1 Week
With daily dosing, Tadalafil may reach steady levels in the system, providing continuous background support to the nitric oxide and cGMP pathway that govern how blood vessels relax and dilate.1 3
Longevity
Tadalafil for Longevity Rx
One low daily dose for both men and women that may help blood vessels stay relaxed and responsive, supporting circulation to the heart, brain, muscles, and organs for years to come.
Helps blood vessels relax for healthier circulation⁴
Associated with 44% lower risk of all-cause death + 60% reduction in major heart events²
Targets the same biology shown to also improve heart health in women⁶
Quarterly billed $155 first 3 months
Clinician-guided
Personalized treatment plans
100% online
Frequently asked questions
How do Tadalafil for Longevity and Tadalafil for ED differ?
Tadalafil for ED or sexual health is typically taken in a higher 10 or 20 mg dose before anticipated sexual activity, with support that may last up to 36 hours.7 Low doses of Tadalafil for Longevity use 2.5 or 5 mg taken daily to provide steadier support for the blood-flow pathway behind vascular, sexual, and urinary health. Its use for longevity is off-label and has not been reviewed or approved by the FDA.
What are the potential longevity benefits of low dose Tadalafil?
Low dose Tadalafil may help cGMP stay active longer, allowing blood vessels to relax and respond more effectively, which may support healthy circulation throughout the body.9 Large studies have found associations between PDE5 inhibitor use and fewer major cardiovascular events, lower all-cause mortality, and lower dementia risk, including in men who didn’t have diagnosed heart disease to begin with.2 9 These findings are observational, based primarily on men.
Can women take Tadalafil?
Yes. Eligible women can take low dose Tadalafil when prescribed off-label by a licensed provider. This isn’t a men’s-only mechanism: PDE5 inhibition works through the same nitric oxide–cGMP pathway in both sexes, and it’s already an approved, effective therapy for pulmonary hypertension in women.6 Randomized trials have studied 5 mg daily in women for overactive bladder symptoms, while a recent trial found improvements in sexual function and clitoral blood-flow measures in a specific female population.1 0 1 1 Evidence for female longevity specifically is still emerging, so treatment should be personalized.
Usage instructions
View all FAQs
Tadalafil for Longevity is taken once per day, at approximately the same time, according to your provider-guided treatment plan. It may be taken with or without food. If prescribed, a US-licensed medical provider will provide a tailored dosage schedule and specific treatment instructions with your care plan.
Important safety information and common side effects
Generally, people who experience side effects usually get them within 12 to 24 hours after taking Tadalafil. Side effects usually resolve on their own within 48 hours. Daily Tadalafil use is usually associated with lower incidence and severity of side effects compared to as-needed Tadalafil dosing.
Most common Tadalafil side effects include headache, indigestion, back and/or muscle pain, flushing, and stuffy nose. Some more serious side effects have been reported. While rare, it is important to stop taking Tadalafil and contact a doctor right away if any of the following occur:
- An erection will not go away (priapism). If you have an erection that lasts longer than 4 hours, get medical help right away. If not treated right away, priapism can permanently damage the penis.
- Sudden vision loss in one or both eyes. Sudden vision loss can be a sign of a serious eye problem called non-arteritic anterior ischemic optic neuropathy (NAION).
- Sudden hearing decrease or hearing loss. Some may also have ringing in the ears (tinnitus) or dizziness.
For a complete list of possible side effects, please review the Mayo Clinic’s Tadalafil resources.
Possible drug interactions
Some drugs/medications may interact with Tadalafil. You should not take Tadalafil if you are taking nitrates (such as nitroglycerin tablets or patches) because the combination of these with Tadalafil could significantly lower blood pressure and lead to fainting or even death. Additionally, do not take Tadalafil if you are taking Cisapride, other ED medications (e.g. Viagra), Adcirca, or Riociguat. Also be sure to report if you smoke, drink alcohol, or use illegal drugs, as some may interact with your medication.
For a complete list of possible drug interactions, please review Drugs.com’s Tadalafil resources.
Other important safety information
Those who have a condition called “left ventricular outlet obstruction” from valvular problems or heart muscle enlargement may experience side effects such as fainting or light-headedness. Because those with recent heart attacks or stroke, heart pains (angina), heart failure, uncontrolled blood pressure or uncontrolled irregular heart beats, severe liver disease, and retinal eye problems have not been studied, Tadalafil (Cialis) is not recommended for these users. There may be rare occurrences of priapism or painful, prolonged erections. This is a serious condition that requires immediate medical attention. Users should seek prompt medical attention if their erection lasts longer than four hours.
After taking a single tablet, Tadalafil can remain in the body for up to two days. It can remain longer if people have problems with their kidneys or liver, or they are taking certain other medications.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. The FDA has not reviewed these statements or approved this product for non-FDA-approved uses, such as longevity.
What is daily low dose Tadalafil?
(tuh-dal-uh-fil)Better blood flow reaches further than you think. A low daily dose may block PDE5, the enzyme that breaks down cGMP, supporting the flow of blood, oxygen, and nutrients to the heart, brain, and organs that depend on them. 2 3 8
More available cGMP and more responsive blood vessels is the through line connecting everything from cardiovascular risk to brain blood flow to improved exercise capacity.9 1 2
One pathway. Whole-body impact to support circulation throughout the body.
How low dose Tadalafil works
2 Months
With PDE5 biology continuously supported, blood vessels may begin responding more efficiently, improving the delivery of oxygen and nutrients to tissues throughout the body and improving recovery.1 2 1 3
3 Months
More flexible, responsive arteries may reduce vascular strain and support healthier circulation across the whole body, not just one region, with individuals potentially noticing improvements in exercise performance.1 1 3
6 Months
Emerging research has observed reductions in inflammatory markers alongside improvements in attention and processing speed.1 4 1 5
1 Year and Beyond
Long-term PDE5 inhibitor use has been associated with fewer heart attacks and lower risk of Alzheimer’s and all-cause mortality in large observational studies, including in generally healthy adults without disease.2 9
1 Week
With daily dosing, Tadalafil may reach steady levels in the system, providing continuous background support to the nitric oxide and cGMP pathway that govern how blood vessels relax and dilate.1 3
2 Months
With PDE5 biology continuously supported, blood vessels may begin responding more efficiently, improving the delivery of oxygen and nutrients to tissues throughout the body and improving recovery.1 2 1 3
3 Months
More flexible, responsive arteries may reduce vascular strain and support healthier circulation across the whole body, not just one region, with individuals potentially noticing improvements in exercise performance.1 1 3
6 Months
Emerging research has observed reductions in inflammatory markers alongside improvements in attention and processing speed.1 4 1 5
1 Year and Beyond
Long-term PDE5 inhibitor use has been associated with fewer heart attacks and lower risk of Alzheimer’s and all-cause mortality in large observational studies, including in generally healthy adults without disease.2 9
Results you can feel
- 0
- fewer major cardiovascular events²
- 0
- lower risk of all-cause mortality²
- 0
- lower risk of Alzheimer's disease⁵
- 0
- lower heart disease risk¹⁶
We study Tadalafil beyond the bedroom
Most platforms stop at sexual health. Our in-house, Stanford PhD-led Research Team follows the emerging evidence across vascular, cognitive, and inflammatory health, then brings that science into personalized daily care.
100,000+ real-world health data points
Stanford PhD-led review of PDE5 and cGMP research
199+ years of combined clinical experience with personalized protocols
Clinically studied
The science of Tadalafil
By blocking PDE5, Tadalafil may help cGMP stay active longer, allowing blood vessels to relax and respond more effectively, which may help oxygen and nutrients reach the heart, brain, muscles, and organs that rely on steady circulation every day.2 3 1 3
Multiple large population studies, including one analyzing over 500,000 men, have found PDE5i use associated with significantly lower rates of all-cause mortality, heart attack, stroke, and dementia, with Tadalafil showing greater benefits than Sildenafil in several analyses.9
Tadalafil works through the nitric oxide–cGMP pathway present in blood vessels throughout the body, in both sexes—it’s already an FDA-approved, effective therapy for pulmonary hypertension in women.1 1 1 2
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Personalized care that starts with you
We believe the best plan is the one that fits your life. Choose monthly flexibility or save with a 3-month plan, both with ongoing support every step of the way.
Starting at $52/month
Applies to 3-month plan billed in full ($60/mo after)
What’s included
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Personalized, clinician-guided treatment plan
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Monthly and 3-month plans
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Dispensed by US-licensed compounding pharmacy
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Unlimited protocol adjustments and messaging
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Ongoing support and check-ins
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Pause or cancel anytime
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Backed by our in-house Stanford PhD-led team
How it works
Choosing how you age starts here
1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
2
Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is fulfilled by a US-licensed, LegitScript-certified pharmacy partner, rigorously inspected for quality, and shipped discreetly to your door.
3
100% online
Receive continuous support
Start with one goal, then keep building over time. With our in-house care team, unlimited provider messaging, easy refills, unlimited dosage adjustments, and 40+ science-backed plans, your care evolves with you.
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Disclaimer
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See above for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
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Frequently asked questions
Yes, mechanistically–this is the best-established part of the science. By blocking PDE5, Tadalafil may keep cGMP active longer, allowing blood vessels to relax and respond more effectively, supporting circulation throughout the body.¹³ This mechanism likely underlies the vascular, cognitive, and cardiovascular associations that are beneficial for longevity.
The mechanism is well-established, and large observational studies have found associations between PDE5 inhibitor use and lower rates of death, cardiovascular events, and dementia–notably including men without pre-existing heart disease, which is the more novel finding.² ⁹ This evidence is observational, not from randomized trials, and can’t fully rule out that healthier men are simply more likely to use and continue this kind of treatment.
Large population studies have found PDE5 inhibitor use associated with meaningfully lower dementia rates, with one large UK cohort study finding a stronger association among men with more sustained Tadalafil use.² ⁹ This is a real and consistent signal across multiple independent studies, but it remains observational.
Yes, off-label and with provider guidance. The underlying nitric oxide–cGMP mechanism is shared between sexes, and PDE5 inhibitors are already approved and effective for pulmonary hypertension in women.¹² ¹⁷ Longevity-specific evidence in women is still developing, since most large studies to date have focused on men, and our research team is leading the charge.
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