and Beyond
With consistent use, studies show users may notice lasting benefits, including sustained energy, recovery, and long-term cognitive health.7 10
2 Weeks
B12 is getting into cells and rewiring the way genes are expressed, influencing cellular metabolism, energy production, and repair.5
2 Months
As tissue regeneration and recovery improves, users may notice improved energy, strength, and endurance.1
3 Months
As brain cell signaling improves, users may experience improved mood, sharper clarity, and less fatigue.2 9
6 Months
Continued B12 optimization supports healthy nerve function, supporting memory, focus, and more restorative sleep.2 10 11
1 Year and Beyond
With consistent use, studies show users may notice lasting benefits, including sustained energy, recovery, and long-term cognitive health.7 10
Results you can feel
- 0
- reported noticeable benefits by second check-in
- 0
- reported less fatigue
- 0
- felt more energized
- 0
- reported better mental clarity
Actual results may vary. Data was self-reported by 1,041 surveyed customers who checked in with their provider between first and second check-in dates between 3/1/25 – 2/1/26. All respondents are AgelessRx customers who were approved for a prescription after completing an assessment with a medical provider.
Raising the B12 care standard
With almost 25,000 B12 users supported, peer-reviewed research, and one of the largest real-world datasets in longevity care, our Stanford PhD-led protocols are built to a higher standard.
Guided by peer-reviewed research and overseen by our in-house Stanford PhD-led Research Team
Protocols continuously refined using real-world user data at no additional cost
Prescription-grade B12 compounded by LegitScript-certified pharmacies
Clinically studied
The science of B12
First introduced in the 1950s, B12 Injections have a long-standing record of safety and efficacy in treating deficiency, improving cognitive function, and reducing inflammation.3 7 12
B12 may support mitochondrial energy production, oxygen delivery, and neurological signaling—all of which helps support brain health and energy.8 Studies have linked optimal B12 levels with improved cognitive function, mood, and reduced risk of neurodegenerative disease.2 4 8
B12 may support mitochondrial energy production, oxygen delivery, and neurological signaling—all of which helps support brain health and energy.8 Studies have linked optimal B12 levels with improved cognitive function, mood, and reduced risk of neurodegenerative disease.2 4 8
How it works
Choosing how you age starts here
1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
2
Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy partner, rigorously inspected for quality, and shipped discreetly to your door.
3
100% online
Receive continuous support
Start with one goal, then keep building over time. With our in-house care team, unlimited provider messaging, easy refills, unlimited dosage adjustments, and 40+ science-backed plans, your care evolves with you.
Get Started
More options
Energy, personalized.
B12/MIC Injection
Support steady weight loss, restore energy, and promote healthy metabolism with a targeted blend of vitamin B12 and lipotropic nutrients tailored to enhance the body’s natural fat-burning systems.
Starting at $110/mo
NAD+ Injection
Boost energy, improve focus, and support cellular health with one of the most effective methods of restoring depleted NAD+ levels for a fraction of the cost of IV infusions.
Starting at $79/ mo
NAD+ Nasal Spray
Support mental clarity, focus, and cognitive energy with an easy, injection-free way to boost NAD+, designed to support brain pathways and sharper thinking on the go.
Starting at $125/ mo
Glutathione Injection
Support energy, immunity, cellular detox, and healthy skin by helping replenish the body’s master antioxidant that naturally declines with age.
Starting at $99/ mo
Low Dose Naltrexone
Unlike other treatments, works with the immune system to support a healthier inflammatory response, potentially helping with pain, energy, brain fog, and overall quality of life.
Starting at $25/ mo
Frequently asked questions
The most common side effect of B12 Injections is irritation at the injection site. If this occurs, consider changing placement on the body or use injections less often.
Do not use B12 Injections if you are currently pregnant, breastfeeding, or plan to become pregnant or breastfeed.
B12 Injections are administered subcutaneously into a fatty layer of skin. Recommended injection sites include the abdomen, outer thigh, or back of the upper arm. Rotating injection sites between doses may help reduce irritation at any single location.
B12 Injections should be stored in a cool, dry place away from direct light. Refrigeration is recommended but not required. Do not freeze. Once opened, use within the timeframe specified in your care instructions. Keep out of reach of children.
B12 Injections may be particularly beneficial for those with low energy, consistent fatigue, or low or suboptimal B12 levels, including older adults whose ability to absorb B12 from food and oral supplements naturally declines with age, individuals following plant-based diets, and those who have not responded well to oral B12 supplementation. A licensed provider will review your health history to determine whether B12 Injections are appropriate for you.
You had me at
peer-reviewed.
We vet everything on PubMed so you don’t have to. Here’s what the science says.