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  • Cream

Each order of prescription-strength Tretinoin cream is crafted and personalized by a certified pharmacy to help improve the appearance of wrinkles and repair sun damage and collagen production.

Starting at $60

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Tretinoin Benefits


Glow more, age less

  • Made-to-order, prescription-strength retinoid
  • Exclusive retinoid, hyaluronic acid + ascorbic acid blend
  • Reduces fine lines and wrinkles in a powerful, pea-sized punch
  • Instantly improves collagen production; no down-time
  • Starts working to repair sun damage immediately
  • Proven treatment for adult acne
  • Personalized Rx-strengths (commonly 0.02% or 0.05%)
See The Science


Background and history

  • Topical form of retinoid applied to the skin
  • Derivative of Vitamin A prescribed for 40+ years
  • Signs of aging skin linked to Vitamin A and collagen depletion
  • OTC creams contain retinol—retinoid is more potent and Rx-only
  • Clinically proven to generate rapid skin cell turnover to boost collagen levels
  • Hydrates the skin and reduces deep lines, wrinkles, crow’s feet
  • Less expensive than OTC creams with added benefits of Hyaluronic Acid and Vitamin C
Tretinoin Background & History

Why AgelessRx?

Our goal is to help you reach your longevity goals, whatever they may be. Our dermatologist-selected ingredients produce noticeable results for even the most sensitive of skin types. That’s no pain, all gain.

Free online

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No insurance

Unlimited and ongoing

What the Tretinoin science says

Tretinoin has been proven to prevent, reduce, and treat wrinkles. By stimulating collagen production in the skin, it strengthens the skin at a structural level, resulting in a more youthful appearance. Many scientific studies have been done on this medication, and medical experts agree that it offers promising anti-aging benefits to the skin.

Dr. Bobby Buka, MDThe Dermatology Specialists in NYC

You can very easily reduce the appearance of wrinkles with the use of a moisturizer. Most of the cosmetic treatments are variations on moisturizers; they immediately reduce the appearance of fine lines by 15%–20%. Preventing their appearance is a different issue. The daily use of retinoids (i.e. Tretinoin) can prevent the appearance of wrinkles; they penetrate into the skin, can work on the extracellular matrix—the collagen and elastin fibers. A retinoid is very important to use even for Botox patients that want to maintain youthful skin.

Skincare in the Aging Female: Myths and TruthsThe Journal of Clinical Investigation (2012)
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$75 / month billed monthly | free shipping
  • 30gm cream pump
  • 0.02%, 0.05% or as prescribed
  • Made-to-order by certified pharmacy
  • Shipped monthly

CODE AGINGSKIN15$15 off first shipment & FREE medical evaluation

Best deal
$60 / month billed $180 quarterly | free shipping
  • 30gm cream pump
  • 0.02%, 0.05% or as prescribed
  • Made-to-order by certified pharmacy
  • Shipped monthly

CODE AGINGSKIN30$30 off first shipment & FREE medical evaluation

Not available in HI.

Doctor may recommend a different dose during medical intake process

You can request daily dose adjustments between refills

You will be automatically billed & sent refills based on your plan

You can pause or cancel at any time before your next shipment

* Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See below for important safety information. Benefits outlined on are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.


How will I use the Tretinoin Anti-Wrinkle Cream?

Cleanse your skin and apply 1 to 2 pumps (pea-sized amount) to your face at bedtime up to 3x per week. Follow with a moisturizer of your choice. Apply a daily SPF 30+.

How do I know Tretinoin is working?

Early signs of Tretinoin at work are mild signs of tingling, burning, or, in some cases, mild peeling within following application. This is due to your skin turning over new layers, resulting in brighter and tighter skin. Most patients see early results within 3-4 weeks, with more significant results after 8-10 weeks.

What strengths does AgelessRx Tretinoin cream come in?

Most commonly, AgelessRx prescribes a starting/initial prescription of 0.02%, working up to 0.05% upon first refill. In some cases, different strengths may be prescribed at the discretion of the reviewing doctor or medical professional. However, we typically do not recommend strengths over 0.05%, as higher concentrations (like 0.1%) are often too strong to properly treat wrinkles and come with exacerbated side effects: the 0.02% and 0.05% formulas offer the best balance of positive cosmetic outcomes while minimizing side effects.

See all FAQs

Important safety information and common side effects

As with any prescription product, there may be side effects. Generally, the vast majority of side effects will subside after the gradual use of the product over 3-4 weeks. If serious burning or irritation occurs, discontinue use and consult a doctor.

Most common Tretinoin side effects

  • Itching
  • Burning
  • Redness
  • Peeling

Less common side effects may include Erythema nodosum (severe skin inflammation), Edema (swelling), Rash Skin hyperpigmentation (dark spots), and/or Skin hypopigmentation (light spots).

​Your skin may be more sensitive to sunlight and weather extremes, such as cold and wind, while using this product. To reduce sensitivity and chance of skin irritation, AgelessRx recommends the following:

  • Start by using gradually (2-3x per week) at bedtime to see how it’s tolerated
  • Use with a hydrating serum or moisturizer with aloe or ceramides
  • Use a daily moisturizer with SPF 30 (or higher)

For a complete list of possible side effects, click here.

Possible drug interactions

Before starting any new prescription, be sure to tell your doctor or healthcare provider about all the medications you take, including prescription and over-the-counter medications, vitamins, and herbal supplements.

​You should not use topical Tretinoin if you take medication that further increases your sensitivity to sunlight, including but not limited to: Tetracyclines (e.g. doxycycline, tetracycline, minocycline), Sulfonylureas (e.g. acetohexamide, chlorpropamide, glimepiride, glipizide, glyburide), Thiazide diuretics (e.g. hydrochlorothiazide/HCTZ or any drug containing HCTZ, chlorthalidone, bendroflumethiazide, methyclothiazide, metolazone), phenothiazines (chlorpromazine, promethazine, perphenazine, thiethylperazine, thioridazine), or Fluoroquinolones (e.g. ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin).

​Additionally, using retinoids concurrently with topical drying agents, such as salicylic acid and benzoyl peroxide, can increase the drying effects of retinoids. Do not apply these agents to the same areas as your topical Tretinoin.

Other important safety information

Do not use Tretinoin if you are pregnant or breastfeeding (including trying to get pregnant or are unsure whether you are pregnant). Tretinoin has been associated with miscarriage and birth defects. Additionally, people with an allergy to Tretinoin, or any of its ingredients, should not take Tretinoin.

Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.