30 Minutes
Tadalafil begins blocking PDE5, the enzyme that breaks down the blood-flow signal behind an erection.5
Tadalafil Rx
Support stronger, longer-lasting erections for up to 36 hours with the same active ingredient in Cialis®, so intimacy can fit your life instead of the other way around.
Take 1–2 hours before sexual activity
Supports erections for up to 36 hours²
Same active ingredient as Cialis® for up to 90% less in price
Quarterly billed $110 first 3 months
Ongoing, expert support
Free, discreet shipping
100% online
Frequently asked questions
How quickly does Tadalafil work?
Tadalafil is taken before anticipated sexual activity and may begin working within 30 to 60 minutes, although timing varies by person.1 Blood levels typically peak around two hours after taking it.4 Because Tadalafil can remain active for up to 36 hours, you may have a wider window for intimacy without needing to time every moment precisely, a genuinely different experience than medications built around a narrow window.2
Will Tadalafil cause an automatic erection?
No, Tadalafil supports the blood-flow response involved in an erection, but sexual stimulation is still required. Tadalafil does not create desire or cause a constant erection. Instead, it may make it easier to get and maintain an erection when you are aroused.
How is Tadalafil for ED different from Tadalafil for Longevity?
Tadalafil for ED, typically 10-20mg, is taken at least 30 minutes before anticipated sexual activity and typically uses a higher dose to provide support for up to 36 hours. Tadalafil Daily uses a lower dose (typically 2.5–5mg) taken every day, creating consistent medication levels without needing to plan a dose around sexual activity—potentially a better fit for those who’d rather not think about timing at all.
Usage instructions
View all FAQs
Tadalafil is taken before anticipated sexual activity according to your provider-guided dosing schedule. If prescribed, a US-licensed medical provider will provide a tailored dosage schedule and specific treatment instructions with your care plan.
Important safety information and common side effects
Generally, people who experience side effects usually get them within 12 to 24 hours after taking Tadalafil. Side effects usually resolve on their own within 48 hours.
Most common Tadalafil side effects include headache, indigestion, back and/or muscle pain, flushing, and/or stuffy nose.
Some more serious side effects have been reported. While rare, it is important to stop taking Tadalafil and contact a doctor right away if any of the following occur:
- Priapism (a persistent, unwanted erection). An erection lasting more than 4 hours is a medical emergency—seek care immediately. Delayed treatment can result in permanent damage to the penis.
- Sudden vision loss in one or both eyes. Sudden vision loss can be a sign of a serious eye problem called non-arteritic anterior ischemic optic neuropathy (NAION).
- Sudden hearing decrease or hearing loss. Some may also have ringing in the ears (tinnitus) or dizziness.
For a complete list of possible side effects, please review the Mayo Clinic’s Tadalafil resources.
Some drugs/medications may interact with Tadalafil. You should not take Tadalafil if you are taking nitrates (such as nitroglycerin tablets or patches) because the combination of these with Tadalafil could significantly lower blood pressure and lead to fainting or even death. Additionally, do not take Tadalafil if you are taking Cisapride, other ED medications (e.g. Viagra), Adcirca, or Riociguat. Also be sure to report if you smoke, drink alcohol, or use illegal drugs, as some may interact with your medication.
For a complete list of possible drug interactions, please review Drugs.com’s Tadalafil resources.
Those who have a condition called “left ventricular outlet obstruction” from valvular problems or heart muscle enlargement may experience side effects such as fainting or light-headedness. Because those with recent heart attacks or stroke, heart pains (angina), heart failure, uncontrolled blood pressure or uncontrolled irregular heart beats, severe liver disease, and retinal eye problems have not been studied, Tadalafil (Cialis) is not recommended for these users. There may be rare occurrences of priapism or painful, prolonged erections. This is a serious condition that requires immediate medical attention. Users should seek prompt medical attention if their erection lasts longer than four hours.
After taking a single tablet, Tadalafil can remain in the body for up to two days. It can remain longer if users have problems with their kidneys or liver, or they are taking certain other medications.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate.
What is Tadalafil?
(tah-da-la-fil)ED can make sex feel uncertain before it even begins. Tadalafil, the active ingredient in Cialis®, blocks PDE5, an enzyme that breaks down the signal helping blood vessels relax during arousal.
With PDE5 suppressed, more blood can flow more freely through the body, supporting stronger, longer-lasting erections when you’re sexually stimulated.3 4
With PDE5 suppressed, more blood can flow more freely through the body, supporting stronger, longer-lasting erections when you’re sexually stimulated.3 4
One pill. 36-hour window for intimacy.
36 hours
How Tadalafil works
2 Hours
With PDE5 suppressed, blood vessels can relax and more blood can flow through the body when you’re sexually stimulated.1 3
24 Hours
Better blood flow may make it easier to get and stay erect, with more freedom around when intimacy happens.3
36 Hours
Tadalafil’s longer half-life helps the cGMP signal stay active into the next day, giving the body a larger window to respond when arousal happens.4 5
Over Time
Your provider can refine your dose and timing for more dependable results, while emerging research continues to explore PDE5 inhibition and broader vascular health.6
30 Minutes
Tadalafil begins blocking PDE5, the enzyme that breaks down the blood-flow signal behind an erection.5
2 Hours
With PDE5 suppressed, blood vessels can relax and more blood can flow through the body when you’re sexually stimulated.1 3
24 Hours
Better blood flow may make it easier to get and stay erect, with more freedom around when intimacy happens.3
36 Hours
Tadalafil’s longer half-life helps the cGMP signal stay active into the next day, giving the body a larger window to respond when arousal happens.4 5
Over Time
Your provider can refine your dose and timing for more dependable results, while emerging research continues to explore PDE5 inhibition and broader vascular health.6
Results you can feel
- 0
- reported stronger or longer erections
- 0
- saw noticeable benefits
- 0
- reported better intimacy
- 0
- saw better sexual function
Actual results may vary. Data was self-reported by 2,312 surveyed customers who checked in with their provider on their first check-in between 4/7/22-2/10/26. All respondents are AgelessRx Tadalafil customers who were approved for a prescription after completing an assessment with a medical provider.
We’re experts in Tadalafil
ED meds are everywhere. Finding a trusted partner to get you the best outcomes is where expertise matters. Our in-house team combines 199+ years of clinical experience with real-world outcomes from thousands of Tadalafil users to refine your dose, timing, and long-term plan.
Personalized dosing with ongoing adjustments, not a one-size-fits-all ED plan
Stanford PhD-led review of PDE5, cGMP, and vascular-health research
Expert-guided care by longevity specialists that connects sexual function with long-term health
Clinically studied
The science of Tadalafil
Tadalafil works by keeping the body’s erection signal active longer than shorter-acting alternatives, giving the body more time to respond when arousal happens rather than requiring you to plan around the medication.3 4
In one randomized crossover study, 73% of men preferred Tadalafil to Sildenafil.7 Men also reported higher sexual self-confidence and spontaneity with fewer time-related concerns, on Tadalafil compared to Sildenafil.8
Subscribe & save
Personalized care that starts with you
We believe the best plan is the one that fits your life. Choose monthly flexibility or save with a 3-month plan, both with ongoing support every step of the way.
$45/month
Quarterly plan billed $135/every 3 months
What’s included
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Flexible Monthly + Quarterly plans
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Personalized, clinician-guided plan
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Dispensed by US-licensed compounding pharmacy
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Unlimited protocol adjustments and messaging
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Ongoing support and check-ins
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Pause or cancel anytime
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Backed by our in-house Stanford PhD-led team
How it works
Choosing how you age starts here
1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
2
Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is fulfilled by a US-licensed, LegitScript-certified pharmacy partner, rigorously inspected for quality, and shipped discreetly to your door.
3
100% online
Receive continuous support
Start with one goal, then keep building over time. With our in-house care team, unlimited provider messaging, easy refills, unlimited dosage adjustments, and 40+ science-backed plans, your care evolves with you.
Get Started
Disclaimer
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
More options
Sexual health, personalized.
Tadalafil for Longevity
One low daily dose for both men and women that may help blood vessels stay relaxed and responsive, supporting circulation to the heart, brain, muscles, and organs for years to come.
Starting at $60/ mo
PT-141 Injection
New
When attraction is still there but desire isn’t, support the brain pathways behind arousal and responsiveness—helping intimacy feel more natural again.
Starting at $149/ mo
PT-141 Nasal Spray
New
When attraction is still there but desire isn’t, support the brain pathways behind arousal and responsiveness with a fast-acting, needle-free option for men and women.
Starting at $149/ mo
Frequently asked questions
Tadalafil is the active ingredient in Cialis®. Generic Tadalafil works through the same PDE5 pathway and is available in the same commonly prescribed strengths, without the brand-name price.
Tadalafil and Viagra® (Sildenafil) both increase blood flow to support erections during sexual stimulation, but they differ most in how long they work.⁹ Sildenafil, the active ingredient in Viagra®, typically has a shorter window. Tadalafil may support erectile function for up to 36 hours, giving you more flexibility around when intimacy happens. In head-to-head trials, a clear majority of men who tried both ultimately preferred Tadalafil, citing less pressure around timing as one of the main reasons.⁷ ⁸
Tadalafil is FDA approved for erectile dysfunction, not premature ejaculation. Some studies suggest it may help certain men improve ejaculatory timing, particularly when erection difficulties and premature ejaculation occur together.¹⁰ Results vary, so your provider can help determine whether Tadalafil fits your symptoms and treatment goals.
Because the medication is the same wherever you get it. The difference is what happens around it. You get a real clinician reviewing your case, a dose and regimen actually tailored to you rather than a default prescription, and an in-house team you can message when something needs adjusting. In a category full of one-size-fits-all pill mills, that clinical seriousness is the actual product.
If you cite it,
they will come.
We vet everything on PubMed so you don’t have to. Here’s what the science says.