Week 1
Start low, go slow. Your provider helps guide the adjustment to minimize side effects as Zepbound® begins quieting hunger signals.6
Weight
Zepbound® Access & Monitoring Rx
Lose 20% of your body weight with Zepbound®, a once-weekly FDA-approved injection that helps quiet hunger and food noise through dual GIP + GLP-1 support.
Starting at
$364
/ mo
- Billed $65/mo for membership
- Rx billed via LillyDirect® starting at $299/mo
- Ongoing provider support & monitoring
- Pause or cancel anytime
Best for those looking to lose 20-50 lbs
Outperformed Semaglutide for weight loss in head-to-head trials³
Unlimited provider messaging, dose support, and side-effect guidance
HSA / FSA
Free, discreet shipping
Ongoing, expert support
100% online
Frequently asked questions
What is Zepbound®?
Zepbound® is a once-weekly FDA-approved Tirzepatide injection for adults ready for meaningful weight loss of 20-50 lbs. Zepbound® is designed for chronic weight management in adults with obesity, or overweight adults with a weight-related condition like high blood pressure or type 2 diabetes. It’s also FDA-approved for moderate-to-severe obstructive sleep apnea in adults with obesity.4
Through AgelessRx, Zepbound® comes with a full, in-house team of expert support that helps make treatment easier to start, with provider-guided dosing, ongoing monitoring, and help navigating dose changes and side effects over time.
How does Zepbound® work?
Zepbound® works on two natural hormone pathways, GIP and GLP-1, that help regulate appetite, fullness, and blood sugar. Hitting both tends to produce a more potent combined effect than either pathway alone. That dual-pathway approach helps quiet hunger, slow digestion, and signal fullness to the brain, making it easier to eat less without feeling like weight loss depends on willpower alone.5
Zepbound® is taken once weekly and works best alongside nutrition changes, regular movement, and provider-guided dose adjustments.
What is the Zepbound® dosing schedule?
Zepbound® starts low and builds gradually. Most people begin with 2.5mg once weekly for four weeks. From there, your provider may increase your dose in 2.5mg steps about every four weeks, based on how your body responds, how well you tolerate treatment, and what dose makes sense for your goals. The goal isn’t to rush to the highest dose as soon as possible, but rather to find the dose that helps support the best progress while keeping treatment manageable.
Usage instructions
View all FAQs
Zepbound® is injected once weekly. If prescribed, a US-licensed medical provider will provide a tailored dosage schedule and specific treatment instructions with your care plan.
Important safety information and common side effects
Zepbound® should be used with a reduced-calorie meal plan and increased physical activity. Zepbound® contains Tirzepatide and should not be used with other GLP-1 or GIP receptor agonist medications, or any other products containing Tirzepatide.
Most common side effects
Zepbound® may have the following side effects: nausea, diarrhea, vomiting, constipation, abdominal (stomach) pain, headache, fatigue, dyspepsia (indigestion), dizziness, abdominal distension, eructation (belching), hypoglycemia (low blood sugar) in patients with type 2 diabetes, delayed gastric emptying, flatulence (gas buildup), gastroenteritis (an intestinal infection), and gastroesophageal reflux disease (a type of digestive disorder).
Common side effects normally go away on their own within a few days, or up to 2-3 weeks. If you find that any side effects persist for longer than this or get worse over time, stop taking Zepbound® and contact your prescriber as soon as possible.
Other important safety information
Do not use Zepbound® if you are allergic to Tirzepatide, pregnant or breastfeeding, or planning to become pregnant or breastfeed. Stop taking Zepbound® at least 2 months before trying to conceive.
Zepbound® should not be used by anyone who has a personal or family history of medullary thyroid carcinoma (MTC), multiple endocrine neoplasia syndrome 2 (MEN2), or pancreatitis.
Tirzepatide may make oral contraceptives less effective. If you’re taking an oral contraceptive, ask your prescriber about potential alternatives before starting Tirzepatide, or switch to a non-oral contraceptive.
Note: This product alone is not intended to diagnose, treat, cure, or prevent any disease. Please consult a medical professional to determine whether or not GLP-1 products are appropriate for you.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate.
Zepbound® through AgelessRx + LillyDirect®
How it works
Membership
$65
Every month
- Expert medical review
- Rx access if approved
- Unlimited provider messaging
- Ongoing check-ins
- Pause or cancel anytime
Medication
$299
first month
- Save on first two months
- $399/second mo, $449/mo ongoing
- Monthly shipments
- Fulfilled by LillyDirect®
Total monthly cost is $364/first mo, $464/second mo, then $514/mo ongoing.
*
Medication pricing varies by dose. Most patients start at 2.5mg ($299) and increase over time to 5mg ($399) and 7.5mg ($449); 10mg, 12.5mg, and 15mg ($449) are available by request based on medical needs. Special introductory prices are only available for the first order and refills made within 45 days of your last delivery.
20%
average weight loss in 1 year on Zepbound®1
Select your
current weight
current weight
202
lbs
Weight you
could lose (lbs)
could lose (lbs)
40
lbs
Get started
Average weight loss in 1 year is 20% based on a 72-week clinical trial studying the highest doses of Zepbound® in non-diabetic users with obesity and/or overweight with a weight-related condition, when paired with healthy lifestyle changes.
How Zepbound® works
3 Months
Momentum builds, with many seeing weight loss of almost 10% of body weight by the 3 month mark.1
6 Months
By now, most people have reached and settled into their maintenance dose. This is a natural point to check in with your provider and reassess your plan.
9 Months
Support stays with you as your plan evolves, from dose questions to consistency and maintenance.
1 Year and Beyond
Long-term care shifts from starting weight loss to sustaining progress and protecting what changed, with adults losing up to 20% of body weight.1
Week 1
Start low, go slow. Your provider helps guide the adjustment to minimize side effects as Zepbound® begins quieting hunger signals.6
3 Months
Momentum builds, with many seeing weight loss of almost 10% of body weight by the 3 month mark.1
6 Months
By now, most people have reached and settled into their maintenance dose. This is a natural point to check in with your provider and reassess your plan.
9 Months
Support stays with you as your plan evolves, from dose questions to consistency and maintenance.
1 Year and Beyond
Long-term care shifts from starting weight loss to sustaining progress and protecting what changed, with adults losing up to 20% of body weight.1
What is Zepbound®?
(zehp-bownd)Unlike single-pathway GLP-1s, Zepbound® works on two metabolic pathways, GIP and GLP-1, helping support appetite regulation, fullness, and weight management from more than one angle.5
But the medication is only part of the plan. Our expert in-house care team, with 199+ years of combined clinical expertise, helps you start with clarity, adjust safely, and stay supported as your dose changes, side effects come up, and progress builds, so you get the best results.
But the medication is only part of the plan. Our expert in-house care team, with 199+ years of combined clinical expertise, helps you start with clarity, adjust safely, and stay supported as your dose changes, side effects come up, and progress builds, so you get the best results.
20% average weight loss in clinical studies.1
20%
In a 72-week clinical trial, adults taking Zepbound® lost 20% of their body weight on average, about 40 lbs for those starting at 200 lbs.1
Zepbound® vs. Wegovy®
| Zepbound® | Wegovy® |
|---|---|
| Targets both GIP + GLP-1 pathways for dual appetite and metabolic signaling support3 | Targets GLP-1 pathways that help to regulate appetite, fullness, and reduce food noise7 |
| Best for those seeking the strongest available weight-loss option | An established, extensively studied GLP-1 with strong cardiovascular outcomes7 |
| 20% average weight loss | 15% average weight loss |
| $364/first mo | $264/first mo |
| $514/mo ongoing cost | $414/mo ongoing cost |
The above chart is not meant for medical diagnosis purposes. Your prescriber will approve or disapprove a Wegovy® prescription at their discretion after careful consideration of your unique health profile. Approval is not guaranteed based on the above criteria.
Benefits beyond weight loss
More than a prescription. Care for what comes next.
Starting a GLP-1 can change your appetite, your routine, your energy, and the questions you need answered next. With a fully in-house medical team, longevity researchers, and 40+ science-backed treatment plans designed to support the bigger picture of your health, we’re built for that support.
Fully in-house care team with 199+ years of combined clinical experience
Unlimited provider messaging for side effects, dose questions, refills, and next steps
Stanford PhD-led Research Team behind 11+ longevity clinical trials and 9 peer-reviewed publications
40+ science-backed treatment plans across weight, energy, recovery, and prevention
Clinically studied
The science of Zepbound®
Tirzepatide is the first dual agonist to combine GIP and GLP-1 activity in a single molecule, engaging two natural hormone pathways at once rather than one–a combination that drives greater weight loss and often better tolerability than single-pathway GLP-1s in head-to-head trials.3 5
Beyond weight loss, Tirzepatide has shown real improvements in blood sugar, blood pressure, and cholesterol, with improved heart outcomes in adults with diabetes and cardiovascular disease.8 Broader effects on long-term cellular aging and inflammation are a genuinely promising area of ongoing research.5 11
Beyond weight loss, Tirzepatide has shown real improvements in blood sugar, blood pressure, and cholesterol, with improved heart outcomes in adults with diabetes and cardiovascular disease.8 Broader effects on long-term cellular aging and inflammation are a genuinely promising area of ongoing research.5 11
How it works
Choosing how you age starts here
1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
2
Fast, discreet shipping
Get your discreet shipment
If approved, your Zepbound® prescription is fulfilled through the appropriate pharmacy partner and shipped discreetly to your door.
3
100% online
Receive continuous support
Start with one goal, then keep building over time. With our in-house care team, unlimited provider messaging, easy refills, unlimited dosage adjustments, and 40+ science-backed plans, your care evolves with you.
Get Started
Disclaimer
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See above for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
More options
Which GLP-1 is right for you?
Wegovy® Access & Monitoring
Lose meaningful weight with Wegovy®, a once-weekly FDA-approved GLP-1 injection shown to help adults lose 30+ lbs on average, quiet food noise, and lessen cravings.
Starting at $264/ mo
Wegovy® Pill Access & Monitoring
New
Lose up to 20% of your body weight with Wegovy® Pill, the first FDA-approved oral GLP-1 for weight loss. A once-daily tablet that helps quiet hunger and food noise, without injections.
Starting at $199/ mo
Zepbound® Access & Monitoring
Lose 20% of your body weight with Zepbound®, a once-weekly FDA-approved injection that helps quiet hunger and food noise through dual GIP + GLP-1 support.
Starting at $364/ mo
Frequently asked questions
Zepbound® and Mounjaro® both contain Tirzepatide, but they are approved for different health goals. Mounjaro® is FDA-approved for adults with type 2 diabetes to help manage blood sugar. Zepbound® is FDA-approved for chronic weight management and for moderate-to-severe obstructive sleep apnea in adults with obesity. Same active ingredient, but different approved uses.4
Zepbound® and Wegovy® are both once-weekly FDA-approved weight loss injections, but they use different active ingredients.
Most GLP-1 medications activate a single hormone pathway. Zepbound® activates two–GIP and GLP-1–at once, which is why it tends to produce greater weight loss and often better tolerability in head-to-head trials than single-pathway options.3
In clinical studies, adults taking Zepbound® lost up to 20.9% of their body weight on average, depending on dose.1 For someone starting at 200 pounds, that would mean about 42 pounds.
Many see meaningful movement by 3 months, with most reaching a maintenance dose and steadier progress by 6 months.1
Individual results vary based on dose, lifestyle, treatment consistency, side effects, and how your body responds.
Some lean-mass loss is a normal part of any significant, relatively fast weight loss, and this isn’t unique to Tirzepatide. It’s also substantially preventable: adequate protein intake and resistance training meaningfully protect muscle during treatment, which is why nutrition guidance is part of your program, not an afterthought.12
Nobody puts our citations
in the corner.
We vet everything on PubMed so you don’t have to. Here’s what the science says.