What is PT-141?
- Sexual desire is regulated by brain signaling and reflects overall health and vitality 2 3
- Often attributed to stress or relationships, changes in libido stem from underlying neurochemical shifts4
- Changes in signaling may occur with age, stress, or hormonal shifts for men and women5
- As signaling shifts, it can result in reduced desire, arousal, and sexual satisfaction6
- PT-141 is a melanocortin receptor agonist that supports arousal signaling in the brain1
- Unlike blood flow therapies, PT-141 targets central mechanisms of sexual function7
- May be beneficial for those experiencing low libido, including during menopause1
- Compounded by US-licensed pharmacies
PT-141 BENEFITS
Sexual Health and Vitality Support
- Sexual health is closely tied to cardiovascular, immune, mental health, and long-term health8 9
- Sexual desire reflects the state of key systems, including the brain and hormone balance6
- Changes in libido can signal shifts in mood, motivation, and overall physiological health3
- PT-141 may target brain pathways involved in desire, motivation, and pleasure1
- Works at the level of central brain signaling, not just physical response or blood flow7
- Complements hormone therapy and lifestyle habits to support long-term health
- Simple, discreet, on-demand use that fits into your routine
PT-141 has been approved by the FDA for Hypoactive Sexual Desire Disorder (HSDD) for premenopausal women, but has not been approved by the FDA for use as sexual enhancement in men or post-menopausal women.
The Science of PT-141
Clinically studied and centrally acting: Central neuropeptide signaling declines with age, adversely affecting libido, desire, and overall brain health.10 11 PT-141 crosses the blood-brain barrier, binding to melanocortin-4 receptors, enhancing dopamine release and amplifying sexual motivation, arousal, and pleasure.1
Supports central signaling and vitality: PT-141 directly targets the brain’s control center for desire and arousal, making it broadly effective across sexes1 7. Emerging research suggests it may support brain signaling pathways that reduce stress, inflammation, and broader markers of health, connecting sexual function with longevity.8 12
Why AgelessRx?
Personalized care guided by US-licensed clinicians
Backed by our Stanford PhD-led Research Team
Treatments are clinically vetted and clinician-reviewed
100% online, ongoing check-ins, and free shipping
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I’d give 6 stars if possible!! I was skeptical. But no longer. The products are of highest quality and customer service is fast, convenient and thorough. Highly recommend!
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No hidden fees, no monthly fees. I only pay for the medication itself. I can’t stop raving about AgelessRx because every other company I looked into was the complete opposite.
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- 100% online medical assessment
- Free shipping and ongoing support
- Unlimited dosing adjustments and provider messaging
- On-demand use, taken as directed prior to sexual activity
- Compounded at US-licensed pharmacy
- Pause or cancel anytime
Code PT141INJ50: $149 for first month and FREE medical evaluation ($199/month after)
PT-141 Injections are not available in AL, AR, MN, & NC.
You will be automatically billed & sent refills based on your plan
You can pause or cancel at any time before your next shipment
The FDA has not approved or reviewed PT-141 for safety, efficacy, quality, or for any use, including the AgelessRx compounded product.
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See below for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
FAQs
What is PT-141?
PT-141 (Bremelanotide) is a melanocortin receptor agonist peptide that works through the central nervous system to support sexual desire and arousal.1 It acts on pathways in the brain involved in sexual response rather than directly affecting blood flow.7
How does PT-141 work?
PT-141 activates melanocortin receptors in the brain associated with sexual motivation and arousal signaling. This may help enhance sexual interest, responsiveness, and satisfaction in some individuals.1
What benefits can I expect from PT-141?
Individual results vary, and benefits are not guaranteed. Some users may experience increased sexual desire and libido, improved arousal response, enhanced sexual satisfaction, and improved overall mood and motivation.1 2 7
See all FAQsImportant safety information and common side effects
Side effects
The most common side effects of PT-141 include:
- Nausea
- Facial flushing
- Headache
- Fatigue
- Temporary increase in blood pressure
- Mild irritation or sensitivity
These side effects are typically mild and often go away on their own within a week or two.
For a full list of side effects, please review Mayo Clinic’s Bremelanotide resources.
Potential drug interactions
PT-141 may have the following interactions with certain drugs:
- Naltrexone for alcohol or opioid use disorder
May decrease naltrexone levels and efficacy. - PDE-5 Inhibitors (sildenafil, tadalafil)
May increase the risk of priapism or prolonged erection, a medical emergency. - Potassium Citrate and Potassium Chloride
May increase risk of ulcerative colitis or stenotic lesions. - Antibiotics and Anti-Tuberculosis Agents
May decrease peak antibiotic levels.
Please read the full list of possible drug interactions with PT-141 (Bremelanotide).
Other important safety information
PT-141 is intended for adults only. Your prescriber may ask you for additional information if you have cardiovascular risk factors or severe liver or kidney disease.
Do not use PT-141 if you have uncontrolled high blood pressure or if you have significant heart dysfunction (ejection fraction <50% or NYHA Class 3 or greater).
Do not use PT-141 if you have an active cancer, or if you have had cancer within the last two years.
Do not use PT-141 if you are pregnant, breastfeeding, or planning to become pregnant or breastfeed. If you become pregnant during treatment, discontinue immediately and consult your OB.
Though rare, allergic reactions to PT-141 are still possible. If you notice any shortness of breath or swelling around your face, tongue, or throat after using PT-141, stop use and contact emergency services right away.
As with any prescription medication, the dose prescribed is for you and you alone. Do not, under any circumstances, allow anyone else to use your PT-141.
Show me the science.
All our claims are backed by science, and we’ve got the receipts.
| 1. A clinical review highlighting PT-141 as a melanocortin receptor agonist that improves sexual desire, arousal, and pleasure in women with hypoactive sexual desire disorder. | Neurol Int., 2022 |
| 2. A review highlighting PT-141 effects on female sexual desire by modulating central neurotransmitter pathways, particularly through increased dopamine release in the brain. | Camb Core, 2021 |
| 3. A large study demonstrating that declines in sexual desire, activity, and function in adults over 50 are associated with increased risk of adverse health outcomes, including chronic illness, cardiovascular disease, and cancer. | Arch Sex Behav., 2019 |
| 4. A review highlighting the role of PT-141 in regulating sexual behavior through actions in key brain regions. | Prog Neuro, 2013 |
| 5. A review outlining how neurotransmitters and hormones such as dopamine, serotonin, oxytocin, and cortisol interact to influence desire, arousal, orgasm, and overall sexual well-being, particularly under conditions of stress. | Journ Psy Health, 2026 |
| 6. A clinical review highlighting hypoactive sexual desire disorder (HSDD) as a common condition in women, driven by neuroendocrine imbalances and the effectiveness of PT-141 as a therapeutic. | J Midwifery Womens Health, 2022 |
| 7. A clinical evaluation highlighting the role of PT-141 in men, suggesting improvements in sexual function, satisfaction, and arousal through its effects on increased dopamine and blood flow. | Journ of Uro, 2024 |
| 8. A large study demonstrating that higher frequency of sexual activity is associated with reduced risk of all-cause and cancer mortality in middle-aged adults, suggesting sexual activity as an indicator of overall health. | The Journ of Sex Med, 2020 |
| 9. A study demonstrating that higher frequency of sexual activity is associated with reduced inflammatory markers and improved quality of life, particularly in older adults. | The Journ of Sex Med, 2017 |
| 10. A review highlighting that sexual behavior is regulated by complex interactions between neurotransmitter systems, particularly dopamine and serotonin, and emphasizing its critical role in overall health and quality of life. | Brain Behav. 2019 |
| 11. A study demonstrating that age-related declines in dopamine signaling are associated with reduced cognitive performance, suggesting that enhancing dopamine function may support brain health. | Amer Journ Sci, 1998 |
| 12. A review highlighting melanocortin signaling as a key regulator of immune function with demonstrated anti-inflammatory and immunomodulatory effects. | Front. Endocrinol, 2019 |
