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PT-141

Working in the brain’s desire pathways, PT-141 may support sexual desire and arousal, upstream of the blood‑flow treatments most people know.

PT-141:
How does it work?

Desire starts in the brain. PT-141 is a melanocortin agonist that acts on the signaling behind desire and arousal, rather than blood flow.1

That brain-first action is why it’s studied in both men and women, and why researchers connect healthy sexual function to whole-body health.3 5

What PT-141 may support

Because desire starts in the brain before the body responds, PT-141 is studied for low desire and arousal rather than simply improving blood flow.
May support sexual desire and arousal in women.1
May act on brain signaling, upstream of blood flow, for both men and women.3
Most trial evidence is in women with Hypoactive Sexual Desire Disorder, but melanocortin signaling also plays a role in male sexual function.3
Available as clinician-guided PT-141 Injection and Nasal Spray.

How PT-141 works

Think of desire like a signal that has to be strong enough for the body to respond.

PT-141 may help turn up that signal in the brain, making arousal pathways more responsive before any physical response happens.4

Explore PT-141

In a Phase 3 trial, 58% of women taking bremelanotide reported improved sexual desire.2

58%

PT-141 benefits

What PT-141 may support for sexual health and healthy aging, with the evidence behind each.

Sexual desire

May support desire and arousal in women with low desire. Human trials.1

Central mechanism

Acts on brain signaling, upstream of blood flow. Human trials.3

Men & women

Melanocortin pathways also studied in male sexual function. Human trials.3

Sustained use

In a long-term study, benefits held with good tolerability. Human trials.2

Whole-health signal

Sexual function tracks with broader health in older adults. Observational studies.5

Beyond sex

Melanocortin signaling also helps regulate immune balance. Preclinical and Clinical studies.6

What we still don’t know

We believe in full transparency. Here’s what PT-141 research doesn’t yet answer.

Trial focus

Most controlled trials are in premenopausal women with HSDD.

Individual response

How much it helps varies; a clinician decides if it fits you.

We take sexual health seriously

PT-141 is one of the more clinically studied peptides in sexual health, and our in-house team brings together longevity-focused clinicians and a Stanford PhD-led Research Team to translate that evidence into personalized care.
199+ years of combined clinical experience behind your care.
Our Research Team tracks the peptide and sexual-health evidence.
Read our Research
Science-backed

Choose the experts

Get a flexible plan with clinician-guided dosing, regular check-ins, unlimited provider messaging, and adjustments along the way.
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PT-141 Injection

New
PT-141 Injection Vial

When attraction is still there but desire isn’t, support the brain pathways behind arousal and responsiveness—helping intimacy feel more natural again.

Starting at $149/ mo
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Frequently asked questions

01 Is PT-141 FDA-approved?

Bremelanotide, the compound in PT-141, is FDA-approved as Vyleesi to treat hypoactive sexual desire disorder in premenopausal women. AgelessRx’s compounded PT-141, including its use in men and other forms, is prescribed off‑label.

02 How is PT-141 different from ED medications?

Most erectile‑dysfunction medications work on blood flow. PT-141 works earlier, on the brain’s melanocortin signaling that starts desire and arousal, which is why it’s studied in both men and women.

03 Who might consider PT-141?

People noticing lower sexual desire or arousal, including changes that come with age, stress, or hormones. A provider reviews your health history to decide whether it’s appropriate for you.

04 How will I know if it's working?

Most people track changes in desire, arousal, and satisfaction over time. Response varies from person to person, and a provider adjusts the plan with you.

05 Injection or nasal spray, which is right for me?

Both deliver PT-141. The nasal spray is needle‑free and taken as needed, and the injection is another as-needed option. A clinician helps you choose based on your goals and preferences.

06 Who is PT-141 not for?

It isn’t right for everyone, and it can affect blood pressure, so a provider reviews your health history and current medications before prescribing.

Our idea of a bedtime story?
PubMed.

We vet everything on PubMed so you don’t have to. Here’s what the science says.
1
This clinical review describes PT-141 (bremelanotide) as a melanocortin agonist that improved sexual desire and arousal in women with hypoactive sexual desire disorder across trials.
Neurol Int, 2022
2
This long-term study found bremelanotide was well tolerated and continued to support sexual desire while reducing distress in premenopausal women with HSDD.
Obstet Gynecol, 2019
3
This review of melanocortin receptors and erection describes PT-141 as a centrally acting option that works upstream of blood‑flow-based treatments.
Curr Top Med Chem, 2009
4
This review of the neuroanatomy of human sexual behavior describes how brain chemistry, especially dopamine and serotonin, regulates desire and arousal.
Brain Behav, 2019
5
This study of older adults found that declines in sexual activity and function predicted later health problems, tying sexual health to overall health.
Arch Sex Behav, 2019
6
This review describes melanocortin signaling, the pathway PT-141 acts on, as a broader regulator of immune balance with anti-inflammatory effects.
Front Endocrinol, 2019