Product image for DMAE FIRMING GEL


Restore skin’s youthfulness with this one-of-a-kind hydrating face gel proven to firm, tighten, smooth, and plump tired skin.

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DMAE Benefits


Glow More, Age Less

  • The first & only Rx-compounded DMAE gel (ARX exclusive)
  • Highly effective anti-aging gel for tired & sagging skin
  • Tightens & firms crepey neck, crow’s feet & forehead lines
  • Diminishes dark under-eye circles
  • Improves lip shape & fullness
  • Blended Hyaluronic & Alpha Lipoic Acids hydrate & help to reduce sensitivity
  • Contains 3% Rx-strength DMAE compared to OTC brands
See the Science


Background & History

  • DMAE stands for dimethylaminoethanol (deanol for short)
  • An organic & topical compound traditionally from fatty fish (salmon, sardines, anchovies)
  • Increases production of Acetylcholine, a neurotransmitter crucial for helping nerve cells send signals
  • Tightens nasolabial folds to firm skin on face & neck
  • Builds back the skin barrier we’ve lost to age
  • Shown to hydrate better than fillers or injections
  • Well-tolerated treatment (i.e. little to no side effects) for aging skin
DMAE Background and History

Why AgelessRx?

Our goal is to help you reach your longevity goals, whatever they may be. Our dermatologist-selected ingredients produce noticeable results for even the most sensitive of skin types. That’s no pain, all gain.

Free Online Consultation

Free online

Personalized strengths


No insurance required

No insurance

Unlimited & ongoing support

Unlimited & ongoing

What DMAE Customers Say

I wanted to try the DMAE Firming Gel due to concern over what I’d consider to be advanced fine lines and wrinkled for my age…I noticed a difference in the plumpness of my skin, particularly around my lips, within about a week of using the DMAE Firming Gel. After only 4 weeks, I could tell a difference in my crow’s feet and 11’s – they looked less deep, and the lines appeared to be shorter. Even my laugh lines look more age-appropriate to me now.

39 Year Old Female
DMAE Results

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$75 / month billed monthly | free shipping
  • 30gm gel pump
  • 3% DMAE, Hyaluronic & Alpha Lipoic Acid blend
  • Made-to-order by certified pharmacy
  • Shipped monthly

CODE AGINGSKIN15$15 off first shipment & FREE medical evaluation

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Best deal
$60 / month billed $180 quarterly | free shipping
  • 30gm gel pump
  • 3% DMAE, Hyaluronic & Alpha Lipoic Acid blend
  • Made-to-order by certified pharmacy
  • Shipped monthly

CODE AGINGSKIN30$30 off first shipment & FREE medical evaluation

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Not available in HI.

Doctor may recommend
a different dose during
medical intake process

You can request daily
dose adjustments
between refills

You will be automatically
billed & sent refills based
on your plan

You can pause or cancel at any time before your next shipment

* Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See below for important safety information. Benefits outlined on are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.


How will I use the DMAE Firming Gel?

Moisten your skin and apply 1 pump to your face twice daily (once in the AM, once in the PM). Spread a thin, even layer over the face and neck and gently smooth into your skin. Allow the gel to completely absorb before continuing with any other serums, treatments, or moisturizers of choice. Apply a daily SPF 30+.

How do I know DMAE is working?

Early signs of DMAE at work are mild signs of tingling, burning, or, in some cases, mild peeling following application. Many patients see results within just a few weeks of treatment. Significant overall skin tone improvement should be visible within 16 weeks.

Why should I request DMAE from AgelessRx?

Our exclusive DMAE Firming Gel contains a blend of DMAE, Hyaluronic Acid, and Alpha Lipoic Acid. When used together, this combination is significantly more effective in reducing signs of skin aging than when used alone. Our dermatologist-selected strength is the only prescription-strength DMAE cream in the industry; it has been rigorously tested to provide all the benefits without the harsh side effects.

See all FAQs


As with any prescription product, there may be side effects. Generally, the vast majority of side effects will subside after the gradual use of the product over 3-4 weeks. If serious burning or irritation occurs, discontinue use and consult a doctor.

Most Common DMAE Side Effects

  • Itching
  • Burning
  • Redness
  • Peeling

​Your skin may be more sensitive to sunlight and weather extremes, such as cold and wind, while using this product. To reduce sensitivity and chance of skin irritation, AgelessRx recommends using a daily moisturizer with SPF 30 (or higher).

For a complete list of possible side effects, click here.

Possible Drug Interactions

Before starting any new prescription, be sure to tell your doctor or healthcare provider about all the medications you take, including prescription and over-the-counter medications, vitamins, and herbal supplements.​

You should not use topical DMAE if you take any of the following medications: acetylcholinesterase inhibitors (i.e. Aricept, Cognex, Reminyl), anticholinergic medications (used for Parkinson’s Disease, COPD, and overactive bladder), cholinergic medications (used for Alzheimer’s and glaucoma), anticoagulants (i.e. blood thinners).​

Additionally, using DMAE concurrently with topical drying agents, such as salicylic acid and benzoyl peroxide, can increase drying effects. Do not apply these agents to the same areas as your topical DMAE.

Other Important Safety Information

Do not use DMAE if you are pregnant or breastfeeding (including trying to get pregnant or are unsure whether they are pregnant). Additionally, people with an allergy to fish or fish products, DMAE, or any of its ingredients, should not take DMAE.

Note: All information included on this page is a summary. It may not cover all possible information. If you have questions about this medication, talk to a doctor, pharmacist, or health care provider.

Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.