Frequently Asked Questions

At AgelessRx, we strive for excellent service with a passion for your health. You are free to cancel, postpone, or pause your subscription at any time (and for any reason) prior to your next refill date. If at all possible, we kindly ask for a minimum of 48 hours notice before your next order is set to process.

AgelessRx cannot guarantee refunds for any cancellation requests received after our pharmacy partner has received your order. Furthermore, AgelessRx does not accept returns nor can we offer any refunds for any prescription product once it has left our pharmacy partner.

If you experience any issues with your shipment, or are dissatisfied with your product, please contact your care team within 30 days following your order fulfillment. We will be happy to review your request.

Yes, shipping is included on all the subscription products.

HSA/FSA cards may be accepted as payment at AgelessRx. If you would like to try using your HSA or FSA card for an order, simply enter your card information at checkout as you would any other card. 

Read more about using HSA/FSA funds before getting started. Please note that AgelessRx products and services are not eligible for direct insurance coverage or reimbursement.

Yes, we currently service every US state, but certain treatments may not be available in all states. Some treatments, such as cold-shipped injectables, cannot be reliably shipped to noncontiguous states like Alaska or Hawaii, while other treatments are restricted by regional law.

You can find the state-specific availability for each individual treatment underneath the “Get started” button on the treatment page. If you find that a particular treatment is not available in your state, our expert team can help you find an alternative that’s right for you.

No, our medical providers are only licensed to service people within the United States.

While we would love to support our members worldwide, at this time, we are only able to support people living in and residing at a US-based residential address.

Injections have better bioavailability than oral supplements as they bypass the digestive system completely, providing a direct supply of B12 into the bloodstream to fuel your body. Oral supplements might work for some, however, as we age, our ability to break down oral supplements often decreases.

The most common side effect of B12 injections is irritation at the injection site. If this occurs, consider changing placement on the body, or talk with your provider about using injections less often.

Rarer side effects may include headache, flushing, anxiety or jitteriness, and acne.

Do not use B12 injections if you are currently pregnant, breastfeeding or plan to become pregnant or breastfeed.

B12 Injections should be stored in a cool, dry place away from direct light. Refrigeration is recommended but not required. Do not freeze. Once opened, use within the timeframe specified in your care instructions. Keep out of reach of children.

B12/MIC provides the same great vitamin supplementation as B12 injections, but with a few added benefits. MIC (methionine, inositol, and choline) is a blend of lipotropic compounds that support fat metabolism. When combined with MIC, the metabolism-supporting principles of the injection are amplified, enhancing the body’s ability to break through weight loss stagnation.

B12 shots may help support more than just daily energy levels. Maintaining healthy B12 levels may also support cognitive function, vision health, and lower risk for age-related conditions like osteoporosis, macular degeneration, and cardiovascular disease. B12 shots also may help promote better sleep alongside healthier skin and nails.

Most side effects of B12/MIC are generally mild in nature and dissipate within a short time frame following administration. Common side effects may include pain, redness or itching at the injection site. You may also experience occasional GI upset, headache, flushing, or jitteriness.

If irritation continues to occur, apply an over-the-counter itch cream, or talk to your provider if symptoms persist for several weeks or become intolerable.

B12 Injections may be particularly beneficial for those with low energy, consistent fatigue, or low or suboptimal B12 levels, including older adults whose ability to absorb B12 from food and oral supplements naturally declines with age, individuals following plant-based diets, and those who have not responded well to oral B12 supplementation. A licensed provider will review your health history to determine whether B12 Injections are appropriate for you.

Every body is different. Depending on your weight loss goals, lifestyle choices, and any underlying medical conditions, the results you see on the scale may vary. B12/MIC should be used in combination with diet and exercise to maximize results.

All B12/MIC injections are only available as intramuscular injections.

Subcutaneous injections deliver medication into the layer of tissue just below the skin, while intramuscular injections go one layer deeper, directly into the muscle.

Subcutaneous B12/MIC injections may be associated with an increased risk for irritations and reactions at the injection site. As such, our pharmacy partners only provide standard intramuscular injections.

B12/MIC Injections should be stored in a cool, dry place away from direct light. Refrigeration is recommended but not required. Do not freeze. Keep out of reach of children.

Methylene Blue belongs to a class of medications known as oxidation-reduction agents. It is a metabolic enhancer with antioxidant, antimicrobial, and neuroprotective properties, considered the first synthetic drug used in medicine. 

Methylene Blue is FDA-approved for the treatment of methemoglobinemia, a rare blood disorder. A growing body of research also suggests it may support mitochondrial function, reduce oxidative stress, and enhance cognitive performance, including focus and healthy brain aging.

Methylene Blue has been studied for its potential to support healthy aging and cognitive function, with a wide range of potential longevity benefits.

For cognitive support and memory enhancement, Methylene Blue may help maintain brain health by improving memory, focus, and overall cognitive function. Methylene Blue also enhances mitochondrial efficiency and increases ATP production, which may improve energy while reducing fatigue and brain fog. Methylene Blue also offers anti-inflammatory support, regulating inflammatory pathways that cause inflammation in the brain by reducing cellular stress from mitochondrial dysfunction. Through neuroprotection and healthy brain aging, Methylene Blue may slow cognitive decline by improving mitochondrial function and enhancing blood flow to the brain, helping protect against age-related diseases.

Methylene Blue is both fat soluble and water soluble, allowing it to cross the blood-brain barrier and freely enter cells and inner structures, including mitochondria. Our mitochondria produce ATP, which acts as fuel for the brain to repair, grow, and keep you operating at optimal energy.

But part of what makes Methylene Blue unique is that research suggests it may help restore damaged mitochondria. When Methylene Blue gets into damaged mitochondria, it optimizes the movement of electrons, increases ATP production in the mitochondria, and reduces oxidative stress, giving our neurons plenty of energy to keep everything tip-top in the brain.

The result is that Methylene Blue may support cognitive health while helping to support mitochondrial energy and cellular health and reduce age-related damage from free radicals.

The most common side effects of Methylene Blue include blue urine, nausea, vomiting, stomach pain, diarrhea, and loss of appetite.

Blue urine is a normal reaction to Methylene Blue and is not cause for concern. If you notice that your urine is blue after taking Methylene Blue, wait until your urine clears before taking another dose. Feces, saliva, and sweat may also be temporarily discolored with a blue tint. Most people clear the medication from their system within 4-6 hours, or up to 24 hours.

Most side effects are mild and go away on their own within a week or two. Taking Methylene Blue with a full glass of water and a meal may help minimize the chances of side effects.

Some people may also notice anxiety or insomnia, mild urinary irritation, or hypersensitivity to UV (sun) exposure. To minimize the risk of these side effects, take Methylene Blue in the morning, drink plenty of water, and be mindful when spending time outside, especially during peak sun hours.

Methylene Blue should not be used by those with G6PD sensitivity. People who have or are at risk of renal dysfunction should check with their provider to see if taking Methylene Blue is safe and appropriate.

If you are currently taking antidepressants like SSRIs or MAOIs, you should not use Methylene Blue. This includes Trazodone, a mild SARI (serotonin antagonist and reuptake inhibitor) that may interact with Methylene Blue. Please inform your provider of all medications you are taking, including supplements and over-the-counter medications. For a full list of Methylene Blue side effects, please review the Mayo Clinic’s Methylene Blue resources.

Methylene Blue is not recommended for people under 18 years old or for people with kidney, liver, or cardiovascular disease. It is also not recommended for those taking antidepressants like SSRIs, SNRIs, or MAOIs.

If one of the above describes you, talk with your provider about possible alternatives.

Please note that Trazodone is a mild SARI (serotonin antagonist and reuptake inhibitor) that may interact with Methylene Blue. If you are a member who is currently taking Trazodone, do not take Methylene Blue.

Most medications are safe to use with Methylene Blue, including most AgelessRx products. The only exception is Trazodone, a mild SARI (serotonin antagonist and reuptake inhibitor) that may interact with Methylene Blue. If you are a member who is currently taking Trazodone, do not take Methylene Blue.

You should always tell your provider of all medications you’re taking before getting started with Methylene Blue, especially those for G6PD deficiency or those that affect your serotonin levels.

Your provider will only recommend a Methylene Blue prescription if they feel it is safe and appropriate for you. Please review the full list of possible drug interactions with Methylene Blue before requesting a prescription.

Methylene Blue capsules allow for simple, precise dosing so you can get consistent results. Our capsules are prepared by licensed, US-based pharmacy partners. Capsules also remove the risk of teeth or tongue staining and limit the bitter taste of Methylene Blue solution.

If you chewed your capsule and it stained your mouth, tongue, or teeth, try swishing your mouth with lemon juice or vinegar water for 30 seconds, then rinsing. Repeat this step several times if necessary. You should also stay hydrated by drinking water throughout the day.

If Methylene Blue stains your skin or clothes, try scrubbing with the same lemon juice or vinegar water solution, or using a full-strength, skin-safe detergent. You can remove Methylene Blue from objects or surfaces with most commercial stain removers. Please note that there is no reliable method to reduce the appearance of blue urine after taking Methylene Blue. In most cases, urine will not clear until 2-6 hours after your last dose, or up to 24 hours.

Methylene Blue is sometimes described as a nootropic because researchers have studied its potential effects on memory, attention, functional brain activity, and mitochondrial energy.^{1 5 9} It is a prescription medication rather than a conventional stimulant or dietary supplement. Research in healthy adults is promising, but individual results vary.

No. Methylene Blue is FDA approved to treat acquired methemoglobinemia, a condition in which the blood cannot carry oxygen effectively.¹¹ Oral compounded Methylene Blue is not FDA approved for cognitive performance, healthy brain aging, or longevity, though several studies suggest these benefits.⁶ Methylene Blue may be prescribed off-label when a licensed provider determines that it is appropriate for an individual’s medical history and goals.

Much of the Methylene Blue sold online as a supplement is industrial or laboratory-grade, manufactured for staining or research use, not human consumption, and can carry heavy-metal contaminants never intended to enter the body.¹⁰

Pharmaceutical-grade Methylene Blue is manufactured and tested to a human-use standard. With AgelessRx, your Methylene Blue plan includes verified pharmaceutical-grade purity, a dose calibrated to your body rather than a generic suggested range, and a licensed clinician who reviews your health history before you start and can adjust your protocol over time. 

Liraglutide is a GLP-1 receptor agonist that is often sold as Saxenda (for weight loss) and Victoza (for diabetes). It helps regulate blood sugar, appetite, and digestion by mimicking the natural GLP-1 hormone. Brand-name versions of Liraglutide are FDA approved for weight management (Saxenda®) and the treatment of type 2 diabetes (Victoza®). Compounded Liraglutide has not been reviewed or approved by the FDA for safety, efficacy, or quality.

Liraglutide works by mimicking the natural hunger hormone, GLP-1, which plays a key role in regulating blood sugar and appetite. 

Liraglutide is designed to be as biochemically similar to the GLP-1 hormone as possible. The main difference is that it has a longer half-life. This allows the effects of the GLP-1 hormone to last longer in the body, helping to slow digestion and suppress cravings so you feel fuller for longer.

The most common side effects of Compounded Liraglutide are gastrointestinal issues such as nausea, vomiting, or diarrhea. These normally go away on their own within a few days, or up to 2-3 weeks, and many members develop a tolerance to these side effects. You can help prevent or ease these side effects by eating slower and at more regular intervals throughout the day, taking Compounded Liraglutide at the same time of day, drinking only water or clear, unsweetened beverages, and avoiding fried, greasy foods in favor of healthier, low-fat options.

For a complete list of side effects for Compounded Liraglutide, please review the Mayo Clinic’s Compounded Liraglutide resources.

Compounded Liraglutide is a daily medication, unlike many GLP-1 medications that are taken weekly. You can take Compounded Liraglutide with or without food, at any time of day or night. For the best results, try to take it around the same time each day.

For the best results, consider a reduced-calorie meal plan and increased physical activity while taking Compounded Liraglutide. If you already have a diet and exercise plan, great! If not, talk to your AgelessRx provider about a diet and exercise plan that works for you. 

A well-balanced diet with fresh fruits and vegetables and high-quality protein sources is key. Resistance training also helps to maintain your body composition and muscle, but any exercise is a step in the right direction, as long as you exercise for about 150 minutes each week.

Compounded Semaglutide is a semaglutide-based medication compounded by our partner pharmacies to address the ongoing national Semaglutide shortage so people unable to access semaglutide-based medications while they remain on the FDA’s Drug Shortage List can avoid lapse in treatment. Compounded Semaglutide has not been reviewed or approved by the FDA for safety, efficacy, or quality.

Compounded Semaglutide has not been reviewed by the FDA*, but our members report the following side effects: nausea, vomiting, diarrhea, stomach pain, and constipation. These normally go away on their own within a few days, or up to 2-3 weeks, and many members develop a tolerance to these side effects. You can help prevent or ease these side effects by eating slower and at more regular intervals throughout the day, taking Compounded Semaglutide at the same time of day each week, drinking only water or clear, unsweetened beverages, and avoiding fried, greasy foods in favor of healthier, low-fat options.

*Compounded Semaglutide has not been reviewed or approved by the FDA for safety, efficacy, or quality.

Microdosing GLP-1 is a low-dose therapy using compounded Injectable GLP-1 in small, gradual doses to help optimize health and longevity benefits while minimizing side effects.

Microdosing is the medical practice of administering very small doses of a drug, often to provide dose-specific benefits that might be different than the regular dose, while minimizing side effects.

Our medical experts expect that, by microdosing with GLP-1 medications, people could optimize the longevity benefits of GLP-1 with a lower risk of side effects. Clinical trials are underway to try to confirm these benefits.

Unlike higher doses of Semaglutide that are typically prescribed for diabetes or weight loss, Microdosing GLP-1 focuses on broader health and longevity benefits with reduced side effects.

The first difference is a lower dose. Microdosing GLP-1 is prescribed at very low doses, starting at about half the usual starting dose up to about ⅕ the full dose. The second is precision health benefits. Evidence suggests that microdosing could unlock longevity benefits like improved immunity¹, heart health², and cognitive function³. Clinical trials are underway to try to confirm these benefits. The third is reduced side effects. With lower doses also comes a potentially lower risk of side effects. If you do experience side effects, they’re more likely to be brief and mild.

¹J Clin Tran Endo, 2024. This review study analyzes human GLP-1 trials, including protocols via injection that may be considered low dose or microdosing.
²NEJM, 2016. The SUSTAIN 6 clinical trial, sponsored by Novo Nordisk, explores cardiovascular outcomes for people taking Semaglutide injections at doses as low as 0.5mg.
³Aging and Disease, 2022. This review study analyzes human and animal trials of various GLP-1 medications for their role in addressing the hallmarks of aging, such as mitochondrial function and oxidative stress, including low-dose protocols via injection for people with Parkinson’s on exenatide.

Low doses of GLP-1 medications have been shown to have several benefits. They may modulate inflammatory pathways¹ and may reduce risk of cognitive decline². They may also support cardiovascular health³ and may improve mitochondrial function and oxidative stress².

Low doses may also reduce side effects.

¹J Clin Tran Endo, 2024. This review study analyzes human GLP-1 trials, including protocols via injection that may be considered low dose or microdosing.
²Aging and Disease, 2022. This review study analyzes human and animal trials of various GLP-1 medications for their role in addressing the hallmarks of aging, such as mitochondrial function and oxidative stress, including low-dose protocols via injection for people with Parkinson’s on exenatide.
³NEJM, 2016. The SUSTAIN 6 clinical trial, sponsored by Novo Nordisk, explores cardiovascular outcomes for people taking Semaglutide injections at doses as low as 0.5mg.
⁴JAMA Network, 2022. A human trial analyzing people on Semaglutide injections that shows people who stopped at lower doses of GLP-1 medications experienced less side effects.

Microdosing GLP-1 is not intended as a weight loss treatment. Some people may achieve weight loss, but at low doses, any weight loss benefits are expected to be mild, if any at all. But don’t worry! If weight loss is your main goal, we have science-backed weight loss solutions that may be a better fit for you.

Microdosing GLP-1 is a low-dose GLP-1 prescription, which our experts expect may result in lower risk and severity of potential side effects than full-dose Semaglutide.

Injectable GLP-1 has not been evaluated by the FDA, but side effects are expected to be similar to other GLP-1 based medications reviewed by the FDA, which have the following side effects: nausea, diarrhea, vomiting, constipation, abdominal (stomach) pain, headache, fatigue, dyspepsia (indigestion), dizziness, abdominal distension, eructation (belching), hypoglycemia (low blood sugar) in people with type 2 diabetes, flatulence (gas buildup), gastroenteritis (an intestinal infection), and gastroesophageal reflux disease (a type of digestive disorder).

Common side effects normally go away on their own within a few days or up to 2-3 weeks. If you find that any side effects persist for longer than this or get worse over time, stop taking your medication and contact your provider as soon as possible.

This is only a summary of potential side effects and how to address them. For more information, please reference the Mayo Clinic’s Semaglutide resources, or ask your provider.

Tirzepatide may make oral contraceptives less effective. If you’re taking an oral contraceptive, ask your provider about potential alternatives before starting Compounded Tirzepatide + Glycine, or switch to a non-oral contraceptive.

This is one of the more genuinely exciting parts of the GLP-1 story. Research shows GLP-1 receptor agonists lower CRP, a key inflammation marker, through mechanisms that go beyond weight loss alone.⁵ In clinical studies, Tirzepatide has been shown to reduce CRP, IL-6, and other inflammatory markers independent of weight loss.³ ⁵ Most of this evidence comes from standard weight loss doses, but the underlying biology and real-world data is a reasonable basis for interest in a lower-dose approach.

Wegovy® is a once-weekly injectable medication or daily oral tablet that is FDA approved to support weight loss in adults with a BMI of 30 or more, or adults with a BMI of 27 or more with a weight-related health condition. Wegovy® contains Semaglutide, a GLP-1 receptor agonist that helps regulate appetite, blood sugar, and digestion.

Yes. If your goals change or you need more support, your provider can help determine whether a full-dose GLP-1 prescription may be a better fit.

Wegovy® works by imitating the natural GLP-1 hormone in the body that helps manage blood sugar and appetite. GLP-1 helps block glucagon, a hormone that increases blood sugar, and stimulates insulin release from the pancreas after you eat. By mimicking this gut hormone, Wegovy® slows down digestion and helps us feel fuller for longer.

The first thing you can do is calculate your BMI.

Wegovy® is FDA approved to treat weight loss in adults with a BMI of 30 or greater, or adults with a BMI of 27 or greater who also have at least one weight-related medical issue.

However, each potential Wegovy® candidate will be reviewed on a case-by-case basis, and approval is not guaranteed based on these criteria: your provider needs a full picture of your unique health profile to understand whether Wegovy® treatment is appropriate.

Those with BMIs below 25 will not be approved for Wegovy® treatment with AgelessRx, unless there is previous usage and treatment is for maintenance.

While Wegovy® is FDA approved for ages 12 and older, we do not treat children. Our services are for adults only.

Tirzepatide works on two pathways, GIP and GLP-1, that are involved in appetite, fullness, and metabolic response.¹ ² Microdosing uses lower amounts than standard dosing, with provider-guided adjustments over time aimed at the lowest dose that helps you hit your goals while minimizing side effects.

At full doses, Semaglutide acts on a single pathway, GLP-1, and has the longer track record, including a large trial showing meaningful cardiovascular risk reduction. Tirzepatide acts on two pathways, GLP-1 and GIP, and tends to produce somewhat greater appetite suppression at comparable standard doses.⁹

Your Body Mass Index, or BMI, is a simple rule of thumb used by healthcare providers around the world to broadly categorize a healthy spectrum of height and weight differentials.

To calculate your BMI, divide your total weight by the square of your height, or use this BMI calculator. For most adults, a healthy BMI range is 18.5 to 24.9. A BMI of 25 to 30 is considered overweight, and a BMI above 30 is considered obese: Class 1 (30-34.9), Class 2 (35-39.9), and Class 3 (severe, 40+).

In a 68-week medical study of 1,961 adults living with obesity or excess weight with a related medical problem, adults lost ~35 lbs (or ~15% body weight) with Wegovy® injections. People taking placebo lost an average of 6 lbs (or ~2.5% body weight). The average starting weight for both groups was ~232 lbs.**

In a 64-week medical study, 1 in 4 adults lost 20% of body weight (~47 pounds) with the Wegovy® pill among 307 adults living with obesity or with overweight and at least one weight-related medical problem were studied. All participants were instructed to follow a reduced-calorie diet and increase their physical activity. 

**Results are from a 68-week medical study of adults with obesity (BMI ≥30) and adults with excess weight (BMI ≥27) who also had weight-related medical problems.

Microdosing Semaglutide may be a fit for those seeking moderate weight support, help with appetite or food noise, or a gentler way to begin GLP-1 care.¹ ² ³

People respond to medicines differently, so there is no set time for when you can expect to see results with Wegovy^®. Ask your health care provider about what might be a realistic expectation for you.

We offer access to a prescription consultation for Wegovy® pens and oral tablets through NovoCare or Amazon Pharmacy, along with ongoing health monitoring and guidance if approved for a prescription. 

To get started, submit your medical intake to an AgelessRx provider, who will review your unique medical history and health goals to determine if Wegovy® is right for you. If approved, your AgelessRx provider will refer your prescription to the appropriate partner. 

From there, you will receive text messages from NovoCare or Amazon Pharmacy who will help you complete your Wegovy® order and provide payment directly to them. 

Please note, AgelessRx does not assist in any insurance coverage authorizations. 

Once you’ve created your account, you’ll be prompted to pay for your Wegovy® prescription. AgelessRx only provides a consultation to consider your Wegovy® prescription request, as well as ongoing healthcare monitoring for the duration of your prescription, if approved. The cost of the medication is separate and completed with NovoCare or Amazon Pharmacy. You will not receive your Wegovy® delivery until you complete payment with NovoCare or Amazon Pharmacy.

Please note that AgelessRx only charges for prescription access for Wegovy® and ongoing health monitoring. Pricing and shipping of Wegovy® is not provided by AgelessRx or any of its pharmacy partners.

Medication pricing is set by NovoCare (for Wegovy® injections) or Amazon Pharmacy (for Wegovy® Pill) and may change at any time. For current Wegovy® pricing, please refer directly to NovoCare or Amazon Pharmacy.

No, NovoCare or Amazon Pharmacy will fulfill all Wegovy® prescriptions. AgelessRx will only provide prescription access and ongoing monitoring to consider your request for a Wegovy® prescription, along with ongoing healthcare monitoring for the duration of your prescription.

Your AgelessRx provider will review your unique medical history, including your current prescription, and determine the dose that may be best for you. Your provider will always try to start you at a dose that most closely matches your previous prescription so that you can have a seamless transition without losing progress, as long as you have not been off your medication for more than 2 weeks. 

However, if it’s been more than 14 days since you’ve last taken a GLP-1 medication, your provider will have you start at the initial dose and restart your titration. Always follow your provider’s instructions.

The most common side effects of Semaglutide-based medications like Wegovy® are nausea and constipation. Other gastrointestinal issues like indigestion, vomiting, diarrhea, and delayed gastric emptying may occur, though they are less common. Some users may also experience irritation at the injection site. The side effects you may experience will vary depending on your prescribed dose, your medical history, and your lifestyle choices.

Your AgelessRx provider will provide further information on what side effects you may experience, and what you can do to reduce side effects.

NovoCare is a program that helps users and providers maintain easy access to prescriptions like Wegovy®. NovoCare requires a prescription from a prescriber to access Wegovy®. That’s where AgelessRx comes in. AgelessRx provides a consultation to consider your request for a Wegovy® prescription, along with ongoing healthcare monitoring for the duration of your prescription, if approved.

Zepbound® is a once-weekly injectable medication that is FDA approved to support weight loss in adults with a BMI of 30 or more, or adults with a BMI of 27 or more with a weight-related health condition. Zepbound® contains Tirzepatide, a dual-action GLP-1 and GIP receptor agonist that helps regulate appetite, blood sugar, and digestion. 

Zepbound® contains the active ingredient Tirzepatide, which works by imitating 2 natural hormones in your body that help manage blood sugar and appetite: GIP and GLP-1. GIP helps your pancreas release more insulin after you eat, while GLP-1, which also increases insulin, slows down your digestion and reduces hunger. This dual action helps keep your blood sugar levels stable and can assist with weight loss.

That depends on your goals, response, side effects, and provider guidance. Some people continue long term, while others may eventually discuss maintenance or other next steps with their provider.

That depends on your goals, response, side effects, and provider guidance. Some people continue long term, while others may eventually discuss maintenance or other next steps with their provider.

Clinical trials have shown that most Zepbound® users can lose 15-20% of their initial body weight. For a 200lb individual, that equals about 30-40lbs. However, individual results may vary based on your prescribed dose, medical history, and lifestyle choices. For the best results, use Zepbound® with a reduced-calorie meal plan and regular exercise. If you feel that you’re not achieving your expected results, contact your provider to see what’s best for you.

For the best results, Zepbound® should be taken regularly for at least 6-12 months with a reduced-calorie meal plan and regular exercise. Clinical trials show an average of 15-20% weight loss within 72 weeks, or about 17 months, with many participants showing up to 8% weight loss within 12 weeks. However, this can vary depending on your health history, exercise level, and diet. Do not abruptly stop taking Zepbound®, as your appetite and weight may return just as quickly.

Wegovy® Pill has shown weight loss results similar to injectable Wegovy® across separate clinical studies, though the two have not been directly compared head-to-head. Adults taking Wegovy® Pill lost 14% of body weight on average, compared with 15% for the injection.¹ ³

AgelessRx offers a prescription consultation for Zepbound® Single-Member-Use KwikPens®. 

To get started, submit your medical intake to an AgelessRx provider, who will review your unique medical history and health goals to determine if Zepbound® is right for you. If approved, your AgelessRx provider will refer your prescription to LillyDirect®. 

From there, you will receive text messages from LillyDirect®, who will prompt you to verify your identity (through a third-party platform called GiftHealth) and complete payment. Make sure to add injection supplies to check out, if prompted. Once payment is received, LillyDirect® will ship your prescription directly to your doorstep.

If approved, your AgelessRx provider will write you a new prescription each month according to the provider-guided titration schedule that they will provide you. For most people, you will stop increasing your dose after 4 months, unless you request to stay at your current dose.

You can pause your subscription at any time, but if you pause for more than 14 days after your previous prescription has ended, LillyDirect® may charge you a higher price. Pausing for more than 2 weeks may also mean restarting your titration, at your provider’s discretion.

LillyDirect® now offers a convenient multi-dose, Single-Member-Use Zepbound® KwikPens®, which contains 4 fixed doses, one dose taken weekly. These pens are designed for safer handling and increased convenience. Get started to have an AgelessRx provider review your prescription request. 

The price of Zepbound® varies depending on your prescribed dose, and special introductory pricing may apply to your first fills. Because pricing is set by LillyDirect® and is subject to change at any time, please refer directly to LillyDirect® for current Zepbound® pricing.

If you pause your subscription refills for more than 14 days after your previous titration ended, you may be charged a higher price. Pausing for more than 2 weeks may also mean restarting your titration, at your provider’s discretion.

Please note that AgelessRx only charges for a provider consultation for a Zepbound® prescription. Pricing and shipping of Zepbound® is not provided by AgelessRx or any of its pharmacy partners.

No, LillyDirect® fulfills all Zepbound® prescriptions. AgelessRx will only provide a prescription consultation for Zepbound®, as well as ongoing medical monitoring to ensure you’re receiving the best results. If an AgelessRx provider approves your request, they will forward your prescription to LillyDirect®, who will text you to complete your order. This will be completed monthly, as long as you maintain an active Zepbound® Consultation subscription.

Your AgelessRx provider will review your unique medical history, including your current prescription, and determine the dose that may be best for you. 

If you’re switching from Semaglutide to Tirzepatide, your provider may determine a different starting dose for you. Always follow your provider’s titration instructions, even if they differ from the guidelines above.

If you have been off your medication for more than 2 weeks, your provider will have you restart your titration at the starting dose.

The most common side effects of Tirzepatide-based medications are nausea and constipation. Other gastrointestinal issues like indigestion, vomiting, and diarrhea may occur, though they are less common. Some users may also experience irritation at the injection site. The side effects you may experience will vary depending on your prescribed dose, your medical history, and your lifestyle choices.

Your AgelessRx provider will provide further information on what side effects you may experience, and what you can do to reduce side effects.

Tirzepatide is the active ingredient in both Mounjaro® and Zepbound®. The primary difference between these medications is their FDA approved uses. Mounjaro® is FDA approved for managing type 2 diabetes, while Zepbound® is FDA approved for weight management.

Zepbound® and Mounjaro® both contain Tirzepatide, but they are approved for different health goals. Mounjaro® is FDA-approved for adults with type 2 diabetes to help manage blood sugar. Zepbound® is FDA-approved for chronic weight management and for moderate-to-severe obstructive sleep apnea in adults with obesity. Same active ingredient, but different approved uses.⁴

Research into GLP-1 medications is rapidly expanding beyond weight management. Researchers are now exploring GLP-1’s role in a number of closely related conditions, with scientists investigating its potential benefits for metabolic health, cardiovascular health, and even broader chronic disease applications.²

At AgelessRx, our Stanford PhD-led Research Team is actively studying GLP-1 through a longevity lens on two fronts. First, our Microdosing research explores how lower-dose GLP-1 protocols may support metabolic health and healthy aging beyond traditional weight loss applications. 

Second, our Life After GLP-1 clinical trial is studying how people may maintain the metabolic benefits of GLP-1 treatment after stopping medication, addressing one of the most pressing unanswered questions in GLP-1 care. 

Some lean-mass loss is a normal part of any significant, relatively fast weight loss, and this isn’t unique to Tirzepatide. It’s also substantially preventable: adequate protein intake and resistance training meaningfully protect muscle during treatment, which is why nutrition guidance is part of your program, not an afterthought.¹²

GLP-1 is a hormone the body already uses to help regulate appetite, fullness, and blood sugar after meals.¹ GLP-1 medications may enhance that signal, helping support the communication between the gut, brain, and metabolism.¹

Zepbound® and Wegovy® are both once-weekly FDA-approved weight loss injections, but they use different active ingredients.

Most GLP-1 medications activate a single hormone pathway. Zepbound® activates two–GIP and GLP-1–at once, which is why it tends to produce greater weight loss and often better tolerability in head-to-head trials than single-pathway options.³

GLP-1 medications are generally well tolerated. The most commonly reported side effects are gastrointestinal and may include nausea, diarrhea, vomiting, constipation, stomach discomfort, bloating, and indigestion, particularly when first starting treatment or increasing dose. These side effects are often mild and may decrease over time as the body adjusts. Starting at a lower dose and titrating gradually may help reduce discomfort. Please see important safety information and consult your provider about the potential risks and benefits before starting treatment.

GLP-1s may be appropriate for adults looking to support appetite regulation, metabolic health, and long-term weight management goals.^{1 2} At AgelessRx, GLP-1 plans are available in both full-dose and Microdosing options, which broadens the range of individuals who may benefit beyond those seeking significant weight loss alone. Eligibility is always determined by a US-licensed medical provider based on your complete health profile. Approval for treatment is not guaranteed. GLP-1 medications should be used alongside a reduced-calorie meal plan and increased physical activity.

Most GLP-1 care is built around access to medication. AgelessRx is built around the care that happens around it: clinician-guided dosing, a fully in-house medical and care team, unlimited provider messaging, dosage adjustments when appropriate, and a longevity lens that considers metabolism, muscle, energy, and long-term health.

Yes—and this is where Invokana® has real human data. The CANVAS program found Canagliflozin reduced major adverse cardiovascular events by 14% and heart failure hospitalizations by 33% versus placebo in people with type 2 diabetes and elevated cardiovascular risk.⁹

The CREDENCE trial, focused specifically on people with type 2 diabetes and chronic kidney disease, found a 30% reduction in the combined risk of kidney failure, doubling of creatinine, or cardiovascular death.⁶ This tier of evidence—large randomized trials with hard clinical outcomes—is the strongest ground in the entire longevity conversation around this drug class.⁴

A Continuous Glucose Monitor (CGM) is one of the most convenient ways to track your progress. You can compare sugar spikes after eating starchy carbs (with and without Acarbose!) to visibly see the impact Acarbose has on preventing spikes.

Invokana® (Canagliflozin) is an SGLT2 Inhibitor, meaning it blocks a transporter in the kidneys that would otherwise reabsorb glucose back into the bloodstream.² With that transporter blocked, more glucose may leave the body through urine instead of staying in circulation, which is how it may support lower blood sugar and mimic the longevity benefits of calorie restriction. It’s currently FDA-approved for adults with type 2 diabetes, with additional approved indications to reduce cardiovascular and kidney risk in specific populations.⁸

As with Metformin, Acarbose is FDA approved for the treatment of diabetes mellitus, type 2.

The most common side effects are genital yeast infections and urinary tract infections, reported somewhat more frequently with Invokana® than with some other SGLT2 Inhibitors, along with increased urination. Invokana® isn’t recommended for anyone with a history of foot ulcers, poor circulation, or prior amputation, and your provider screens for these factors before prescribing. See the full safety information above for the complete list.

That depends on the Acarbose protocol for which you’re approved: Acarbose (1 Meal/Day), Acarbose (2 Meals/Day), and Acarbose (As Needed). All of these include a starting strength of 25mg tablets (tear-away packets include 2x25mg tablets). However, those taking Acarbose twice daily will eventually titrate up to 50mg tablets. If you’re on one of the Acarbose daily plans, check your Rx bottle to see your titration schedule and which dose you’re receiving. Additionally, you can always view your current Acarbose plan on your AgelessRx portal.

Acarbose specifically inhibits amylose, or starch, from being broken down into sugar. It doesn’t work to inhibit sugary carbs.

Examples of starchy carbs include grains, including rice, corn, wheat, rye, quinoa, millet, oats, barley, and any foods made from them (oatmeal, pasta, bread, cereal, pizza, pastries, etc.). Other starchy carbs include beets, carrots, turnips, potatoes (including sweet potatoes), yams, and peas.

Examples of sugary carbs include fruit juice, sports drinks, candies, honey, jams/jellies, any syrup, soda, table sugar, and brown sugar.

If you’re unsure which dosage is right for you, the best plan is to discuss your options with your provider. But, here are a few things to consider before you do.

First, how often do you eat starchy carbs? Those who enjoy the occasional indulgence may find taking Acarbose As Needed to be more beneficial. If, on the other hand, starchy carbs like rice, potatoes, wheat, or pasta are part of at least one of your meals each day, then you might want to consider one of our Acarbose Daily plans.

Second, decide whether your goals are short term or long term. Are you looking to reduce your risk for heart disease or stroke, or even further optimize your healthspan? If so, then one of our Acarbose Daily plans might best match your goals. But if you’re just looking to avoid crashes, headaches, or other more immediate aftereffects of sugar spikes, then perhaps a less substantial subscription is appropriate.

Finally, be honest with yourself and set realistic expectations. If you’re not ready to add a whole new treatment to your regimen, you can still casually reduce your risk with Acarbose As Needed, which is part of the reason why we designed multiple protocols.

The short answer is absolutely yes. Acarbose is an alpha-glucosidase inhibitor, meaning that it specifically acts on enzymes that break down starches. This only makes it more difficult for our bodies to absorb starch, delaying the digestion of carbohydrates. There is no evidence to suggest that Acarbose prevents the body from absorbing other nutritional components of foods.

Sharp post-meal sugar crashes are often the mirror image of a sharp spike—the body overcorrects after a rapid rise. By slowing the rate sugar enters your bloodstream in the first place, Acarbose helps prevent both the spike and the crash that tends to follow it, which is part of why people use it specifically before carb-heavy meals rather than as a general daily supplement.^{1 8}

SGLT2 Inhibitors like Invokana® (Canagliflozin) and Brenzavvy® (Bexagliflozin) are medications that help the body get rid of excess sugar before it can do long-term damage. Both Invokana® and Brenzavvy® are FDA approved for treatment of type 2 diabetes, but emerging research suggests they may also have extended longevity benefits, such as reduced risk of heart disease, improved kidney and liver health, better cognitive function, and moderate weight loss.

SGLT2 Inhibitors work by flushing excess sugar from the body through urine. They do this by blocking sodium-glucose cotransporter 2 (SGLT2), a protein that reabsorbs sugar from urine back into the bloodstream. By blocking SGLT2, medications like Invokana® and Brenzavvy® allow the body to remove up to 50-80g of glucose per day. By reducing excess glucose, SGLT2 Inhibitors may help people maintain stable blood sugar, which can mimic some benefits of caloric restriction.

Acarbose may block enzymes in the small intestine that break carbohydrates down into absorbable sugar. With those enzymes slowed, carbs from a meal may get digested and absorbed more gradually, which may support a smaller, slower rise in blood sugar after eating rather than a sharp spike.⁴ It’s FDA-approved, alongside diet and exercise, for blood sugar management in adults with type 2 diabetes. In our own clinical trial it was shown to be effective in blunting blood sugar spikes after a carb-heavy meal in generally healthy adults.^{1 4}

The animal data is genuinely some of the strongest in the field: Acarbose reproducibly extended lifespan in a rigorous, multi-site mouse study, in both males and females, and its combination with Rapamycin produced the largest lifespan extension ever recorded in that research program.^{2 7}

Human longevity outcomes remain unproven—that’s true of every compound in this category—but the combination of real animal data, a plausible and increasingly well-characterized mechanism (including gut microbiome effects), and decades of human safety data make it one of the more evidence-backed choices for people building a longevity-focused daily protocol.^{3 4 7}  

Studies show SGLT2 Inhibitors may have several benefits. They have been shown to extend lifespan in mice, and they may reduce inflammation and oxidative stress. They may also lower HbA1c, improve cardiovascular health and kidney health, and lower the risk of dementia and Parkinson’s. In addition, they may help clear senescent cells and encourage moderate weight loss.

Though both Invokana® (Canagliflozin) and Brenzavvy® (Bexagliflozin) work in the same way, Invokana® has more years of research supporting its potential benefits, while Brenzavvy® is a relatively new SGLT2 that may show similar longevity benefits. The best results for each may occur in combination with a reduced-calorie diet and regular exercise.

Because Acarbose leaves more undigested carbohydrate in your gut, digestive side effects are the most common experience, especially early on. Gas, bloating, and loose stools are typical, and they often ease as your body adjusts.⁴ This is also the number one reason people quit Acarbose, and it’s what our low-dose, gradual titration protocol is built to minimize by starting low, increasing slowly, and adjusting based on how you actually respond. 

Acarbose isn’t recommended for anyone with inflammatory bowel disease, bowel obstruction, or significant liver disease. See the full safety information above for the complete list.

Both Invokana® and Brenzavvy® are SGLT2 Inhibitors that work the same way. The only difference is that Invokana® has an extended range of FDA-approved uses: while Brenzavvy® is FDA approved for type 2 diabetes treatment, Invokana® is approved for treating type 2 diabetes and to reduce the risk of heart and kidney disease.

Invokana® has also been patented since 2013, with a wealth of scientific studies to support its extended uses. Though Brenzavvy® is a relatively new SGLT2 (FDA approved in 2023), it still shares the same mechanism of action and may show similar longevity benefits as research continues.

While Brenzavvy® has only been FDA approved since 2023, Invokana® has been patented since 2013, with a wealth of scientific studies to support its extended uses, which may explain its higher price. 

AgelessRx provides both Invokana® and Brenzavvy® at a competitive price according to what our pharmacy partners can source from the manufacturer. The prices listed on AgelessRx.com are out-of-pocket costs and are not affected by insurance: AgelessRx does not accept insurance for Invokana® and does not treat or manage type 2 diabetes or any other FDA-approved condition for SGLT2 Inhibitors.

The most common side effects of SGLT2 Inhibitors include increased urination, dehydration, hypotension (low blood pressure), dizziness, urinary tract infections (UTIs), and genital mycotic infections (yeast infections). Increased urination is a normal side effect of SGLT2 Inhibitors and not cause for concern. 

UTIs and yeast infections are among the most frequently reported side effects of SGLT2 Inhibitors. To reduce the risk of these and other side effects, drink plenty of water throughout the day (around 0.5 to 1 gallon) and follow proper genital hygiene practices. If you experience a UTI or yeast infection, you must seek treatment with your primary healthcare provider or a local urgent care clinic.

If you notice side effects other than increased urination, it’s okay to stop taking the medication until side effects clear, usually after a few days and up to a few weeks. Always let your care team know if you stop your medication so they can adjust your upcoming refills if necessary.

Serious side effects include euglycemic diabetic ketoacidosis (eDKA), Fournier’s gangrene, and acute kidney injury. These side effects typically occur in people with diabetes or compromised kidney function. Please tell your provider if you or anyone in your family has diabetes or compromised kidney function, or any other medical condition. AgelessRx does not manage or treat diabetes.

The above is not an exhaustive list. Please review these resources for Invokana® (Canagliflozin) and Brenzavvy® (Bexagliflozin).

Since Brenzavvy® works on blood sugar and glucose excretion, results may mostly show up in lab work before they show up in how you feel day to day. Blood sugar improvements are often seen within the first few weeks of consistent use, while any changes in weight tend to build more gradually over months, in line with how the calorie deficit adds up over time. Your provider can adjust your plan based on how you respond.

Glutathione has a well-documented absorption problem: taken orally, much of it breaks down during digestion before the body can use it.⁵ Glutathione Nasal Spray is built around a different route, delivering Glutathione directly across the nasal mucosa to the brain, bypassing the digestive tract entirely.¹

In brain imaging studies, Glutathione levels rose measurably within one hour of intranasal dosing, a level of direct, brain-level evidence that oral capsules can’t point to.¹ For people looking to support brain health and cognitive function, the nasal route may offer a simple, injection-free way to support brain antioxidant defense, focus, and mental energy.^{1 2 4}

Most people will notice a lift in energy within an hour or two of injection. Please note you should not use Glutathione Injections (0.5ml per injection) more than 5x per week.

Glutathione plays a central role in protecting cells from oxidative stress—an imbalance between free radicals and antioxidants that accelerates cellular damage and drives forward the aging process across organs in the body.³ As Glutathione levels naturally decline with age, cells may become less equipped to neutralize free radicals and support cellular repair.³ ⁴ Research suggests that maintaining healthy Glutathione levels may help support mitochondrial function, detoxifications, and immune resilience, all of which are relevant to skin health, energy, mental clarity, and healthy aging.⁶ ⁷ ¹⁰ Individual experiences vary and research is ongoing.

Glutathione Nasal Spray is generally well tolerated. Possible side effects may include fatigue, headache, or stomach discomfort. Some may experience temporary nasal irritation after use.

If side effects occur, reduce use or discontinue use entirely and contact your provider. Those who are pregnant, breastfeeding, or managing an existing health condition should discuss Glutathione Nasal Spray with a clinician before starting.

Glutathione is essential for many functions, including cellular rejuvenation and repair. You may or may not feel an immediately noticeable effect of better DNA repair; most of our members who use the Glutathione Patches report some of the following benefits: improved energy, mental clarity, and faster recovery from illness and injury.

It is important to note the above benefits are not seen in all people. As long as instructions for application are properly followed, the GSH will be absorbed into the body regardless of whether a person feels it or not, helping to support higher GSH levels. Depending on how depleted your GSH levels are, you might need to build up your GSH level over a few weeks before noticing any benefits.

Glutathione Patch is generally well tolerated. The most common side effect is irritation where the patch is applied. Rotating placement sites may help reduce irritation. If irritation persists, discontinue use and contact your provider.

Glutathione Injection is generally well tolerated with consistent use. Some studies have associated long-term Glutathione supplementation with lower zinc levels in some individuals, so periodic monitoring may be advisable with extended use. Please see important safety information and consult your provider about the potential risks and benefits.

Glutathione Nasal Spray may help support clearer thinking, steadier focus, brain antioxidant defense, and mental energy.² Because it uses nasal delivery, it is especially suited for those who want brain-first Glutathione support without injections.¹

Glutathione Patch uses iontophoresis, a small battery-powered delivery system that helps move Glutathione through the skin’s outer barrier, a technique used in physical therapy and dermatology for decades. This may allow Glutathione to bypass digestion and support whole-body antioxidant replenishment without injections over several hours, rather than delivering it all at once.⁵

Glutathione Injections (GSH) deliver the antioxidant directly into the bloodstream, bypassing the digestive system where oral supplements may break down before absorption.^{1 3} Subcutaneous Glutathione may help support cellular antioxidant defense, liver detoxification pathways, immune function, and mitochondrial health.^{3 7} Research also suggests Glutathione may help protect skin health by reducing damaging oxidative stress from excess sun exposure and pollutants.^{3 6 4} Because Glutathione levels naturally decline with age, injectable supplementation may help replenish levels more directly in the tissues that need them most.^{4 1 3}

Glutathione Nasal Spray may help support mental clarity, focus, brain antioxidant defense, and long-term brain health.^{2 3 4} Glutathione is often called the body’s master antioxidant because it helps the body manage oxidative stress.⁶ In the brain, that antioxidant support matters for the neural pathways involved in focus, recall, and mental energy.^{3 7}

Glutathione Patch may help support antioxidant defense, cellular energy, detox pathways, immune resilience, and healthy-looking skin.¹ ² ³ ⁴ It is designed for people who want broad Glutathione support in a needle-free format.

Glutathione Injections are generally well tolerated. The most commonly reported side effects are mild and may include a slight sting or burn at the injection site. Long-term use of Glutathione has been associated with lower zinc levels in some individuals, so monitoring zinc levels may be advisable with extended use. Glutathione is not recommended for individuals with asthma, or those who are pregnant or breastfeeding. As with any prescription treatment, please see important safety information and consult your provider about the potential risks and benefits before use.

Both Glutathione Injection and Glutathione Nasal Spray aim to solve the same underlying problem seen in oral Glutathione options–poor oral bioavailability. Glutathione Nasal Spray and Glutathione Injections both may help replenish Glutathione while avoiding the digestive breakdown that can happen with oral supplements, but are designed for different preferences and goals.^{1 5}

Glutathione Injections are a broader whole-body option for antioxidant support. Glutathione Nasal Spray is a needle-free, brain-first format for those focused on mental clarity, focus, and brain fog. A licensed provider can help determine which format fits your health profile and routine.

Glutathione is a naturally occurring antioxidant produced by the liver from three amino acids—cysteine, glycine, and glutamate. Found in every cell in the body, it plays a central role in reducing oxidative stress, supporting liver detoxification, strengthening immune function, and protecting mitochondrial health. Unlike most antioxidants, Glutathione works across all cellular environments in the body.³ Glutathione levels naturally decline with age and may also be reduced by factors such as chronic stress, environmental toxins, and poor nutrition, making replenishment an important consideration for healthy aging.^{4 8}

Glutathione, sometimes called GSH, is a naturally occurring antioxidant produced by the liver from three amino acids—cysteine, glycine, and glutamate. Found in every cell in the body, it plays a central role in reducing oxidative stress, supporting liver detoxification, strengthening immune function, and protecting mitochondrial health.¹

Unlike most antioxidants, Glutathione works across all cellular environments in the body. Glutathione levels naturally decline with age and may also be reduced by factors such as chronic stress, environmental toxins, and poor nutrition, making replenishment an important consideration for healthy aging.¹ ⁶ ⁷

Glutathione Nasal Spray requires a prescription, so it should come through a licensed provider and a qualified compounding pharmacy rather than being sourced on your own.

AgelessRx connects customers with a US-licensed provider who reviews your health history before treatment is approved. If appropriate, your treatment is compounded by a US-licensed pharmacy partner and shipped directly to your door.

Glutathione Injection is the broader whole-body option for people comfortable with injections and one of the more promising delivery options. Glutathione Nasal Spray is a brain-first format for mental clarity and focus combined with simple, on-the-go usage. Glutathione Patch is a needle-free whole-body option for those who want consistent antioxidant support without injections.

Oral Glutathione supplements may be broken down by stomach enzymes during digestion, which can limit how much Glutathione is ultimately absorbed into the bloodstream.¹³ Subcutaneous injections bypass the digestive system entirely, delivering Glutathione more directly into circulation to support cellular uptake.

Oral Glutathione has a well-documented limitation: much of it is broken down during digestion before the body can use it. Glutathione Patch uses iontophoresis—a mild electrical current—to move Glutathione through the skin and into the bloodstream directly, bypassing digestion entirely, offering a needle-free middle ground between the convenience of a pill and the direct absorption of an IV.

Glutathione Patch may help support whole-body antioxidant defense, cellular energy, detox pathways, immune resilience, and healthy-looking skin for people who want systemic antioxidant support in a needle-free format.^{1 2 3 4}

Atorvastatin is a member of a class of prescription medications called ‘statins’ that work to reduce the amount of cholesterol in your liver and help remove cholesterol already in the blood. As a result, it helps to lower your overall cholesterol levels.

Most statins, like Atorvastatin, require approximately 4-6 weeks to help cholesterol levels stabilize. You will complete a blood test within the first 3-6 months of treatment to check cholesterol levels (e.g. LDL, HDL, Total Cholesterol and Triglycerides) to identify measurable improvements.

Generally, Atorvastatin is safe to take long term, and, according to some experts, actually works best when taken over a long period of time.

Some evidence suggests that Atorvastatin can raise blood sugar in some people. If you have any concerns, speak to your provider.

Yes, you will be asked to complete a blood draw within 90 days of receiving your first fulfillment, then annually thereafter. While blood draw requisitions are included with your subscription, any valid labs completed within the prior 6 months can also be considered at the discretion of your assigned medical professional.

The point of taking statin medication is to lower cholesterol levels and prevent accumulation of cholesterol in the arteries, thereby reducing risk of heart disease. Ask your provider if Atorvastatin is right for you.

Atorvastatin is simply the generic version of Lipitor.

Atorvastatin supports lower cholesterol while you’re taking it, but that support doesn’t carry over once you stop. Cholesterol levels generally drift back up without ongoing use. Most people stay on it long-term as part of managing cardiovascular risk, similar to how blood pressure medication tends to work. Talk to your provider before making any changes to your regimen, including stopping.

In most cases, Telmisartan can help to lower blood pressure within about two weeks. It often requires about four weeks to get the full effects of lowering blood pressure. However, everybody is different and it may take more or less time.

We offer 20mg tablets of Telmisartan. We only offer Telmisartan with a quarterly plan, supplying 90 daily doses per quarter (1 tablet daily, or as prescribed).

Atorvastatin is used to lower LDL cholesterol and triglycerides, and to help reduce the risk of heart attack, stroke, and other cardiovascular events, particularly in adults with elevated cardiovascular risk from high cholesterol, type 2 diabetes, or a family history of heart disease.⁶

It’s studied both in people who haven’t yet had a cardiovascular event and in those managing risk after one.² Rather than working only once symptoms show up, Atorvastatin lowers both LDL and ApoB, the particles most linked to plaque buildup in artery walls.¹⁰

Telmisartan supports lower blood pressure while you’re taking it consistently, and blood pressure tends to drift back up once it’s stopped. Most people stay on it long term as part of ongoing cardiovascular management. Talk to your provider before making any changes to your regimen, including stopping.

This is where Telmisartan gets genuinely interesting, and it’s not just a class-wide ARB effect. Telmisartan is the strongest activator PPAR-γ among ARBs studied, and separately has been shown to activate the AMPK pathway—pathways tied to insulin sensitivity, inflammation control, tissue fibrosis, and longevity, not just blood pressure.⁶

Telmisartan is an angiotensin receptor blocker (ARB) that is FDA-approved for the treatment of high blood pressure in adults. It blocks a receptor that angiotensin II uses to narrow blood vessels, so vessels can stay relaxed and open. That supports lower blood pressure and may help ease the workload on the heart over time.⁵

All ARBs block the same angiotensin receptor to lower blood pressure, but Telmisartan has a distinct additional mechanism most other ARBs don’t share—it’s the strongest known PPAR-γ activator in its class, and separately activates PPAR-δ and AMPK pathways tied to inflammation and tissue fibrosis.^{6 14}

The blood-pressure effect is a class effect; this broader mechanism is genuinely Telmisartan-specific. 

Telmisartan is generally well tolerated, with a notably low rate of the dry cough sometimes seen with other blood pressure medications, one of the reasons people appreciate it. The main thing to watch for is hyperkalemia, elevated potassium, which is more likely if you have kidney impairment, heart failure, or you’re taking potassium supplements or certain diuretics alongside it. Telmisartan isn’t recommended during pregnancy, and your provider screens for kidney, liver, and heart conditions before prescribing. See the full safety information above for the complete list.

Naltrexone binds to opioid receptors, which are found all over the body including immune cells. In doing so, it displaces the endorphins which would normally stay bound to these receptors. By binding to the opioid receptors, it displaces the body’s naturally produced Opioid Growth Factor. When using naltrexone at a low dose (hence LDN), the binding is temporary and causes the body to then up-regulate or increase the opioid receptors, thereby restoring the endorphin system and balancing the immune system.

Yes! Studies have shown that LDN is not only safe to take for individuals with a compromised immune system, but that it may actually help to improve the ability of the immune system to function. Individuals with autoimmune diseases or compromised immune systems typically have lower levels of endorphins than those without autoimmunity or a lowered immune response. Due to the increase of endorphins triggered by Low Dose Naltrexone, we believe that LDN is a safe and possibly helpful therapy for these individuals. See the Science Page for more information.

In general, Low Dose Naltrexone should not be used by anyone taking opioids, such as Codeine, Hydrocodone, Fentanyl, Hydromorphone, Meperidine, Methadone, Morphine, Oxycodone, or Oxycontin. Because Naltrexone and prescription opioids bind to the opioid receptors, they can render one another ineffective, or worse, cause opioid withdrawal syndrome. LDN should be avoided in people with significantly impaired kidney or liver function.

If you are on thyroid medication, you may need to monitor your thyroid levels more closely as you start LDN. If you develop symptoms of hyperthyroidism while taking LDN, such as heart racing, increased anxiety, restlessness, or trouble sleeping, please stop LDN and talk to the provider who prescribes your thyroid medication.

Other conditions that require a modified protocol or require further consideration prior to use include Lyme Disease or other Chronic Infections (EBV, CMS, Bebesosis, Borellia, etc.), Mast Cell Activation Syndrome/Disease (MCAS/MCAD), and Ehlers Danlos Syndrome (EDS). A modified protocol or further consideration also applies to multiple chemical sensitivities or drug allergies (3 or more), mold or black mold illness or exposure, and mental illness (e.g. schizophrenia).

To derive the biggest benefit from LDN studies indicate it should be taken over an extended period. The longer a member takes LDN, the better it has been shown to “push back” diseases of aging, according to several research studies in both humans and lab animals (see our Science page).

Some benefits from LDN, such as increased energy and sleep quality and decreased pain, are realized relatively quickly, while others, such as cancer or heart disease reduction, may never be “felt” (i.e. you won’t know that tumors or blocked arteries have been prevented if they never develop).

We are serious about the safety of the products that we offer. Low Dose Naltrexone is compounded on site at a licensed compounding pharmacy based in the USA, with materials supplied by the Professional Compounding Centers of America (PCCA).

Unfortunately, no. AgelessRx does not work with people with any active form of cancer. You may seek an alternative LDN telemedicine service, such as LDN Direct.

The short answer is “No.”

Naltrexone is FDA approved for the treatment of opioid and alcohol addiction, and, in combination with bupropion, for weight management. These are known as the on-label indications. However, like many medications, naltrexone is used off-label for conditions such as Hashimoto’s, Crohn’s, Ulcerative Colitis, Ankylosing Spondylitis, PCOS, Type 2 Diabetes, Depression, anxiety, Fibromyalgia, Chronic Fatigue, MCAS/MCAD, ADHD, and many symptoms and conditions. Like with any medication, once the FDA has approved a medication for one use, a licensed provider can prescribe it in any way they see fit for their members.

Absolutely not! Our therapies are meant as an extra layer of protection. We strongly encourage our members to adopt a healthy lifestyle, including leveraging such practices as intermittent fasting, physical activity, stress reduction, etc.

If you are curious how you might live a longer, healthier life, you might consider a personalized Longevity Consultation.

Yes, Low Dose Naltrexone requires a prescription from a licensed medical provider. At AgelessRx, you can complete an online medical intake form to connect with a US-licensed provider who will review your health history to determine if LDN is appropriate for you. If approved, your prescription will be fulfilled by one of our licensed compounding pharmacy partners and delivered directly to your door.

In the short term, users report an improvement or reduction of symptoms related to inflammation and rampant oxidative stress, such as joint pain, back pain, fatigue, weight gain, and more.

The most common LDN side effects are vivid dreams, mild anxiety, insomnia, and headache, and they’re usually mild and temporary. If they’re bothersome, slowing your titration schedule, changing the time of day you take LDN, or switching to a lower capsule strength may help your body adjust. Talk to your provider if side effects persist.

Because LDN works by temporarily binding to opioid receptors, it is important to avoid taking opioid medications while using LDN, as this may interfere with its mechanism of action. You should also avoid taking LDN within 4–6 hours of any opioid-containing medication. Let your provider know about all medications you are currently taking before starting LDN.

Infinite is manufactured under GMP (Good Manufacturing Practice) standards, which govern how consistently and carefully a product is produced.

Our manufacturing partner follows Good Manufacturing Practice (GMP*). Infinite ingredients are vegetarian and include calcium alpha-ketoglutarate, quercetin, glucosamine, carnosine, pterostilbene, astaxanthin, and curcumin.

*Good manufacturing practice (GMP) is a system for ensuring that products are consistently produced and controlled according to quality standards

The hallmarks of aging are a set of biological processes, first identified by researchers in 2013 and expanded since, that are believed to drive aging at the cellular level, including mitochondrial dysfunction, cellular waste buildup, and inflammation.¹

Infinite Longevity Support’s ingredients were selected by doctors to align with several of these processes at once, based on current research into each one, rather than targeting just a single pathway the way many single-ingredient supplements do.

Infinite is a daily, pill-form supplement formulated around the 9 hallmarks of aging and key tenets of the Kaufmann Protocol. Our team consulted with industry professionals to build Infinite by AgelessRx around quality ingredients and current science. We have plans in place to further study the results, and in the meantime, our suite of longevity tests can provide instant access to the results of your product experience.

Our team of experts suggests you may notice benefits within 30 days of supplementation. Like any supplement, everyone reacts differently and the timeframe of when you fully feel the results from daily use can vary.

Ideally, you will incorporate Infinite into your daily routine indefinitely. It is designed to be a long-term supplement that you can start at any age to support your longevity goals over time.

Glucosamine, one of the key ingredients of Infinite Longevity Support, is often sourced from the shells of shellfish such as shrimp. However, glucosamine is not derived from the protein that causes shellfish allergies. As such, it is normally safe to consume, even for those with shellfish allergies.

Your dosage will depend on whether you are approved for Generic Rapamycin or Compounded Rapamycin.

For Generic Rapamycin, you will start at 2mg per week and slowly titrate up to your target dose of 6-8mg (determined at the discretion of your provider) over 3 months.

For Compounded Rapamycin, you will start at 5mg per week and slowly titrate up to your target dose of 10-15mg (determined at the discretion of your provider) over 3 months.

You can only receive medication following a medical review and initial screening from an AgelessRx provider, who will determine your titration and target dose based on your unique medical history and health goals.

A Generic Rapamycin prescription contains Sirolimus tablets that are commercially available, while Compounded Rapamycin prescriptions contain Sirolimus capsules that are compounded and mixed by a US-licensed compounding pharmacy following applicable state and federal regulations.

Compounded Rapamycin may be less potent than Generic Rapamycin, which could lead to reduced side effects as well as reduced absorption or bioavailability. For this reason, Compounded Rapamycin is typically prescribed at higher doses than Generic Rapamycin.

Depending on your state’s regulations, one or both options may be available to you. If only one option is available to you, then we must comply with your state’s regulations and only consider the available option. If both options are available in your state, then you can choose to get started with either generically available Rapamycin, or Rapamycin that is compounded to order.

Compounded Rapamycin is typically less potent than Generic Rapamycin. That means Compounded Rapamycin may have a reduced risk of side effects. It also means Compounded Rapamycin is less bioavailable than Generic Rapamycin. To account for this, our medical experts typically prescribe Compounded Rapamycin at higher doses than Generic Rapamycin.

You will receive quarterly refills (once every 3 months) for your Rapamycin prescription, as long as you continue to do your required blood tests and electronic check-ins. Each quarterly refill will be equivalent to 3 monthly refills. However, you will be billed once per month for your prescription.

You must be at least 40 years of age, clinically stable, and in relatively good health (all of which will be assessed during your initial and ongoing visits) to take Rapamycin. You must also be able to give informed consent of your willingness to take off-label Rapamycin and to undergo routine blood work, as well as technologically capable to join virtual meetings and fill out online forms. There are no limitations on sex or ethnicity, and no maximum age limit.

Once approved, you will receive an automated message in your AgelessRx portal with the link to schedule your blood draw and a copy of your requisition form.

Your blood work is required to determine your continued eligibility. It should be completed as soon as possible. Once received, our experts will review your results and notify you of your approval status.

If you are approved, our team will generate a prescription for you with our partnering, US-based pharmacy. You will also receive updates and tracking information for your first shipment and all subsequent shipments through your AgelessRx portal.

From there, you will continue to provide blood work, fill out questionnaires, and meet as needed with your provider to track any benefits/side effects and determine that you remain eligible.

If you have anemia or other blood disorders, your provider may suggest other medications. Similarly, premenopausal or menopausal females may not receive approval.

Those who are scheduled to undergo major surgery, chemotherapy or immunosuppressant therapy for a transplant within the next 6 months are also considered to have risk factors that could prevent your approval. Other exclusion criteria include: chronic infection (such as HIV/AIDS, Lyme disease, etc.); any primary or secondary immune dysfunction or deficiency, and allergy to Rapamycin.

Our providers may not currently be open to discussing Rapamycin enrollment with women who are pregnant or planning to become pregnant.

Side effects of Rapamycin are generally mild, especially if taken in lower doses. The most common side effect is stomatitis (mouth ulcers). Diarrhea and nausea are also common. More serious side effects include susceptibility to bacterial infections like pneumonia, but these are usually reported in transplant recipients taking Rapamycin at higher doses.

Rapamycin was the first name given to the compound isolated on Easter Island (for its native name, Rapa Nui), but the first name given to Rapamycin medications was Sirolimus. As such, there seems to have been a bit of a schism in the scientific community regarding the correct nomenclature for this compound/medication. However, Rapamycin and Sirolimus are effectively interchangeable terms that mean the same thing.

Our medical team may be able to work with you, depending on your current dosage and the reasons you are taking it, but ultimately this is a discussion between you and your provider.

If you are taking a lower dose of Rapamycin that is similar to the dosages listed on our protocols, you may be eligible. Work with your assigned provider to confirm.

If you are taking a higher dose of Rapamycin (>15mg), our medical team will need to better understand why you are at these doses to determine if it is safe to transition you to the lower doses of our protocols.

All who enroll must be able to follow the same titration plan, regardless of whether you are currently prescribed Rapamycin, were previously enrolled in the PEARL trial, or have never taken Rapamycin before.

No. Sirolimus is FDA approved for specific medical uses, including preventing organ rejection after kidney transplantation and treating lymphangioleiomyomatosis.¹² It is not FDA approved to slow aging, extend lifespan, or improve healthspan. However, there are various studies, including the PEARL Trial, that have shown Rapamycin’s potential for longevity usages. Rapamycin may be prescribed off-label for longevity when a licensed provider determines it may be appropriate.⁵

In animal models, robustly–it’s extended lifespan in every species tested, from yeast to primates, making it one of the most replicated findings in aging biology. In humans, that’s not yet proven.⁴ ⁶ Our own PEARL trial, the largest published human trial of its kind, found real, significant improvements in specific measures like muscle mass and pain in women, as well as general health and well-being, at lower doses over 48 weeks.⁵

PEARL stands for Participatory Evaluation of Aging with Rapamycin for Longevity. Researchers from our Stanford PhD-led Research Team designed and led the 48-week randomized, double-blind, placebo-controlled trial to study the effects of low-dose weekly Rapamycin in healthy adults ages 50 to 85.⁵

A total of 114 participants completed the study while our Research Team tracked safety, blood markers, body composition, and quality of life. The trial’s primary measure–visceral fat–didn’t show a significant change, but meaningful secondary findings did: women taking 10mg of compounded Rapamycin saw significant improvements in muscle mass and pain, and participants taking 5mg weekly reported improvements in general health and emotional well-being. The results were published in the peer-reviewed journal Aging in 2025.⁶

Rapamycin temporarily reduces activity in mTOR, a nutrient-sensing pathway that tells cells when to grow and when to repair. Giving that signal a break may create more time for autophagy, the process cells use to break down and recycle damaged material.^{2 3} Rapamycin has extended lifespan across every model organism it’s been tested in including yeast, worms, mice, and primates, making it one of the most consistently replicated longevity compounds in geroscience, and a genuinely promising candidate for extending human healthspan.⁶

Metformin is not thought to drop blood sugar to dangerously low levels, a condition known as hypoglycemia. However, some people tolerate lower levels of blood sugar than others. For this reason, Metformin might cause some people to have symptoms of low blood sugar such as lightheadedness, nausea, and fatigue. Starting at a low dose and increasing slowly can help. In our experience, most people with a history of hypoglycemia can tolerate lower doses of Metformin. 

If you run into any issues, or if you have any questions on Metformin, please contact us.

You might find it helpful to use a Continuous Glucose Monitor (CGM) to monitor your blood sugar levels for a few days. You can learn more about CGM here.

Significant lactic acidosis is almost never seen in people who have properly functioning kidneys. Out of precaution, we ask that people stop taking Metformin at least 3 days before going for any kind of medical procedure or imaging that requires contrast (such as a CT scan). Ask the physician doing the procedure or ordering a test about Metformin to be sure.

People with pre-existing kidney problems may be at greater risk of lactic acidosis, regardless of dose.

Serious side effects for Metformin are very rare, making it among one of the safest prescription medications that are commonly prescribed. However, it should not be used by anybody who has an allergy to Metformin; anyone who has poor kidney function; or diabetics who are poorly controlled (unless closely supervised by their local provider). There are many situations where Metformin can be used, but with caution or at lower doses than typically prescribed. Our medical team takes all of these factors into account when reviewing requests for prescriptions.

There is no agreed upon “optimal dosing” for longevity. Some longevity experts take and recommend 1000mg per day. Others recommend 1500mg per day. The TAME trial will be looking at 1500mg per day. Some health goals, such as weight loss support, may even require higher doses for you to achieve your desired outcomes.

Typical dosage consists of two 500mg extended release (ER) pills per day. However, your actual dosage will be determined by a licensed medical professional after taking into account multiple factors, including your medical history, drug interactions, and age, as well as your overall health goals.

Our medical staff will balance these factors to determine the best target dose for you.

The benefits of Metformin include lower blood sugar levels, more stable energy throughout the day, and better glucose and insulin sensitivity, all of which can reduce our risk for age-related diseases. But these benefits may be hard to feel in our day-to-day lives.

Fortunately, tools like a Continuous Glucose Monitor (CGM) can help people see how Metformin decreases their blood sugar levels and glucose sensitivity. You can learn more about CGMs here.

Biological age testing can also help people see if Metformin has helped slow down their biological aging, as compared to their chronological aging. You can learn more about biological age tests here.

After several months of taking Metformin, people may be able to notice some benefits on their own, including less appetite, more stable energy throughout the day, and better sleep.

People may also experience weight loss while taking Metformin, but the best weight loss results occur after at least 6 months of use, and usually at higher doses. Talk with your provider to see if increasing your dose is right for you.

See our Metformin Science page for more details on how Metformin works and what can be measured to verify this.

To derive the biggest benefit from Metformin, studies indicate that it should be taken over an extended period. The longer a member takes Metformin, the better it has been shown to “push back” diseases of aging, according to several research studies in both humans and lab animals (see our Metformin Science section). 

Some benefits from Metformin, such as reduced appetite and lowered blood sugar control, can be felt and appreciated relatively quickly (especially with the help of a CGM); many members report feeling these benefits by the second check-in, or within 2-3 months.

Other benefits, such as reduced risk for cancer or heart disease, may never be “felt,” as these benefits are happening on a cellular level to prevent these conditions before they occur. In other words, we may never know that a tumor or blocked artery has been prevented if neither are able to develop.

Those taking Metformin primarily for weight loss benefits may have to take higher doses for a longer period of time. Talk with your provider to see if increasing your dose is right for you.

Some people cannot tolerate tablets and require liquid or topical versions. We do not currently offer liquid or topical Metformin.

Absolutely not! Our therapies are meant as an extra layer of protection. We strongly encourage our members to adopt a healthy lifestyle, including leveraging such practices as intermittent fasting, physical activity, stress reduction, etc. It is also important to look at other potentially helpful factors, including dietary supplements like resveratrol, vitamin D, and/or B12.

No. Metformin is FDA approved for people with Type 2 diabetes mellitus. This is the on-label indication for Metformin.

However, like many medications, Metformin is used off-label for conditions such as PCOS, obesity, and cancer. Once the FDA has approved a medication for one use, a provider can prescribe it in any way they see fit for their members. Metformin has been approved by the FDA to be studied specifically for human longevity as part of the TAME trial that started in 2020.

First, Metformin benefits and its mechanism of action have been studied much more extensively than Berberine. Second, as Berberine is a supplement, quality control and potency are not nearly as strictly controlled as Metformin which is distributed by a licensed, US-based pharmacy that is inspected and regulated by the FDA and state boards of pharmacy. Third, there might be overlap between Metformin and Berberine, but they have different mechanisms of action and have different benefits.

That depends largely on what dosage you’re receiving and how long you take Metformin.

The most commonly prescribed dosage of Metformin is 2 tabs (1000mg) per day. At these doses, many members won’t notice significant weight loss within 6-12 months. 

Studies that focus on doses between 1500mg and 2250mg per day have shown modest but consistent weight loss for people. At these doses, people may lose 3-12lbs (or 5-7% of their body weight) within 6-12 months. People may experience the lower ranges of weight loss within 2-3 months, while those with a higher BMI may achieve higher estimates of weight loss within a shorter period of time. Doses above 2000mg may also increase the incidence of side effects. 

These studies were done with immediate release (IR) Metformin, which is why we offer IR for weight loss. If you would prefer the extended release (ER) version, you can request a change with your care team.

If you’re taking Metformin primarily for weight loss, talk with your provider to see if increasing your dose is right for you. Adopting healthy lifestyle choices (such as regular exercise and a reduced calorie meal plan) may also help you achieve better weight loss outcomes while taking Metformin.

SCORED (Screening for Occult Renal Disease) is a clinical tool designed to help providers decide when to screen people for renal insufficiency, or kidney problems. 

Those taking the SCORED test will be asked 9 questions, such as your age range and gender, and whether you’re diabetic. Checking “Yes” to any question generates a certain number of points. Any score of 4 or more indicates that renal screening is necessary to assess kidney function.

If your provider recommends Metformin at a dose over 2000mg, they will also ask that you complete the SCORED assessment. People who score a 4 or more may be asked to complete additional blood work.

While Metformin is widely used in diabetes care and is also being studied for its potential longevity-related benefits, AgelessRx does not treat clinically diagnosed diseases and is not a replacement for an individual’s primary care provider.

An HbA1c above 7.5 may indicate a health condition that requires more comprehensive medical management. In these situations, our providers may determine that a member would be better served under a dedicated diabetes care plan with closer monitoring and ongoing care through the member’s primary care provider and other specialists.

Many of our users use Metformin as part of a broader longevity protocol alongside other treatments, such as NAD+, Rapamycin, Microdosing GLP-1, and Vitamin B12. Your care team will continue to monitor your progress and adjust your protocol over time.

Some research suggests Metformin may blunt certain exercise adaptations, particularly muscle gains from strength training, in some individuals. This effect isn’t universal and appears dose- and person-dependent. If you strength train regularly, mention this to your provider. Your dose and protocol can be adjusted based on your goals and how your body responds.

Individual experiences vary. Some may begin noticing initial changes such as more stable energy levels and reduced appetite within the first few weeks of consistent use. Changes in blood sugar levels may become more noticeable over 2–3 months, particularly when monitored with tools like a Continuous Glucose Monitor. 

Some people notice changes in appetite or energy within the first few weeks; others feel less directly since much of what Metformin supports happens at the cellular level. Blood sugar and metabolic markers, biological age testing, and routine labs are the more reliable way to track progress over time. Your AgelessRx provider will monitor your results and may adjust your protocol as needed.

No. While Metformin is FDA-approved for type 2 diabetes, it is widely used off-label for its potential metabolic and longevity benefits in non-diabetic individuals. Research suggests Metformin may help support insulin sensitivity, cognitive function, heart health, and cellular health in people without diabetes.^{3 1 1}

The most commonly reported side effects of Metformin are gastrointestinal in nature and may include nausea, stomach upset, or diarrhea, particularly when first starting the medication. These side effects are often mild and may decrease over time as the body adjusts. Taking Metformin with food and starting at a lower dose may help reduce gastrointestinal discomfort.

Long-term use of Metformin may also affect Vitamin B12 absorption in some individuals, which is why monitoring B12 levels is recommended. Please see important safety information and consult your provider about the potential risks and benefits.

Metformin is a prescription medication with over 60 years of safety data.³ Research suggests Metformin activates AMPK, an energy sensor inside cells.⁶ Think of it as flipping a switch that tells the body to burn stored energy, clean out cellular waste, also known as autophagy, and reduce inflammation.⁷ This may activate some of the same cellular pathways associated with calorie restriction and exercise, two of the most well-established longevity levers.⁸

Targeting these pathways with precision may help overcome biological resistance to change that accumulates with age.⁹

These mechanisms form the basis for Metformin’s growing interest as a longevity intervention, including the first-ever FDA-approved longevity clinical trial (Targeting Aging with Metformin, TAME) built to study its effects on preventing age-related disease and extending longevity.⁴ Metformin is widely prescribed off-label by US-licensed providers based on a growing body of peer-reviewed research demonstrating effects on slowing organ aging and reducing the incidence of age-related disease.^{1 0}

Most people will notice a lift in energy within an hour or two of injection. Please note you should not use NAD+ Injections more than 3x per week.

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell in the body that plays a central role in cellular energy metabolism and DNA repair processes. NAD+ levels naturally decline with age. Supplementing with NAD+ may help support mitochondrial function, cellular repair mechanisms, and overall energy metabolism. Injectable NAD+ delivers the coenzyme directly into the bloodstream, bypassing the digestive system for more efficient absorption compared to oral forms or supplements.

Most people will feel effects within an hour of using NAD+ Nasal Spray.

NAD+ Nasal Spray delivers NAD+ (nicotinamide adenine dinucleotide) intranasally, allowing the coenzyme to bypass the digestive system and absorb directly through the nasal mucosa into the bloodstream.^{5 6} This delivery method may help support more direct cellular uptake compared to oral supplements, which require conversion and may vary in absorption between individuals.⁷

NAD+ Injections should be refrigerated at all times. Unopened vials should be kept in the refrigerator until ready for use. Once opened, vials must be used within 28 days and discarded after that period, regardless of remaining volume. Do not freeze. Keep out of direct light.

NAD+ is not absorbed well through the intestines, and any that is absorbed is destroyed by the liver. The most effective methods of getting NAD+ into the body involve bypassing the intestines to deliver directly into the bloodstream, as is the case with our NAD+ injections. The next best method seems to be using iontophoresis patches that use a small battery-powered device to produce an electric current to drive the NAD+ under the skin and into the blood circulation.

Refrigeration is recommended. Keeping your NAD+ Nasal Spray refrigerated may help preserve the integrity of the solution. Do not freeze. Keep out of direct light and out of reach of children. Follow any additional storage instructions included with your prescription.

The iontophoresis patches have a small battery operated device that facilitates the absorption of the medication (NAD+ or Glutathione) through your skin into your bloodstream, and because of this mechanism the patches are considered a medical device and are only available by prescription.

You may feel a slight sting or burn when administering the injection, but it varies from person-to-person.

NAD+ Nasal Spray is generally well tolerated. The most commonly reported side effects are mild and may include a slight burning or stinging sensation upon administration, nasal irritation, or temporary congestion. Side effects typically resolve on their own. As with any prescription treatment, please see important safety information and consult your provider about the potential risks and benefits before use.

NAD+ is essential for many functions, including DNA repair. You may or may not feel an immediately noticeable effect of better DNA repair; most of our members who use the NAD+ Patches report some of the following benefits: improved energy, mental clarity, decreased cravings, better sleep, better mood, alleviation of depression/anxiety symptoms, faster recovery from illness and injury, as well as post workout recovery. This is not seen in all people. As long as instructions for application are properly followed, the NAD+ will be absorbed into the body regardless of whether a person feels it or not, helping to support higher NAD+ levels. Depending on how depleted your NAD+ levels are you might need to build up your NAD+ level over a few weeks before noticing any benefits.

We have a number of people who used NAD+ patches to help with addictions (tobacco, alcohol, and other substance abuse), and have reported positive results. There is clinical evidence suggesting benefits of NAD+ for addiction treatment. This is not something we specialize in, but we are happy to accommodate your NAD+ patch orders for the purpose of addiction treatment.

NAD+ Nasal Spray may help support cellular energy metabolism, focus, and mental clarity.^{1 2} Because intranasal delivery may allow NAD+ to be absorbed directly into the bloodstream, it may support brain energy and cognitive function as part of a broader longevity or wellness protocol.^{1 3}

For member safety, our licensed providers do not prescribe NAD+ for those with active cancer, as there are some unknown risks associated with NAD+ and people with cancer. We plan to stay up-to-date as new findings emerge on this and will continue to keep our member’s wellbeing at the foundation of our decision making.

For those in remission or with a history of cancer, a U.S. licensed provider would review the intake form to determine whether or not it’s appropriate. If additional information is needed prior to approval, the reviewing provider would reach out.

Both NAD+ Nasal Spray and NAD+ Injections bypass the digestive system to potentially support more direct cellular absorption, but through different delivery mechanisms. Injections deliver NAD+ directly into the bloodstream via subcutaneous administration to support cellular energy and recovery.⁸ Nasal Spray delivers NAD+ intranasally through the nasal mucosa, which may help support focus and mental clarity.^{1 5}

NAD+ Patches are generally well tolerated. The most commonly reported side effects are mild and may include skin irritation or redness at the patch site. If irritation occurs, consider changing the placement location on the body. As with any prescription treatment, please see important safety information and consult your provider about the potential risks and benefits before use.

Both NAD+ Patches and NAD+ Injections bypass the digestive system to potentially support more direct cellular absorption, but through different delivery mechanisms.

Injections deliver NAD+ subcutaneously into the bloodstream directly, while patches use iontophoresis technology to drive NAD+ transdermally through the skin. Patches offer a needle-free option for those who prefer to avoid injections, while injections may be preferred by those looking for a more established delivery method.

NAD+ Patches use a technology called iontophoresis, a small battery-powered device within the patch produces a mild electric current that drives NAD+ through the skin and into the bloodstream. This transdermal delivery method bypasses the digestive system, where oral NAD+ bioavailability may be limited.^{1 0}

Individual experiences vary. Some people may begin noticing initial changes with consistent use, while others may find that effects become more noticeable over several weeks as NAD+ levels build over time.¹ ² Individual experiences depend on factors including age, baseline NAD+ levels, lifestyle habits, and adherence to the recommended protocol.¹⁰ Your AgelessRx provider will monitor your progress and may adjust your protocol as needed.

NAD+ Patches use iontophoresis technology to deliver NAD+ transdermally, bypassing the digestive system to potentially support more direct cellular absorption. NAD+ plays a central role in cellular energy metabolism, mitochondrial function, and DNA repair processes—all of which naturally decline as NAD+ levels decrease with age.^{4 7} Supporting healthy NAD+ levels may help support energy, stamina, and focus, as well as cellular repair mechanisms.^{5 6}

Sermorelin is a peptide medication that mimics growth hormone-releasing hormone (GHRH). This triggers the pituitary gland in the brain to naturally produce human growth hormone (HGH). 

Sermorelin doesn’t simply replace HGH like other therapies. Instead, Sermorelin helps your body make more HGH naturally, reducing some of the risks associated with synthetic HGH therapy or other hormone-replacement therapies.

Sermorelin imitates growth hormone-releasing hormone (GHRH), which stimulates the pituitary gland to secrete human growth hormone (HGH). Through this action, Sermorelin works with the body to support HGH production in a natural rhythm.

In turn, HGH promotes the production of insulin growth factor-1 (IGF-1), a key driver of tissue repair, muscle health, cognitive function, and physiological fitness.

Sermorelin is taken as a subcutaneous injection into a fatty layer of tissue such as your thigh or abdomen. If you’re approved for a Sermorelin prescription, your provider will provide a tailored titration schedule and dosing instructions. Your shipment will also come with enough needles and syringes to complete your monthly titration schedule.

Sermorelin is generally well tolerated with a minimal risk of side effects. In fact, Sermorelin is often considered safer than other HGH therapies because it works with the body’s natural systems to produce HGH, as opposed to direct HGH replacement. However, there are risks with any treatment. Please see important safety information for Sermorelin and consult your provider about the potential risks and benefits.

No, Sermorelin has a different mechanism of action than steroids. 

Sermorelin is a synthetic peptide that mimics growth hormone-releasing hormone (GHRH), stimulating the pituitary gland in the brain to release more of the body’s natural human growth hormone (HGH). 

Steroids mimic hormones directly, acting as a replacement without stimulating the body to release its own hormones. This increases the risk of hormone imbalance, mood disorders, liver damage, and other related side effects.

Sermorelin is generally well-tolerated with a minimal risk of side effects. The most common side effects include pain, redness, or irritation at the injection site, as well as face or neck flushing, headache, and nausea.

Most side effects are mild and fade away on their own within a week or two.

Sermorelin should not be used by anyone below age 30, or by those with untreated hypothyroidism, untreated hyperglycemia or diabetes, moderate to severe liver dysfunction, moderate to severe kidney disease, or a known allergy to Sermorelin. It should also not be used by anyone who has or has had cancer within the last 2 years, or by anyone who is pregnant or breastfeeding, or planning to become pregnant or breastfeed.

Sermorelin was FDA approved in 1997 under the brand name Geref for the treatment of growth hormone deficiency or growth failure in children. However, the manufacturer discontinued Geref in 2008, ending its availability as a commercially available FDA approved medication. The FDA confirmed that the medication was not withdrawn for safety or effectiveness concerns.

Sermorelin imitates growth hormone-releasing hormone (GHRH), which stimulates the pituitary gland to secrete human growth hormone (HGH). Through this action, Sermorelin works with the body to support HGH production in a natural rhythm. 

In turn, HGH promotes the production of insulin growth factor-1 (IGF-1), a key driver of tissue repair, muscle health, cognitive function and physiological fitness.

Sermorelin Nasal Spray delivers Sermorelin through the nasal mucosa. This delivery pathway supports the body’s natural release of GHRH and enables a convenient, needle-free alternative method of administration.

Because it is needle-free, nasal spray delivery significantly lowers the barrier for individuals who may be uncomfortable with daily injections, making it easier to stay consistent with treatment over time.

Individual results vary, and benefits are not guaranteed. Some people may begin noticing initial changes within 4–6 weeks of starting Sermorelin, while more pronounced changes may emerge between 3–6 months of consistent use.

Results vary based on individual factors including age, baseline HGH levels, lifestyle habits, sleep quality, and adherence to dosing schedule. Because Sermorelin works by potentially supporting the body’s natural HGH production rather than replacing HGH directly, results may develop gradually and in a more physiologically natural rhythm. Your provider will monitor your progress and may adjust your dosing over time.

Sermorelin Nasal Spray is taken as an intranasal spray. If you’re approved for a Sermorelin Nasal Spray prescription, your provider will provide a tailored titration schedule and dosing instructions.

Some medications may ship with cold packs routinely or seasonally. This depends on each individual pharmacy’s packaging protocols and the stability of the medication during transit. Many medications can remain stable at room temperature for a defined shipping window, even if they are stored refrigerated after arrival.

If your medication arrives warm or without ice packs, it does not necessarily mean it is unsafe or ineffective. However, if the package is damaged or you have concerns about the condition of your medication, please contact our team for assistance.

Sermorelin is generally well tolerated, with a minimal risk of side effects. The most common side effects include post-nasal drip to throat, burning during administration, congestion, face or neck flushing, headache, and nausea.

Most side effects are mild and fade away on their own within a week or two.

Same peptide, meaningfully different evidence and delivery profile. Injectable Sermorelin is absorbed efficiently and has a longer track record in clinical literature.⁴ Nasal delivery may offer a more direct route to the brain, bypassing general circulation, to engage growth hormone receptors in the brain for improved sleep, mental clarity, and cognitive recovery.^{1 2 7}

Sermorelin is generally well tolerated with a minimal risk of side effects.⁹ Sermorelin is often considered safer than other HGH therapies because it works with the body’s natural systems to produce HGH, as opposed to direct HGH replacement.⁶ However, there are risks with any treatment. Please see below for important safety information for Sermorelin and consult your provider about the potential risks and benefits.

Sermorelin is a peptide medication that mimics growth hormone-releasing hormone (GHRH). This triggers the pituitary gland in the brain to naturally produce human growth hormone (HGH). Sermorelin Nasal Spray doesn’t simply replace HGH like other therapies. Instead, Sermorelin may help the body make more HGH naturally, reducing some of the risks associated with synthetic HGH therapy or other hormone-replacement therapies.⁶

Sermorelin Nasal Spray is for people who want to explore GH support without an injection, specifically for sleep and cognitive benefits, and who are comfortable trying a promising but less-established route based on sound mechanistic reasoning and published literature suggesting enhanced growth hormone signaling.^{2 10} If you want the most established, best-evidenced version of this therapy, Sermorelin Injections have a deeper track record in clinical research.

PT-141 (Bremelanotide) is a melanocortin receptor agonist peptide that works through the central nervous system to support sexual desire and arousal. It acts on pathways in the brain involved in sexual response rather than directly affecting blood flow.

While PT-141 is not FDA-approved to treat medical conditions, it is used clinically to support sexual health and arousal in appropriate users under medical supervision.

PT-141 activates melanocortin receptors in the brain associated with sexual motivation and arousal signaling. This may help enhance sexual interest, responsiveness, and satisfaction in some individuals.

Individual results vary, and benefits are not guaranteed. Some users may experience increased sexual desire and libido, improved arousal response, enhanced sexual satisfaction, and improved overall mood and motivation.

PT-141 typically begins working within 45-60 minutes. Response timing varies based on dose, metabolism, and individual user sensitivity.

Most common side effects include nausea, flushing, headache, and temporary increase in blood pressure. Users of PT-141 Nasal Spray may experience post-nasal drip to the throat.

Less common but more serious reactions may include allergic reactions (rash, swelling, hives), significant hypertension, bradycardia, and acute hepatitis.

Stop use and contact your provider if significant or concerning symptoms occur. Seek immediate medical care for difficulty breathing or signs of a severe allergic reaction.

Do not use this medication if you have uncontrolled hypertension, serious cardiovascular disease, known hypersensitivity to peptide ingredients, active cancer, or if you are pregnant or breastfeeding.

Speak with your provider before use if you have heart disease, high blood pressure, kidney or liver disease, or use medications affecting blood pressure or heart rate.

Yes. Vyleesi’s FDA approval is specific to premenopausal women with hypoactive sexual desire disorder based on two large Phase 3 clinical trials showing significant improvement in desire and reduction in related distress compared to placebo.¹ Compounded PT-141 Injection is prescribed off-label to both men and women based on individual evaluation.

Tadalafil is the generic form of Cialis, an FDA approved medication to treat erectile dysfunction in men since 2003. It is also FDA approved to treat enlarged prostate, a condition called benign prostatic hyperplasia (BPH), since 2011.

Tadalafil is the same active ingredient as found in branded Cialis. Tadalafil works by inhibiting phosphodiesterase type 5 (PDE5) enzymes, which enhances erectile function by the release of nitric oxide (NO). It is offered as a daily or as needed medication; Tadalafil is only available with a prescription.

At higher doses (20mg/day or more), Tadalafil is also used in both men and women to treat pulmonary arterial hypertension.

Yes. While Vyleesi’s FDA approval is specific to premenopausal women with hypoactive sexual desire disorder, AgelessRx’s compounded PT-141 Nasal Spray is prescribed off-label to both men and women based on an individual evaluation.

Tadalafil is the active ingredient used in Cialis and is the generic equivalent. As clinically evidenced, Tadalafil is just as safe and effective as branded Cialis; it works for the same amount of time and delivers the same lasting effects.

Tadalafil and similar medications support blood flow once arousal is already present—they help the body respond, but they don’t create desire itself.⁶ PT-141 works upstream of that, on the brain pathways that generate sexual motivation in the first place.¹ Some people use both, guided by their care team, since they address genuinely different parts of the process rather than competing with each other.

Note: combining PT-141 with PDE-5 inhibitors carries an interaction risk (increased risk of priapism) and should only be done under direct clinician guidance.  

Taking Tadalafil daily at a lower daily dose (2.5mg or 5mg) reduces many common side effects and allows the freedom to be intimate on your own time without having to plan ahead.

The benefits go far beyond sexual health. When taken daily over the course of many years, Tadalafil may offer numerous longevity-enhancing benefits. Recent clinical research suggests that Tadalafil’s ability to improve blood flow may reduce the risk of heart disease and even lower the risk of dementia. These benefits stem from Tadalafil’s primary mechanism of action of improving blood flow.

As-needed tadalafil is dosed at 10mg and 20mg typically, but should only be taken no more frequently than once every other day. These higher, less-frequent doses are only used only for erectile dysfunction in men and are not expected to have much in the way of longevity benefits.

Both deliver the same active compound and work through the same brain-based mechanism, the difference is the route in and what comes with it. The nasal spray is needle-free and easy to self-administer, but absorption is somewhat less predictable and typically requires a higher dose to compensate. PT-141 Injection tends to deliver more consistent absorption at a lower dose, with the trade-off being a needle. Your provider can help you decide which fits your preferences better.

Tadalafil sets itself apart from other ED medications in three distinct ways.

First, it is the only ED medication available for daily use. This means you can be intimate at any time, rather than needing to take a pill from time to time, as needed, like other brands (e.g. Viagra).

Second, when taken as needed, a single dose can remain active up to 36 hours. Tadalafil is often referred to as “the weekend pill” because a single dose can remain active for up to 36 hours (whereas others, such as Viagra, remain active for only a few hours). Tadalafil provides the opportunity for spontaneity.

Third, it is earning clinical support for a variety of health and longevity benefits. We explore some of the latest research in this blog.

Not exactly. Vyleesi is the FDA-approved, fixed-dose autoinjector version of bremelanotide for premenopausal women with hypoactive sexual desire disorder.¹ PT-141 Nasal Spray is compounded and dosed individually by your care team, offering a needle-free option, but it’s used off-label outside that specific FDA approval.

As with any drug product, there may be side effects. Generally, people who experience side effects usually get them within 12 to 24 hours after taking Tadalafil. Side effects usually resolve on their own within 48 hours.

The most common Tadalafil side effects are headache, indigestion, back and muscle pain, flushing, and stuffy nose.

Some more serious side effects have been reported. While rare, it is important to stop taking Tadalafil and contact your provider right away if you experience an erection that will not go away (priapism) or lasts longer than four hours, a sudden loss of vision in one or both eyes, a sudden decrease in hearing or hearing loss. The above information is only a summary. It may not cover all possible information. For a more complete list of possible side effects, click here.

Some drugs/medications may interact with Tadalafil. You should not take Tadalafil if you are taking nitrates (such as nitroglycerin tablets or patches), Cisapride, other ED medications (e.g. Viagra), Adcirca, or Riociguat.

For a more complete list of possible drug interactions, click here.

Anti-aging benefits: A clinical analysis cited PDE5 inhibitors, such as daily Tadalafil, as a worthwhile addition to any “anti-aging drug mixture because ED and BPH are most prevalent age-related conditions in aging men.” Furthermore, the analysis states that by “relaxing the tension [in senescent cells] may slow senescent-associated pathology… causing anti-vasoconstriction, anti-proliferative and anti-inflammatory effects.”

Reducing health risks related to aging: The same clinical analysis cited above suggests that by fighting against cellular senescence, PDE5 inhibitors, such as Tadalafil, may also help to reduce health risks related to aging, such as heart hypertrophy, myocardial infarction, cancer, neurodegenerative diseases, cystic fibrosis, diabetes, obesity and metabolic syndrome.

Anti-inflammatory properties: Per this clinical study in Scientific Reports, “chronic inflammation plays an important role in BPH/LUTS (lower urinary tract symptoms) and contributes to the clinical progression of BPH-related symptoms… Tadalafil, but not sildenafil or vardenafil, reduces pro-inflammatory factors.”

Improved cognitive function: In this clinical study, researchers state: “Erectile dysfunction is commonly associated with depression, and treatment with PDE5 inhibitors improves cognitive functions and depression, in addition to erectile dysfunction. Therefore, treatment of BPH/LUTS-ED with Tadalafil could improve people’ quality of life and their cognitive functions.”

Improved heart health: In this clinical study, researchers cite support for PDE5 inhibitors, such as Tadalafil, “improved contractile function, reduced chamber dilatation and reduced LVH.” In other words, keeping the heart rate normal, increasing blood flow and the ability for the heart to supply the body with enough blood, and reducing blood pressure to decrease the heart’s workload.

Yes, Tadalafil is FDA approved to treat erectile dysfunction (ED). At different doses, it is also FDA approved to treat symptoms of BPH and pulmonary arterial hypertension.

AgelessRx only partners with US-based pharmacies that are FDA registered and inspected facilities. As such, they routinely undergo strict manufacturing and approval processes for safety and efficacy that makes them available nationally to all other pharmacies in the country (including large and well-known providers, like Walgreens and CVS).

Yes, off-label and with provider guidance. The underlying nitric oxide–cGMP mechanism is shared between sexes, and PDE5 inhibitors are already approved and effective for pulmonary hypertension in women.¹² ¹⁷ Longevity-specific evidence in women is still developing, since most large studies to date have focused on men, and our research team is leading the charge.

Yes. Eligible women can take low dose Tadalafil when prescribed off-label by a licensed provider. This isn’t a men’s-only mechanism: PDE5 inhibition works through the same nitric oxide–cGMP pathway in both sexes, and it’s already an approved, effective therapy for pulmonary hypertension in women.⁶ Randomized trials have studied 5 mg daily in women for overactive bladder symptoms, while a recent trial found improvements in sexual function and clitoral blood-flow measures in a specific female population.^{1 0 1 1} Evidence for female longevity specifically is still emerging, so treatment should be personalized.

Tadalafil is FDA approved for erectile dysfunction, not premature ejaculation. Some studies suggest it may help certain men improve ejaculatory timing, particularly when erection difficulties and premature ejaculation occur together.¹⁰ Results vary, so your provider can help determine whether Tadalafil fits your symptoms and treatment goals.

Yes, mechanistically–this is the best-established part of the science. By blocking PDE5, Tadalafil may keep cGMP active longer, allowing blood vessels to relax and respond more effectively, supporting circulation throughout the body.¹³ This mechanism likely underlies the vascular, cognitive, and cardiovascular associations that are beneficial for longevity.

Large population studies have found PDE5 inhibitor use associated with meaningfully lower dementia rates, with one large UK cohort study finding a stronger association among men with more sustained Tadalafil use.² ⁹ This is a real and consistent signal across multiple independent studies, but it remains observational.

Tadalafil is taken before anticipated sexual activity and may begin working within 30 to 60 minutes, although timing varies by person.¹ Blood levels typically peak around two hours after taking it.⁴ Because Tadalafil can remain active for up to 36 hours, you may have a wider window for intimacy without needing to time every moment precisely, a genuinely different experience than medications built around a narrow window.²

Tadalafil and Viagra® (Sildenafil) both increase blood flow to support erections during sexual stimulation, but they differ most in how long they work.⁹ Sildenafil, the active ingredient in Viagra®, typically has a shorter window. Tadalafil may support erectile function for up to 36 hours, giving you more flexibility around when intimacy happens. In head-to-head trials, a clear majority of men who tried both ultimately preferred Tadalafil, citing less pressure around timing as one of the main reasons.⁷ ⁸

Because the medication is the same wherever you get it. The difference is what happens around it. You get a real clinician reviewing your case, a dose and regimen actually tailored to you rather than a default prescription, and an in-house team you can message when something needs adjusting. In a category full of one-size-fits-all pill mills, that clinical seriousness is the actual product. 

No, Tadalafil supports the blood-flow response involved in an erection, but sexual stimulation is still required. Tadalafil does not create desire or cause a constant erection. Instead, it may make it easier to get and maintain an erection when you are aroused.

DMAE stands for dimethylaminoethanol (deanol for short). It is an organic, topical compound traditionally derived from fatty fish (salmon, sardines, anchovies). Studies suggest DMAE may help increase dermal (skin) thickness while also hydrating the skin. Used consistently, DMAE may have skin-firming effects.

Our Rx-exclusive gel contains Dimethylaminoethanol Bitartrate (DMAE), Hyaluronic acid (Sodium Hyaluronate), Alpha Lipoic Acid, Preserved Water, and Lavender Oil. This combination is formulated to be more effective than using any one of these ingredients alone.

Many members see results within just a few weeks of treatment. Significant overall skin tone improvement should be visible within 16 weeks.

While using DMAE, you may experience: Itching, Burning, Redness, or Peeling. Less common side effects may include muscle twitching, insomnia, sneezing/coughing/wheezing, severe eye irritation, or convulsion.

If you experience severe burning or rash, discontinue use and contact your care team.

Some over-the-counter creams may contain DMAE, however, at much lower percentages than available via a prescription. Some oral forms of DMAE are also available OTC, such as tablets or powders, however, they do not present the same anti-aging skin benefits as a topical form, such as gel or cream.

Based on available research, long-term use (1 year or more) of topical DMAE is associated with a good safety profile.

No. DMAE is linked to birth defects and miscarriage. Stop using DMAE immediately if you become pregnant. Do not use DMAE if you are pregnant or breastfeeding (including trying to get pregnant or are unsure whether you are pregnant).

DMAE is known to have a somewhat unpleasant smell, and our pharmacists describe DMAE as smelling vaguely like ammonia, which can smell fishlike to some. Our unique formulation of DMAE contains lavender oil to help reduce any unpleasant smells. Some may still detect the smell of ammonia, but the scent does not linger or stick to your skin, so you shouldn’t let this detract you from the benefits of DMAE.

GHK-Cu (Copper Tripeptide-1) is a naturally occurring peptide found in the body that supports skin repair and renewal processes, including collagen production and overall skin quality. Levels of GHK-Cu naturally decline with age. 

While GHK-Cu is not FDA-approved to treat medical conditions, it is commonly used in cosmetic dermatology for skin appearance and rejuvenation.

DMAE Firming Gel contains the 3% DMAE concentration studied in published research, plus hyaluronic and alpha lipoic acids for hydration and antioxidant support.^{1 6 7} Unlike many cosmetic formulas—where DMAE may be present at a fraction of a percent, well below the range shown to matter in research—the active strength is clearly disclosed, and the treatment requires clinician approval.

GHK-Cu Cream works locally within the skin layers (epidermis and dermis). Research suggests it may help support collagen and elastin production, promote tissue repair and remodeling, help regulate inflammatory signaling in the skin, support skin barrier integrity, and provide antioxidant activity within the skin. This treatment is intended for external skin use only.

GHK-Cu and retinol work through different mechanisms. Retinol accelerates cellular turnover to resurface the skin, while GHK-Cu works locally, signaling cells to repair and remodel, support collagen and elastin production, and build density and elasticity. Additionally, GHK-Cu does not cause photosensitivity and does not trigger a retinoid response, which can include initial breakouts, known as purging.

Individual results vary, and benefits are not guaranteed. With consistent use, some users may notice benefits such as improved skin firmness and elasticity, reduction in the appearance of fine lines, improved skin texture and tone, support for recovery from environmental stressors, and enhanced overall skin appearance.

GHK-Cu supports the skin’s own firmness pathways, so it may help with the appearance of mild laxity over time. It may signal the skin to produce collagen and elastin, the proteins that give skin its structure and bounce, which can improve firmness, density, and elasticity with consistent use. Individual results vary and are not guaranteed.

Skin renewal takes time. Some users may notice subtle improvements within a few weeks, while optimal results may appear after 2–3 months of regular use. Consistency is key for the best outcomes.

GHK-Cu is generally well tolerated, and copper toxicity is not a realistic concern with topical use. The most common side effects are mild and localized, such as temporary redness, tingling or warmth, dryness, or mild irritation, and these usually settle within a week or two.

Both strengths use the same peptide; the difference is intensity, and the right one depends on your skin and your goals.

The 0.5% cream is our gentle, everyday starting point. It is ideal if you are new to copper peptides or have sensitive or reactive skin, and it suits delicate areas like the face and around the eyes. It builds results gradually with a low chance of irritation.

The 3% cream is our higher-intensity option. It is formulated for skin that is already comfortable with active ingredients, for tougher or thicker-skinned areas, and for more advanced goals like firmness and deeper-set texture, delivering more peptide per application for those who want to push results further. Many people begin at 0.5% and step up to 3% as their skin adapts. Your provider will help match the strength to your goals and tolerance.

Most side effects are mild and localized to the application site. Common side effects may include mild redness or irritation, dryness, temporary tingling or warmth, and increased skin sensitivity.

Less common but more serious reactions may include allergic reaction (rash, swelling, hives), contact dermatitis, worsening of inflammatory skin conditions, and/or infection if applied to open or broken skin.

Stop use and contact your provider if significant irritation or concerning symptoms occur. Seek immediate medical care for signs of a severe allergic reaction, difficulty breathing, or signs of infection.

Do not use this medication if you have a known allergy to copper peptides or formulation ingredients, known copper metabolism disorders (such as Wilson’s disease), active or untreated skin infection at the application site, have active or recent cancer, significant heart dysfunction, or if you are pregnant, breastfeeding, or planning to become pregnant or breastfeed.

Speak with your provider before use if you have sensitive or reactive skin, eczema, psoriasis, rosacea, chronic skin conditions, or any history of contact dermatitis. Please also discuss any recent cosmetic procedures, such as chemical peels, microneedling, or laser treatments, as well as the use of retinoids, exfoliating acids, or other active skincare treatments.

Many members report seeing benefits within 30 minutes to 1 hour of using the product. Dermatologists sometimes demonstrate this by applying our cream to one of their member’s eyes at the beginning of the appointment. At the end of the 30 minute appointment, they hand them a mirror and show them the difference. So, results may be seen in as little as 30 minutes, and may continue to improve skin with prolonged use.

It is not expected to. We have not had reports of this cream causing breakouts or irritation, and some people use it on acne-prone skin.

Our NAD+ Face Cream contains NAD+ powder, sodium hydroxide (10% solution), propylene glycol, and HRT Botanical Base. 100% vegan, cruelty free.

NAD+ is a coenzyme that plays a central role in cellular energy metabolism and DNA repair.³ As NAD+ levels naturally decline with age, the skin’s ability to support cellular repair and maintain healthy function may decrease over time.⁶ Topical NAD+ Face Cream delivers NAD+ directly to the skin, where it may help support cellular energy production, skin barrier function, and overall skin health.^{1 3 4} Individual experiences vary and depend on factors including skin type, age, and consistency of use.

Tretinoin is a topical form of retinoid applied to the skin. It is only available via prescription.

Yes, NAD+ Face Cream may be applied around the eye area. Take care to avoid direct contact with the eyes themselves. If irritation occurs, discontinue use around the eye area and consult your provider.

Our Tretinoin Anti-Wrinkle Cream contains retinoic acid (commonly 0.02% or 0.05%), hyaluronic acid, and ascorbic acid.

NAD+ Face Cream is a topical skincare formulation containing nicotinamide adenine dinucleotide (NAD+), a coenzyme found in every cell in the body that plays a central role in cellular energy metabolism and DNA repair.⁸ As NAD+ levels naturally decline with age, skin cells may become less efficient at supporting cellular repair and renewal.⁶ NAD+ Face Cream delivers the coenzyme directly to the skin, where it may help support the cellular processes that contribute to healthy-looking skin over time.^{1 4}

Most people see early results within 3-4 weeks, with more significant results after 8-10 weeks. If you are using Tretinoin as an acne treatment, noticeable results may take longer, between two to six months.

Most commonly, we prescribe a starting/initial prescription of 0.02%, working up to 0.05% upon first refill. In some cases, different strengths may be prescribed at the discretion of your provider. However, we typically do not recommend strengths over 0.05%, as higher concentrations (like 0.1%) are often too strong to properly treat wrinkles and come with exacerbated side effects: the 0.02% and 0.05% formulas offer the best balance of positive cosmetic outcomes while minimizing side effects.

Refrigeration helps preserve the potency of the NAD+ in the cream, particularly during warmer months or in warm climates. Keeping the cream at a lower temperature prior to application may also help support skin comfort upon use.

You may experience itching, burning, redness, or peeling in the first days or weeks after starting Tretinoin. These are sometimes referred to as “retinoid reactions,” which are an initial skin response to retinoids like Tretinoin. 

Less common side effects may include edema (swelling), rash, skin hyperpigmentation (dark spots), and skin hypopigmentation (light spots).

If Tretinoin gets too close to your eye, it may cause a dry eye condition known as meibomian gland dysfunction/atrophy. Be careful to apply Tretinoin no further than your orbital bone (eye socket) to ensure that the medication stays out of your eye.

If you experience severe burning or rash, stop using Tretinoin and contact your care team.

For more information on Tretinoin side effects, please review the Mayo Clinic’s Tretinoin resources.

No. Topical Tretinoin is only available with prescription and is not sold over the counter.

Studies show that it’s safe to use Tretinoin over the long term, with some studies examining the effects of Tretinoin for as long as four years.

Though absorption from topical Tretinoin is minimal, we do not recommend using it during pregnancy or breastfeeding due to the theoretical risk of birth defects. Do not use Tretinoin if you are pregnant, breastfeeding, trying to become pregnant, or unsure whether you are pregnant. Stop using Tretinoin immediately if you become pregnant.

Trazodone is a serotonin agonist and reuptake inhibitor (SARI) that is FDA approved as an antidepressant. In recent years, Trazodone has also developed a reputation as a potent sleep aid: when taken at low doses (25-100mg), Trazodone acts strongly as a serotonin agonist to produce a sedative effect that has been shown to potentially improve sleep onset and duration.

When compared to benzodiazepines and other sleep aids, Trazodone is non-habit-forming with less side effects. Trazodone also stands out for having a shorter half-life, and thus a lower risk of daytime drowsiness and side effects.

Trazodone blocks serotonin type 2 (5-HT2), histamine H1, and alpha-1 adrenergic receptors, which reduces neurotransmitters associated with arousal. Studies show that this results in a calming sedative effect that may induce and maintain high-quality sleep.

Studies show that Trazodone’s unique mechanism of action can produce a calming effect that may help you fall asleep faster and stay asleep longer, while restoring healthy sleep patterns over time.

Studies also show that Trazodone may also help improve moods, reduce anxiety, and enhance cognitive function like memory recall and concentration.

Unlike other sleep aids, studies indicate Trazodone isn’t habit-forming or addictive, with a shorter half-life that also reduces the risk of side effects like grogginess.

The most common side effects of Trazodone are drowsiness, dizziness, headache, dry mouth, and nausea. Most side effects are mild and go away within a week or two, as your body adjusts to the medication.

Some side effects of Trazodone may affect your ability to drive a vehicle, operate heavy machinery, and perform other tasks requiring concentration and coordination. Plan to stay home or arrange a ride for the first few days after starting Trazodone, until you’re sure you won’t be drowsy, dizzy, or fatigued after taking the medication.

The side effects of Trazodone are dose-dependent and may indicate that a particular dose is too high. If you find you cannot tolerate your current dose, talk to your provider, who may lower your dose by 25mg until your side effects resolve. If you cannot tolerate 25mg of Trazodone, consider taking an alternative sleep aid such as Tran-Q Sleep.

Trazodone can be taken by generally healthy adults who are at least 25 years old.

People taking MAOI medications or antidepressants should not take Trazodone, as the combination may increase the risk of serotonin syndrome. Do not take Trazodone within 14 days of discontinuing an MAOI medication or antidepressant.

If you are pregnant or breastfeeding, or planning to become pregnant or breastfeed, do not take Trazodone.

Trazodone may not be appropriate for people with a history of heart, liver, or kidney conditions. People with compromised organ function may be at greater risk of side effects or increased complications with these organs.

Trazodone may also increase the risk of psychological side effects in younger people, and the risk of falling in older people.

The initial feeling of drowsiness normally occurs within 30-60 minutes after taking Trazodone. Clinical trials suggest that benefits like better sleep, improved memory recall, and enhanced concentration can be achieved within 4 weeks for most people. However, all people react uniquely to Trazodone, and results may vary. If you feel you’re not meeting your health goals on your prescribed dose, contact your care team to see if changing your target dose is right for you.

No, Trazodone is not habit-forming or addictive. However, Trazodone can cause a recurrence of side effects and sleep disturbances if you stop taking it suddenly. For this reason, most people should slowly wean off Trazodone before discontinuing the medication.

It is best to avoid alcohol while taking Trazodone. Alcohol can amplify the sedative effects of Trazodone, leading to increased drowsiness, dizziness, and impaired coordination. This combination may also negatively impact the quality of your sleep, reducing the restorative effects of the medication​.

Trazodone is safe for long-term use at low doses between 25-100mg. If you are approved for a prescription, your provider will reassess your prescription every 3-6 months to determine your ongoing eligibility based on your progress and health goals.

Trazodone can affect eating habits and make some people feel more or less hungry than usual. Though uncommon, some people may notice they slightly gain or lose weight as a result. Losing or gaining weight is not an intended effect of Trazodone. Do not take Trazodone expecting to see weight loss.

Most people can safely combine Trazodone with Tran-Q Sleep. However, you should always discuss this option with your provider before proceeding.

Some over-the-counter sleep supplements like melatonin and magnesium are usually safe to use with Trazodone. But you should always discuss any combination with your healthcare provider.

We can think of sleep architecture as “the house we sleep in,” or how well our brain is able to build a foundation of quality sleep.

Sleep architecture is defined by our brain activity as we sleep, or how well we pass through the stages of high-quality, restorative sleep: light sleep (stages 1-2), deep sleep (stages 3-4), and dream sleep (stage 5). The brain takes about 90 minutes to go through all of these stages, starting with the base (stages 1-2), then the siding (stages 3-4), and finally the roof (stage 5).

Just like a reliable house needs all of these parts to be comfortable, so too does reliable sleep. If it takes too long for us to fall asleep, or if our sleep is fragmented, then the quality of each stage deteriorates, leading to weaker sleep, or a less comfortable house to sleep in.

Those with healthy sleep patterns have good sleep architecture. On the other hand, those with insomnia are said to have poor sleep architecture, or poor sleep patterns that make it difficult to fall and stay asleep.

Studies show that users of Trazodone experience improved sleep architecture, fall asleep faster and stay asleep longer, while experiencing increased time spent in non-REM deep sleep (slow-wave sleep). Over time, this helps develop a more balanced sleep cycle with minimal impact on REM sleep​​.

Controlled sleep studies have found Trazodone may measurably increase slow-wave sleep, the deepest, most physically restorative stage of the sleep cycle, without significantly suppressing REM sleep the way some other sleep medications do.^{1 3} That distinction of more time in deep sleep, not just more time asleep, is the core of why Trazodone has been studied for sleep quality.

Most prescription and OTC sleep aids work by activating the GABA pathway to sedate you. Trazodone works by potentially blocking receptors that promote wakefulness and arousal, which can be associated with increased slow-wave (deep) sleep rather than simple sedation, and doesn’t carry the same tolerance or dependence risk as GABA-acting hypnotics. It’s a different mechanism aimed at a different goal: sleep quality, not just sleep quantity.^{1 4}

No. Trazodone is FDA approved for major depressive disorder. Its use for sleep is off-label, meaning a licensed provider may prescribe it when they determine it is medically appropriate.

You may experience initial daytime drowsiness once you first start taking Trazodone, which is why you should avoid driving until you understand how Trazodone will affect you. Drowsiness may come back briefly if you increase your dose, so plan ahead.

The good news is that Trazodone side effects are dose-dependent.¹ That means side effects like grogginess can be an indication that your current dose is too much for you. If you find that your grogginess doesn’t get better after a week or two, you may still be able to cut down your dose to improve groginess. Always talk with your provider before adjusting your dose.

No. iollo is intended for wellness and informational purposes and does not diagnose medical conditions. Discuss abnormal results, symptoms, or healthcare decisions with a qualified healthcare professional.

Most users are surprised to find that the application is painless. The Continuous Glucose Monitor (CGM) uses a tiny flexible filament (not a rigid needle) that sits just under the skin. Once applied, it is water-resistant and durable. You can swim, shower, and exercise confidently knowing it is designed to stay secure for its full wear duration.

The price of the Biological Age Test includes a provider’s order for testing, all lab and testing fees, and a copy of your results (revealing your Biological Age).

Your report groups your 600+ biomarkers into patterns tied to specific systems—metabolic, immune, liver, kidney, and more—so rather than a single score, you see where your biggest deviations actually cluster. Your AgelessRx clinician can review this with you to identify your dominant pattern, also known as your ageotype in research terminology, and explain what it means for your specific biology.

A calorie deficit tells part of the story. Nutrisense can show how meals, sleep, stress, and movement align with glucose levels throughout the day, helping you spot patterns that are difficult to see through calorie tracking alone.

Stelo captures the data, the Nutrisense app turns it into clear trends, and eligible members can work with a registered dietitian to test more personalized strategies without relying on guesswork.

First, purchase the Biological Age Test from AgelessRx, then schedule your blood draw at Quest or a lab of your choice. Once you collect your blood draw results, enter your results into the Biological Age Calculator to reveal your Biological Age.

No. As part of your test price, AgelessRx provides an order from a licensed provider in your state through our network.

Routine blood work generally measures a relatively limited selection of individual markers. iollo measures 600+ biomarkers and evaluates patterns across 19 health areas to provide a broader view of your current biochemistry.

We’ve partnered with Nutrisense to give you exclusive access to their advanced continuous glucose monitoring program. Other programs give you a sensor, automated alerts, and data without interpretation. Nutrisense gives you Nora, an AI dietitian that analyzes your patterns 24/7, plus a glucose-certified human dietitian who uses Nora’s insights to build a plan specific to your body and goals. That’s the actual differentiator: not the sensor, which is largely the same across programs, but what happens with what it finds.

Unfortunately, no. All laboratory testing must be privately paid for at the time of purchase.

If you would like to see if this test will be reimbursed by your insurance, you can download a copy of your receipt from your account dashboard.

A glucose biosensor like Stelo offers a window into your body’s glucose response, not just an average. HbA1c gives you a single number reflecting roughly three months of average blood sugar; it can’t tell you that a specific breakfast spikes your glucose levels while a similar-calorie lunch barely moves the needle, or that your glucose runs higher after a poor night’s sleep.⁶

That level of individual, real-time insight is something no once-a-year blood draw can show you, and it’s often the missing piece between generic nutrition advice and something that actually works for your body. 

On its own, a list of 600 biomarker values means very little to most people. What it means depends on which markers deviate together, which points to a specific underlying system under strain, and what that implies about realistic next steps. That interpretation is what a clinician-guided review adds on top of the test itself.

A Continuous Glucose Monitor is a small, flexible sensor worn just under the skin that measures your glucose levels continuously, every 15 minutes, rather than the single-point-in-time snapshot you get from a finger prick. Scan it with your phone or a reader, and you can see where your blood sugar has been over the last several hours, not just where it is right now.

Sugars like glucose, lipids like cholesterol, vitamins like vitamin B12, hormones like T3 and T4, are all metabolite biomarkers and science has so far identified 40,000+ of them in blood. The collection of all of these metabolite biomarkers are what is known as the blood metabolome.¹

‍While your genetic makeup gives you risk scores that can be used to indicate what might happen, your metabolome indicates what is happening in your body right now. Leading metabolomics researchers estimate genetics account for a relatively small share of most disease risk, with the majority tied to metabolic, lifestyle, and environmental factors your blood metabolome directly reflects.²

If you purchased your blood test through AgelessRx, you can go to any of the thousands of Quest Lab locations nationwide.

Once your order has been confirmed, you will receive the Biological Age Test User Guide which will guide you through the process of setting up an appointment.

If it is possible, yes. We encourage everyone to use their own doctor and health insurance for blood tests. However, if that is not possible or not as affordable, AgelessRx can help you arrange a blood draw at a local Quest Labs.

Once you have submitted your order, you will receive access to the Biological Age Test User Guide that outlines how to schedule an appointment at Quest Labs.

The Stelo Glucose Biosensor is a pioneering over-the-counter (OTC) device, approved in early 2024. Since the summer of the same year, it’s been available to buy without a prescription across the United States.



It is designed for a broad audience—for example, people with type 2 diabetes who are not on insulin, those with prediabetes, and even those who want to learn more about how their eating habits affect their glucose levels. As one of the first non-prescription Continuous Glucose Monitors (CGM), Stelo offers a simple, no-frills option for beginner glucose monitoring.

Accuracy: Stelo provides reliable glucose readings. While sensors are designed to last up to 15 days, note that around 20 percent may not last the entire duration, and 10 percent may only last for 12 days.

App Compatibility: The Stelo app integrates with Apple Health, providing basic glucose tracking without advanced analytics. When paired with Nutrisense, users benefit from deeper data insights and better tracking options.

Recommendations may address nutrition, physical activity, sleep, supplements, and other lifestyle habits. They are personalized using your results and are intended to help you identify practical areas of focus.

We encourage everyone to complete a Biological Age Test before starting a certain therapy. Then, repeat the test again within the next 6-12 months to see how the therapy has impacted your aging process.

Blood sugar swings affect energy, focus, cravings, and mood well before anyone would call it a diabetes diagnosis, and glucose regulation is one of the earliest systems to show strain as metabolic health declines, often years before it affects a standard lab value.^{2 3 5}  Wearing a CGM lets you see, in real time, how specific meals, workouts, sleep, or stress actually move your glucose, which turns vague dietary advice into something personal and specific.

After completing the calculator exercise, you will receive a personalized report detailing your Phenotypic Age and Chronological Age. Specifically, the difference between the two ages.

The test measures nine markers. Albumin and Alkaline Phosphatase measure liver function, while Creatinine measures kidney function. Glucose reflects metabolism, and C-reactive Protein reflects inflammation. Lymphocyte, Mean Cell Volume, Red Cell Distribution Width, and White Blood Cells all relate to the immune system.

You can learn more about each of the 9 blood markers on our Product Science Page.

Yes! If you’ve had recent standard bloodwork done, AgelessRx’s free calculator may be able to estimate your biological age from those results alone, no new sample needed.

Cologuard is a non-invasive, at-home stool test designed to detect the presence of colorectal cancer or precancerous conditions by analyzing DNA and blood in the stool. Cologuard is a prescription-only product that must be ordered by a healthcare provider on your behalf.

AgelessRx does not provide Cologuard collection kits directly. AgelessRx only offers medical consultations with expert providers to see if a Cologuard prescription is appropriate for you.

If you are approved for a Cologuard prescription, you must contact Exact Sciences, the manufacturer of Cologuard, directly to confirm your identity and remit payment to receive your collection kit.

Different biological age tests (epigenetic clocks, different types of organ age tests, PhenoAge) measure different biological inputs and were built and validated differently, so they can legitimately produce different numbers for the same person.³ That’s not evidence biological age tests are nonsense, it’s evidence you should know which specific layer of biology you’re assessing and what risks the clock is trained to predict. This is where scientific expertise and clinical guidance is so important.

PhenoAge, the model behind this test, was developed and validated using data from over 11,000 adults, and has been independently shown to predict all-cause mortality, disease risk, and physical functioning—even in healthy, disease-free people—better than chronological age alone.¹ That’s a genuinely strong evidence base. Even so, no biological age test today can pin down exactly how long you’ll live or diagnose a specific condition. Think of the result as a meaningful, well-validated data point to track over time, not a verdict.

Cologuard detects specific changes in the DNA and the presence of blood in your stool, which can be indicators of cancer or precancerous polyps. Each sample is analyzed by a US-licensed laboratory technician at Exact Sciences, the pathology company who launched Cologuard, who will deliver a positive or negative confirmation based on your sample.

Please note that a negative result does not rule out colorectal cancer, and a positive result is not a diagnosis. Cologuard should be used in addition to routine cancer screening tests with your healthcare provider, who will help you interpret your results and advise you on next steps.

No. This test uses standard blood markers to calculate Phenotypic Age. Methylation tests examine chemical patterns associated with DNA and use a different method to estimate biological age. This test offers a lower-cost way to establish a biological age baseline using a standard Quest blood draw.

Cologuard is recommended for individuals aged 45 and older who are at average risk for colorectal cancer and who do not have symptoms. Your AgelessRx provider will review your request to determine if Cologuard is right for you.

Cologuard is a prescription stool test provided by Exact Sciences. In order to receive Cologuard, you must receive a prescription from a licensed provider, such as your AgelessRx provider.

To get Cologuard, you can start by setting up a virtual visit with your AgelessRx provider, who will determine if Cologuard is right for you and provide a prescription if appropriate.

If you’re approved, your prescription will be sent to Exact Sciences, who will contact you directly to help you complete the process.

Please note that AgelessRx only provides a provider consultation to see if Cologuard is right for you. AgelessRx does not provide the Cologuard collection kit. You must complete your payment with Exact Sciences to receive your Cologuard collection kit.

Chronological age is just a count of years. Biological age looks at how your cells, organs, and systems are actually holding up. It factors in genetics, lifestyle, and environment, so it tends to track more closely with how you actually feel and function than your birth certificate does.²

The out-of-pocket cost for Cologuard is $382 if you choose not to go through insurance. You can always use your insurance if you prefer, but you may be charged more in the event that your insurance does not cover your Cologuard prescription.

Biological age is a broad term for estimates of how the body is aging. PhenoAge is a published, peer-reviewed algorithm developed by researchers at Yale and the National Institute on Aging, combining chronological age with nine standard clinical blood markers into a single estimate of biological aging.¹

It was built and validated using data from thousands of adults across multiple independent studies, and has been shown to predict mortality, disease onset, and physical functioning more accurately than chronological age alone—including in people with no diagnosed disease.¹ Different biological age tests may produce different results because they measure different aspects of aging, which is exactly why knowing which specific model you’re looking at matters.³

No, Cologuard is not a replacement for a colonoscopy. Cologuard detects 42% of large polyps on average, while colonoscopies detect 95% of large polyps. Cologuard is an alternative screening option for those at average risk of colorectal cancer.

The calculator is free if recent bloodwork includes every marker it needs. Many routine panels leave out at least one required value, commonly C-reactive protein. The $75 test includes the lab order, all nine markers, and Quest testing fees, so you can generate your Phenotypic Age without chasing down missing labs.

Cologuard is generally recommended every three years if your results are negative and you remain at average risk for colorectal cancer. Your provider may recommend you take Cologuard more often based on your unique medical background.

Cologuard can detect 92% of colorectal cancer and 42% of precancerous polyps. Cologuard also has a 13% false-positive rate, with an 8% false-negative rate.

Cologuard has been shown to be effective in detecting certain DNA and blood markers associated with colorectal cancer, but Cologuard does not provide a positive or negative diagnosis of cancer. Like all tests, it is not 100% accurate and may not detect all cancers. For this reason, it’s best utilized as an alternative screening tool for those at average risk of colorectal cancer. You should consult your primary care physician about your Cologuard results to determine next steps.

No, Cologuard is not recommended for individuals experiencing symptoms of colorectal cancer. In such cases, a diagnostic colonoscopy is advised.

Many insurance plans, including Medicare, cover the Cologuard test, but usually only ordered through a member’s primary care provider. AgelessRx does not facilitate the billing of insurance. All people ordering Cologuard through AgelessRx are expected to pay for the test out-of-pocket and AgelessRx does not help coordinate payment with insurance companies.

Cologuard is typically recommended for those with an average risk of colorectal cancer. Those who have a personal or family history of colorectal cancer are often considered to be at high risk and should consult with their healthcare provider for appropriate screening recommendations.

There is no direct risk involved in taking the Cologuard test, as it is a non-invasive stool-based DNA test.

Our Core Longevity Panel is a first-of-its-kind blood test that helps assess your risk for heart disease, diabetes/insulin resistance, and inflammation. This test measures 10 key biomarkers critical to your health and longevity.

When your sample is processed and reviewed by our world-class medical team, an easy-to-read copy of your digital lab report will be made available to you on your AgelessRx portal. You should always discuss results with your doctor, especially for any abnormal values.

Tests are currently only for adults aged 18 and older.

A comprehensive list of scientific journal references that reinforce our testing methodology are included below.

Cardiovascular health:

Courtney Nagel Sandler, MDMarie E. McDonnell, MD 2016 May, The role of hemoglobin A1c in the assessment of diabetes and cardiovascular risk Cleveland Clinic Journal of Medicine ; 83 Suppl 1(5):S4-S10

Ivana R Sequeira, Sally D Poppitt1 2017, HbA1c as a marker of prediabetes: A reliable screening tool or not, Review Article – Insights in Nutrition and Metabolism () Volume 1, Issue 1

Ho-Pham LT, Nguyen UDT, Tran TX, Nguyen TV. August 17, 2017, Discordance in the diagnosis of diabetes: comparison between HbA1c and fasting plasma PLOS ONE. doi:10.1371/journal.pone.0182192

Simmons RK, Rahman M, Jakes RW, et al. 2011, Effect of population screening for type 2 diabetes on mortality: long-term follow-up of the Ely cohort. Diabetologia.; 54(2): 312–319.

Couderc R1, Antar M1, Bonnefont-Rousselot D2, Paul JL3, Therond P4. Couderc R, et al. Ann Biol Clin (Paris). 2017. Blood lipid tests in 2017. Review article

Screening for Dyslipidemia in Younger Adults: A Systematic Review for the U.S. Preventive Services Task Force. Chou R, Dana T, Blazina I, Daeges M, Bougatsos C, Jeanne TL Ann Intern Med. 2016;165(8):560.

Clinical utility of different lipid measures for prediction of coronary heart disease in men and women. Ingelsson E, Schaefer EJ, Contois JH, McNamara JR, Sullivan L, Keyes MJ, Pencina MJ, Schoonmaker C, Wilson PW, D’Agostino RB, Vasan RS. JAMA. 2007;298(7):776.

Lipid parameters for measuring risk of cardiovascular disease. Arsenault BJ, Boekholdt SM, Kastelein JJ; Nat Rev Cardiol. 2011 Apr;8(4):197-206. Epub 2011 Feb 01.

Clinical Utility of a Fingerstick Technology to Identify Individuals With Abnormal Blood Lipids and High-Sensitivity C-Reactive Protein Levels Parin Parikh, MD, Heidi Mochari, MPH, RD, and Lori Mosca, MD, MPH, PhD; Am J Health Promot. 2009 Mar–Apr; 23(4): 279–282. doi: 10.4278/ajhp.071221140

Diabetic health:

Courtney Nagel Sandler, MDMarie E. McDonnell, MD 2016 May, The role of hemoglobin A1c in the assessment of diabetes and cardiovascular risk Cleveland Clinic Journal of Medicine ; 83 Suppl 1(5):S4-S10

Ivana R Sequeira, Sally D Poppitt1 2017, HbA1c as a marker of prediabetes: A reliable screening tool or not, Review Article – Insights in Nutrition and Metabolism () Volume 1, Issue 1

Ho-Pham LT, Nguyen UDT, Tran TX, Nguyen TV. August 17, 2017, Discordance in the diagnosis of diabetes: comparison between HbA1c and fasting plasma PLOS ONE. doi:10.1371/journal.pone.0182192

Simmons RK, Rahman M, Jakes RW, et al. 2011, Effect of population screening for type 2 diabetes on mortality: long-term follow-up of the Ely cohort. Diabetologia.; 54(2): 312–319.

Couderc R1, Antar M1, Bonnefont-Rousselot D2, Paul JL3, Therond P4. Couderc R, et al. Ann Biol Clin (Paris). 2017. Blood lipid tests in 2017. Review article

Screening for Dyslipidemia in Younger Adults: A Systematic Review for the U.S. Preventive Services Task Force. Chou R, Dana T, Blazina I, Daeges M, Bougatsos C, Jeanne TL Ann Intern Med. 2016;165(8):560.

Clinical utility of different lipid measures for prediction of coronary heart disease in men and women. Ingelsson E, Schaefer EJ, Contois JH, McNamara JR, Sullivan L, Keyes MJ, Pencina MJ, Schoonmaker C, Wilson PW, D’Agostino RB, Vasan RS. JAMA. 2007;298(7):776.

Lipid parameters for measuring risk of cardiovascular disease. Arsenault BJ, Boekholdt SM, Kastelein JJ; Nat Rev Cardiol. 2011 Apr;8(4):197-206. Epub 2011 Feb 01.

Clinical Utility of a Fingerstick Technology to Identify Individuals With Abnormal Blood Lipids

Inflammation:

High-Sensitivity C-Reactive Protein Levels Parin Parikh, MD, Heidi Mochari, MPH, RD, and Lori Mosca, MD, MPH, PhD; Am J Health Promot. 2009 Mar–Apr; 23(4): 279–282. doi: 10.4278/ajhp.071221140

LP(a) is one of the most significant biomarkers of heart disease. Short for lipoprotein(a), LP(a) is a type of LDL particle that has an apo(a) protein on top of it. LDL is sometimes referred to as bad cholesterol, and our bodies try to clean as much LDL from our bodies as possible. Apo(a) acts like a mask, disguising LDL particles so they can’t be recognized by our cells, making them much harder to clear from our bloodstream. This means LP(a) particles are much more likely to stick around in the blood, get into blood vessel walls, and cause plaque formation, leading to conditions like atherosclerosis.

The Core Longevity Panel measures 10 key biomarkers most likely to impact your longevity: five heart markers, four diabetes markers, and one inflammation marker.

The five heart markers are ApoB, LDL, HDL, total cholesterol, and triglycerides.

The four diabetes markers are glucose, HbA1c, insulin, and HOMA-IR.

The inflammation marker is hs-CRP.

With the Core Longevity Panel + LP(a) bundle, you can also measure your LP(a), a critical heart biomarker.

A standard physical usually covers the basics. This panel goes further into markers like ApoB and HOMA-IR, which can flag heart and metabolic risk earlier than they typically show up on a routine screening and connect them into a single picture of where your risk is actually concentrated, not a list of isolated flags.^{3 4} It’s meant to work alongside your primary care relationship, filling in some of the gaps a standard checkup tends to miss.

The Multi-Cancer Early Detection Test detects more than 50 types of cancer, many of which are not commonly screened for today, through a simple blood draw. The test does not diagnose cancer and not all cancers may be detected in the blood.

The test looks for signals present in the blood that may be associated with cancer at the time of your blood draw. If a cancer signal is detected, results can point to where in the body the cancer is coming from to help your healthcare provider guide next steps.

Once your results are in, you’ll get an easy-to-read report in your portal breaking down what each marker means, alongside the full lab PDF for your records. From there, one of our in-house experts can help translate those numbers into an actual plan—connecting specific patterns to specific interventions, whether that means adjusting lifestyle factors, exploring a treatment like a targeted Microdosing GLP-1, NAD+, Glutathione, or LDN, or simply tracking a marker over time to see how it moves.

Both options measure 40+ biomarkers. The $115 panel also includes Lp(a), a largely inherited marker associated with cardiovascular risk that may not be included in routine bloodwork.

The test is recommended for use in adults with an elevated risk for cancer, such as those aged 50 or older.

The test is intended to be used in addition to, and not replace, other cancer screening tests your healthcare provider recommends.

Family history is only one of many risk factors associated with cancer development. These risk factors include eating habits, lifestyle, living or working environments, genetics, and many others. Talk to your healthcare provider to determine whether the test is right for you.

In a large-scale, clinical validation sub-study of CCGA, the test detected more than 50 cancer types across all stages.

The test is only available in the U.S. at this time. It is only available by prescription.

Annual screening provides the opportunity to detect more cancers early. It is up to your healthcare provider to determine the appropriate screening interval based on your underlying risk factors. You should discuss a recommended interval with your primary healthcare provider.

The test is not intended to replace guideline-recommended cancer screening tests. One of the most pressing unmet needs in early cancer detection is to identify cancers for which there are no existing recommended screening tests. This test is designed to detect many cancer types, including those that lack routine screenings. The United States Preventive Services Task Force (USPSTF) currently recommends screening paradigms for lung (for high-risk smokers), breast, cervical, prostate, and colorectal cancers.

Furthermore, the test detects more than 50 cancers, and not all cancers may be detected in the blood. Recommended routine cancer screening tests such as colonoscopy or mammograms are commonly used and have been shown to reduce cancer deaths. This test is intended to be used in addition to and not replace these tests and can help maximize the benefits of early cancer detection. Missing recommended screening or ignoring symptoms could lead to a delayed diagnosis of cancer. Ask your healthcare provider about what cancer screening tests are right for you.

Accuracy varies by cancer type and stage. In GRAIL’s PATHFINDER 2 study, Galleri detected a signal in about 74% of the twelve cancers responsible for most cancer deaths, and around 40% across all cancer types studied together. Specificity was high, over 99%, meaning a signal detected result is rarely a false alarm.¹

And when Galleri does detect something, related research found the majority of those cancers were caught at an early, more treatable stage, with another study showing meaningful reduction in late-stage (Stage 4) diagnoses.² Still, no test like this catches everything, which is exactly why it’s designed to work alongside your other screenings rather than in place of them.

Other genetic tests, such as 23andMe, simply look at the genetic sequencing of an individual, which you have no control over. With an epigenetic test, such as TruMe™, you can address the modifiable parts of your DNA (gene expression) with lifestyle changes to better take control of things like disease risk and rate of aging.

As an example, think about a light bulb and its components. Looking at the way the light bulb is constructed is like looking at DNA sequences (genetics). However, looking at epigenetic modifications is like looking at if the light bulb is on or off.

After your online evaluation, if you’re approved, you’ll get a blood draw kit and schedule your draw at a nearby lab. Your sample goes to GRAIL’s lab for analysis, and results typically land in your AgelessRx portal, along with an email notification, about two weeks after your sample arrives.

Genetics tells you what genes you have. More importantly, epigenetics tells you what genes are active. Epigenetics is the study of how the body adds and removes chemical “tags” to our DNA, to turn specific genes on or off. These tags record events that happen in your life: diseases, lifestyle, diet, environmental conditions.

Epigenetic changes happen way before symptoms of disease appear, and that makes epigenetics the most effective way to predict diseases. As a result, your epigenetic profile is often more important than just your genome because it reflects your ACTUAL state of health and predicts your health’s near or mid-term future.

The technology TruMe™ uses measures your DNA methylation at only a tiny fraction of the billions of nucleotides (the components that make up your DNA) and is subject to statistical error. Based on TruMe™ studies, they have approximately a 4.75 years’ error rate. If you see what you think is an error, please feel free to contact TruMe™ directly. Also, keep in mind that these are initial results. As people continue to join we will continue to update and improve your testing accuracy.

<span style=”font-weight: 400;”>No, Galleri has not been cleared or approved by the FDA. It’s offered as a laboratory-developed test, which operates under a different regulatory framework (CLIA) than an FDA-approved drug or device. GRAIL has submitted PATHFINDER 2 data to the FDA as part of a formal approval application </span><span style=”font-weight: 400;”>expected to complete in 2026</span><span style=”font-weight: 400;”>, so the regulatory picture is actively evolving, but as of now, no FDA clearance exists.¹</span>

We recommend taking the test every six months because your DNA methylation measurably changes within that time. Plus, by taking the test more than once, you’ll be able to notice if the treatments (e.g. Metformin) and lifestyle changes (e.g. diet or exercise) you have applied to your health have been effective in reducing your biological age.

A “signal detected” result isn’t a cancer diagnosis, it means the test found a pattern worth investigating further. Galleri’s ability to predict where a signal likely originated helps that follow-up start in a more targeted place rather than from scratch.

No. The TruMe™ test is a research study. The protocols TruMe™ uses are suitable for genetic research only, not for clinical genetic testing like you would receive at a hospital or doctor’s office. Clinical genetic testing is held to higher standards and is done in laboratories, which are certified by governmental regulations called CLIA (Clinical Laboratory Improvement Amendments). If you use the TruMe™ data for diagnostic purposes, you should always contact the doctor and have the results confirmed by tests recommended by a medical professional.

Once you receive your kit in the mail, register the code on your saliva sample with the link sent by your provider or included in your kit.

A Longevity Consultation is an opportunity to speak one-on-one with a longevity expert regarding possible treatment options. You will first provide information about your medical history for the expert to review and customize a Longevity Report specific to your needs. Together, you will discuss the report recommendations via a virtual consultation at a date/time of your choosing.

Your personalized Longevity Report contains Age-Related Recommendations & Therapies, Lifestyle Ratings & Recommendations, Suggested Longevity Interventions (Rx & Supplements), Suggestions for Additional Testing, an AgelessRx Member Checklist, and Tips for Next Steps/Getting Started. Your report also contains Lab Results and an Aging Score (Advanced Consultation Only).

Everything happens virtually so you can complete your entire consultation from wherever you are, on your schedule. You’ll receive a detailed longevity report with all your findings.

Not at all. Plenty of people book a consultation simply to understand how their current habits are shaping their long-term health, or to get ahead of issues before they show up. Your expert looks at your full picture, energy, sleep, stress, diet, and more, so the conversation is just as useful for fine-tuning an already healthy routine as it is for addressing something specific.

Dehydroepiandrosterone (DHEA) is a steroid hormone produced by the adrenal glands, the same glands responsible for cortisol and adrenaline production. Here, DHEA serves a dual function as a precursor to Testosterone and Estrogen, acting as the building block to selectively build these hormones as needed; and a signaling molecule that balances metabolism, mood, immunity, and brain function. 

DHEA levels gradually decline with age, then drop significantly with perimenopause and post-menopause. Low DHEA levels can lead to fatigue, mood changes, low libido, vaginal atrophy, and metabolic decline. 

When used as part of bioidentical hormone replacement therapy (BHRT), DHEA is bioidentical to endogenous human DHEA and may help support declining levels associated with perimenopause, menopause, and aging. As a precursor hormone, it can be converted into androgens and estrogens, potentially contributing to improvement in related symptoms.

The most common side effects of DHEA, when used as part of bioidentical hormone replacement therapy (BHRT), include acne, hirsutism (facial or body hair growth), and thinning hair or hair loss. Spironolactone, an anti-androgen medication, may help block these effects; your provider may recommend Spironolactone as part of your treatment plan if you experience any of these symptoms. Always talk to your provider if your side effects become bothersome.

No, we only prescribe bioidentical DHEA, or DHEA that is chemically identical to the body’s own levels, as part of bioidentical hormone replacement therapy (BHRT). Both Oral DHEA and DHEA Cream contain bioidentical DHEA.

We offer Oral DHEA tablets, topical DHEA Cream, and DHEA Vaginal Suppositories. Your provider will advise on the best option based on your unique health history, medical needs, and symptoms.

Oral DHEA, DHEA Cream, and DHEA Suppositories all contain bioidentical DHEA. The only difference is how you take the medication: Oral DHEA tablets should be swallowed by mouth with a glass of water, while DHEA Cream should be rubbed evenly where your provider directs. Never apply DHEA Cream to breast tissue. DHEA Suppositories are inserted vaginally and are designed to support vaginal health and comfort. Always check your AgelessRx portal for your personalized dosing instructions.

Estradiol is one of three major types of estrogen produced naturally within the body. 

Estradiol levels gradually decline with age and significantly drop with perimenopause and menopause. This may lead to symptoms like hot flashes and vaginal dryness; signs of aging skin like thinning skin, reduced skin elasticity, and decreased collagen levels; and hallmarks of aging like inflammation, bone loss, and cognitive decline.

When used as part of bioidentical hormone replacement therapy (BHRT), Estradiol is designed to be bioidentical to human Estradiol, replacing depleted levels that may alleviate the symptoms of perimenopause, menopause, and aging.

As an estrogen hormone, Estradiol binds to estrogen receptors throughout the body, regulating diverse systemic functions, such as temperature control, blood flow, skin elasticity, sleep, and mood. Estradiol medications work by introducing bioidentical Estradiol to replace natural levels, which decline with perimenopause and menopause. This may help protect against osteoporosis and cognitive decline and relieve many symptoms of perimenopause and menopause, such as hot flashes, vaginal dryness, aging skin, and hallmarks of aging like inflammation, bone loss, and cognitive decline.

We offer Oral Estradiol tablets, transdermal Estradiol Cream, and Estradiol Patches. Your provider will advise on the best option based on your unique health history, medical needs, and symptoms.

Oral Estradiol, Estradiol Cream, and Estradiol Patch all contain bioidentical Estradiol. The only difference is how you take the medication: Oral Estradiol tablets should be swallowed by mouth with a glass of water, while Estradiol Cream should be rubbed evenly where your provider directs, typically the inner arm or thigh. Never apply Estradiol Cream to breast tissue. Estradiol Patch is applied to clean, dry skin on the lower abdomen or buttocks, never on breast tissue, and application sites rotated with each new patch. Always check your AgelessRx portal for your personalized dosing instructions.

Many women notice improvements within a few weeks, while some benefits may take several months to notice. However, results may vary from person to person. For the best results, take Estradiol consistently for as long as you need to manage perimenopause or menopause symptoms.

The most common side effects of Estradiol therapy include breast tenderness, fluid retention or bloating, and vaginal bleeding or spotting. If you experience nausea, try taking your dose with food. Limiting the salt content in your diet may also help reduce bloating.

Talk to your provider if your side effects become bothersome. If you experience vaginal bleeding, reach out to your provider immediately.

Progesterone is a key hormone for women’s health, alongside Estrogen and Testosterone, helping regulate the menstrual cycle, body temperature, sleep, uterine health, bone health, cardiovascular health, cognitive function, and mood. Progesterone also helps balance the effects of Estrogen: where Estrogen controls the first half of the menstrual cycle, Progesterone controls the second half, or the luteal phase. 

Both Estrogen and Progesterone levels slowly decline with age, and significantly drop with perimenopause and post-menopause. Taking Estrogen alone to treat these symptoms can increase the risk of uterine cancer, but combining bioidentical Progesterone balances these hormones and reduces the risk.

Progesterone works by binding to various receptors throughout the body, including those responsible for menstruation, sleep, and mood. When Progesterone levels start declining from age, perimenopause, and post-menopause, it can no longer influence these receptors as efficiently, leading to menstruation irregularities, mood changes, sleep disturbances, headaches, and weight gain. 

When used as part of bioidentical hormone replacement therapy (BHRT), Progesterone is designed to be chemically equivalent to natural Progesterone, replenishing depleted levels and restoring menstrual, sleep, body temperature, and mood cycles while protecting uterine health, cardiovascular health, bone health, and cognitive function.

The most common side effects of Progesterone therapy include drowsiness, dizziness, breast tenderness, headache, mood changes, bloating or fluid retention, and irregular periods or cessation of periods. 

The risk and severity of many of these side effects can be reduced by taking Progesterone at least 2 hours after your last meal at bedtime. Reducing salt in your diet may also help reduce bloating.

Drowsiness and dizziness may affect daytime activities and become dangerous if operating vehicles or machinery. To reduce the risk of daytime drowsiness, always take Progesterone before bedtime.

Nausea and fatigue are less common side effects of Progesterone that often go away on their own as your body adjusts to the medication. 

Talk to your provider if your side effects become bothersome. If you experience vaginal bleeding, reach out to your provider immediately for guidance.

No, we only prescribe bioidentical Micronized Progesterone as part of bioidentical hormone replacement therapy (BHRT). Our compounded Micronized Progesterone is designed to be chemically equivalent to natural Progesterone and better absorbed than other commercially available alternatives.

Yes, but take caution and pay close attention to your moods while taking Progesterone, especially in the initial weeks after starting the treatment. If you notice that your depression or anxiety worsens during this time, stop taking Progesterone and talk to your provider immediately.

Only synthetic Progesterone has been associated with a higher risk of cancer. Bioidentical Progesterone, which is designed to be chemically equivalent to natural human Progesterone, has been associated with a lower breast cancer risk when used in combination with Estrogen, as compared to synthetic Progesterone.

Hormone therapy has been widely studied and is commonly prescribed to support symptoms associated with menopause.⁷ One of our trusted clinicians will review your health history to determine whether hormone therapy is appropriate for you.

After completing your medical intake, you’ll select and schedule a time to meet 1:1 with a licensed provider who will review your symptoms and health history. Your provider will go over your treatment options during your consultation. After your consultation, you’ll receive a secure message with your personalized plan from your provider, where you’ll select and confirm your preferred treatments. After confirming and paying for your preferred treatment(s), your treatments will ship directly to your door.