Frequently Asked Questions

We set ourselves apart with our commitment to patient outcomes. We start with the customer and work backwards, working to provide you expert guidance, ongoing support, personalized recommendations, and science-backed treatment plans.

We’re here to help you take control of your health with our comprehensive patient onboarding to fully understand your unique medical background and goals. With on-demand access to online visits with our base of US-licensed prescribers, they’ll work with you to help you understand the risks and benefits of longevity treatments and how they may help delay or prevent the onset of age-related disease.

Our platform is designed to give you healthcare on your terms with easy access to online doctor visits, 100% online prescription and refill requests, and expert-designed tools to show your progress, all from the comfort and privacy of your home. Each treatment that we offer is backed by the latest peer-reviewed scientific studies, and every prescription is fulfilled by a US-licensed pharmacy with numerous methods of quality assurance.

We also believe in transparency with education to side effects and the ability to pause or cancel your prescription at any time – no strings attached.

As your longevity journey continues, your expert medical team and dedicated customer support team will check in regularly on your progress to ensure that you’re hitting all your health goals and make any necessary adjustments to help you succeed.

At AgelessRx, we believe in the power of preventative healthcare, with a focus on not just how many years you live (lifespan), but the quality of those years (healthspan).

Our mission is to unlock the potential of human longevity by being the most trusted longevity platform, providing research-driven products to not only democratize awareness to promising longevity interventions, but to empower every person to take control of their healthspan. To do that, we provide the longevity tools and guidance you need so you can defy the gravity of aging and improve your quality of life for years to come.

To get started, you’ll complete an online medical intake form to gather information for the healthcare provider about your lifestyle, health habits, and medical history. Once you’ve completed your intake, our system will match you with a US-licensed medical provider who will review your unique medical history to see if your preferred treatment is right for you. Depending on your state, we may require a video consultation with one of our prescribers prior to approving your prescription.

If the provider determines that a prescription is appropriate for your unique medical history, we will work with one of our certified pharmacy partners to start your order. Allowing for a few days to ensure quality control, your prescription will be delivered to the address you provided in discreet packaging, free of charge.

If your provider has any concerns your requested prescription is not appropriate for you, they will work with you to find an alternative that’s a better fit for your unique medical background.

All our partner pharmacies are certified 503A compounding pharmacies, which requires strict FDA compliance requirements, including regular inspections of their facilities and products, while rigorously following state and federal regulations. Our partnering pharmacies choose to go above and beyond that to achieve voluntary certifications and accreditations, such as LegitScript certification, National Association of Boards of Pharmacy® (NABP®), and/or PCAB Accreditation.

Our pharmacy partners are all certified with their individual state pharmacy boards. As 503A compounding pharmacies, every compounded product is overseen by licensed pharmacists with specialty training for compounding. Each product is carefully tested for quality and efficacy by our pharmacy partners before it reaches your doorstep to ensure that you receive the safest, highest quality product possible.

Our Co-Founder and Chief Medical Officer, Dr. Sajad Zalzala, is a member of the American Telemedicine Association and board certified in all 50 states. Our expert medical team upholds the highest standards of telemedical care who undergo continued education and training to stay at the forefront of their expertise. All patients meet with a US-licensed prescriber who is certified to practice in their state.

Lastly, all our employees, from our medical team to our customer service team, are trained in HIPAA compliance to ensure the highest level of protection for our patients’ privacy.

We set ourselves apart with our dedicated commitment to patient outcomes.

Our comprehensive medical intakes ask each patient to provide their unique health history so our expert prescribers can provide hand-tailored guidance and ensure qualification for any prescription.

Unlike other telemedicine services, our medical support doesn’t stop after your purchase. Each patient has continuous access to their provider and customer support team, completely online to align with your schedule, with recurring check-ins to help you see your progress.

Our comprehensive approach to patient care is supported by scientifically rigorous, evidence-based insights and effectiveness studies. Our Applied Sciences department, with publications in top medical research journals, spearhead our own observational studies and randomized controlled trials, that allow us to optimize, personalize, and develop precision longevity intervention regimens and recommendations based on clinical effectiveness data we collect across treatments, biomarkers, and concerns. We continually seek to advance the longevity field by applying the latest cutting-edge science to our offering.

All medications offered on our platform are subject to the same FDA audit and quality controls as any pharmacy medication in the US Similar to your local pharmacy, medications may originate from the US or another country (this is especially common for generic drugs). All medications are dispensed and shipped from a certified US based pharmacy, subject to strict manufacturing and approval processes. All medication is purchased from a facility that is registered and inspected by the FDA.

We are serious about the safety of the products we offer and make every effort to ensure you receive the highest quality medications. Our products are evaluated by the same standards and approval processes that allow these and other medications to be sold at national pharmacies like Walgreens and CVS. If you would like to know more about where your products are manufactured or how they are dispensed, please do not hesitate to contact our team.

We partner with US-based licensed pharmacies that are 503A compounding pharmacies, which require strict FDA compliance, including undergoing regular inspections of their facilities and products while following state and federal regulations.

All our pharmacy partners go through rigorous quality assurance testing, sourcing from FDA-approved distributors, complying with state boards, and receiving a valid Certificate of Analysis (COA). Our pharmacy partners choose to go above and beyond, achieving voluntary certifications and accreditations, including LegitScript certification, National Association of Boards of Pharmacy® (NABP®), and/or PCAB Accreditation.

Every pharmacy we work with is 503A certified, meaning all compounding is overseen by licensed pharmacists with compounding-specific training.

Every pharmacy we work with is 503A certified, meaning all compounding is overseen by licensed pharmacists with compounding-specific training. All compounding takes place at a licensed pharmacy, complies with state boards, receives a valid Certificate of Analysis (COA), and is made at a FDA-registered facility.

All compounding products are produced in compliance with United States Pharmacopeia (USP) chapters or the National Formulary (NF) monograph to ensure patient safety and maintain drug quality and purity.

Most compounding pharmacies also function as a standard retail pharmacy. Some of the prescriptions we currently offer are only available through custom compounding (for example NAD+), whereas Metformin is a commercially available medication and does not need compounding. Our pharmacy partners source Metformin from the same manufacturers and wholesalers as all other pharmacies in the US, such as Walgreens or CVS.

We require your ID and selfie to verify your age and identity in order to be in compliance with certain regulations. Any personal information you provide us is stored on a HIPAA compliant server to protect your privacy. If you are not comfortable submitting your ID/Selfie online, please email us at info@agelessrx.com and we can accommodate alternative ways of ID verification (such as a quick video conference with a staff member).

For a small percentage of our patients (around 10%), in order to comply with state regulations, we ask them to book a video consultation with the prescriber. We identify these patients based on the address they provide and send them an email letting them know that their state requires a visual follow up. The consultation will be brief, as we have already collected all the information we need. There is no additional charge for the video consultation (it is already included in your price).

Yes! Each patient has on-demand, continuous access to their provider and customer support team, with recurring check-ins to help you see your progress. Your support team is also trained to provide personalized assistance across multiple, convenient communication channels including email, phone, and your secure patient portal.

We consider ourselves customer-obsessed, typically responding to messages in 1 business day. Our patients have rated their interactions 4.7 out of 5.0 across both medical and customer support consistently for over a year.

We reply to 100% of messages – negative or positive, even if you aren’t a current customer to give you any information you need to make the best decision for you. Plus, all our employees are trained in HIPAA-compliant customer service to always protect your privacy.

No, AgelessRx is a 100% online experience for a convenient and affordable experience.

All prescription requests are reviewed by a US-licensed medical professional to determine whether or not it is appropriate for you based on your unique medical history. Some states do require a synchronous consultation, which requires a medical professional and patient to speak in real time via phone or video.

Should this be required in your state, one of our medical professionals will complete a consultation with you via phone or video prior to determining if a prescription is appropriate. In states that allow for an asynchronous consultation (the majority of states), you and one of our medical professionals can correspond without having to speak by phone or video.

Your privacy and safety are our top priority. We prioritize the privacy of your data and comply with the latest safety regulations, storing all data on a HIPAA-compliant secure server. For more information, you can review our Privacy Policy here.

You can cancel or pause your subscription at any time prior to your next shipment. Simply login to your Customer Portal, click on “Orders”, then click “Manage” on any order you wish to modify.

At AgelessRx, you are free to cancel, postpone, or pause your subscription at any time (and for any reason) prior to your next shipment. If at all possible, we kindly ask for a minimum of 48 hours notice before your next order is set to process.

AgelessRx cannot guarantee refunds for any cancellation requests received after the pharmacy has processed your order. Furthermore, AgelessRx does not accept returns nor can we offer any refunds for any prescription product once it has left our pharmacy partner.

If you experience any issues with your shipment, or are dissatisfied with your product, please contact our team within 30 days following your order fulfillment. We will be more than happy to help make things right.

Login to your Customer Portal, click on the “Hello (Your Name)” menu, then “My Profile”. On the “My Info” row, click “Edit”, then save once you’ve updated your information.

To add a new payment method, login to your AgelessRx profile and click the “Orders” tab at the top of the page. Select the product you’d like to change your payment method, and select “Manage” at the right. The last 4 digits of your current payment method will be visible underneath the product details. Select “Update” next to it, then select “Add a Payment Method” on the next page to start entering your new payment details.

To edit an existing payment method, including changing your billing address, contact us at info@agelessrx.com.

When you login to your AgelessRx portal, you can view all your current and past orders by selecting the “Orders” tab at the top of the page. Your shipping information is indicated by the truck icon for each of your orders. To check your shipping status and tracking information, simply click the link next to the truck icon. We update tracking information for all orders as it becomes available to us, so if the text is not clickable, please wait and try again.

The process for placing a one-time order is no different than that for monthly or quarterly orders. For each one-time order, you will have to select “Buy Now,” complete a new intake, and wait for approval from your AgelessRx prescriber. There is no way to initiate recurring one-time orders; to avoid filling out multiple intake forms and going through repeated approvals, we recommend subscribing to monthly or quarterly orders.

We strive to time your refills automatically, so you’ll never have a lapse in treatment. If you find that you’re running low, you can always request a refill from your AgelessRx portal within 5-7 business days of your next billing cycle.

Yes, shipping is included on all the subscription products.

AgelessRx currently accepts HSA cards to pay for your order on our website. If your desired HSA card does not go through, please contact us and we will provide you with a receipt that you could use to get reimbursed from HSA/FSA plans.

Please note that AgelessRx products and services are not eligible for direct insurance coverage or reimbursement.

At AgelessRx, you are free to cancel, postpone, or pause your subscription at any time (and for any reason) prior to your next shipment. If at all possible, we kindly ask for a minimum of 48 hours notice before your next order is set to process.

AgelessRx cannot guarantee refunds for any cancellation requests received after the pharmacy has processed your order. Furthermore, AgelessRx does not accept returns nor guarantee refunds for any product once it has left the pharmacy.

If you experience any issues with your shipment, or are dissatisfied with your product, please contact our team within 30 days following your order fulfillment. We will be more than happy to help make things right.

Yes, we currently service every US state, but certain treatments may not be available in all states. Some treatments, such as cold-shipped injectables, cannot be reliably shipped to noncontiguous states like Alaska or Hawaii, while other treatments are restricted by regional law.

You can find the state-specific availability for each individual treatment underneath the “Get started” button on the treatment page. If you find that a particular treatment is not available in your state, our expert team can help you find an alternative that’s right for you.

Our money back guarantee only applies to your first fulfillment of select treatments, and only within 60 days of the delivery date of your first fulfillment.

To be eligible for a refund under the money back guarantee, you must meet the following terms and conditions:

• Have an active Metformin or Compounded Semaglutide subscription
• It must be within 60 days of your first fulfillment was delivered
• You must request the refund within the 60-day period
• You must have used the product consistently and as directed by your prescriber

All refunds will be returned to the payment method used to make the original purchase. The money back guarantee is limited to one refund per customer per eligible product.

Please be advised that the refund window does not restart with each subsequent fulfillment. Refund requests for subsequent fulfillments that occur outside of the first 60 days of your subscription will not be accepted. Any additional items from your order that are not covered by the money back guarantee are not eligible for a refund.

AgelessRx reserves the right to forfeit the money back guarantee if we suspect any abuse of this offer.

Metformin can cause a reduction in Vitamin B12 levels, perhaps by interfering with its absorption, or by some other mechanism. For this reason, patients on Metformin should either monitor their B12 levels or take extra B12 out of precaution. However, some studies suggest that there is no significant connection between B12 levels and Metformin.

Regardless of whether or not you take Metformin, it is important to maintain proper levels of Vitamin B12. For adults under age 65, the easiest way to get B12 is to take at least one 2,000mcg supplement each week, or a daily dose of 50mcg. 

As we age, our ability to absorb Vitamin B12 may decline. For those over 65 who eat plant-based diets, the supplementation should probably be increased up to 1,000mcg of B12 each day.

Gastrointestinal (stomach cramps, nausea, diarrhea) symptoms are the most commonly reported side effects and occur in about 5-10% of patients. Using the ER (extended release) version of Metformin helps reduce this down to 2-5%. However, patients with a higher target dose (>2000mg) may have a higher incidence of side effects. Starting with a smaller dose (1 tablet) and ramping up to 2 tablets per day may help prevent or reduce side effects. You can see the tips from our Chief Medical Officer, Dr. Z, on how to help with the gastro-related discomfort here.

Metformin is not thought to drop blood sugar to dangerously low levels, a condition known as hypoglycemia. However, some people tolerate lower levels of blood sugar than others. For this reason, Metformin might cause some patients to have symptoms of low blood sugar such as lightheadedness, nausea, and fatigue. Starting at a low dose and increasing slowly can help. In our experience, most patients with a history of hypoglycemia can tolerate lower doses of Metformin (500mg per day). 

If you run into any issues, or if you have any questions on Metformin, please contact us.

You might find it helpful to use a Continuous Glucose Monitor (CGM) to monitor your blood sugar levels for a few days. You can learn more about CGM here.

There are several reasons why patients experience hypoglycemia. However, in our experience, most patients with a history of hypoglycemia can tolerate lower doses of Metformin (500mg per day). Metformin is not known to abnormally drop blood sugar levels.

If you have any questions on Metformin and hypoglycemia, or are experiencing any issues, please contact us.

You might find it helpful to use a Continuous Glucose Monitor Sensor (CGM) to monitor your blood sugar levels for a few days. You can learn more about CGM here.

Significant lactic acidosis is almost never seen in patients who take appropriate doses and have properly functioning kidneys. Out of precaution, we ask that patients stop taking Metformin at least 3 days before going for any kind of medical procedure or imaging that requires contrast (such as a CT scan). Ask the physician doing the procedure or ordering a test about Metformin to be sure.

Patients taking higher doses of Metformin may be at greater risk of lactic acidosis if they have pre-existing kidney problems. For this reason, all patients taking Metformin at doses above 2000mg are asked to complete the Screening for Occult Renal Disease (SCORED) evaluation to assess their risk for kidney disease.

Serious side effects for Metformin are very rare, making it among one of the safest prescription medications that are commonly prescribed. However, it should not be used by anybody who has an allergy to Metformin; anyone who has poor kidney function; or diabetics who are poorly controlled (unless closely supervised by their local doctor). There are many situations where Metformin can be used, but with caution or at lower doses than typically prescribed. Our medical team takes all of these factors into account when reviewing requests for prescriptions.

Our Metformin tablets are subject to the same FDA audit and quality controls as any medicine you buy from any pharmacy in the U.S. As is common for most generic drugs, Metformin tablets may be sourced from the U.S. or another country. Regardless of origin, medication is always dispensed and shipped from a certified U.S.-based pharmacy. This means any shipment of Metformin that you receive has been subject to strict manufacturing and approval processes and purchased from a facility that is registered and inspected by the FDA.

We are serious about the safety of the products we offer and make every effort to ensure that you receive only the highest quality medications. Our products are evaluated by the same standards and undergo the same approval processes that allow Metformin and other medications to be sold at national pharmacies like Walgreens and CVS. If you would like to know more about where your products are manufactured or how they are dispensed, please do not hesitate to contact our team.

There is no agreed upon “optimal dosing” for longevity. Some longevity experts take and recommend 1000mg per day. Others recommend 1500mg per day. The TAME trial will be looking at 1500mg per day. Some health goals, such as weight loss support, may even require higher doses for you to achieve your desired outcomes, up to 2250mg per day.

Typical dosage consists of two 500mg extended release (ER) pills per day. However, your actual dosage will be determined by a licensed medical professional after taking into account multiple factors, including your medical history, drug interactions, and age, as well as your overall health goals.

Our medical staff will balance these factors to determine the best target dose for you.

You can take your Metformin tabs at the same time or apart, so long as you take your full dose within the same day. For example, if you’re prescribed two 500mg tabs per day, you can take them both at 5pm, or one at noon and the other at 5pm. Which you choose is purely a matter of preference; neither is more effective than the other. However, if you’re experiencing side effects, taking your tabs separately may help reduce discomfort.

The benefits of Metformin include lower blood sugar levels, more stable energy throughout the day, and better glucose and insulin sensitivity – all of which can reduce our risk for age-related diseases. But these benefits may be hard to feel in our day-to-day lives.

Fortunately, tools like a Continuous Glucose Monitor (CGM) can help patients see how Metformin decreases their blood sugar levels and glucose sensitivity. You can learn more about CGMs here.

Biological age testing can also help patients see if Metformin has helped slow down their biological aging, as compared to their chronological aging. You can learn more about biological age tests here.

Patients may be able to notice the following benefits on their own after several months of taking Metformin:

• Less appetite
• More stable energy throughout the day
• Better sleep

Patients may also experience weight loss while taking Metformin, but the best weight loss results occur after at least 6 months of use, and usually at higher doses (1500-2250mg). For patients interested in more pronounced weight loss benefits, contact us to see if increasing your dose is right for you.

To derive the biggest benefit from Metformin, studies indicate that it should be taken over an extended period. The longer a patient takes Metformin, the better it has been shown to “push back” diseases of aging, according to several research studies in both humans and lab animals (see our Metformin Science section). 

Some benefits from Metformin, such as reduced appetite and lowered blood sugar control, can be felt and appreciated relatively quickly (especially with the help of a CGM); many patients report feeling these benefits by the second check-in, or within 2-3 months.

Other benefits, such as reduced risk for cancer or heart disease, may never be “felt,” as these benefits are happening on a cellular level to prevent these conditions before they occur. In other words, we may never know that a tumor or blocked artery has been prevented if neither are able to develop.

Those taking Metformin primarily for weight loss benefits may have to take higher doses for a longer period of time. When dosing at 2 tabs per day (1000mg), some may not notice significant weight loss within the first 6 months. When taking higher doses (1500-2250mg), patients can lose 3-12lbs (or 5-7% of their body weight) within 6-12 months. Those with higher BMIs may experience higher ranges of weight loss more quickly. Some patients may experience the lower ranges of weight loss within 2-3 months, but this may not be true for everyone.

For patients interested in more pronounced weight loss benefits on Metformin, contact your prescriber to see if increasing your dose is right for you.

Some people cannot tolerate tablets and require liquid or topical versions. These are not currently available through AgelessRx.

Absolutely not! Our therapies are meant as an extra layer of protection. We strongly encourage our patients to adopt a healthy lifestyle, including leveraging such practices as intermittent fasting, physical activity, stress reduction, etc. It is also important to look at other potentially helpful factors, including dietary supplements like resveratrol, vitamin D, and/or B12.

If you’re curious how you can live a longer, healthier life, you might consider a Longevity Consultation to learn more about your specific needs/goals as you age.

No. Metformin is FDA approved for people with Type 2 diabetes mellitus. This is the on-label indication for Metformin.

However, like many medications, Metformin is used off-label for conditions such as PCOS, obesity, and cancer. Once the FDA has approved a medication for one use, a medical doctor can prescribe it in any way they see fit for their patient. Metformin has been approved by the FDA to be studied specifically for human longevity as part of the TAME trial that started in 2020.

First, Metformin benefits and its mechanism of action have been studied much more extensively than Berberine. Second, as Berberine is a supplement, quality control and potency are not nearly as strictly controlled as Metformin which is being distributed by a licensed, US-based pharmacy, subject to FDA and US Pharmacy Board audits and purity standards.  Third, there might be overlap between Metformin and Berberine, but they have different mechanisms of action and have different benefits.

Start with a small dose to avoid stomach discomfort (½ or 1 tablet per day with food). Over the next few days, see how your body responds to Metformin. If you do not notice any stomach discomfort, try to increase your dose to what has been prescribed on the bottle. If you do experience stomach discomfort, it should resolve within 2 weeks as your body adjusts to the medication, at which point you should increase to your prescribed dose.

Our default protocol is the extended release (ER) version of Metformin, which reduces stomach discomfort. You will receive more detailed instructions by email, once your order is approved.

Some benefits of Metformin can be seen and appreciated within the first few months. These include reduced appetite and lowered blood sugar, which can be easily measured at home with a Continuous Glucose Monitor (CGM), or at your next doctor visit. 

Other benefits of Metformin, such as weight loss, may take more time and require a dose adjustment with your prescriber. At the target dose of 2 tabs per day, many patients may not notice significant weight loss while taking Metformin. At higher doses (1500 – 2250mg), patients may lose 3-12lbs (or 5-7% of body weight) within 6-12 months. Contact us to see if increasing your dose is right for you.

Metformin achieves its primary benefits by working on our metabolism to improve our health and reduce our risk for disease from a cellular level – all of which goes beyond what can be seen or felt, which may make it difficult for some to appreciate the benefits of Metformin. See our Metformin Science page for more details on how Metformin works to slow down the aging process and what can be measured to verify this.

Our medical team will determine what dose is most appropriate for you based on a variety of factors. You can contact your prescriber at customer@agelessrx.com to explain why you’d like a dose change. Your request will be reviewed and, if deemed safe and appropriate, accommodated the next time your prescription is filled.

At this time, only Metformin tablets can be provided. Please inform your prescriber if you feel you can’t tolerate this form of Metformin.

That depends largely on what dosage you’re receiving and how long you take Metformin.

The most commonly prescribed dosage of Metformin is 2 tabs (1000mg) per day. At these doses, many patients won’t notice significant weight loss within 6-12 months. 

Studies that focus on doses between 1500mg and 2250mg per day have shown modest but consistent weight loss for patients. At these doses, patients may lose 3-12lbs (or 5-7% of their body weight) within 6-12 months. Patients may experience the lower ranges of weight loss within 2-3 months, while those with a higher BMI may achieve higher estimates of weight loss within a shorter period of time. Doses above 2000mg may also increase the incidence of side effects. 

Our experts typically recommend a target dose of 2250mg for the most optimal weight loss benefits, but this may vary depending on your unique health history. 

If you’re taking Metformin primarily for weight loss, contact us to see if increasing your dose is right for you. Adopting healthy lifestyle choices (such as regular exercise and a reduced calorie meal plan) may also help you achieve better weight loss outcomes while taking Metformin.

SCORED (Screening for Occult Renal Disease) is a clinical tool designed to help prescribers decide when to screen patients for renal insufficiency, or kidney problems. 

Those taking the SCORED test will be asked 11 questions, such as your age range and gender, and whether you’re diabetic. Checking “Yes” to any question generates a certain number of points. Any score between 0-3 indicates normal renal function with 99% accuracy. Any score of 4 or more indicates that renal screening is necessary to assess kidney function.

If your prescriber recommends Metformin at a dose over 2000mg, they will also ask that you complete the SCORED assessment. Patients who score a 4 or more may be asked to complete additional blood work.

Doses between 1500mg and 2250mg have shown the best weight loss results for Metformin, averaging at 3-12lbs, or 5-7% of your body weight. On these doses, some patients can experience the lower estimates of weight loss within 2-3 months, with the best outcomes occurring after 6-12 months of use. Patients with higher BMIs may experience better weight loss within a shorter time frame, but this may not be true for everyone.

Our experts typically recommend a target dose of 2250mg for patients taking Metformin primarily for weight loss, but your AgelessRx prescriber may recommend a different dose depending on your unique health history. Talk to your prescriber to see which dose is best for you.

When your body is dehydrated, your blood becomes more concentrated, which may increase the risk of side effects from Metformin. Be sure to drink plenty of water while taking Metformin to avoid dizziness, lightheadedness, and blurred vision, especially during the hot summer months. Aim for at least 8-10 glasses of water each day, and incorporate fruits and vegetables with high water content into your diet.

You will always start by taking 1 capsule at bedtime for the first 2 weeks. As your body adjusts to the medication, you will begin titrating to the target dose. Your titration schedule will vary slightly depending on whether you are receiving 0.5 mg capsules or 1.5 mg capsules.

For 0.5mg capsules, you will increase your dose by 1 capsule every 14 days for about 3 months, until you reach the target dose of 3.0mg, or 6 capsules. You will then begin receiving 1.5mg capsules and cap your dose at 4.5mg, or 3 capsules.

For 1.5mg capsules, you will increase your dose by 1 capsule every 10 days until you reach the target dose of 4.5mg, or 3 capsules.

However, not everyone finds these target doses most beneficial for them. Read our blog How to Find Your ‘Goldilocks’ LDN Dose to learn more about finding which particular dose is most beneficial to you.

Naltrexone binds to opioid receptors–which are found all over the body including immune cells. In doing so, it displaces the endorphins which would normally stay bound to these receptors. By binding to the opioid receptors, it displaces the body’s naturally produced Opioid Growth Factor. When using naltrexone at a low dose (hence LDN), the binding is temporary and causes the body to then up-regulate or increase the opioid receptors, thereby restoring the endorphin system and balancing the immune system.

Yes! Studies have shown that LDN is not only safe to take for individuals with a compromised immune system, but that it may actually help to improve the ability of the immune system to function. Individuals with autoimmune diseases or compromised immune systems typically have lower levels of endorphins than those without autoimmunity or a lowered immune response. Due to the increase of endorphins triggered by Low Dose Naltrexone, we believe that LDN is a safe and possibly helpful therapy for these individuals. See the Science Page for more information.

If you are having a hard time tolerating LDN, or fear you may as you begin your treatment, you may consider a slower ramp-up period or a lower daily dosage. Read our blog post for a ton of helpful information to remedy your tolerance of LDN.

If, at any time, you are unable to tolerate LDN, discontinue use or talk to a licensed medical professional ASAP.

In general, Low Dose Naltrexone should not be used by anyone taking opioids, such as Codeine, Hydrocodone, Fentanyl, Hydromorphone, Meperidine, Methadone, Morphine, Oxycodone, or Oxycontin. Because Naltrexone and prescription opioids bind to the opioid receptors, they can render one another ineffective–or worse, cause opioid withdrawal syndrome. LDN should be avoided in patients with significantly impaired kidney or liver function.

If you are on thyroid medication, you may need to monitor your thyroid levels more closely as you start LDN. If you develop symptoms of hyperthyroidism while taking LDN, such as heart racing, increased anxiety, restlessness, or trouble sleeping, please stop LDN and talk to your doctor who prescribes your thyroid medication.

Other conditions that require a modified protocol or require further consideration prior to use include:

• Lyme Disease or other Chronic Infections (EBV, CMS, Bebesosis, Borellia, etc.)
• Mast Cell Activation Syndrome/Disease (MCAS/MCAD)
• Ehlers Danlos Syndrome (EDS)
• Multiple chemical sensitivities or drug allergies (3 or more)
• Mold or black mold illness or exposure
• Mental illness (e.g. schizophrenia)

Most LDN side effects can be easily remedied and minimized by simply adjusting the dose. This is largely why we start new patients at a lower dosage and slowly ramp up to the prescribed dose.

If you’re taking 1.5 mg capsules, try slowing your titration schedule a bit or reducing the total number of capsules you’re taking at once. Another option is to reduce the frequency at which you take LDN – for example, taking it every other day or every third day may help your body adjust to a regular dose. You could also consider changing the time of day at which you take LDN; taking LDN in the morning or at night may help offset side effects such as sleep disturbance.

If you’re only taking a single 1.5 mg capsule and still find that the side effects are intolerable, we recommend switching to 0.5 mg capsules. This may be just the dose your body needs to allow it to adjust.

For more information on how to have the best experience with LDN, be sure to read our blog, Maximizing the Benefits of LDN.

The most widely studied LDN dose is 4.5mg, so the dose we commonly prescribe starts with a single 1.5mg capsule each night before bed, increasing by 1 capsule every 10 days until the target dose of 3 capsules is achieved.

We also offer 0.5mg capsules for those who have trouble tolerating larger doses. This ramp-up process is much slower, starting with a single capsule before bed and increasing by 1 capsule every 14 days until the target dose of 6 capsules is reached. At this point, the 0.5mg capsules will be replaced by 1.5mg capsules, and the target dose will increase to 4.5mg, or 3 capsules per night.

However, actual dosage will be determined by a licensed medical professional after taking into account multiple factors, including medical history, possible drug interactions, and the age of the patient.

In the short term, people often notice an improvement or reduction of symptoms related to inflammation and rampant oxidative stress. These symptoms will vary from person to person, but can include chronic flatulence, cramping, diarrhea, constipation, headache, joint pain, brain fog, muscle pain, fatigue, unexplained weight gain, lower back pain, skin issues/rashes, excessive mucus production, seasonal allergies, food sensitivities, trouble falling asleep, or trouble staying asleep.

To derive the biggest benefit from LDN studies indicate it should be taken over an extended period. The longer a patient takes LDN, the better it has been shown to “push back” diseases of aging, according to several research studies in both humans and lab animals (see our Science page).

Some benefits from LDN, such as increased energy and sleep quality and decreased pain, are realized relatively quickly, while others, such as cancer or heart disease reduction, may never be “felt” (i.e. you won’t know that tumors or blocked arteries have been prevented if they never develop).

We are serious about the safety of the products that we offer. Low Dose Naltrexone is compounded on site at a certified compounding pharmacy based in the USA, with materials supplied by the Professional Compounding Centers of America (PCCA).

If you are having trouble ramping up to your recommended dose, please contact us.

The solution may be as simple as switching to a lower dose of 0.5 mg capsules, or adjusting when you take your medication. We may also be able to adjust your current dose or recommend you to a partnering doctor for further evaluation. However, everyone reacts and adjusts to LDN differently, and there’s no copy/paste solution that works the same for everyone, so it’s important to explore solutions with a healthcare professional before attempting any on your own.

Unfortunately, no. AgelessRx does not work with patients with any active form of cancer. You may seek an alternative LDN telemedicine service, such as LDN Direct.

The short answer is “No.”

Naltrexone is FDA approved for obesity and the treatment of opioid and alcohol addiction- also known as the on-label indication. However, like many medications, naltrexone is used off-label for conditions such as Hashimoto’s, Crohn’s, Ulcerative Colitis, Ankylosing Spondylitis, PCOS, Type 2 Diabetes, Depression, anxiety, Fibromyalgia, Chronic Fatigue, MCAS/MCAD, ADHD, and many symptoms and conditions. Like with any medication, once the FDA has approved a medication for one use, a medical doctor can prescribe it in any way they see fit for their patient.

Absolutely not! Our therapies are meant as an extra layer of protection. We strongly encourage our patients to adopt a healthy lifestyle, including leveraging such practices as intermittent fasting, physical activity, stress reduction, etc.

If you are curious how you might live a longer, healthier life, you might consider a personalized Longevity Consultation.

NAD+ is not absorbed well through the intestines, and any that is absorbed is destroyed by the liver. The most effective methods of getting NAD+ into the body involve bypassing the intestines to deliver directly into the bloodstream, as is the case with our NAD+ injections. The next best method seems to be using iontophoresis patches that use a small battery-powered device to produce an electric current to drive the NAD+ under the skin and into the blood circulation.

The iontophoresis patches have a small battery operated device that facilitates the absorption of NAD+ through your skin into your bloodstream, and because of this mechanism the patches are considered a medical device and are only available by prescription.

There is no firmly established dosage for NAD+. Based on consensus from our scientific advisors, 400mg once a week of NAD+ was the optimal for an average AgelessRx customer (a 50 year old person), and was shown to increase NAD+ levels by up to 5x. Other people who are older or younger, or who might have other reasons for using NAD+ patches (for example, addiction therapy) might use patches more or less frequently than one time per week. If you use two patches at a time, or more than one time per week, the NAD+ boosting results compound.

There is no firmly established dosing for NAD+. Based on consensus from our scientific advisors, 400mg once a week of NAD+ was the optimal for an average AgelessRx customer (a 50 year old person), and was shown to increase NAD+ levels by up to 5x.

Depending on your age, how depleted your NAD+ levels are, and your objectives, you could use the patch more or less often than our default protocol of one time per week.

Our typical protocol is to use the patch once per week after loading it with the NAD+ solution (as shown in our educational videos), and wearing the patch for 4 hours. It is normal for the patch to not be completely dry after 4 hours.

NAD+ is essential for many functions, including DNA repair. You may or may not feel an immediately noticeable effect of better DNA repair; most of our customer who use the NAD+ Patches report some of the following benefits: improved energy, mental clarity, decreased cravings, better sleep, better mood, alleviation of depression/anxiety symptoms, faster recovery from illness and injury, as well as post workout recovery. This is not seen in all clients. As long as instructions for application are properly followed, the NAD+ will be absorbed into the body regardless of whether a person feels it or not, and will achieve higher NAD+ levels needed for better health and longevity. Depending on how depleted your NAD+ levels are you might need to build up your NAD+ level over a few weeks before noticing any benefits.

While using the patch, if you end up having excess niacinamide, your body will use a methylation process to eliminate the excess amounts. This methylation process creates a need for extra methyl donors, which is why we suggest supplementing with trimethylglycine (TMG also known as betaine), 1000mg on the days when the NAD patch is used. TMG is easily obtainable on Amazon or any other vitamin retailer.

The 4 hour patches have a battery that stops working after 4 hours. After that you can keep the patch on for a few more hours but absorption will be minimal.

Please refer to our visual demonstration.

The patch is a small adhesive bandage that you can place anywhere on your body. Upper arm is the most common placement, but it can be put wherever is most comfortable for you. When sticking the patch to your body, hold the entire patch in your open hand and apply in one motion.

To ensure it doesn’t come free, the adhesive used for the patch is quite strong. At the end of four hours, you can soak the patch for a few minutes with warm water to make the removal easier.

NAD+ has a tendency to be a different shade of yellow, depending on pH. For the iontophoresis solution, the pH is between 4 and 5. The closer the pH is to 4, the less yellow it will be. The closer the pH is to 5, the more yellow it will be. Our partner pharmacy has tested the solution at both ends of the pH, and the potency remains the same.

We have a number of clients who used NAD+ patches to help with addictions (tobacco, opioids, and other substance abuse), and have reported positive results. There is a lot of clinical evidence suggesting benefits of NAD+ for addiction treatment. This is not something we specialize in, but we are happy to accommodate your NAD+ patch orders for the purpose of addiction treatment.

A small percent of patients report a rash where they applied the patch. Please contact us for further advice.

Sometimes, it helps to apply the patch over a joint, such as the knees or wrists. It seems that skin on some parts of the body are more prone to develop rash than others.

For patient safety, our licensed prescribers generally caution the use of NAD+ for those with active cancer, as there are some unknown risks associated with NAD+ and cancer patients. We plan to stay up-to-date as new findings emerge on this and will continue to keep our patient’s wellbeing at the foundation of our decision making.

For those in remission or with a history of cancer, a U.S. licensed prescriber would review the intake form to determine whether or not it’s appropriate. If additional information is needed prior to approval, the reviewing prescriber would reach out.

You can use your NAD+ nasal spray 1-2x daily or as needed.

Your NAD+ Nasal Spray (14 ml bottle) contains enough solution for approximately 120 sprays.

You may feel a slight burn or sting when administering the nasal spray.

Most patients will feel effects within an hour.

Yes. Refrigeration may help preserve the potency of the NAD+.

You will draw up the prescribed amount with the provided insulin needle and syringe, then inject subcutaneously. The recommended dose of general health is to start out with 0.1ml and, as desired, slowly ramp up to 0.5ml (100mg) up to 3x per week.

Each 0.1ml (10 units) of solution equals 20mg of NAD+. As such, 0.1ml (10 Units) = 20mg NAD+, 0.25ml (25 Units) = 50mg of NAD+, and 0.5ml (50 Units) = 100mg of NAD+.

Ideally, the injection is administered into a fatty layer of skin, such as: back of arm, abdomen, or flank/lumbar region.

Each 0.1ml (10 units) of solution equals 20mg of NAD+. As such, 0.1ml (10 Units) = 20mg NAD+, 0.25ml (25 Units) = 50mg of NAD+, and 0.5ml (50 Units) = 100mg of NAD+.

Your NAD+ injection order will arrive with the following: one (1) 5ml vial of NAD+ injectable solution (200 mg/ml concentration), syringes, and needles for administration.

You can purchase additional insulin syringes and/or needles from a local pharmacy or drugstore, such as Walgreens or CVS.

You may feel a slight sting or burn when administering the injection, but it varies from person-to-person.

Most patients will notice a boost in energy within an hour or two of injection. Please note you should not use NAD+ Injections more than 3x per week.

Yes. Refrigeration may help preserve the potency of the NAD+.

If all is still sealed and the needle sheath is still on it, it is OK to use. You will want to use a new syringe or needle if anything was unsealed/open as it hit the floor.

NAD Injections have a BUD of 90 days after the pharmacy compounds it. The potency remains stable if kept cold (refrigerated or frozen). However, once you puncture a multi-dose vial, you should discard it after 28 days.

For patient safety, our licensed prescribers generally caution the use of NAD+ for those with active cancer, as there are some unknown risks associated with NAD+ and cancer patients. We plan to stay up-to-date as new findings emerge on this and will continue to keep our patient’s wellbeing at the foundation of our decision making.

For those in remission or with a history of cancer, a U.S. licensed prescriber would review the intake form to determine whether or not it’s appropriate. If additional information is needed prior to approval, the reviewing prescriber would reach out.

NAD+ injections are generally clear in color. If your solution is a yellowish color, this can be due to a slight variation in PH. Solution that is yellow/gold is still good and safe to use. If it is dark/brown in color, please reach out to our customer service team with a photo for further assistance.

While using the injections, if you end up having excess niacinamide, your body will use a methylation process to eliminate the excess amounts. This methylation process creates a need for extra methyl donors, which is why we suggest supplementing with trimethylglycine (TMG also known as betaine), 1000mg on the days when the NAD injection is used. TMG is easily obtainable on Amazon or any other vitamin retailer.

You can purchase additional insulin syringes and/or needles from a local pharmacy or drugstore, such as Walgreens or CVS.

Splash water on your face to moisten your skin, then apply an even layer once before bed. Allow the cream enough time to absorb and dry before adding any other cosmetic creams or products.

Since our cream is pure NAD+, there is currently no way to add a fragrance to help with the scent. The scent does, however, typically diminish within the first hour or two of use.

Yes, of course. We have not had any reports of skin irritation or break outs when used with other creams.

Likely, you will see benefits within 30-minutes to 1-hour of using the product. Dermatologists sometimes demonstrate this by applying our cream to one of their patient’s eyes at the beginning of the appointment. At the end of the 30 minute appointment, they hand them a mirror and show them the difference. So, results can be seen in 30 minutes, but will continue to improve skin with prolonged use.

Wetting your face before applying the cream allows it to spread easier and more evenly than it would if your face was dry. This also keeps you from using more cream than necessary, so you don’t go through the cream faster than intended.

Refrigeration, especially in the summer months or if you live in a warm climate, will help preserve the potency of the NAD+. Having the cream at lower temperatures when applying may also help to reduce any skin inflammation (an added benefit).

Yes, but be cautious not to get any cream in the eyes. The cream visibly reduces eye bags and puffiness.

No. We have patients who use it to treat acne. We have not had anyone report that this cream has caused a break out or irritation.

Yes. Most of our patients report that their make-up goes on smoother after they have applied the cream (and let it dry first).

Our NAD+ Face Cream contains NAD+ powder, sodium hydroxide (10% solution), propylene glycol, and HRT Botanical Base. 100% vegan, cruelty free.

DMAE stands for dimethylaminoethanol (deanol for short). It is an organic and topical compound traditionally from fatty fish (salmon, sardines, anchovies). It’s been clinically proven to increase dermal (skin) thickness while also hydrating better than many OTC moisturizing products. Used consistently, DMAE can have acute skin-firming effects.

Our Rx-exclusive gel contains Dimethylaminoethanol Bitartrate (DMAE), Hyaluronic acid (Sodium Hyaluronate), Alpha Lipoic Acid, Preserved Water, and Lavender Oil. This combination has been scientifically-proven to be more effective than using one or the other alone.

Moisten your skin and apply 1 pump to your face twice daily (once in the AM, once in the PM). Spread a thin, even layer over the face and neck and gently smooth into your skin. Allow the gel to completely absorb before continuing with any other serums, treatments, or moisturizers of choice. Apply a daily SPF 30+.

Early signs of DMAE at work are mild signs of tingling, burning, or, in some cases, mild peeling following application.

Many patients see results within just a few weeks of treatment. Significant overall skin tone improvement should be visible within 16 weeks.

While using DMAE, you may experience: Itching, Burning, Redness, or Peeling. Less common side effects may include muscle twitching, insomnia, sneezing/coughing/wheezing, severe eye irritation, or convulsion.

If you experience severe burning or rash, discontinue use and consult your doctor or medical professional.

Some over-the-counter creams may contain DMAE, however, at much lower percentages than available via a prescription. Some oral forms of DMAE are also available OTC, such as tablets or powders, however, they do not present the same anti-aging skin benefits as a topical form, such as gel or cream.

Yes. Your skin may be more sensitive to sunlight while during DMAE. As such, AgelessRx recommends a daily SPF of 30 or higher.

Generally, yes. Using DMAE concurrently with topical drying agents, such as salicylic acid and benzoyl peroxide, can increase the drying effects. Do not apply these agents to the same areas as your topical DMAE.

Store your DMAE at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep away from children and pets. Do not share your prescription cream with anyone else.

Yes. Early signs of DMAE at work may be mild signs of tingling, burning, or, in some cases, mild peeling following application.

Based on available research, long-term use (1 year or more) of topical DMAE is associated with a good safety profile.

No. DMAE is linked to birth defects and miscarriage. Stop using DMAE immediately if you become pregnant. Do not use DMAE if you are pregnant or breastfeeding (including trying to get pregnant or are unsure whether you are pregnant).

Yes. Studies show that prescription-strength DMAE is effective in reducing the appearance of sagging neck skin. Just apply enough product (a pea-sized amount) to produce a thin layer on the desired skin area, such as the neck.

Yes, you absolutely can use both together. You will want to apply the DMAE to clean skin once in the AM and again in the PM. You can also apply your NAD+ Cream in the AM and again the PM (your preference).

Be sure to apply the DMAE to clean, dry skin and allow it to completely dry out on your skin before you apply the NAD+ Cream. Once dry, you can lightly moisten your skin with a few drops of water and then apply your NAD+ Cream. Be sure to allow the cream to dry completely before applying any other moisturizers or cosmetics.

DMAE is a great all-over corrector but focuses on rehydrating tired and sagging skin. It’s great to use on your neck, as well. NAD+ Cream, on the other hand, is great for reversing signs of sun damage, fine lines and wrinkles, and improving overall texture. It also can help treat adult acne.

DMAE is known to have a somewhat unpleasant smell—our pharmacists describe DMAE as smelling vaguely like ammonia, which can smell fishlike to some. Our unique formulation of DMAE contains lavender oil to help reduce any unpleasant smells. Some may still detect the smell of ammonia, but the scent does not linger or stick to your skin, so you shouldn’t let this detract you from the benefits of DMAE.

Tretinoin is a topical form of retinoid applied to the skin. It is only available via prescription.

AgelessRx’s Tretinoin Anti-Wrinkle Cream contains retinoic acid (commonly 0.02% or 0.05%), hyaluronic acid, and ascorbic acid.

Cleanse your skin and apply 1 to 2 pumps (pea-sized amount) to your face at bedtime up to 3x per week. Follow with a moisturizer of your choice. Apply a daily SPF 30+.

Early signs of Tretinoin at work are mild signs of tingling, burning, or, in some cases, mild peeling within following application. This is due to your skin turning over new layers, resulting in brighter and tighter skin. Most patients see early results within 3-4 weeks, with more significant results after 8-10 weeks.

Most patients see early results within 3-4 weeks, with more significant results after 8-10 weeks. If you are using Tretinoin as an acne treatment, noticeable results may take longer, between two to six months.

Most commonly, AgelessRx prescribes a starting/initial prescription of 0.02%, working up to 0.05% upon first refill. In some cases, different strengths may be prescribed at the discretion of the reviewing doctor or medical professional. However, we typically do not recommend strengths over 0.05%, as higher concentrations (like 0.1%) are often too strong to properly treat wrinkles and come with exacerbated side effects: the 0.02% and 0.05% formulas offer the best balance of positive cosmetic outcomes while minimizing side effects.

Sometimes referred to as “retinoid reactions,” you may experience: Itching, Burning, Redness, or Peeling. Less common side effects may include Erythema nodosum (severe skin inflammation), Edema (swelling), Rash Skin hyperpigmentation (dark spots), and/or Skin hypopigmentation (light spots).

If you experience severe burning or rash, discontinue use and consult your doctor or medical professional.

No. Topical Tretinoin is only available with prescription and is not sold over the counter.

Yes. Your skin may be more sensitive to sunlight while during Tretinoin. As such, AgelessRx recommends a daily SPF of 30 or higher.

Generally, yes. Using retinoids concurrently with topical drying agents, such as salicylic acid and benzoyl peroxide, can increase the drying effects of retinoids. Do not apply these agents to the same areas as your topical Tretinoin.

Store your Tretinoin at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep away from children and pets. Do not share your prescription cream with anyone else.

Yes. Early signs of Tretinoin at work are mild signs of tingling, burning, or, in some cases, mild peeling within following application. This is due to your skin turning over new layers, resulting in brighter and tighter skin. Most patients see early results within 3-4 weeks, with more significant results after 8-10 weeks.

AgelessRx recommends to stop using Tretinoin for at least 5-7 days prior to any facial waxing, especially around the area being waxed. This is due to your skin becoming more sensitive when using Tretinoin, which can result in skin that is irritated, red, and painful, giving a “rug burn” appearance when waxed.

Studies show that it’s safe to use Tretinoin over the long term, with some studies examining the effects of tretinoin for as long as four years.

No. Tretinoin is linked to birth defects and miscarriage. Stop using Tretinoin immediately if you become pregnant. Do not use Tretinoin if you are pregnant or breastfeeding (including trying to get pregnant or are unsure whether you are pregnant).

Yes. Tretinoin can help reduce and prevent wrinkles on the neck. If you elect to apply Tretinoin to your neck area, be sure to apply a daily SPF 30+ as it can increase the risk of sun sensitivity and damage.

Tadalafil is the generic form of Cialis, an FDA approved medication to treat erectile dysfunction in men since 2003. It is also FDA approved to treat enlarged prostate, a condition called benign prostatic hyperplasia (BPH), since 2011.

Tadalafil is the same active ingredient as found in branded Cialis. Tadalafil works by inhibiting phosphodiesterase type 5 (PDE5) enzymes, which enhances erectile function by the release of nitric oxide (NO). It is offered as a daily or as needed medication; Tadalafil is only available with a prescription.

At higher doses (20mg/day or more), Tadalafil is also used in both men and women to treat pulmonary arterial hypertension.

Tadalafil is the active ingredient used in Cialis and is the generic equivalent. As clinically evidenced, Tadalafil is just as safe and effective as branded Cialis; it works for the same amount of time and delivers the same lasting effects.

Dosage and instructions differ depending on if you choose/are prescribed to take Tadalafil daily or as needed.

Tadalafil – Daily: You will take a single tablet (2.5mg or 5mg) with a glass of water at approximately the same time each day. Tadalafil can be taken with or without food; it is taken without regard to sexual activity.

Tadalafil – As Needed: You will take a single tablet (10mg or 20mg) with a glass of water a minimum of 1-2 hours before sexual activity. Tadalafil can be taken at any time of day or night, with or without food.

Taking Tadalafil daily at a lower dose (2.5mg versus 10mg) than what would be prescribed for as needed reduces many common side effects. Furthermore, it allows you the freedom to be intimate on your own time (and at any time) versus having to take a pill.

Lastly, more recent clinical research suggests added health and longevity benefits, such as anti-inflammatory properties, better blood flow to all major organs, and improved cognitive function and mental clarity.

Tadalafil sets itself apart from other ED medications in three distinct ways:

1. It is the only ED medication available for daily use. This means you can be intimate at any time, rather than needing to take a pill from time to time, as needed, like other brands (e.g. Viagra).
2. When taken as needed, a single dose can remain active up to 36 hours. Tadalafil is often referred to as “the weekend pill” because a single dose can remain active for up to 36 hours (whereas others, such as Viagra, remain active for only a few hours). Tadalafil provides the opportunity for spontaneity.
3. It is earning clinical support for a variety of health and longevity benefits. We explore some of the latest research in this blog.

As with any drug product, there may be side effects. Generally, patients who experience side effects usually get them within 12 to 24 hours after taking Tadalafil. Side effects usually resolve on their own within 48 hours.

The most common Tadalafil side effects are:

• Headache
• Indigestion
• Back and muscle pain
• Flushing
• Stuffy nose

Some more serious side effects have been reported. While rare, it is important to stop taking Tadalafil and contact a doctor right away if you experience an erection that will not go away (priapism) or lasts longer than four hours, a sudden loss of vision in one or both eyes, a sudden decrease in hearing or hearing loss. The above information is only a summary. It may not cover all possible information. For a more complete list of possible side effects, click here.

Some drugs/medications may interact with Tadalafil. You should not take Tadalafil if you are taking nitrates (such as nitroglycerin tablets or patches), Cisapride, other ED medications (e.g. Viagra), Adcirca, or Riociguat.

For a more complete list of possible drug interactions, click here.

Anti-aging benefits: A clinical analysis cited PDE5 inhibitors, such as daily Tadalafil, as a worthwhile addition to any “anti-aging drug mixture because ED and BPH are most prevalent age-related conditions in aging men.” Furthermore, the analysis states that by “relaxing the tension [in senescent cells] may slow senescent-associated pathology… causing anti-vasoconstriction, anti-proliferative and anti-inflammatory effects.”

Reducing health risks related to aging: The same clinical analysis cited above suggests that by fighting against cellular senescence, PDE5 inhibitors, such as Tadalafil, may also help to reduce health risks related to aging, such as heart hypertrophy, myocardial infarction, cancer, neurodegenerative diseases, cystic fibrosis, diabetes, obesity and metabolic syndrome.

Anti-inflammatory properties: Per this clinical study in Scientific Reports, “chronic inflammation plays an important role in BPH/LUTS (lower urinary tract symptoms) and contributes to the clinical progression of BPH-related symptoms… Tadalafil, but not sildenafil or vardenafil, reduces pro-inflammatory factors.”

Improved cognitive function: In this clinical study, researchers state: “Erectile dysfunction is commonly associated with depression, and treatment with PDE5 inhibitors improves cognitive functions and depression, in addition to erectile dysfunction. Therefore, treatment of BPH/LUTS-ED with Tadalafil could improve patients’ quality of life and their cognitive functions.”

Improved heart health: In this clinical study, researchers cite support for PDE5 inhibitors, such as Tadalafil, “improved contractile function, reduced chamber dilatation and reduced LVH.” In other words, keeping the heart rate normal, increasing blood flow and the ability for the heart to supply the body with enough blood, and reducing blood pressure to decrease the heart’s workload.

If you miss a dose while taking this medicine once daily for an erection problem, benign prostatic hyperplasia, or both, take it as soon as you remember, however, do not take more than one dose per day.

If you are taking this medicine as needed for erection problems, this does not apply. Simply take a single tablet 1-2 hours prior to sexual activity.

When taking Tadalafil As Needed, no loading dose is required—a single tab is effective. Simply take a single Tadalafil tablet 1-2hours before sexual activity. A single dose can remain effective for up to 36 hours.

Store your medication at room temperature (no higher than 86 F). You should throw away any unused medication after the expiration date on your prescription bottle.

As with all prescription medications, keep out of reach of children and pets. Do not share your medication with anyone else.

Yes, Tadalafil is FDA approved to treat erectile dysfunction (ED). At different doses, it is also FDA approved to treat symptoms of BPH and pulmonary arterial hypertension.

AgelessRx only partners with U.S. based pharmacies that are FDA registered and inspected facilities. As such, they routinely undergo strict manufacturing and approval processes for safety and efficacy that makes them available nationally to all other pharmacies in the country (including large and well-known providers, like Walgreens and CVS).

You can use your GSH nasal spray 1-2x daily or as needed.

Your GSH Nasal Spray (15 ml bottle) contains enough solution for approximately 150 sprays.

You may feel a slight burn or sting when administering the nasal spray.

Most patients feel effects within one hour.

Yes. Refrigeration may help preserve the potency of the GSH.

The iontophoresis patches have a small battery operated device that facilitates the absorption of GSH through your skin into your bloodstream, and because of this mechanism the patches are considered a medical device and are only available by prescription.

Standard protocol is to wear the patch once per week for four hours. Depending on your age, how depleted your GSH levels are, and your objectives, you may elect to use the patch more or less often.

Ideally, place the patch where hair will not interfere with mild adhesive. Common locations are upper arm, abdomen, back, and thigh.

The 4 hour patches have a battery that stops working after 4 hours. After that you can keep the patch on for a few more hours but absorption will be minimal.

GSH is essential for many functions, including cellular rejuvenation and repair. You may or may not feel an immediately noticeable effect of better DNA repair; most of our customers who use the GSH Patches report some of the following benefits: improved energy, mental clarity, and faster recovery from illness and injury.

It is important to note the above benefits are not seen in all clients. As long as instructions for application are properly followed, the GSH will be absorbed into the body regardless of whether a person feels it or not, and will achieve higher GSH levels needed for better health and longevity. Depending on how depleted your GSH levels are, you might need to build up your GSH level over a few weeks before noticing any benefits.

To ensure it doesn’t come free, the adhesive used for the patch is quite strong. At the end of four hours, you can soak the patch for a few minutes with warm water to make the removal easier.

A small percent of patients report a rash where they applied the patch. Please contact us for further advice.

Sometimes, it helps to apply the patch over a joint, such as the knees or wrists. It seems that skin on some parts of the body are more prone to develop rash than others

You will draw up the prescribed amount with the provided insulin needle and syringe, then inject subcutaneously. The recommended dose is 0.5ml (100mg GSH) up to 5x per week.

Each 0.1ml (10cc/units on syringe) of solution equals 20mg of GSH. As such, 0.1ml = 20mg GSH, 0.25ml(25 Units) = 50mg of GSH, and 0.5ml = 100mg of GSH.

Some syringes may come with Units instead of mL. To convert, 0.5mL equals 50 Units on your syringe.

Ideally, the injection is administered into a fatty layer of skin, such as: back of arm, abdomen, or flank/lumbar region.

Each 0.1ml (10 units on syringe) of solution equals 20mg of GSH. As such, 0.1ml = 20mg GSH, 0.25ml(25 Units) = 50mg of GSH, and 0.5ml = 100mg of GSH.

The standard injection of GSH is 0.5ml (50 units on syringe), which equates to 100mg GSH per injection.

Your GSH injection order will arrive with the following: one (1) 10ml vial of GSH injectable solution (200 mg/ml concentration), syringes, and needles for administration.

You can purchase additional insulin syringes and/or needles from a local pharmacy or drugstore, such as Walgreens or CVS.

You may feel a slight sting or burn when administering the injection, but it varies from person-to-person.

Most patients will notice a boost in energy within an hour or two of injection. Please note you should not use GSH Injections (0.5ml per injection) more than 5x per week.

Yes. Refrigeration will help preserve the potency of the GSH.

If all is still sealed and the needle sheath is still on it, it is OK to use. You will want to use a new syringe or needle if anything was unsealed/open as it hit the floor.

GSH Injections have a BUD of 90 days after the pharmacy compounds it. The potency remains stable if kept cold (refrigerated or frozen). However, once you puncture a multi-dose vial, you should discard it after 28 days.

Injections have better bioavailability than oral supplements as they bypass the digestive system completely, providing a direct supply of B12 into the bloodstream to fuel your body. Oral supplements might work for some, however, as we age, our ability to break down oral supplements often decreases.

The solution contains 1000mcg of B12 per ml/cc.

Start by injecting 1ml/cc per injection once per week. If you feel you’re not getting your expected results, please contact your prescriber.

AgelessRx patients are typically prescribed subcutaneous B12 injections. Take the time to review how to draw up B12 solution and how to administer a subcutaneous injection before you get started.

The most common side effect of B12 injections is irritation at the injection site. If this occurs, consider changing placement on the body or use injections less often.

Do not use B12 injections if you are currently pregnant, breastfeeding or plan to become pregnant or breastfeed.

It is essential to follow an aseptic technique to prevent infection from bacteria, viruses, and other pathogens. Use needles and syringes only once. Dispose of your used supplies in an FDA-approved sharps container. Additionally, dispose of punctured vials within 28 days. You can read more about this technique, and get additional tips on how to dispose of your supplies, here.

In a general medical context, sterile essentially means germ-free. Though this is often applied to medical environments like operating rooms and medical tools like scalpels, sterile can also be used to refer to medications. Sterile medications are compounded in a sterile environment to keep the medication free of germs from the time it’s compounded to the time it’s used. This method is necessary for injections, eye drops, and any medication that bypasses your body’s normal defense system.

We offer Methylcobalamin B12 injections for all states except California and New York. Due to state regulations, patients located in California and New York will receive Cyanocobalamin B12 injections.

Cyanocobalamin and Methylcobalamin are both forms of B12. The only difference is which molecule is attached to the cobalt (cobalamin) ion: the former contains a molecule of the cyano group, while the latter contains a molecule of the methyl group. Both share the same potential longevity benefits, and both solutions contain 1000mcg of B12 per ml/cc.

No. Cyanocobalamin B12 is made by adding a molecule of the cyano group to a cobalt ion. To alter this process with further additives would create a compound that is fundamentally different from Cyanocobalamin B12.

As with any injectable medication, Cyanocobalamin B12 injections will often have trace amounts of benzyl alcohol as a preservative, and acetic acid or acetate as a buffer.

Like Methylcobalamin B12, Cyanocobalamin B12 is considered safe and well-tolerated. Both have a well-established safety profile as a supplement and an injection.

There is some evidence to suggest that Cyanocobalamin B12 may be absorbed better, while Methylcobalamin B12 may be retained better. Other studies suggest that Methylcobalamin B12 may have a wider range of potential health benefits, like improving nerve function.

However, both Methylcobalamin B12 and Cyanocobalamin B12 share many of the same benefits, including better energy, better sleep, and better cognitive function. Further studies are needed to determine if any form of B12 is more effective than others, both as a supplement and as a prescription injectable.

Cyanocobalamin B12 injections have the same standard dosage and titration as Methylcobalamin B12, but your prescriber may recommend a different dosage and titration plan depending on your goals and unique medical history. Always follow the dosage and titration plan set by your prescriber.

Both are offered as subcutaneous injections.

When a compound is synthesized, it is created from other substances by a chemical reaction.

While Methylcobalamin B12 is a naturally occurring form of B12 found in animal-based foods like meat and eggs, Cyanocobalamin B12 is not found in nature. Instead, Cyanocobalamin B12 is chemically synthesized by attaching a molecule of the cyano group to a cobalt ion. By contrast, Methylcobalamin has a molecule of the methyl group attached to a cobalt ion.

However, this isn’t to suggest that Methylcobalamin B12 is always derived from a natural source. In fact, Methylcobalamin B12 may also be synthesized in a laboratory, though to do so, it is usually reduced from Cyanocobalamin B12.

For these reasons, Cyanocobalamin B12 is often the simplest and least labor-intensive form of B12 to produce, which may explain why it’s the most commonly prescribed form of B12 by both physicians and pharmacies.

Cyanocobalamin B12 is often created by reducing another naturally occurring form of B12 known as adenosylcobalamin, which comes from microbial fermentation. To do this, scientists reduce adenosylcobalamin and add a molecule of the cyano group through chemical reaction, a process referred to as synthesizing.

Methylcobalamin B12 can be extracted from the sources where it naturally occurs, but it can also be produced in a laboratory by a similar method described above. The only difference is that Methylcobalamin is created from a reduced form of Cyanocobalamin B12 with the addition of a molecule from the methyl group.

Cyanocobalamin B12 injections are not known to have different side effects than other B12 injectables. These side effects include headache, nausea, fatigue, diarrhea, and rash at the injection site. For a full list of potential side effects, please reference the Mayo Clinic’s resources here.

B12/MIC provides the same great vitamin supplementation as B12 injections, but with a few added benefits. When combined with MIC, the metabolism-boosting principles of the injection are amplified, enhancing the body’s ability to break through weight loss stagnation.

Start by injecting 1ml/cc per injection up to 2 times per week or use as prescribed. We’re here to help. Contact our team to adjust your prescription.

Most side effects of B12/MIC are generally mild in nature and dissipate within a short time frame following administration. Common side effects may include pain, redness or itching at the injection site.

​​If irritation continues to occur, apply an over-the-counter itch cream, or talk to your AgelessRx provider if symptoms persist for several weeks or become intolerable.

Every body is different. Depending on your weight loss goals, lifestyle choices, and any underlying medical conditions, the results you see on the scale may vary. B12/MIC should be used in combination with diet and exercise to maximize results.

B12/MIC injections are administered intramuscularly. Below are a few helpful videos to help you get started:

1. This brief & informative video from our pharmacy partner will help you understand how to properly draw up your solution.
2. This video helps to illustrate the proper techniques for administering your injection.

It is essential to follow an aseptic technique to prevent infection from bacteria, viruses, and other pathogens. Use needles and syringes only once. Dispose of your used supplies in an FDA-approved sharps container. Additionally, dispose of punctured vials within 28 days.

You can read more about this technique, and get additional tips on how to dispose of your supplies, here.

All B12/MIC injections are only available as intramuscular injections.

Subcutaneous injections deliver medication into the layer of tissue just below the skin, while intramuscular injections go one layer deeper, directly into the muscle.

Subcutaneous B12/MIC injections may be associated with an increased risk for irritations and reactions at the injection site. As such, our pharmacy partners only provide standard intramuscular injections.

Wegovy^® (semaglutide) injection 2.4 mg is an injectable prescription medicine used for adults with obesity (BMI ≥30) or overweight (excess weight) (BMI ≥27) who also have weight-related medical problems to help them lose weight and keep the weight off.

• Wegovy^® should be used with a reduced-calorie meal plan and increased physical activity.
• Wegovy^® contains semaglutide and should not be used with other semaglutide-containing products or other GLP-1 receptor agonist medicines.
• It is not known if Wegovy^® is safe and effective when taken with other prescription, over-the-counter, or herbal weight-loss products.
• It is not known if Wegovy^® can be used safely in people with a history of pancreatitis.
• It is not known if Wegovy^® is safe and effective for use in children under 18 years of age.

Wegovy^® works by mimicking a hormone that targets areas of the brain involved in regulating appetite and food intake. This can help you eat less, which can lead to weight loss.

Your Body Mass Index, or BMI, is a simple rule of thumb used by healthcare providers around the world to broadly categorize a healthy spectrum of height and weight differentials.

To calculate your BMI, divide your total weight by the square of your height, or use this BMI calculator. For adults, you should expect a result somewhere between 18 and 30.

The first thing you can do is calculate your BMI.

Wegovy® is FDA approved to treat weight loss in adults with a BMI of 30 or greater, or adults with a BMI of 27 or greater who also have at least one weight-related medical issue.

However, each potential Wegovy® candidate will be reviewed on a case-by-case basis, and approval is not guaranteed based on these criteria: your prescriber needs a full picture of your unique health profile to understand whether Wegovy® treatment is appropriate.

Those with BMIs below 25 will not be approved for Wegovy® treatment with AgelessRx.

In a 68-week medical study of 1,961 adults living with obesity or excess weight with a related medical problem, adults lost ~35 lbs (or ~15% body weight). People taking placebo lost an average of 6 lbs (or ~2.5% body weight). The average starting weight for both groups was ~232 lbs.

**Results are from a 68-week medical study of adults with obesity (BMI ≥30) and adults with excess weight (BMI ≥27) who also had weight-related medical problems including high blood pressure or high cholesterol. People with type 2 diabetes were excluded. Both groups were instructed to take the medicine along with a reduced-calorie meal plan and increased physical activity. 7% of people taking Wegovy™ (92 people) left the medical study due to side effects, compared to 3.1% of people taking placebo (20 people).

People respond to medicines differently, so there is no set time for when you can expect to see results with Wegovy^®. Ask your health care provider about what might be a realistic expectation for you.

The most common side effects of Wegovy^® may include: nausea, diarrhea, vomiting, constipation, stomach (abdomen) pain, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, gas, stomach flu, and heartburn.

Tell your health care provider if you have any side effects that bother you.

It is possible to travel with your Wegovy^® pen:

• When traveling by air, keep your Wegovy^® pen with you or in your carry-on, as it may freeze in the baggage compartment. Be sure to check with the airline to see if they have any specific baggage rules.
• If needed, Wegovy^® may be stored between 46°F and 86°F in the original carton for up to 28 days.

Wegovy^® is taken once a week, any time of day, with or without food.

Wegovy^® comes in 5 different doses: 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg. Each dose comes in its own color pen.

Yes, it’s recommended that you take Wegovy^® on the same day every week at a time that is most convenient for you.

Take Wegovy^® 1 time each week, on the same day each week, at any time of the day. You may change the day of the week you take Wegovy^® as long as your last dose was given 2 or more days before.

You can take Wegovy^® with or without food.

If you miss a dose of Wegovy^® and the next scheduled dose is more than 2 days away (48 hours), take the missed dose as soon as possible.

If you miss a dose of Wegovy^® and the next scheduled dose is less than 2 days away (48 hours), do not administer the dose. Take your next dose on the regularly scheduled day.

If you miss doses of Wegovy^® for more than 2 weeks, take your next dose on the regularly scheduled day or call your health care provider to talk about how to restart your treatment.

Wegovy^® should be clear and colorless. If it is not clear and colorless, DO NOT USE IT. Safely dispose of the Wegovy^® pen and contact our pharmacy directly (information listed on your prescription) or our team for a replacement.

It’s important to properly dispose of your used Wegovy^® pens. Do not throw the pen away in your household trash. Instead, use an FDA-cleared sharps disposal container or a sturdy household container with a tight-fitting lid, like a heavy-duty plastic container. Other requirements include puncture resistant, upright and stable during use, leak resistant and properly labeled.

Upon arrival, refrigerate your Wegovy® pens between 36°F and 46°F. Do not freeze or store under 36°F.

After using a Wegovy® pen, you can safely store it at room temperature between (46°F and 86°F). Once a pen has been used or exposed to non-refrigerated temperatures, it must be used within 28 days.

Your Wegovy® prescription will arrive with a temperature tag attached to indicate whether it was exposed to brief (2 hours), moderate (12 hours), or prolonged (48 hours) temperatures during transit. If the temperature tag indicates prolonged exposure, please contact us for a replacement.

Ozempic® is a semaglutide-based medication that is FDA approved to treat type 2 diabetes. Clinical trials have also demonstrated that Ozempic®, as well as semaglutide medications like Wegovy® (also manufactured by Novo Nordisk), can reduce weight, regulate appetite, and lower cardiovascular risk factors.

The active ingredient in Ozempic® is semaglutide. Semaglutide falls into a category of medications known as GLP-1 receptor agonists (GLP-1 RAs), which imitate the GLP-1 hormone to reduce the amount of glucose delivered into the bloodstream and encourage more insulin production from your pancreas. GLP-1 RAs also act on the digestive system to delay gastric emptying, thereby delaying the release of food from the stomach, and modulate brain activity to suppress appetite.

The most common side effects of Ozempic® include nausea, diarrhea, vomiting, constipation, abdominal (stomach) pain, headache, fatigue, dyspepsia (indigestion), dizziness, abdominal distension, eructation (belching), hypoglycemia (low blood sugar) in patients with type 2 diabetes, flatulence (gas buildup), gastroenteritis (an intestinal infection) and gastroesophageal reflux disease (a type of digestive disorder).

Ozempic® must be refrigerated until your first use. Once you’ve used the pen at least once, it can be stored at room temperature for up to 56 days. If you’re traveling, make sure to pack an Ozempic® pen that you’ve already used. If you’ll be traveling for more than 56 days, make sure your Ozempic® pens are properly stored in a refrigerated pack between 36°F and 46°F.

You only need to take Ozempic® once per week. It’s best to take your injection on the same day each week. You can take your dose at any time of that day, with or without food.

Wegovy® pens are single-use injections that have one dose predialed and ready to go; once they’re used, they can be safely discarded in a sharps container. The spring-loaded plunger will also click twice when the injection is successfully administered to notify you that you’re finished.

Ozempic® pens, on the other hand, are designed with multiple doses to be used multiple times. Users must insert a fresh needle tip for each use and manually dial in their prescribed dose by turning the dial on the top of the pen clockwise until the window displays the correct dosage. When administering your dose, you will press down on the plunger until the window dials back down to 0 – about six seconds. There are no click indicators on an Ozempic® pen, so pay close attention to the dial and count slowly to six before removing the needle.

Taking Ozempic® on the same day each week yields the best results. Not only does this give your body the best chance to acclimate to the medication, but it balances the amount of medication in your system, so you can achieve consistent outcomes with just the right dose.

It’s perfectly acceptable to adjust your dosing schedule, if the day of the week you chose previously is no longer best for you. You can simply start taking Ozempic® on your newly chosen day, so long as at least 48 have passed since your last injection.

Ozempic® can be taken with or without a meal.

If you miss your scheduled day, just take your dose whenever you can next, so long as it’s within 5 days of the missed dose, then resume your normal dosing schedule. Never double up on doses if you missed one the previous week. We recommend setting a once-weekly reminder on your phone so you have the best opportunity to take Ozempic® as consistently as possible.

If the solution in your pen appears cloudy or discolored, do not use the pen and contact AgelessRx customer support.

Always dispose of your Ozempic® pens in an FDA-cleared sharps container. Sharps containers can be reused and are often available for less than $10 at your local pharmacy.

Upon arrival, refrigerate your Ozempic® pens between 36°F and 46°F. Do not freeze or store under 36°F.

After using an Ozempic® pen, you can safely store it at room temperature between (46°F and 86°F). Once a pen has been used or exposed to non-refrigerated temperatures, it must be used within 56 days.

All of our pharmacy partners take special care to insulate each Ozempic® shipment to stay within appropriate temperatures during transit. Depending on which of our pharmacy partners fulfills your prescription, Ozempic® may arrive with a temperature tag to indicate whether it was exposed to brief (2 hours), moderate (12 hours), or prolonged (48 hours) temperatures during transit. If the temperature tag indicates prolonged exposure, please contact us immediately.

If you do not receive a temperature tag, check the interior of the package and the medications packaging with the back of your hand. If either is hot to the touch, please contact us immediately.

Compounded Semaglutide is a semaglutide-based medication compounded by our partner pharmacies to address the ongoing national Semaglutide shortage so patients unable to access semaglutide-based medications while they remain on the FDA’s Drug Shortage List can avoid lapse in treatment. Compounded Semaglutide has not been reviewed or approved by the FDA for safety, efficacy, or quality.

Semaglutide falls into a category of medications known as GLP-1 receptor agonists (GLP-1 RAs), which imitate the GLP-1 hormone to reduce the amount of glucose delivered into the bloodstream and encourage more insulin production from your pancreas. GLP-1 RAs also act on the digestive system to delay gastric emptying, thereby delaying the release of food from the stomach, and modulate brain activity to suppress appetite.

Compounded Semaglutide has not been reviewed by the FDA*, but our patients report the following side effects: nausea, vomiting, diarrhea, stomach pain, and constipation. These normally go away on their own within a few days, or up to 2-3 weeks, and many patients develop a tolerance to these side effects. You can help prevent or ease these side effects by:

• Eating slower and at more regular intervals throughout the day
• Taking Compounded Semaglutide at the same time of day each week
• Drinking only water or clear, unsweetened beverages
• Avoiding fried, greasy foods in favor of healthier, low-fat options

*Compounded Semaglutide has not been FDA approved for weight loss, but is temporarily approved by the FDA as a short-term alternative due to the ongoing Semaglutide shortage.

Yes! As long as you follow proper storage guidelines during your trip, you can safely travel with Compounded Semaglutide.

As a reminder, your Compounded Semaglutide vials must be refrigerated before using. Once the top of the vial has been pierced, you must discard the vial after 28 days, even if there is still some solution remaining. It is best to bring a refrigerated travel case with you to safely store your vials, especially if you plan to travel for more than 28 days.

It’s perfectly acceptable to adjust your dosing schedule. You can simply start taking Compounded Semaglutide on your newly chosen day, so long as at least 48 hours have passed since your last injection.

If you miss taking Compounded Semaglutide on your scheduled day, you can still take your dose whenever you can, so long as it’s within 5 days of the missed dose. You can then resume your normal dosing schedule. If more than 5 days have elapsed, skip this dose and take it on your next normally scheduled day. Never double up on doses if you missed one the previous week.

Compounded Semaglutide is made in an FDA-registered compounding pharmacy. Further, we have ensured that all formulations will only be compounded using pure semaglutide base, rather than salt-based peptides. Our partner pharmacies will continue to uphold our same standards of excellence for this and all other products, so that you can have the best outcomes possible.

No, our compounding pharmacies do not use any type of Semaglutide salt in any formulation of Compounded Semaglutide. We’ve gone to great lengths to ensure that our partner pharmacies uphold the same standards of excellence for this product as they would with any other, which means only using the safest and purest formulations available. Our partner pharmacies have also provided certificates of authenticity confirming that they use pure semaglutide base.

The FDA’s warning on Compounded Semaglutide specifies that consumers should be wary of 1) Semaglutide that is compounded from an unregulated, unlicensed source; 2) Semaglutide that is sold without a prescription; and 3) medications compounded with different active ingredients than Semaglutide, such as salt forms of Semaglutide.

Our compounding pharmacies are both FDA regulated and US licensed. Further, they have provided certificates of authenticity certifying that they compound semaglutide from pure Semaglutide base, without any trace of any form of Semaglutide salt. Our licensed prescribers only recommend Compounded Semaglutide with a prescription, and only after they have deemed it appropriate following a virtual visit.

The FDA has also specified that compounded versions of Semaglutide should only be prepared to address a shortage of Semaglutide; when Semaglutide is no longer on the FDA’s Drug Shortage List, we will resume prescribing non-compounded Semaglutide as available.

With a mission to democratize access to prevention-first and longevity-driven therapies, we’ve heard the frustrations of our patients in light of the national Semaglutide shortage. While the shortage is ongoing, we will offer Compounded Semaglutide as an accessible, affordable alternative for those who are qualified.

Once the shortage is over, we will work closely with our prescribers, pharmacies, and patients to find the best alternative. However, we plan to offer therapies that are no longer in shortage for our patients. In the meantime, we will be sure to update everyone affected as soon as we have any news regarding the shortage.

Oral Semaglutide Drops are a form of Semaglutide that is designed to be absorbed under the tongue (or, sublingually). This allows Semaglutide to be absorbed directly into the bloodstream through the mucosal tissue of the mouth. By bypassing the digestive system, this method may provide more bioavailable Semaglutide than other oral forms of Semaglutide.

Oral Semaglutide Drops are prepared with a state-of-the-art base known as SubMagna SL HMW that allows the medication to be absorbed under the tongue, instead of through tablet form or injection.

Semaglutide normally cannot be absorbed through the mouth. When combined with SubMagna SL HMW, Semaglutide gains improved solubility, allowing it to be absorbed into the bloodstream through the mucosal tissue of the mouth.

SubMagna SL HMW is the base solution of Oral Semaglutide Drops. To put it simply, SubMagna is the reason why Oral Semaglutide Drops can be absorbed under the tongue.

SubMagna is an anhydrous base that forms an emulsion when it mixes with our saliva. This emulsion allows certain medications to be absorbed differently than they normally would, including Semaglutide. SubMagna also has unique properties that improve absorption, potentially providing more bioavailable Semaglutide.

The final product is a Semaglutide medication that can be absorbed directly into the bloodstream without needles, and while bypassing digestion, potentially maximizing results while minimizing gastrointestinal side effects.

Oral Semaglutide Drops are taken by dropping the medication under your tongue with the oral syringe that comes with your prescription vial. Carefully draw up your prescribed dose into the oral syringe, then squeeze the contents of the oral syringe under your tongue. Hold the medication under your tongue for as long as possible, or at least 90 seconds, then swallow.

Do not eat or drink anything for at least 30 minutes after taking Oral Semaglutide Drops to ensure the medication is properly absorbed. If you’re having trouble timing your dose with your meals, try taking your weekly dose 30 minutes before you plan to eat your first meal of the day.

Take a few sips of water before taking Oral Semaglutide Drops, but do not eat or drink anything for at least 30 minutes after taking the medication. Be careful to always stay well hydrated while taking Oral Semaglutide Drops, especially during hot summer months.

Oral Semaglutide Drops should be taken three times weekly, unlike most other Semaglutide medications that are taken once weekly. This dosing schedule may be difficult for some patients to adjust to, especially if they’ve taken other Semaglutide-based medications before. If you miss a dose, try to set a reminder to remind you when you should take Oral Semaglutide Drops. Many patients also find it helpful to take Oral Semaglutide Drops first thing in the morning, 30 minutes before their breakfast.

Oral Semaglutide Drops are compounded with SubMagna SL HMW base, which is available either with banana or caramel flavors. The taste is not overwhelming, but don’t forget you’re still taking medication—the flavorings are there only to provide a taste that is more pleasant than the medication alone. Our partner pharmacies cannot currently take requests for a particular flavor.

Oral Semaglutide Drops are taken three times weekly. If you missed your dose yesterday, skip it and take your next dose when you normally would. Never double up on doses to make up for a missed dose. Always follow your prescriber’s dosing instructions. If more than 2 weeks goes by without taking a dose, please contact your prescriber, as you might want to start over again on the titration schedule.

The most common side effects are expected to be similar to other Semaglutide-based medications, including nausea, vomiting, diarrhea, stomach pain, and constipation. These normally go away on their own within a few days, or up to 2-3 weeks. Any side effects you may experience will vary, depending on your prescribed dose, medical history, and lifestyle choices.

Your AgelessRx prescriber will provide further information on what side effects you may experience, and what you can do to reduce side effects.

Absolutely! Just be sure to keep your bottle of Oral Semaglutide Drops at room temperature (between 68°F and 77°F) for the duration of your trip. If you’re traveling during hot summer months, you may want to bring a temperature-controlled medicine container, just in case.

No, Oral Semaglutide Drops are not absorbed as effectively as injections. Oral Semaglutide Drops must be absorbed through the mucosal membrane of the mouth—underneath the tongue—where it is then absorbed into the bloodstream. By contrast, injections can bypass the mucosal membrane and deliver the medication directly into the bloodstream.

As a result, Oral Semaglutide Drops do not provide as much bioavailable Semaglutide as with traditional injections. However, Sublingual Semaglutide still bypasses digestion, potentially providing more bioavailable Semaglutide than with tablets that must be ingested.

Oral Semaglutide Drops emerge as a fantastic middle-ground for patients who find it difficult to self-inject medications, providing an alternative delivery method without drastically compromising potency.

Try to plan your dose of Oral Semaglutide Drops so that you always take it 30 minutes before your first meal of the day. Here’s why:

Eating or drinking anything (except water) within 30 minutes of taking Oral Semaglutide Drops can interfere with how well it’s absorbed from underneath your tongue.

It’s okay to drink a little bit of water, but try to drink a small cup of water before your dose. That way, you won’t have to drink as much for at least 30 minutes.

Even though you’re bypassing digestion by taking Oral Semaglutide Drops sublingually, timing your breakfast 30 minutes after your dose helps you establish a steady routine, so your body has the best chance to get used to the medication. This can help reduce side effects, as well.

When you’ve taken your dose, you should ideally avoid swallowing for as long as possible; 90 seconds is the absolute minimum, but you can wait longer if you are comfortable.

The effectiveness of Oral Semaglutide Drops depends on your unique medical history, your dose, and how long you take it. As with any form of Semaglutide, you should take Oral Semaglutide Drops over an extended period of at least 6-12 months to experience the most optimal benefits.

Oral Semaglutide Drops are not absorbed as effectively as injections. To account for this, Oral Semaglutide Drops are taken three times weekly. Further, our partner pharmacies compound Oral Semaglutide Drops with SubMagna SL HMW as a base to improve absorption by an estimated 25-35%. Still, it is possible that the maximum dose of Oral Semaglutide Drops may not be potent enough for some patients to achieve maximum weight loss. If you feel you’re not getting your expected results, contact your prescriber to understand what solutions are available to you.

Trazodone is a serotonin agonist and reuptake inhibitor (SARI) that is FDA approved as an antidepressant. In recent years, Trazodone has also developed a reputation as a potent sleep aid: when taken at low doses (25-100mg), Trazodone acts strongly as a serotonin agonist to produce a sedative effect that has been shown to potentially improve sleep onset and duration.

When compared to benzodiazepines and other sleep aids, Trazodone is non-habit-forming with less side effects. Trazodone also stands out for having a shorter half-life, and thus a lower risk of daytime drowsiness and side effects.

Trazodone blocks serotonin type 2 (5-HT2), histamine H1, and alpha-1 adrenergic receptors, which reduces neurotransmitters associated with arousal. Studies show that this results in a calming sedative effect that may induce and maintain high-quality sleep.

Studies show that Trazodone’s unique mechanism of action can produce a calming effect that may help you fall asleep faster and stay asleep longer, while restoring healthy sleep patterns over time.

Studies also show that Trazodone may also help improve moods, reduce anxiety, and enhance cognitive function like memory recall and concentration.

Unlike other sleep aids, studies indicate Trazodone isn’t habit-forming or addictive, with a shorter half-life that also reduces the risk of side effects like grogginess.

The most common side effects of Trazodone are drowsiness, dizziness, headache, dry mouth, and nausea. Most side effects are mild and go away within a week or two, as your body adjusts to the medication.

Some side effects of Trazodone may affect your ability to drive a vehicle, operate heavy machinery, and perform other tasks requiring concentration and coordination. Plan to stay home or arrange a ride for the first few days after starting Trazodone, until you’re sure you won’t be drowsy, dizzy, or fatigued after taking the medication.

The side effects of Trazodone are dose-dependent and may indicate that a particular dose is too high. If you find you cannot tolerate your current dose, you may reduce your dose by 25mg until your side effects resolve. If you cannot tolerate 25mg of Trazodone, consider taking an alternative sleep aid such as Tran-Q Sleep.

Trazodone can be taken by generally healthy adults who are at least 25 years old.

Patients taking MAOI medications or antidepressants should not take Trazodone, as the combination may increase the risk of serotonin syndrome. Do not take Trazodone within 14 days of discontinuing an MAOI medication or antidepressant.

If you are pregnant or breastfeeding, or planning to become pregnant or breastfeed, do not take Trazodone.

Trazodone may not be appropriate for patients with a history of heart, liver, or kidney conditions. Patients with compromised organ function may be at greater risk of side effects or increased complications with these organs.

Trazodone may also increase the risk of psychological side effects in younger patients, and the risk of falling in older patients.

Studies show that Trazodone’s sleep-inducing effects are strongest 30-60 minutes before you plan to go to bed at night. This is about how long it takes for Trazodone to take effect.

To reduce your risk of gastrointestinal side effects, you should also take Trazodone 1-2 hours after you’ve eaten, so you don’t take Trazodone on an empty stomach.

Trazodone may not be best for those who must sleep during the day. Doing so may not beneficially alter your sleep architecture. If you have a job or other occupation that demands an abnormal sleep schedule, let your prescriber know. They may recommend an alternative sleep aid such as Tran-Q Sleep.

The initial feeling of drowsiness normally occurs within 30-60 minutes after taking Trazodone. Clinical trials suggest that benefits like better sleep, improved memory recall, and enhanced concentration can be achieved within 4 weeks for most patients. However, all patients react uniquely to Trazodone, and results may vary. If you feel you’re not meeting your health goals on your prescribed dose, contact your prescriber to see if changing your target dose is right for you.

Be careful not to drive a car after you start taking Trazodone until you understand how the medication affects you. Though Trazodone has a lower risk of side effects than most FDA-approved sleep aids, some patients may still experience daytime drowsiness, confusion, dizziness, or fatigue, especially after initially starting Trazodone.

Try starting Trazodone on a Friday night, or whenever you won’t have plans for two or more days in a row, so you can safely assess how you feel without interrupting your schedule. If you must start Trazodone on a weeknight before work, arrange for a friend to drive you the next few mornings. If your job requires you to drive, operate heavy machinery, or perform similarly hazardous tasks that require coordination, it may be best to obtain a note from your prescriber and take some time off.

Please note that you are responsible for determining whether it is safe for you to drive after taking Trazodone. If you’re not sure, don’t drive.

No, Trazodone is not habit-forming or addictive. However, Trazodone can cause a recurrence of side effects and sleep disturbances if you stop taking it suddenly. For this reason, most patients should slowly wean off Trazodone before discontinuing the medication.

Some patients may be advised to discontinue Trazodone at least 24 hours before surgery requiring anesthesia. If you’re not sure whether you need to stop Trazodone for a particular procedure, speak with the doctor who ordered the procedure. Do not resume taking Trazodone until your doctor advises you that it is safe.

Trazodone has a lower risk of side effects than FDA-approved sleep aids, including a lower risk for next-day grogginess or daytime drowsiness. This may be because Trazodone also has a shorter half-life.

However, drowsiness is still one of the most common side effects of Trazodone. You may experience initial daytime drowsiness once you first start taking Trazodone, which is why you should avoid driving until you understand how Trazodone will affect you. Drowsiness may come back briefly if you increase your dose, so plan ahead.

The good news is that Trazodone side effects are dose-dependent. That means side effects like grogginess can be an indication that your current dose is too much for you. If you find that your grogginess doesn’t get better after a week or two, you may still be able to cut down your dose by 25mg. Always talk with your prescriber before adjusting your dose.

If you forget to take your dose of Trazodone and it’s close to your usual bedtime, take it as soon as you remember. If it’s already close to morning, skip the missed dose and take your next dose at the usual time.

Do not double up on doses to compensate for a missed dose. Be careful not to miss multiple, consecutive doses to avoid increased side effects.

It is best to avoid alcohol while taking Trazodone. Alcohol can amplify the sedative effects of Trazodone, leading to increased drowsiness, dizziness, and impaired coordination. This combination may also negatively impact the quality of your sleep, reducing the restorative effects of the medication​.

Trazodone is safe for long-term use at low doses between 25-100mg. If you are approved for a prescription, your prescriber will reassess your prescription every 3-6 months to determine your ongoing eligibility based on your progress and health goals.

Trazodone can affect eating habits and make some patients feel more or less hungry than usual. Though uncommon, some patients may notice they slightly gain or lose weight as a result. Losing or gaining weight is not an intended effect of Trazodone. Do not take Trazodone expecting to see weight loss.

Do not stop taking Trazodone suddenly. Your AgelessRx prescriber may recommend that you gradually reduce your dose by 25mg every 1-2 weeks before discontinuing the medication. However, you should not stop taking Trazodone without first discussing it with your AgelessRx prescriber.

Most patients can safely combine Trazodone with Tran-Q Sleep. However, you should always discuss this option with your prescriber before proceeding.

Some over-the-counter sleep-boosting supplements like melatonin and magnesium are usually safe to use with Trazodone. But you should always discuss any combination with your healthcare provider.

We can think of sleep architecture as “the house we sleep in,” or how well our brain is able to build a foundation of quality sleep.

Sleep architecture is defined by our brain activity as we sleep, or how well we pass through the stages of high-quality, restorative sleep: light sleep (stages 1-2), deep sleep (stages 3-4), and dream sleep (stage 5). The brain takes about 90 minutes to go through all of these stages, starting with the base (stages 1-2), then the siding (stages 3-4), and finally the roof (stage 5).

Just like a reliable house needs all of these parts to be comfortable, so too does reliable sleep. If it takes too long for us to fall asleep, or if our sleep is fragmented, then the quality of each stage deteriorates, leading to weaker sleep, or a less comfortable house to sleep in.

Those with healthy sleep patterns have good sleep architecture. On the other hand, those with insomnia are said to have poor sleep architecture, or poor sleep patterns that make it difficult to fall and stay asleep.

Studies show that users of Trazodone experience improved sleep architecture, fall asleep faster and stay asleep longer, while experiencing increased time spent in non-REM deep sleep (slow-wave sleep). Over time, this helps develop a more balanced sleep cycle with minimal impact on REM sleep​​.

Though rare, Trazodone may not effectively induce and sustain sleep in some patients. Contact your prescriber if you do not feel any sleep benefits of Trazodone after reaching the target dose on your titration schedule. Your prescriber may recommend that you increase your dose, but don’t increase your dose without first discussing with your prescriber.

Alternatively, some patients may not be able to tolerate Trazodone side effects like drowsiness, even at the lowest therapeutic dose of 25mg. Your prescriber may recommend that you slowly wean off Trazodone, so don’t stop taking Trazodone suddenly without first discussing with your prescriber.

Tran-Q Sleep is a plant-based sleep supplement featuring a blend of natural extracts like passionflower, jujube, California poppy, and lavender.

Each of these ingredients are carefully selected to enhance the response of gamma-aminobutyric acid (GABA) in the body, which can induce a calming effect that promotes soothing, restorative sleep.

Each of the ingredients in Tran-Q Sleep works together to increase GABA activity in the body. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that works by blocking certain signals sent between neurons of the central nervous system. GABA helps to calm hyperactive neurotransmitters that keep us alert, awake, and sometimes anxious. Increasing GABA activity in the body can produce a calming effect that may reduce anxiety and improve quality, restorative sleep.

Tran-Q Sleep encourages gamma-aminobutyric acid (GABA)signaling in the brain, which inhibits overstimulation of wakefulness neurotransmitters to produce a calm, relaxing feeling that helps users fall asleep faster and stay asleep longer.

Passionflower increases levels of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that may block excitement signals in the brain to produce a calming, sedative effect.

Jujube spinosa further boosts sleep-promoting neurotransmitter activity to help you fall asleep faster and stay asleep longer.

When combined with other herbs, California poppy enhances the collective soothing effects of Tran-Q Sleep by enhancing GABA signaling in the brain and relaxing muscles in the body.

Lavender rounds out this carefully curated blend with proven anxiety-reducing effects that may make it easier to fall asleep.

As a plant-based supplement, Tran-Q Sleep contains natural ingredients that work in synchrony to potentially increase GABA activity in the brain and create a mind-body environment that invites natural sleep without the risk of next-day grogginess.

There are no known side effects of Tran-Q Sleep when taken as recommended in the doses provided. However, the individual ingredients of Tran-Q Sleep may cause some mild side effects in certain people: passionflower may cause drowsiness and confusion, while jujube extract and lavender may cause drowsiness, diarrhea, or constipation. Any side effects should be mild and go away on their own within a week or two, as your body adjusts to the ingredients.

In rare cases, some individuals may experience an allergic reaction to the ingredients of Tran-Q Sleep. Allergic reactions may cause fever, rash, hives. swelling, or difficulty breathing. If you know you are allergic to any of the ingredients of Tran-Q Sleep, consider an alternative sleep aid such as Trazodone.

Metagenics’ Tran-Q Sleep contains an expert-curated blend of passionflower (726mg), jujube (554mg), California poppy (250mg), and English lavender (80mg). Each of these are carefully selected for their effects on gamma-aminobutyric acid (GABA), which converge as one complementary force that creates a potentially calming effect that promotes healthy sleep, without serious side effects or habit-forming medications.

Tran-Q Sleep is best for those who occasionally need help falling asleep, but don’t want to resort to prescriptions that may cause daytime drowsiness. As a plant-based supplement, Tran-Q Sleep may be preferred by those looking for vegetarian, gluten-free, or non-GMO options that do not contain melatonin or medications. Tran-Q Sleep may also be preferred by older adults seeking a milder sleep aid that does not significantly increase the risk of daytime drowsiness or fall injuries.

Tran-Q Sleep is intended for adults and may not be recommended for those under the age of 25. Those who are pregnant or breastfeeding or planning to become pregnant or breastfeed should not take Tran-Q Sleep.

Tran-Q Sleep contains passionflower, jujube extract, California poppy, and lavender, which may interact with certain medications such as antidepressants, blood thinners, or blood pressure medications. If you are allergic to any of these ingredients or currently prescribed one of these medications, you should not take Tran-Q Sleep.

Tran-Q Sleep is a natural supplement that has no known side effects, but its ingredients may make some users experience mild drowsiness after waking up. Though the risk of next-day drowsiness is low, users should be cautious to observe how they feel in the morning within the first few weeks of starting Tran-Q Sleep. If you do feel groggy after taking Tran-Q Sleep, avoid driving, operating heavy machinery, or performing other hazardous tasks requiring concentration and coordination.

If you normally sleep during the day, you may still take Tran-Q Sleep as long as you still take it as recommended and do not experience drowsiness after waking up. Always ensure that you can sleep for at least 7-8 hours before taking Tran-Q Sleep to reduce your chances of grogginess.

Tran-Q Sleep has no known side effects. However, some of the ingredients of Tran-Q Sleep may cause side effects like daytime grogginess that may inhibit your ability to drive. Though any side effects should be mild and go away on their own, users should still pay close attention to how they feel in the morning after taking Tran-Q Sleep. If you do experience grogginess, your symptoms should go away within a few days or weeks, but you should still plan to stay home or arrange for a ride in that time.

Please note that you are responsible for determining whether it is safe for you to drive after taking Tran-Q Sleep. If you’re not sure, don’t drive.

No, Tran-Q Sleep is not addictive. Tran-Q Sleep is a plant-based supplement that does not contain any medications, hormones, or melatonin. Its active ingredients—passionflower, jujube extract, California poppy, and lavender—are all natural and not known to be addictive or habit-forming at any dose.

Simply swallow 1-2 tablets of Tran-Q Sleep with a glass of water about 30-60 minutes before bedtime.

You should take 1-2 tablets of Tran-Q Sleep about 30-60 minutes before bedtime.

Most users report feeling the calming effects of Tran-Q Sleep within 30-60 minutes of taking 1-2 tablets. Results may vary based on your dose, metabolism, or unique medical background.

If you forget to take your dose of Tran-Q Sleep and it’s close to your usual bedtime, take it as soon as you remember. If it’s already close to morning, skip the missed dose and take your next dose at the usual time. Do not double up on doses to compensate for a missed dose.

Some users note that Tran-Q Sleep has a lingering lavender taste. To reduce any potential taste, try taking Tran-Q Sleep with a meal and/or a glass of water, and do not split the tablets.

Tran-Q Sleep is a mild, plant-based supplement that is not known to interact with any medications when taken at the recommended doses. However, some ingredients of Tran-Q Sleep may interact with certain medications when taken in larger doses than recommended: jujube extract may interact with antidepressants, while California poppy may interact with blood thinners or blood pressure medications.

When completing your medical intake, be sure to list all medications, vitamins, or supplements you are currently taking so your prescriber can best decide if Tran-Q is right for you.

Tran-Q Sleep is not FDA approved or reviewed, and there are no long-term studies on its safety or efficacy, so there is no clear answer as to whether it’s safe for long-term use. However, each of the ingredients of Tran-Q Sleep—passionflower, jujube extract, California poppy, and lavender—have been extensively researched with no evidence of addiction or long-term side effects.

Sleep aids work best when combined with healthy lifestyle options. Try to create a good sleep environment for yourself and stick to a regular sleep schedule to get the best results with Tran-Q Sleep. Light therapy, meditation, and regular exercise can also promote better sleep, while avoiding caffeine, nicotine, and alcohol can reduce nighttime awakenings.

It’s possible that some users may not achieve better sleep with Tran-Q Sleep. If you find that you aren’t achieving your desired outcomes with Tran-Q Sleep, try to first increase your dose to 2 tablets each night. If you’re already taking 2 tablets each night, talk to your AgelessRx prescriber to see if stronger sleep aids like Trazodone could be right for you.

Most patients can safely combine Trazodone with Tran-Q® Sleep. However, you should always discuss this option with your prescriber before proceeding.

Infinite is taken once daily (1 sachet = 3 capsules), preferably in the morning.

No. If you miss a dose, simply take your dose as soon as you remember (not more than once daily). Do not double your next dose.

No. You can take Infinite with or without food. We do recommend taking it with a small glass of water.

Our manufacturing partner only follows GMP*, and this leads to a top-quality, highly tested product. Infinite ingredients are vegetarian and include calcium alpha-ketoglutarate, quercetin, glucosamine, carnosine, pterostilbene, astaxanthin, and curcumin.

*Good manufacturing practice (GMP) is a system for ensuring that products are consistently produced and controlled according to quality standards

Infinite is a first and only daily, pill-form product that addresses the 9 hallmarks of aging and key tenets from the Kaufmann Protocol. Additionally, our team has consulted with the top industry professionals to ensure that Infinite by AgelessRx is of the highest quality ingredients, the best methods of action and based on the latest science. There are plans in place to thoroughly test the results – and in the meantime, our suite of longevity tests can provide instant access to the results of your product experience.

Our team of experts indicate that you will experience noticeable benefits within 30 days of supplementation. Like any supplement, everyone reacts differently and the timeframe of when you can fully enjoy the positive results from daily usage can vary.

Ideally, you will incorporate Infinite into your daily routine indefinitely. It is designed to be a long-term supplement that you can start at any age to help slow down the aging process.

Glucosamine, one of the key ingredients of Infinite Longevity Support, is often sourced from the shells of shellfish such as shrimp. However, glucosamine is not derived from the protein that causes shellfish allergies. As such, it is normally safe to consume, even for those with shellfish allergies.

Atorvastatin is a member of a class of prescription medications called ‘statins’ that work to reduce the amount of cholesterol in your liver and help remove cholesterol already in the blood. As a result, it helps to lower your overall cholesterol levels.

Atorvastatin is taken once daily around the same time. Your dose can be taken either with or without food, on a full or empty stomach.

Most statins, like Atorvastatin, require approximately 4-6 weeks to help cholesterol levels stabilize. You will complete a blood test within the first 3-6 months of treatment to check cholesterol levels (e.g. LDL, HDL, Total Cholesterol and Triglycerides) to identify measurable improvements.

Generally, Atorvastatin is safe to take long term, and, according to some experts, actually works best when taken over a long period of time.

If you stop taking Atorvastatin, your cholesterol levels may rise again. If you want to stop taking your medication, consider finding other ways to lower your cholesterol.

In the event you forget to take your daily dose within the same day, take it as soon as you remember. If you don’t remember until the following day, skip the missed dose and take the next one when you normally do.

If you take more than your prescribed dose, it’s unlikely to harm you. Consult with your doctor if you have any concerns.

You can take Atorvastatin with or without food. However, if it makes you feel sick, taking it after you eat can help.

Some evidence suggests that Atorvastatin can raise blood sugar in some people. If you have any concerns, speak to your doctor.

Yes, this can be provided to AgelessRx based on your most recent doctor or laboratory visit or can be purchased via AgelessRx with our Core Longevity Panel. Any valid labs completed within the prior 6 months will be considered at the discretion of your assigned medical professional.

The point of taking statin medication is to lower cholesterol levels and prevent accumulation of cholesterol in the arteries, thereby reducing risk of heart disease. Ask your doctor if Atorvastatin is right for you.

Atorvastatin is simply the generic version of Lipitor.

Yes, we recommend patients take at least 100mg of CoQ10 per day while on any statin.

Take your prescribed dose with the first bite of a starch-heavy meal, such as pizza or pasta. Tablets can be swallowed with a drink of water or chewed with your first mouthful of food. Do not take more than prescribed. If you are subscribed to an Acarbose Daily plan, your meals don’t always have to be carb-heavy to take Acarbose, so don’t feel like you have to carb load every day – in fact, it’s bad for your longevity to do so. Just take Acarbose with whatever your heaviest meal of the day would be.

Each Acarbose Protocol calls for a different frequency that will change how often you take Acarbose. For Acarbose (As Needed), you can take Acarbose up to 8 times a month with the first bite of a carb-heavy meal – which meals you take it with are up to you. For our Acarbose Daily plans, you will take 1-2 tablets either with 1 meal/day or 2 meals/day, according to your titration schedule.

Your AgelessRx prescriber will help you guide you to the protocol that best suits your needs.

A Continuous Glucose Monitor (CGM) is one of the most convenient ways to track your progress. You can compare sugar spikes after eating starchy carbs (with and without Acarbose!) to visibly see the impact Acarbose has on preventing spikes.

As with Metformin, Acarbose is FDA approved for the treatment of diabetes mellitus, type 2.

Acarbose is most effective when taken with the first bite of a high-carb meal.

Talk to your doctor to see if Acarbose is right for you.

Every person is different. You should talk to your doctor about monitoring options while on Acarbose (if prescribed).

That depends on the Acarbose protocol for which you’re approved – Acarbose (1 Meal/Day), Acarbose (2 Meals/Day), and Acarbose (As Needed). All of these include a starting strength of 25mg tablets (tear-away packets include 2x25mg tablets). However, those taking Acarbose twice daily will eventually titrate up to 50mg tablets. If you’re on one of the Acarbose daily plans, check your Rx bottle to see your titration schedule and which dose you’re receiving. Additionally, you can always view your current Acarbose plan on your AgelessRx portal.

A carb-heavy meal has about 30 grams of starch or more. This is roughly equivalent to half of a bagel.

Some may find that even less starch can make their meals seem “heavy,” but when considering whether to take Acarbose with your meal, 30 grams of starch should be your reference.

Those who keep a longevity-friendly, low-starch diet can take Acarbose with any meal. Just pick one or two meals per day with which to take Acarbose.

Acarbose specifically inhibits amylose, or starch, from being broken down into sugar. It doesn’t work to inhibit sugary carbs.

Examples of starchy carbs include:

• Grains
• Including rice, corn, wheat, rye, quinoa, millet, oats, barley, and any foods made from them (oatmeal, pasta, bread, cereal, pizza, pastries, etc.)
• Beets
• Carrots
• Turnips
• Potatoes (including sweet potatoes)
• Yams
• Peas

Examples of sugary carbs include:

• Fruit juice
• Sports drinks
• Candies
• Honey
• Jams/jellies
• Any syrup
• Soda
• Table sugar & brown sugar

If a dose is missed, simply move on to the next scheduled dose. Never double up your dose to make up for the one you missed; only use Acarbose as prescribed.

If you’re unsure which dosage is right for you, the best plan is to discuss your options with your AgelessRx prescriber. But, here are a few things to consider before you do.

First, how often do you eat starchy carbs? Those who enjoy the occasional indulgence may find taking Acarbose As Needed to be more beneficial. If, on the other hand, starchy carbs like rice, potatoes, wheat, or pasta are part of at least one of your meals each day, then you might want to consider one of our Acarbose Daily plans.

Second, decide whether your goals are short term or long term. Are you looking to reduce your risk for heart disease or stroke, or even further optimize your healthspan? If so, then one of our Acarbose Daily plans might best match your goals. But if you’re just looking to avoid crashes, headaches, or other more immediate aftereffects of sugar spikes, then perhaps a less substantial subscription is appropriate.

Finally, be honest with yourself and set realistic expectations. If you’re not ready to add a whole new treatment to your regiment, you can still casually reduce your risk with Acarbose As Needed – which is part of the reason why we designed multiple protocols.

The short answer is absolutely yes. Acarbose is an alpha-glucosidase inhibitor, meaning that it specifically acts on enzymes that break down starches. This only makes it more difficult for our bodies to absorb starch, delaying the digestion of carbohydrates. There is no evidence to suggest that Acarbose prevents the body from absorbing other nutritional components of foods.

Your dosage will depend on whether you are approved for Generic Rapamycin or Compounded Rapamycin.

For Generic Rapamycin, you will start at 2mg per week and slowly titrate up to your target dose of 6-8mg (determined at the discretion of your prescriber) over 3 months.

For Compounded Rapamycin, you will start at 5mg per week and slowly titrate up to your target dose of 10-15mg (determined at the discretion of your provider) over 3 months.

You can only receive medication following a medical review and initial screening from an AgelessRx prescriber, who will determine your titration and target dose based on your unique medical history and health goals.

A Generic Rapamycin prescription contains Sirolimus tablets that are commercially available, while Compounded Rapamycin prescriptions contain Sirolimus capsules that are compounded and mixed by a US-licensed, certified compounding pharmacy following rigorous state and federal quality controls.

Compounded Rapamycin may be less potent than Generic Rapamycin, which could lead to reduced side effects as well as reduced absorption or bioavailability. For this reason, Compounded Rapamycin is typically prescribed at higher doses than Generic Rapamycin.

Depending on your state’s regulations, one or both options may be available to you. If only one option is available to you, then we must comply with your state’s regulations and only consider the available option. If both options are available in your state, then you can choose to get started with either generically available Rapamycin, or Rapamycin that is compounded to order.

Compounded Rapamycin is typically less potent than Generic Rapamycin. That means Compounded Rapamycin may have a reduced risk of side effects. It also means Compounded Rapamycin is less bioavailable than Generic Rapamycin. To account for this, our medical experts typically prescribe Compounded Rapamycin at higher doses than Generic Rapamycin.

You will receive quarterly refills (once every 3 months) for your Rapamycin prescription, as long as you continue to do your required blood tests and electronic check-ins. Each quarterly refill will be equivalent to 3 monthly refills. However, you will be billed once per month for your prescription.

If, after doctor review and screening, you are approved for Rapamycin, you will only take one dose of Rapamycin each week. You may take more than one pill as part of your titration plan, but the frequency will not change.

You must be at least 40 years of age, clinically stable, and in relatively good health (all of which will be assessed during your initial and ongoing visits) to take Rapamycin. You must also be able to give informed consent of your willingness to take off-label Rapamycin and to undergo routine blood work, as well as technologically capable to join virtual meetings and fill out online forms. There are no limitations on sex or ethnicity, and no maximum age limit.

Once approved, you will receive an automated message in your AgelessRx portal with the link to schedule your blood draw and a copy of your requisition form.

Your blood work is required to determine your continued eligibility. It should be completed as soon as possible. Once received, our experts will review your results and notify you of your approval status.

If you are approved, our team will generate a prescription for you with our partnering, US-based pharmacy. You will also receive updates and tracking information for your first shipment and all subsequent shipments through your AgelessRx portal.

From there, you will continue to provide blood work, fill out questionnaires, and meet as needed with our AgelessRx physician to track any benefits/side effects and determine that you remain eligible.

Rapamycin starts at $150 per month and includes the cost of ongoing blood tests, monitoring, and electronic check-ins. You will be billed once per month unless you pause or cancel, but you will receive refills once every 3 months, or once per quarter.

If you do not complete your ongoing blood tests or electronic check-ins, your subscription may be suspended, but you will not be charged until your prescription is resumed by your prescriber once the requirements have been met.

If you have anemia or other blood disorders, your doctor may suggest other medications. Similarly, premenopausal or menopausal females may not receive approval.

Those who are scheduled to undergo major surgery, chemotherapy or immunosuppressant therapy for a transplant within the next 6 months are also considered to have risk factors that could prevent your approval. Other exclusion criteria include: chronic infection (such as HIV/AIDS, Lyme disease, etc.); any primary or secondary immune dysfunction or deficiency, and allergy to Rapamycin.

At AgelessRx, physicians may not currently be open to discussing Rapamycin enrollment with women who are pregnant or planning to become pregnant.

Side effects of Rapamycin are generally mild, especially if taken in lower doses. The most common side effect is stomatitis (mouth ulcers). Diarrhea and nausea are also common. More serious side effects include susceptibility to bacterial infections like pneumonia, but these are usually reported in transplant patients taking Rapamycin at higher doses.

Rapamycin was the first name given to the compound isolated on Easter Island (for its native name, Rapa Nui), but the first name given to Rapamycin medications was Sirolimus. As such, there seems to have been a bit of a schism in the scientific community regarding the correct nomenclature for this compound/medication. However, Rapamycin and Sirolimus are effectively interchangeable terms that mean the same thing.

Our medical team may be able to work with you, depending on your current dosage and the reasons you are taking it, but ultimately this is a discussion between you and your prescriber.

If you are taking a lower dose of Rapamycin that is similar to the dosages listed on our protocols, you may be eligible. Work with your assigned prescriber to confirm.

If you are taking a higher dose of Rapamycin (>15mg), our medical team will need to better understand why you are at these doses to determine if it is safe to transition you to the lower doses of our protocols.

All who enroll must be able to follow the same titration plan, regardless of whether you are currently prescribed Rapamycin, were previously enrolled in the PEARL trial, or have never taken Rapamycin before.

Monitoring your Sirolimus blood levels allows your healthcare team to gather important data on how the drug is processed by your body. While it doesn’t directly impact your current treatment plan, this research is crucial for understanding how different individuals respond to Rapamycin, with the ultimate goal of personalizing treatment to maximize benefits and minimize risks in the future.

Currently, we are in the exploratory phase of understanding sirolimus blood levels, which means we do not usually adjust dosages based solely on these results. The primary aim is to collect data that could help tailor treatments more effectively in the future, rather than making immediate changes to your treatment regimen.

The monitoring is part of a broader research effort to pave the way for personalized medicine in longevity therapy. By understanding how different people metabolize Rapamycin and how it affects them, researchers can work towards developing individualized treatment plans that optimize efficacy and minimize side effects, enhancing overall outcomes for patients in the long term.

The future goal is to move towards a personalized medicine approach, where dosing can be tailored to each individual’s unique response to rapamycin. This research aims to establish a foundation for determining the most effective and safest doses for each patient, potentially revolutionizing how we approach treatment for longevity and healthspan enhancement.

At this stage, interpreting Sirolimus blood levels is complex and primarily a tool for research. Your healthcare provider will discuss any significant findings with you, but it’s important to remember that we do not yet have specific target levels associated with optimal outcomes. The focus is on safety and collecting data that will inform future treatment strategies. If you have concerns about your results, it’s best to discuss them directly with your doctor, who can provide context and understanding tailored to your individual health situation.

Telmisartan is taken daily. Take it around the same time each day with a small glass of water, with or without food.

In most cases, Telmisartan can help to lower blood pressure within about two weeks. It often requires about four weeks to get the full effects of lowering blood pressure. However, everybody is different and it may take more or less time.

There are some medications to avoid when taking Telmisartan, depending on your health. Talk to your healthcare provider prior to starting Telmisartan if you take blood thinners, have diabetes or kidney disease, take blood pressure medications like Aliskrien, and/or take nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen.

AgelessRx offers 20mg tablets of Telmisartan. We only offer Telmisartan with a quarterly plan, supplying 90 daily doses per quarter (1 tablet daily, or as prescribed).

Administer the topical spray once daily at bedtime, coating the desired surface area (approximately 12 sprays). Powers Hair Solution is gentle enough to be used on all skin types and is safe to use on color-treated hair.

Powers Hair Solution is uniquely formulated to help both men and women reduce balding, shedding, and thinning of hair by restoring and helping to grow (and regrow) hair follicles. Fight back against thinning of the crown, thinning through your natural part, and/or receding hairline.

When used daily, most patients begin to see growth within 2-3 months, with the most noticeable results within 4-6 months. To help restore a receding hairline, results typically take a bit longer, between 6-9 months.

Hair loss can be tricky. It can depend on heredity, age, health and overall wellbeing, nutritional habits, environmental factors, and even our stress levels. Problematic hair loss can present itself as a gradual shedding, thinning, and loss of hair on top of the head, patterned loss, circular or patchy bald spots, sudden loosening of hair, and in some cases rapid hair loss.

Powers Hair Solution brings life back into hair, healing the scalp and helping regrow hair from the inside out. Your hair will grow, and your confidence will show. Fresh, soft hair will help bring a more youthful, vibrant, and assured YOU.

While this isn’t very common, it can happen. If you experience this condition you should reduce the number of sprays used at night. If the condition persists or is intolerable, stop using the solution and contact your prescriber.

As a general note, Biotin helps hair grow everywhere. If you only want to encourage hair growth on your scalp, the topical spray is all you need to do just that (Biotin is one of the ingredients, after all). Additional Biotin supplementation is not necessary, but probably will not affect the results either.

At this time, we only offer Dr. Powers’ formula and do not have the ability to change or customize the formula.

Yes! Dr. Powers’ formula is designed to be equally effective for both men and women. You do not need a separate formula based on gender.

AgelessRx provides the FreeStyle Libre 3 Plus CGM, the most recent version available.

Originally created for diabetics, this device has since become popular among health conscious individuals who want an easy way to measure their glucose levels. It provides actionable insights into how food, exercise and other everyday activities impact blood glucose levels, and can help establish better lifestyle habits.

No, the FreeStyle Libre 3 Plus does not require a separate reader. All you need is the LibreLink app installed on your smartphone.

If you do not have a smartphone that is compatible with the FreeStyle Libre 3 app, you must request a FreeStyle Libre 3 reader device with your CGM order (for an extra cost) in order for your CGM to work.

The sensor kit includes the following items: one Freestyle Libre sensor, sensor applicator, alcohol wipe, CGM patch (to help protect your device), and product insert.

Our partnering pharmacies will send the FreeStyle Libre 3 Plus by default. If, for some reason, stock is not available, the FreeStyle Libre 3 will be provided.

You will not need to manually calibrate or scan your sensor. All FreeStyle Libre 3 Plus CGM Sensors are factory calibrated, and all glucose readings will be sent automatically to the FreeStyle Libre app on your smartphone using Bluetooth technology.

CGM sensors are considered a medical device that requires a prescription.

Yes! With the new FreeStyle Libre 3 Plus, you can wear your CGM for up to 15 days straight.

After that, your CGM will no longer report readings. For comprehensive glucose monitoring, consider a Monthly CGM subscription.

Yes, the sensor is designed to be worn while running, showering, and doing any other daily activities. While you can go about your daily activities in a regular way, be careful not to pull the sensor off by accidentally tugging on it.

If you do plan to engage in strenuous activity while wearing the sensor, you may elect to purchase an OTC band or external adhesive for the CGM, or you could wrap it in an elastic bandage to ensure it remains intact.

If you’re experiencing any difficulties, such as premature detachment or inaccurate readings, we’re here to help. You may be eligible for a complimentary replacement directly from the manufacturer. Simply give them a call at 855-632-8658, available 7 days a week from 8 AM to 8 PM Eastern Time, excluding holidays. Alternatively, you can also use their webform for easy assistance and to check if you’re eligible for a replacement. Please have your device’s serial number (found in your app) handy for efficient assistance.

Most people feel either nothing, or a very small prick on their skin when they insert the sensor. The small needle that helps insert the CGM retracts immediately, leaving only a small filament that samples the glucose levels.

Remove the sensor prior to MRI, CT scan, X-ray or diathermy treatment.

AgelessRx recommends non-diabetic patients aim for a range between 75-125. 70 to 80 is considered an ideal fasting sugar level, and meals should not spike sugar higher than 125mg/dl. However, there are some people who cannot tolerate these lower levels and need to work on bringing them down into this range over time. On the other hand, there are some people who are “fat adapted” and thrive on lower levels of blood glucose. The above guidelines are for non-diabetic people, who are using CGM.

You can pause CGM alerts to your mobile device by disabling Bluetooth and force closing the FreeStyle Libre app. Just remember to turn Bluetooth back on and open the app again in the morning!

While certain nighttime alarms from your CGM sensor can be an emergency for diabetics, it can also be a nuisance for non-diabetics. The low blood glucose alarm can be particularly persistent. In fact, Johns Hopkins Medicine reports that half of all episodes of low blood glucose occur during sleep. However, because AgelessRx does not prescribe CGMs to diabetics, these alarms are most often not a concern for our subscribers and can be safely ignored until the morning.

The CGM is designed for diabetic patients and therefore many of the instructions and warnings are meant for diabetics. If you are non-diabetic and are prompted to verify the reading with a finger prick and you feel fine, then it is probably fine to ignore the instructions – you might need to adjust the warning parameters instead.

If you’re experiencing any difficulties, such as premature detachment or inaccurate readings, we’re here to help. You may be eligible for a complimentary replacement directly from the manufacturer. Simply give them a call at 855-632-8658, available 7 days a week from 8 AM to 8 PM Eastern Time, excluding holidays. Alternatively, you can also use their webform for easy assistance and to check if you’re eligible for a replacement. Please have your device’s serial number (found in your app) handy for efficient assistance.

AgelessRx recommends a non-diabetic fasting glucose between 70-85. The goal is to eat foods that keep levels from rising higher than 125.

Due to the current limitations of the technology for CGM Sensors, there is an expected margin of error % within ±20/20%. This is true for all CGM Sensors on the market.

Additionally, there is about a 10-15 minute “phase” delay between what is measured by the CGM (interstitial fluid) and what can be measured by a finger stick (capillary blood).

Cologuard is a non-invasive, at-home stool test designed to detect the presence of colorectal cancer or precancerous conditions by analyzing DNA and blood in the stool. Cologuard is a prescription-only product that must be ordered by a healthcare provider on your behalf.

AgelessRx does not provide Cologuard collection kits directly. AgelessRx only offers medical consultations with expert prescribers to see if a Cologuard prescription is appropriate for you.

If you are approved for a Cologuard prescription, you must contact Exact Sciences, the manufacturer of Cologuard, directly to confirm your identity and remit payment to receive your collection kit.

Cologuard detects specific changes in the DNA and the presence of blood in your stool, which can be indicators of cancer or precancerous polyps. Each sample is analyzed by a US-licensed laboratory technician at Exact Sciences, the pathology company who launched Cologuard, who will deliver a positive or negative confirmation based on your sample.

Please note that a negative result does not rule out colorectal cancer, and a positive result is not a diagnosis. Cologuard should be used in addition to routine cancer screening tests with your healthcare provider, who will help you interpret your results and advise you on next steps.

Cologuard is recommended for individuals aged 45 and older who are at average risk for colorectal cancer and who do not have symptoms. Your AgelessRx provider will review your request to determine if Cologuard is right for you.

Cologuard is a prescription stool test provided by Exact Sciences. In order to receive Cologuard, you must receive a prescription from a doctor, such as your AgelessRx provider.

To get Cologuard, you can start by setting up a virtual visit with your AgelessRx provider, who will determine if Cologuard is right for you and provide a prescription if appropriate.

If you’re approved, your prescription will be sent to Exact Sciences, who will contact you directly to help you complete the process.

Please note that AgelessRx only provides doctor consultation to see if Cologuard is right for you. AgelessRx does not provide the Cologuard collection kit. You must complete your payment with Exact Sciences to receive your Cologuard collection kit.

The out-of-pocket cost for Cologuard is $382 if you choose not to go through insurance. You can always use your insurance if you prefer, but you may be charged more in the event that your insurance does not cover your Cologuard prescription.

No, Cologuard is not a replacement for a colonoscopy. Cologuard detects 42% of large polyps on average, while colonoscopies detect 95% of large polyps. Cologuard is an alternative screening option for those at average risk of colorectal cancer.

Cologuard is generally recommended every three years if your results are negative and you remain at average risk for colorectal cancer. Your prescriber may recommend you take Cologuard more often based on your unique medical background.

A positive result indicates that DNA and/or blood associated with cancer or precancerous polyps were detected. It is not a diagnosis of cancer. A follow-up colonoscopy is necessary to investigate further.

A negative result means that the test did not detect DNA and/or blood associated with colorectal cancer or precancerous polyps. A negative result does not rule out the presence of colorectal cancer and should be followed up with your primary care physician to confirm the next best steps for you.

If your test is positive, you will be asked to complete a video consultation with a member of our medical team where next steps will be discussed.

Cologuard can detect 92% of colorectal cancer and 42% of precancerous polyps. Cologuard also has a 13% false-positive rate, with an 8% false-negative rate.

Cologuard has been shown to be effective in detecting certain DNA and blood markers associated with colorectal cancer, but Cologuard does not provide a positive or negative diagnosis of cancer. Like all tests, it is not 100% accurate and may not detect all cancers. For this reason, it’s best utilized as an alternative screening tool for those at average risk of colorectal cancer. You should consult your primary care physician about your Cologuard results to determine next steps.

No, Cologuard is not recommended for individuals experiencing symptoms of colorectal cancer. In such cases, a diagnostic colonoscopy is advised.

There are no specific dietary or medication restrictions for Cologuard, and there is no special preparation recommended before you collect your sample.

Your sample should be whatever is typical for you in terms of consistency, so try not to eat or drink anything that causes abnormal bowel movements. Besides that, you’re good to go!

The testing process involves collecting a stool sample at home using the provided kit and sending it back to the lab for analysis. The expert technicians at Exact Sciences will analyze your sample for traces of DNA and blood that are associated with colorectal cancer.

Your collection kit will come with clear instructions on how to use Cologuard at home. You can also find more helpful tips and tricks in your Cologuard product guide and in your product instructions email once you are approved.

Many insurance plans, including Medicare, cover the Cologuard test – but usually only ordered through a patient’s primary care provider. AgelessRx does not facilitate the billing of insurance. All patients ordering Cologuard through AgelessRx are expected to pay for the test out-of-pocket and AgelessRx does not help coordinate payment with insurance companies.

Results are typically available within 2 weeks from the time the lab receives your sample. Results will be sent to your provider as soon as they’re available. You can also create an account with Exact Sciences to view your results when they’re available.

Cologuard is typically recommended for those with an average risk of colorectal cancer. Those who have a personal or family history of colorectal cancer are often considered to be at high risk and should consult with their healthcare provider for appropriate screening recommendations.

There is no direct risk involved in taking the Cologuard test, as it is a non-invasive stool-based DNA test.

Your stool sample is analyzed at a lab for specific DNA markers and the presence of blood that could indicate colorectal cancer or precancerous conditions.

The results are reviewed by a qualified laboratory professional and then sent to be reviewed by the AgelessRx medical team.

Exact Sciences can help you with any questions regarding sample collection. You can call their Customer Care Center at +1 (844)-870-8870.

The price of the Biological Age Test includes:

• A doctor’s order for testing
• All lab and testing fees
• A copy of your results (revealing your Biological Age)

1. Purchase the Biological Age Test from AgelessRx
2. Schedule your blood draw at Quest or a lab of your choice
3. Collect your blood draw results
4. Enter your results into the Biological Age Calculator
5. Reveal your Biological Age

No. As part of your test price, AgelessRx provides an order from a licensed doctor in your state through our network.

Unfortunately, no. All laboratory testing must be privately paid for at the time of purchase.

If you would like to see if this test will be reimbursed by your insurance, you can download a copy of your receipt from your account dashboard.

Yes, you can use both FSA or HSA cards.

Additionally, you can download a copy of your receipt from your account dashboard should you wish to get reimbursed from your FSA or HSA accounts.

If you purchased your blood test through AgelessRx, you can go to any of the thousands of Quest Lab locations nationwide.

Once your order has been confirmed, you will receive the Biological Age Test User Guide which will guide you through the process of setting up an appointment.

If it is possible, yes. We encourage everyone to use their own doctor and health insurance for blood tests. However, if that is not possible or not as affordable, AgelessRx can help you arrange a blood draw at a local Quest Labs.

Once you have submitted your order, you will receive access to the Biological Age Test User Guide that outlines how to schedule an appointment at Quest Labs.

We encourage everyone to complete a Biological Age Test before starting a certain therapy. Then, repeat the test again within the next 6-12 months to see how the therapy has impacted your aging process.

For the most accurate values, you will be required to fast for ten hours prior to your scheduled blood draw.

Ideally, try and schedule an appointment as early in the day as possible to minimize fasting to the recommended ten hours.

FYI: Do your best to increase your water intake on both the day before your scheduled blood draw and the day of. This will help prevent your blood from getting too concentrated/thick—making it easier on you and the technician or nurse to get your blood.

After completing the calculator exercise, you will receive a personalized report detailing your Phenotypic Age and Chronological Age. Specifically, the difference between the two ages.

1. Albumin – Liver function
2. Alkaline Phosphatase – Liver function
3. Creatinine – Kidney function
4. Glucose – Metabolism
5. C-reactive Protein – Inflammation
6. Lymphocyte – Immune System
7. Mean Cell Volume – Immune System
8. Red Cell Distribution Width – Immune System
9. White Blood Cells – Immune System

You can learn more about each of the 9 blood markers on our Product Science Page.

If your Phenotypic Age is lower than your chronological age, keep up the great work! But don’t just stop here—take this opportunity to consider doing even more to increase the gap between your chronological age and Phenotypic age. Better sleep and diet, more exercise, and certain longevity treatments can all make an impact.

If your Phenotypic Age is equal to or higher than your chronological age, you have the opportunity to make improvements to your lifestyle, environment, and/or adherence to longevity protocols. The higher your Phenotypic Age, the more likely you may be to experience co-existing morbidities, physical functioning problems, and increased risk of coronary heart disease.

First, be sure you are hydrated before beginning the process. Spit directly into the circles on the provided sample selection card. Wait about 45 minutes (or until your saliva completely soaks into the card). Then, package your sample into the designated collection bag, seal inside the pre-paid envelope, and drop it off at your local post office.

Other genetic tests, such as 23andMe, simply look at the genetic sequencing of an individual, which you have no control over. With an epigenetic test, such as TruMe™, you can address the modifiable parts of your DNA (gene expression) with lifestyle changes to better take control of things like disease risk and rate of aging.

As an example, think about a light bulb and its components. Looking at the way the light bulb is constructed is like looking at DNA sequences (genetics). However, looking at epigenetic modifications is like looking at if the light bulb is on or off.

Genetics tells you what genes you have. More importantly, epigenetics tells you what genes are active. Epigenetics is the study of how the body adds and removes chemical “tags” to our DNA, to turn specific genes on or off. These tags record events that happen in your life–diseases, lifestyle, diet, environmental conditions.

Epigenetic changes happen way before symptoms of disease appear, and that makes epigenetics the most effective way to predict diseases. As a result, your epigenetic profile is often more important than just your genome because it reflects your ACTUAL state of health and predicts your health’s near or mid-term future.

Once you receive your kit in the mail, register the code on your saliva sample here.

The technology TruMe™ uses measures your DNA methylation at only a tiny fraction of the billions of nucleotides (the components that make up your DNA) and is subject to statistical error. Based on TruMe™ studies, they have approximately a 4.75 years’ error rate. If you see what you think is an error, please feel free to contact TruMe™ directly. Also, keep in mind that these are initial results. As people continue to join we will continue to update and improve your testing accuracy.

We recommend taking the test every six months because your DNA methylation measurably changes within that time. Plus, by taking the test more than once, you’ll be able to notice if the treatments (e.g. Metformin) and lifestyle changes (e.g. diet or exercise) you have applied to your health have been effective in reducing your biological age.

No. The TruMe™ test is a research study. The protocols TruMe™ uses are suitable for genetic research only, not for clinical genetic testing like you would receive at a hospital or doctor’s office. Clinical genetic testing is held to higher standards and is done in laboratories, which are certified by governmental regulations called CLIA (Clinical Laboratory Improvement Amendments). If you use the TruMe™ data for diagnostic purposes, you should always contact the doctor and have the results confirmed by tests recommended by a medical professional.

Our Core Longevity Panel is a first-of-its-kind blood test that helps assess your risk for heart disease, diabetes/insulin resistance, and inflammation. This test measures 10 key biomarkers critical to your health and longevity.

When your sample is processed and reviewed by our world-class medical team, an easy-to-read copy of your digital lab report will be made available to you on your AgelessRx portal. You should always discuss results with your doctor, especially for any abnormal values.

We strive to deliver test results within 2 weeks.

If 7 business days have passed and you still have not received your results, please contact us via your AgelessRx portal.

You will receive your results through your patient portal, approximately 2 weeks after your blood draw.

Furthermore, once your results are ready, you’ll receive a notification from us. You can then login and view your results within your AgelessRx portal.

Tests are currently only for adults aged 18 and older.

A comprehensive list of scientific journal references that reinforce our testing methodology are included below.

Cardiovascular health:

1. Courtney Nagel Sandler, MDMarie E. McDonnell, MD 2016 May, The role of hemoglobin A1c in the assessment of diabetes and cardiovascular risk Cleveland Clinic Journal of Medicine ; 83 Suppl 1(5):S4-S10
2. Ivana R Sequeira, Sally D Poppitt1 2017, HbA1c as a marker of prediabetes: A reliable screening tool or not, Review Article – Insights in Nutrition and Metabolism () Volume 1, Issue 1
3. Ho-Pham LT, Nguyen UDT, Tran TX, Nguyen TV. August 17, 2017, Discordance in the diagnosis of diabetes: comparison between HbA1c and fasting plasma PLOS ONE. doi:10.1371/journal.pone.0182192
4. Simmons RK, Rahman M, Jakes RW, et al. 2011, Effect of population screening for type 2 diabetes on mortality: long-term follow-up of the Ely cohort. Diabetologia.; 54(2): 312–319.
5. Couderc R1, Antar M1, Bonnefont-Rousselot D2, Paul JL3, Therond P4. Couderc R, et al. Ann Biol Clin (Paris). 2017. Blood lipid tests in 2017. Review article
6. Screening for Dyslipidemia in Younger Adults: A Systematic Review for the U.S. Preventive Services Task Force. Chou R, Dana T, Blazina I, Daeges M, Bougatsos C, Jeanne TL Ann Intern Med. 2016;165(8):560.
7. Clinical utility of different lipid measures for prediction of coronary heart disease in men and women. Ingelsson E, Schaefer EJ, Contois JH, McNamara JR, Sullivan L, Keyes MJ, Pencina MJ, Schoonmaker C, Wilson PW, D’Agostino RB, Vasan RS. JAMA. 2007;298(7):776.
8. Lipid parameters for measuring risk of cardiovascular disease. Arsenault BJ, Boekholdt SM, Kastelein JJ; Nat Rev Cardiol. 2011 Apr;8(4):197-206. Epub 2011 Feb 01.
9. Clinical Utility of a Fingerstick Technology to Identify Individuals With Abnormal Blood Lipids and High-Sensitivity C-Reactive Protein Levels Parin Parikh, MD, Heidi Mochari, MPH, RD, and Lori Mosca, MD, MPH, PhD; Am J Health Promot. 2009 Mar–Apr; 23(4): 279–282. doi: 10.4278/ajhp.071221140

Diabetic health:

1. Courtney Nagel Sandler, MDMarie E. McDonnell, MD 2016 May, The role of hemoglobin A1c in the assessment of diabetes and cardiovascular risk Cleveland Clinic Journal of Medicine ; 83 Suppl 1(5):S4-S10
2. Ivana R Sequeira, Sally D Poppitt1 2017, HbA1c as a marker of prediabetes: A reliable screening tool or not, Review Article – Insights in Nutrition and Metabolism () Volume 1, Issue 1
3. Ho-Pham LT, Nguyen UDT, Tran TX, Nguyen TV. August 17, 2017, Discordance in the diagnosis of diabetes: comparison between HbA1c and fasting plasma PLOS ONE. doi:10.1371/journal.pone.0182192
4. Simmons RK, Rahman M, Jakes RW, et al. 2011, Effect of population screening for type 2 diabetes on mortality: long-term follow-up of the Ely cohort. Diabetologia.; 54(2): 312–319.
5. Couderc R1, Antar M1, Bonnefont-Rousselot D2, Paul JL3, Therond P4. Couderc R, et al. Ann Biol Clin (Paris). 2017. Blood lipid tests in 2017. Review article
6. Screening for Dyslipidemia in Younger Adults: A Systematic Review for the U.S. Preventive Services Task Force. Chou R, Dana T, Blazina I, Daeges M, Bougatsos C, Jeanne TL Ann Intern Med. 2016;165(8):560.
7. Clinical utility of different lipid measures for prediction of coronary heart disease in men and women. Ingelsson E, Schaefer EJ, Contois JH, McNamara JR, Sullivan L, Keyes MJ, Pencina MJ, Schoonmaker C, Wilson PW, D’Agostino RB, Vasan RS. JAMA. 2007;298(7):776.
8. Lipid parameters for measuring risk of cardiovascular disease. Arsenault BJ, Boekholdt SM, Kastelein JJ; Nat Rev Cardiol. 2011 Apr;8(4):197-206. Epub 2011 Feb 01.
9. Clinical Utility of a Fingerstick Technology to Identify Individuals With Abnormal Blood Lipids

Inflammation:

1. High-Sensitivity C-Reactive Protein Levels Parin Parikh, MD, Heidi Mochari, MPH, RD, and Lori Mosca, MD, MPH, PhD; Am J Health Promot. 2009 Mar–Apr; 23(4): 279–282. doi: 10.4278/ajhp.071221140

LP(a) is one of the most significant biomarkers of heart disease. Short for lipoprotein(a), LP(a) is a type of LDL particle that has an apo(a) protein on top of it. LDL is sometimes referred to as bad cholesterol, and our bodies try to clean as much LDL from our bodies as possible. Apo(a) acts like a mask, disguising LDL particles so they can’t be recognized by our cells, making them much harder to clear from our bloodstream. This means LP(a) particles are much more likely to stick around in the blood, get into blood vessel walls, and cause plaque formation, leading to conditions like atherosclerosis.

The Core Longevity Panel measures 10 key biomarkers most likely to impact your longevity – five heart markers, four diabetes markers, and one inflammation marker.

The five heart markers are ApoB, LDL, HDL, total cholesterol, and triglycerides.

The four diabetes markers are glucose, HbA1c, insulin, and HOMA-IR.

The inflammation marker is hs-CRP.

With the Core Longevity Panel + LP(a) bundle, you can also measure your LP(a), a critical heart biomarker.

The Multi-Cancer Early Detection Test detects more than 50 types of cancer, many of which are not commonly screened for today, through a simple blood draw. The test does not diagnose cancer and not all cancers may be detected in the blood.

The test looks for signals present in the blood that may be associated with cancer at the time of your blood draw. If a cancer signal is detected, results can point to where in the body the cancer is coming from to help your healthcare provider guide next steps.

The test is recommended for use in adults with an elevated risk for cancer, such as those aged 50 or older.

The test is intended to be used in addition to, and not replace, other cancer screening tests your healthcare provider recommends.

Family history is only one of many risk factors associated with cancer development. These risk factors include eating habits, lifestyle, living or working environments, genetics, and many others. Talk to your healthcare provider to determine whether the test is right for you.

In a large-scale, clinical validation sub-study of CCGA, the test detected more than 50 cancer types across all stages.

The test is only available in the U.S. at this time. It is only available by prescription.

Annual screening provides the opportunity to detect more cancers early. It is up to your healthcare provider to determine the appropriate screening interval based on your underlying risk factors. You should discuss a recommended interval with your primary healthcare provider.

The test is not intended to replace guideline-recommended cancer screening tests. One of the most pressing unmet needs in early cancer detection is to identify cancers for which there are no existing recommended screening tests. This test is designed to detect many cancer types, including those that lack routine screenings. The United States Preventive Services Task Force (USPSTF) currently recommends screening paradigms for lung (for high-risk smokers), breast, cervical, prostate, and colorectal cancers.

Furthermore, the test detects more than 50 cancers, and not all cancers may be detected in the blood. Recommended routine cancer screening tests such as colonoscopy or mammograms are commonly used and have been shown to reduce cancer deaths. This test is intended to be used in addition to and not replace these tests and can help maximize the benefits of early cancer detection. Missing recommended screening or ignoring symptoms could lead to a delayed diagnosis of cancer. Ask your healthcare provider about what cancer screening tests are right for you.

To complete your blood draw, simply schedule an appointment at your local Quest lab. Depending on your location, your Quest lab may also offer walk-ins without an appointment.

You will need an unopened sample collection kit and your test requisition form (sent to your email from Grail labs) for your blood draw. Please plan to complete your blood draw no later than 2 weeks after you receive your collection kit. Do not use your collection kit if more than 6 months have passed since you received it.

Once you receive your collection kit, please do not break the quality seal on it. The collection kit should be opened by the trained practitioner who draws your blood sample. Make sure you store it at room temperature until your blood draw appointment. The contents are sensitive to extreme temperatures. For example, avoid storing your collection kit in the trunk of your car for long periods of time.

The trained practitioner who draws your blood will pack and ship your sample back to the laboratory for processing.

No preparation or fasting is required for the test.

Approximately 1.5 tablespoons (or about 20 mL) of blood in two tubes typically from a vein in your arm.

Test results should be available within about 2 weeks after our lab partner receives your kit. In rare instances, your results may take longer than 2 weeks to deliver due to shipping delays, invalid samples, or other circumstances outside of our control. You can always check the status of your results on the ‘Orders’ tab of your AgelessRx portal. Should you have any questions about the status of your lab results, please don’t hesitate to contact our team.

This means that there is a suspicion of cancer but not a diagnosis of cancer. The test can point to where in the body the cancer is coming from to help your healthcare provider guide next steps. Your healthcare provider will discuss appropriate follow-up testing to confirm if cancer is present.

This means that no cancer signal was found. However, not all cancers can be detected by the test. Continue with all routine screening tests that your healthcare provider recommends. Missing routine screenings or ignoring symptoms can lead to a delayed diagnosis of cancer.

The test does not measure your genetic risk of developing cancer in the future and is instead looking for the presence of cancer at the time your blood is drawn. You may develop cancer in the future. Your healthcare provider is the best person to determine when to take the test again as apart of your routine screening based on any underlying risk factors.

All results are automatically shared with the provider who ordered the test. If you would like us to fax your results to an additional healthcare provider, please contact Customer Service by emailing info@agelessrx.com or sending us a message via your AgelessRx Portal.

A Longevity Consultation is an opportunity to speak one-on-one with a longevity expert regarding possible treatment options. You will first provide information about your medical history for the expert to review and customize a Longevity Report specific to your needs. Together, you will discuss the report recommendations via a virtual consultation at a date/time of your choosing.

Once your personalized longevity report is ready, our team will email you to schedule your consultation. To schedule your consultation, simply:

1. Click on the scheduling link provided by AgelessRx
2. Choose your desired date/time & click “Continue”
3. Enter your contact info & click “Complete Appointment”

All consultations are virtual (phone or video). When you book your longevity consultation, information will be provided on how to connect with your expert at the time of your appointment.

Should you wish to use video, please be sure to have a working webcam.

If you purchased an Advanced Consultation, you can complete your blood draw at a local Quest Lab in your area. An AgelessRx Customer Service team member will provide you with Quest registration details and instructions on how to book your appointment within 1-3 business days following your order. Blood draw results will automatically be made available to AgelessRx staff. All you will be required to do is book and attend your Quest appointment.

If, for any reason, Quest Labs is unavailable in your area or you prefer to visit a lab or clinic of your choice, AgelessRx can provide a manual requisition. Please note that these lab costs are separate and not included in the Longevity Consultation fee. If desired, you may run these labs through your insurance. Additionally, you will be required to fax or email blood draw results to AgelessRx prior to receiving your personalized Longevity Report.

Your personalized Longevity Report contains:

• Age-Related Recommendations & Therapies
• Lifestyle Ratings & Recommendations
• Suggested Longevity Interventions (Rx &
• Supplements)
• Suggestions for Additional Testing
• AgelessRx Patient Checklist
• Tips for Next Steps/Getting Started
• Lab Results (Advanced Consultation Only)
• Aging Score (Advanced Consultation Only)

You will be awarded a 5-minute grace period at the start of your consultation time. If you fail to show up for your consultation appointment, you will be required to pay a $35 rescheduling fee prior to rebooking an appointment. This fee, as with all Longevity Consultation fees, is non-refundable.

For any Rx recommended interventions, you can complete an order on Agelessrx.com. You will receive approval within 24-hours and your prescription will be shipped direct to your door within a few business days.

For any Supplement recommended interventions, you will be provided with a personalized link to FullScripts or other online platform. You can place an online order for your supplements and have them shipped directly to your door.

If your longevity expert recommended additional testing, they will provide you with information about next steps (such as a link to register).

If you are unsure about where to go for your test, or have other questions regarding testing options, you can always email info@agelessrx.com for assistance.

Yes! A copy of your report will be emailed to you at the time you book your consultation. You can download, print, or save for future reference.

If you need to communicate with your longevity expert following your consultation, please email info@agelessrx.com and include a detailed message about your request. Customer Service staff will work with your longevity expert to provide any follow-up.