Day 1
Within 24 hours, immune signaling shifts as endorphin activity increases, quieting overactive immune cells that drive inflammation.1 0 1 1
Pain & Energy
Low Dose Naltrexone Rx
Unlike other treatments, works with the immune system to support a healthier inflammatory response, potentially helping with pain, energy, brain fog, and overall quality of life.
Starting at
$25
/mo
- Monthly, 3-mo, and 6-mo plans
- Tested for purity
- US-licensed pharmacies
- Pause or cancel anytime
92% felt noticeable benefits by 3rd check-in
Shown to help ease persistent pain and inflammation⁴
May support energy, mental clarity, and mood¹
HSA / FSA
Ongoing, expert support
Free, discreet shipping
100% online
Frequently asked questions
How often do I take Low Dose Naltrexone (LDN)?
You will always take your LDN dose every night before bedtime (between 9pm and 2am). To start, you will take 1 capsule (0.5mg or 1.5mg), and slowly ramp up to the target dose (3.0mg or 4.5mg).
How can I monitor my response to Low Dose Naltrexone (LDN)?
In the short term, users report an improvement or reduction of symptoms related to inflammation and rampant oxidative stress, such as joint pain, back pain, fatigue, weight gain, and more.
What form of Low Dose Naltrexone (LDN) will I receive?
AgelessRx provides LDN in capsule form with sucrose as the standard filler. If you are taking LDN for the first time, you will start out with a lower dose (0.5mg or 1.5mg) and slowly work up to the prescribed dose (3.0mg or 4.5mg) over a 20-day to 3-month period, depending on your titration schedule.
Usage Instructions
View all FAQs
Low Dose Naltrexone is taken daily according to your provider-guided titration schedule. If prescribed, a US-licensed provider will provide a tailored dosage schedule and specific treatment instructions with your care plan.
Important safety information and common side effects
When starting LDN, you may experience mild to moderate levels of the below-listed side effects during the first 3 to 5 days. These typically diminish on their own as your body adjusts to the medication, usually by the fifth day.
If you are on thyroid medication, you may need to monitor your thyroid levels more closely as you start LDN. If you develop symptoms of hyperthyroidism while taking LDN, such as heart racing, increased anxiety, restlessness, or trouble sleeping, please stop LDN and talk to the provider for your thyroid medication.
You MUST stop taking LDN at least 48 hours before any surgical or diagnostic procedure requiring sedation. If you’re scheduled for a procedure and not sure whether you should stop taking LDN, please ask the doctor ordering the test or procedure. Additionally, you CANNOT resume LDN until at least 48 hours after you have finished any prescribed medication for the procedure.
Most common LDN side effects
- Vivid dreams
- Mild anxiety
- Insomnia
- Headache
For a full list of possible side effects, please review the Mayo Clinic’s Naltrexone resources.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality.
What is Low Dose Naltrexone?
(nal-trek-sown)Chronic pain, persistent fatigue, and brain fog often share a common root: low-grade inflammation that conventional medicine rarely addresses directly.6
Unlike standard treatments, LDN works with the immune system at low doses to help promote healthy endorphin signaling and support a more balanced inflammatory response, helping the body work the way it should.4
Unlike standard treatments, LDN works with the immune system at low doses to help promote healthy endorphin signaling and support a more balanced inflammatory response, helping the body work the way it should.4
92% of AgelessRx LDN users felt noticeable benefits by their 3rd check-in
92%
How Low Dose Naltrexone works
30 Days
As immune balance begins normalizing, users may notice subtle improvements in pain and mood with reductions in pro-inflammatory factors.1 1 2
3 Months
With continued use, users may experience quality of life benefits from reduced systemic inflammation as they feel more energetic. 1
6 Months
As immune reactivity calms and endorphin levels remain steady, many report clearer thinking, steadier mood, and relief from inflammation-driven symptoms.1 2
1 Year and Beyond
With consistent use, immune balance can be maintained, supporting sustained relief from inflammation-driven pain while helping reduce the risk of age-related decline.1 1 2
Day 1
Within 24 hours, immune signaling shifts as endorphin activity increases, quieting overactive immune cells that drive inflammation.1 0 1 1
30 Days
As immune balance begins normalizing, users may notice subtle improvements in pain and mood with reductions in pro-inflammatory factors.1 1 2
3 Months
With continued use, users may experience quality of life benefits from reduced systemic inflammation as they feel more energetic. 1
6 Months
As immune reactivity calms and endorphin levels remain steady, many report clearer thinking, steadier mood, and relief from inflammation-driven symptoms.1 2
1 Year and Beyond
With consistent use, immune balance can be maintained, supporting sustained relief from inflammation-driven pain while helping reduce the risk of age-related decline.1 1 2
Results you can feel
- 0
- felt benefits by second check-in
- 0
- reported less aches and pains
- 0
- reported less inflammation
- 0
- reported better moods
Actual results may vary. Data was self reported by 4,472 surveyed customers who checked in with their provider between second and third check-in dates between 3/1/25 – 2/9/26. All respondents are AgelessRx customers who were approved for a prescription after completing an assessment with a medical provider.
We’re global leaders in LDN
When it comes to Low Dose Naltrexone, no one knows (or does) more than us. With several peer-reviewed research studies and one of the largest proprietary LDN datasets in longevity care, we’re not just following the science, we’re leading it.
Over 55,000+ LDN users supported
Peer-reviewed research in aging science, including our latest publication in Aging Biology
An expert team of LDN Research Trust–certified clinicians and active contributors since 2020
Proud sponsors of a lifespan research trial with the University of Washington
Clinically studied
The science of Low Dose Naltrexone (LDN)
Naltrexone has been FDA approved for the treatment of addiction since 1984.1 3 At lower doses, clinical studies suggest Naltrexone may have a different mechanism of action—modulating immune function, boosting endorphin production, and reducing inflammation.4
Research shows Low Dose Naltrexone may help relieve chronic pain, support immune balance, and improve overall health and well-being by targeting low-grade inflammation—a key contributor to aging and age-related diseases.1 4 6
Research shows Low Dose Naltrexone may help relieve chronic pain, support immune balance, and improve overall health and well-being by targeting low-grade inflammation—a key contributor to aging and age-related diseases.1 4 6
How it works
Choosing how you age starts here
1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
2
Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy partner, rigorously inspected for quality, and shipped discreetly to your door.
3
100% online
Receive continuous support
Start with one goal, then keep building over time. With our in-house care team, unlimited provider messaging, easy refills, unlimited dosage adjustments, and 40+ science-backed plans, your care evolves with you.
Get Started
Disclaimer
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. See below for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
More options
Immune support, personalized.
Microdosing GLP-1
New
Microdosing GLP-1 is designed to work in sync with your body, which may minimize side effects and support moderate weight loss.
Starting at $99
NAD+ Injection
Boost energy, improve focus, and support cellular health with one of the most effective methods of restoring depleted NAD+ levels for a fraction of the cost of IV infusions.
Starting at $79/ mo
Rapamycin
One of longevity’s most talked-about therapies, it has extended lifespan across every model organism studied by lowering mTOR, and helping cells clear damage, repair, and stay functional longer.
Starting at $65/ mo
NAD+ Patches
Support steady energy, endurance, and recovery with an easy, injection-free way to boost NAD+ for lasting cellular energy.
Starting at $150/ kit
NAD+ Nasal Spray
Support mental clarity, focus, and cognitive energy with an easy, injection-free way to boost NAD+, designed to support brain pathways and sharper thinking on the go.
Starting at $125/ mo
Frequently asked questions
Naltrexone binds to opioid receptors—which are found all over the body including immune cells. In doing so, it displaces the endorphins which would normally stay bound to these receptors. By binding to the opioid receptors, it displaces the body’s naturally produced Opioid Growth Factor. When using Naltrexone at a low dose (hence LDN), the binding is temporary and causes the body to then up-regulate or increase the opioid receptors, thereby restoring the endorphin system and balancing the immune system.
The most common LDN side effects are vivid dreams, mild anxiety, insomnia, and headache, and they’re usually mild and temporary. If they’re bothersome, slowing your titration schedule, changing the time of day you take LDN, or switching to a lower capsule strength may help your body adjust. Talk to your provider if side effects persist.
Yes, Low Dose Naltrexone requires a prescription from a licensed medical provider. At AgelessRx, you can complete an online medical intake form to connect with a US-licensed provider who will review your health history to determine if LDN is appropriate for you. If approved, your prescription will be fulfilled by one of our licensed compounding pharmacy partners and delivered directly to your door.
Because LDN works by temporarily binding to opioid receptors, it is important to avoid taking opioid medications while using LDN, as this may interfere with its mechanism of action. You should also avoid taking LDN within 4–6 hours of any opioid-containing medication. Let your provider know about all medications you are currently taking before starting LDN.
I solemly swear this is
peer-reviewed.
We vet everything on PubMed so you don’t have to. Here’s what the science says.