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Rapamycin

The most-studied longevity molecule, Rapamycin inhibits mTOR, a growth pathway linked to aging, and has extended lifespan in every animal model tested so far.

Rapamycin:
How does it work?

Rapamycin blocks mTOR, the switch that tells cells to grow. Dialing it down shifts cells toward repair and cleanup (autophagy).1

That shift toward repair is why researchers study it for aging itself, across many systems at once.

What Rapamycin may support

Rapamycin is unusual in longevity research because the signal is broad, not tied to one organ. By dialing down mTOR, researchers are studying whether one pathway can influence several parts of aging at once.
Rapamycin has extended lifespan in every animal model tested so far, including when started later in life.2
Human studies are beginning to test effects on immune, skin, brain, and reproductive aging.5
We designed and led PEARL, the largest published randomized trial of Rapamycin for longevity to date.
Available as clinician-guided Rapamycin with dosing and lab monitoring.

How Rapamycin works

Think of mTOR as a switch between growth and repair. When it stays turned toward growth for too long, cells have less time for cleanup.

Rapamycin may briefly turn that signal down, giving cells more time for autophagy, the process they use to clear damaged material and recycle worn-out parts.1

Explore Rapamycin

In mice, Rapamycin extended median lifespan up to about 14%.2

+14%
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality.

Rapamycin benefits

What Rapamycin may support, with the evidence behind each.

Lifespan

Extended lifespan in mice even when started late in life. Animal.2

Healthspan & tolerability

Our PEARL trial showed it was generally well tolerated in an off-label study of 333 adults. Human.3

Immune function

Improved immune and vaccine response in older adults. Human.5

Brain aging

Reduced amyloid and cognitive deficits in an Alzheimer’s mouse model. Animal.8

Reproductive aging

Delayed ovarian aging in mice. Animal.6

Bone & body composition

Our Rapamycin + DEXA research looks at bone density and body composition to better understand long-term effects. Human.11

Oral & periodontal

Animal research suggests benefits for aging oral tissue. Animal.7

Skin aging

Topical Rapamycin reduced skin senescence markers. Human.10

Combination longevity

With Acarbose, extended mouse lifespan further. Animal.9

What we still don’t know

We believe in full transparency. Here’s what Rapamycin research doesn’t yet answer.

Lifespan extension

No completed human trial yet shows Rapamycin extends human lifespan.

Mostly animal

Much of the longevity data is from mice and other model organisms.

Dose & form

Our study found generic Rapamycin was 3× more bioavailable than compounded, vital for proper dosing.4

The team behind Rapamycin’s biggest healthy aging trial

We’ve been studying Rapamycin for years. Our Research Team has run multiple human studies to answer some of the questions that matter most in real-world use.
We designed and led PEARL, the largest published randomized trial of Rapamycin for healthy aging, following adults for 48 weeks.
Our published bioavailability study found generic Rapamycin was 3× more bioavailable than compounded, helping inform real-world dosing.4
We’ve studied Rapamycin alongside DEXA scans to understand changes in bone density and body composition over time.
We’ve also studied Rapamycin and oral health, looking at how it may affect aging periodontal tissue and broader health.
Read our Research
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Rapamycin

Rapamycin

One of longevity’s most talked-about therapies, it has extended lifespan across every model organism studied by lowering mTOR, and helping cells clear damage, repair, and stay functional longer.

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Frequently asked questions

01 Is Rapamycin proven to extend human lifespan?

No. Rapamycin has extended lifespan across many animal species and is the most-studied longevity molecule, but no completed human trial has shown it extends human lifespan. That research is ongoing.

02 Is using Rapamycin for longevity FDA-approved?

No. Rapamycin (sirolimus) is FDA-approved to prevent organ-transplant rejection and for certain other conditions. Its use for longevity is off-label.

03 What's the difference between generic and compounded Rapamycin?

Both are absorbed, but our own research found generic Rapamycin is roughly three times as available, dose for dose, as compounded.4 A clinician helps choose based on your goals and labs.

04 How is Rapamycin taken for longevity?

It’s prescribed at low doses and adjusted with your clinician through regular lab monitoring. A provider guides the plan around your goals rather than a one-size-fits-all approach.

05 Who may not be a good candidate for Rapamycin?

Rapamycin isn’t right for everyone. It can interact with some medications and with grapefruit, so a clinician reviews your health history, medications, and labs before prescribing.

06 How will I know if Rapamycin is working?

Longevity benefits aren’t something you feel day to day. Your care team tracks labs and health markers over time, and individual response varies from person to person.

Our idea of a bedtime story?
PubMed.

We vet everything on PubMed so you don’t have to. Here’s what the science says.
1
This review explains how Rapamycin slows aging by inhibiting mTOR, the growth pathway that stays overactive in aging tissue.
Aging, 2013
2
Rapamycin extended lifespan in genetically diverse mice even when started late in life, the first drug shown to extend a mammal’s lifespan.
Nature, 2010
3
In 333 adults using off-label Rapamycin, it was generally well tolerated over months to years of use.
GeroScience, 2023
4
Our own real-world study found compounded Rapamycin is about one-third as available, dose for dose, as generic Rapamycin.
GeroScience, 2025
5
In older adults, low-dose mTOR inhibition improved immune function and vaccine response.
Sci Transl Med, 2014
6
In mice, Rapamycin delayed ovarian aging and preserved the ovarian reserve.
Sci Rep, 2018
7
Short-term Rapamycin rejuvenated the aging oral cavity and periodontal tissue in elderly mice.
eLife, 2020
8
In an Alzheimer’s mouse model, Rapamycin reduced amyloid-beta and cognitive deficits by restoring autophagy.
PLoS One, 2010
9
In the Interventions Testing Program, Rapamycin combined with acarbose extended mouse lifespan more than either alone.
Aging Cell, 2022
10
In an exploratory human trial, topical Rapamycin reduced markers of senescence and aging in skin.
GeroScience, 2019
11
This case report describes a 52-year-old woman with osteopenia who experienced a 15.9% increase in lumbar spine bone mineral density after two years on low-dose Rapamycin, later combined with Low-Dose Naltrexone alongside vitamin K2 and oral Progesterone.
Cureus, 2025