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Tadalafil

The blood-flow molecule studied for longevity. Tadalafil is a PDE5 inhibitor that supports circulation, cardiovascular and cognitive health, and erectile function.

Tadalafil:
How does it work?

Tadalafil blocks PDE5, which lets cGMP build up, the messenger that relaxes blood vessels and improves circulation.3 4

Better blood flow is the thread connecting its effects, from erectile function to cardiovascular and brain health.1

What Tadalafil may support

Tadalafil is best known for erectile function, but researchers are studying the same blood flow pathway across the heart, brain, metabolism, and healthy aging.
Researchers are also studying Tadalafil for cognitive health, inflammation, and other effects tied to cGMP signaling.3
Studied for cardiovascular, cognitive, and metabolic health.1
FDA-approved for erectile dysfunction, BPH, and lung-artery pressure.11
Available as clinician-guided low-dose daily tablets, low-dose daily gummies, and higher-dose Tadalafil for sexual function.

How Tadalafil works

Think of cGMP as your blood vessels’ “relax” signal. Tadalafil doesn’t create that signal, but it may help keep the body from switching it off too quickly, giving blood vessels more time to stay relaxed and blood to flow.3
Explore Tadalafil

In one cohort, long-term users had 44% lower all-cause mortality. Observational.1

44%
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality.

Tadalafil benefits

What daily Tadalafil may support, with the evidence behind each.

All-cause mortality

Long-term users showed 44% lower mortality in one cohort. Observational.1

Cardiovascular health

Linked to fewer major cardiac events in men with ED. Observational.2

Cognition

Improved cognition through brain blood flow in men with BPH and erectile dysfunction. Observational.6

Alzheimer's risk

In men with ED, PDE5-inhibitor use linked to lower Alzheimer’s risk. Observational.12

Lower inflammation

cGMP signaling lowered inflammatory markers. Early animal evidence.9

Erectile function

Its established on-label use; PDE5 inhibition supports erections. Human.11

Immune response

Augmented tumor-specific immunity in a small cancer study. Observational.8

Kidney & organ protection

Renoprotective effects seen in an animal model. Preclinical.10

Healthy cellular aging

Proposed in an anti-aging formula via cGMP signaling. Hypothesis.7

What we still don’t know

We believe in full transparency. Here’s what Tadalafil research doesn’t yet answer.

Observational

The mortality and heart findings are observational, not randomized trials.

Mostly men

Longevity data comes largely from men with ED; less is known in women.

Mechanism vs. outcomes

cGMP biology is a strong hypothesis; long-term healthspan trials are pending.

We’re experts in Tadalafil

Most people know Tadalafil for sexual health. Our Stanford PhD-led Research Team follows the emerging science on what better blood flow may mean for the heart, brain, and healthy aging.
NPR recently interviewed our Medical Director to discuss Tadalafil for longevity
100,000+ real-world health data points informing our protocols
Our Research Team tracks the PDE5 evidence and brings it into practice
Read our Research
Science-backed

Choose the experts in Tadalafil

Get a flexible plan with clinician-guided dosing, regular check-ins, unlimited provider messaging, and adjustments along the way.
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Tadalafil for Longevity

tadalafil daily pill

One low daily dose for both men and women that may help blood vessels stay relaxed and responsive, supporting circulation to the heart, brain, muscles, and organs for years to come.

Starting at $60/ mo
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Tadalafil

Tadalafil

Support stronger, longer-lasting erections for up to 36 hours with the same active ingredient in Cialis®, so intimacy can fit your life instead of the other way around.

Starting at $45/ mo
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Don’t know where to start?

Take our quick assessment to get personalized recommendations based on your goals and where you are in your longevity journey.

Frequently asked questions

01 What's the difference between daily and as-needed Tadalafil?

Daily Tadalafil is an ongoing low-dose approach chosen for steady blood-flow support and BPH or erectile-function benefits. As-needed Tadalafil is a higher dose taken before intimacy for erectile dysfunction. A clinician matches the option to your goals.

02 Is using Tadalafil for longevity FDA-approved?

No. Tadalafil is FDA-approved for erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Its use for longevity is off-label.11

03 Does Tadalafil work for women?

Most longevity and cardiovascular evidence is in men. Tadalafil is used in both men and women for pulmonary arterial hypertension, and some cardiometabolic studies include women, but data specific to women’s longevity is still limited.

04 How will I know if Tadalafil is working?

For blood-flow and longevity goals, your care team may follow markers such as blood pressure and other cardiometabolic measures over time, alongside how you feel. Individual response varies, and a clinician guides what to track.

05 Who shouldn't take Tadalafil?

Tadalafil should not be combined with nitrates, which can cause a dangerous drop in blood pressure, and it may not suit people with certain heart conditions. A clinician reviews your health history before prescribing.

06 How fast does Tadalafil work, and how long does it last?

Taken as needed, Tadalafil can take effect within a couple of hours and last up to a day and a half, which is why it’s sometimes called the weekend option. Taken daily, it builds steady levels over time. A clinician guides timing.

Our idea of a bedtime story?
PubMed.

We vet everything on PubMed so you don’t have to. Here’s what the science says.
1
A retrospective cohort of men with erectile dysfunction linked Tadalafil use to about 44% lower all-cause mortality, and up to 60% fewer major cardiac events in the highest-exposure group.
Clin Cardiol, 2024
2
A separate cohort study found Tadalafil use associated with a decreased risk of major adverse cardiac events.
World J Urol, 2022
3
Nitric oxide and cGMP signaling drive the blood-vessel relaxation behind circulation and erectile function.
J Clin Hypertens, 2007
5
cGMP and nitric-oxide signaling decline in the aging brain and in Alzheimer’s disease.
Mol Neurobiol, 2010
6
In men with BPH and erectile dysfunction, daily low-dose Tadalafil improved inflammatory markers and cognitive performance.
Sci Rep, 2019
7
A review proposed low-dose Tadalafil within an anti-aging formula, citing cGMP anti-inflammatory effects and lifespan signaling in C. elegans.
Oncotarget, 2017
8
In people with head-and-neck cancer, Tadalafil augmented tumor-specific immunity in a small study.
Clin Cancer Res, 2016
9
In diabetic mice, Tadalafil reduced inflammation and showed cardioprotective effects.
PLoS One, 2012
10
In a rat model, the PDE5 inhibitor Tadalafil had renoprotective effects.
Physiol Rep, 2020
11
A reference review notes Tadalafil is a PDE5 inhibitor FDA-approved for erectile dysfunction, BPH, and pulmonary arterial hypertension.
StatPearls, 2024
12
A cohort study of men with erectile dysfunction found that starting a PDE5 inhibitor was associated with up to 44% lower risk of developing Alzheimer’s disease.
Neurology, 2024