Before
Spray as directed 30 minutes before intimacy. No needle, no pill—just a few seconds to start the process.2
New
Peptides
Sexual Health
PT-141 Nasal Spray Rx
When attraction is still there but desire isn’t, support the brain pathways behind arousal and responsiveness with a fast-acting, needle-free option for men and women.
Starting at
$149
/ mo
- $50 off first month
- $199/mo ongoing
- Compounded by licensed U.S. pharmacies
- Pause or cancel anytime
Supports the brain pathways involved in desire¹
Needle-free nasal spray that works in as little as 30 minutes²
On-demand support for intimacy
HSA / FSA
Ongoing, expert support
Free, discreet shipping
100% online
Frequently asked questions
What is PT-141 Nasal Spray?
PT-141 (Bremelanotide) is a melanocortin receptor agonist peptide that works through the central nervous system to support sexual desire, arousal, and satisfaction.1 2 PT-141 Nasal Spray provides brain-targeted, rapid-acting support for signaling pathways involved in initiating desire, arousal, and sexual response rather than affecting blood flow alone.1 2 4
How does PT-141 Nasal Spray work?
PT-141 Nasal Spray may activate melanocortin receptors in the brain associated with sexual motivation and arousal signaling.2 This may help enhance sexual interest, responsiveness, and satisfaction in both men and women.1 2
What benefits can I expect from PT-141 Nasal Spray?
Individual results vary, and benefits are not guaranteed. Some users may experience increased sexual desire and libido, improved arousal response, enhanced sexual satisfaction, and improved overall mood and motivation.1 2 3 Because nasal absorption is somewhat less predictable than injection, your provider may need to adjust your dose to find what works consistently for you.
Usage instructions
View all FAQs
Use PT-141 Nasal Spray on demand as directed prior to sexual activity. If prescribed, a U.S.-licensed medical provider will provide personalized dosage and treatment instructions.
Important safety information and common side effects
The most common side effects of PT-141 Nasal Spray include nausea, facial flushing, headache, fatigue, temporary increase in blood pressure, and/or mild irritation or sensitivity. These side effects are typically mild and often go away on their own within a week or two.
For a full list of side effects, please review Mayo Clinic’s Bremelanotide resources.
PT-141 Nasal Spray may have the following interactions with certain drugs:
- Naltrexone for alcohol or opioid use disorder
May decrease naltrexone levels and efficacy. - PDE-5 Inhibitors (Sildenafil, Tadalafil)
May increase the risk of priapism or prolonged erection, a medical emergency. - Potassium Citrate and Potassium Chloride
May increase risk of ulcerative colitis or stenotic lesions. - Antibiotics and Anti-Tuberculosis Agents
May decrease peak antibiotic levels.
Please read the full list of possible drug interactions with PT-141 (Bremelanotide).
PT-141 Nasal Spray is intended for adults only. Your prescriber may ask you for additional information if you have cardiovascular risk factors or severe liver or kidney disease.
Do not use PT-141 Nasal Spray if you have uncontrolled high blood pressure or if you have significant heart dysfunction (ejection fraction <50% or NYHA Class 3 or greater)
Do not use PT-141 Nasal Spray if you have an active cancer, or if you have had cancer within the last two years.
Do not use PT-141 Nasal Spray if you are pregnant, breastfeeding, or planning to become pregnant or breastfeed. If you become pregnant during treatment, discontinue immediately and consult your OB.
Though rare, allergic reactions to PT-141 Nasal Spray are still possible. If you notice any shortness of breath or swelling around your face, tongue, or throat after using PT-141 Nasal Spray, stop use and contact emergency services right away.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality.
What is PT-141?
Sexual response has two sides: physical blood flow and the brain signals behind libido, pleasure, and arousal.5 Most treatments in this category only address the first.
PT-141 Nasal Spray is absorbed through the nasal lining for rapid, needle-free delivery, potentially supporting the upstream brain pathways that initiate desire and arousal—not just the physical response that follows.1 2
PT-141 Nasal Spray Timeline
How PT-141 Nasal Spray works
As it absorbs
The medication is absorbed through the nasal lining, entering circulation without digestion or an injection.2
As signaling builds
PT-141 may activate melanocortin receptors in the brain involved in sexual motivation, pleasure, and arousal.1
During intimacy
Instead of only increasing blood flow, PT-141 may help desire, satisfaction, and physical responsiveness feel more connected.1 4
Ongoing
Use on demand when you want desire to feel easier to access, following your provider’s dosing.
Before
Spray as directed 30 minutes before intimacy. No needle, no pill—just a few seconds to start the process.2
As it absorbs
The medication is absorbed through the nasal lining, entering circulation without digestion or an injection.2
As signaling builds
PT-141 may activate melanocortin receptors in the brain involved in sexual motivation, pleasure, and arousal.1
During intimacy
Instead of only increasing blood flow, PT-141 may help desire, satisfaction, and physical responsiveness feel more connected.1 4
Ongoing
Use on demand when you want desire to feel easier to access, following your provider’s dosing.
Desire care you can trust
You deserve more than another generic ED treatment. PT-141 is one of the few peptides backed by rigorous clinical research, with your care supported by our fully in-house team that understands both the science and biology behind better sexual health.1 3
199+ years of combined clinical experience
Stanford PhD-led Research Team behind 11+ in-house trials
Protocols continuously refined based on real-world data
The AgelessRx Peptide Standard
PT-141 Nasal Spray is supported by the AgelessRx standard for peptide quality, clinical oversight, and pharmacy accountability.
99.8% purity confirmed by laboratory testing
Microbial + Endotoxin testing passed
Compounded by licensed U.S. pharmacies prioritizing quality control
Clinically studied
The science of PT-141
While sexual wellness is often thought of as a physical experience, desire is generated by signaling pathways in the brain.5 This signaling declines with age, impacting libido, desire, and overall brain health.6 7
PT-141 works on brain pathways involved in sexual desire and arousal.1 Unlike therapies that primarily focus on blood flow, nasal spray delivers PT-141 directly to the brain to potentially act on melanocortin pathways associated with sexual responsiveness, helping support the brain-body connection involved in intimacy.1 2
Expert-guided
Personalized care that starts with you
We see desire as real, measurable, and treatable. So you can get care that gets you back to where you deserve to be.
$149/first month
Applies to first month ($199/mo after)
What’s included
-
Personalized, clinician-guided plan
-
Flexible monthly plans
-
Dispensed by US-licensed compounding pharmacy
-
Unlimited protocol adjustments and messaging
-
Ongoing support and check-ins
-
Pause or cancel anytime
-
Backed by our in-house Stanford PhD-led team
How it works
Choosing how you age starts here
1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
2
Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy partner, rigorously inspected for quality, and shipped discreetly to your door.
3
100% online
Receive continuous support
Start with one goal, then keep building over time. With our in-house care team, unlimited provider messaging, easy refills, unlimited dosage adjustments, and 40+ science-backed plans, your care evolves with you.
Get Started
Desire, personalized.
PT-141 Injection
New
When attraction is still there but desire isn’t, support the brain pathways behind arousal and responsiveness—helping intimacy feel more natural again.
Starting at $149/ mo
Tadalafil
Support stronger, longer-lasting erections for up to 36 hours with the same active ingredient in Cialis®, so intimacy can fit your life instead of the other way around.
Starting at $45/ mo
Tadalafil for Longevity
One low daily dose for both men and women that may help blood vessels stay relaxed and responsive, supporting circulation to the heart, brain, muscles, and organs for years to come.
Starting at $60/ mo
Frequently asked questions
Not exactly. Vyleesi is the FDA-approved, fixed-dose autoinjector version of bremelanotide for premenopausal women with hypoactive sexual desire disorder.1 PT-141 Nasal Spray is compounded and dosed individually by your care team, offering a needle-free option, but it’s used off-label outside that specific FDA approval.
PT-141 Nasal Spray is administered directly into the nostril, typically 30 to 60 minutes before anticipated activity. Clear nasal passages help with consistent absorption, so using it when you’re not congested tends to offer more predictable results.
Both deliver the same active compound and work through the same brain-based mechanism, the difference is the route in and what comes with it. The nasal spray is needle-free and easy to self-administer, but absorption is somewhat less predictable and typically requires a higher dose to compensate. PT-141 Injection tends to deliver more consistent absorption at a lower dose, with the trade-off being a needle. Your provider can help you decide which fits your preferences better.
Yes. While Vyleesi’s FDA approval is specific to premenopausal women with hypoactive sexual desire disorder, AgelessRx’s compounded PT-141 Nasal Spray is prescribed off-label to both men and women based on an individual evaluation.
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I do care about sources.
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