Day 1
Within hours, Metformin begins working in the liver and gut, where it may help reduce how much extra sugar enters the bloodstream.5
Metabolism & Longevity
Metformin Rx
A once-daily pill that may help the body use sugar more efficiently, support appetite control, and build a stronger metabolic foundation for long-term health.
Starting at
$25
/mo
- US-licensed pharmacies
- Gentle ramp-up protocol
- Clinician-guided dosing
- Pause or cancel anytime
Works across the body to support healthier sugar metabolism⁵
May help shift sugar toward energy use instead of excess storage⁶
Supports the cellular pathways behind weight, energy, and long-term health⁶
HSA / FSA
Free, discreet shipping
Ongoing, expert support
100% online
Frequently asked questions
What is Metformin and how does it work for longevity?
Metformin is a prescription medication with over 60 years of safety data.3 Research suggests Metformin activates AMPK, an energy sensor inside cells.6 Think of it as flipping a switch that tells the body to burn stored energy, clean out cellular waste, also known as autophagy, and reduce inflammation.7 This may activate some of the same cellular pathways associated with calorie restriction and exercise, two of the most well-established longevity levers.8
Targeting these pathways with precision may help overcome biological resistance to change that accumulates with age.9
These mechanisms form the basis for Metformin’s growing interest as a longevity intervention, including the first-ever FDA-approved longevity clinical trial (Targeting Aging with Metformin, TAME) built to study its effects on preventing age-related disease and extending longevity.4 Metformin is widely prescribed off-label by US-licensed providers based on a growing body of peer-reviewed research demonstrating effects on slowing organ aging and reducing the incidence of age-related disease.1 0
Is Metformin only for people with diabetes?
No. While Metformin is FDA-approved for type 2 diabetes, it is widely used off-label for its potential metabolic and longevity benefits in non-diabetic individuals. Research suggests Metformin may help support insulin sensitivity, cognitive function, heart health, and cellular health in people without diabetes.3 1 1
What are the side effects of Metformin?
The most commonly reported side effects of Metformin are gastrointestinal in nature and may include nausea, stomach upset, or diarrhea, particularly when first starting the medication. These side effects are often mild and may decrease over time as the body adjusts. Taking Metformin with food and starting at a lower dose may help reduce gastrointestinal discomfort.
Long-term use of Metformin may also affect Vitamin B12 absorption in some individuals, which is why monitoring B12 levels is recommended. Please see important safety information and consult your provider about the potential risks and benefits.
Usage instructions
View all FAQs
Start with half a tablet or one tablet daily with food, and increase to your prescribed dose over the following days as your body adjusts. If prescribed, a US-licensed provider will provide a tailored dosage schedule and specific treatment instructions with your care plan.
Important safety information and common side effects
Metformin is generally a safe and well-tolerated medication. In 1997, Metformin was included in the World Health Organization’s List of Essential Medicines, a catalogue of the safest and most effective medications available.
You must stop taking Metformin at least a week before any surgical procedure or medical diagnostic requiring contrast, such as a CT scan. If you are unsure if you should stop Metformin for any surgery or medical procedure, please ask the doctor ordering the test or procedure.
Most common Metformin side effects
Gastrointestinal (GI) side effects are common when first starting Metformin, but often go away on their own within a few weeks. Side effects may return when increasing your dose.
Our patients report* the following as the most common side effects of Metformin:
- Diarrhea (20%)
- Upset stomach (16%)
- Nausea (11%)
- Fatigue (8%)
- GI cramping (7%)
Most people start with a small dose and slowly increase to their prescribed dose to avoid stomach discomfort.
To help prevent side effects from occurring or persisting, try the following strategies:
- Eat slower and at more regular intervals throughout the day
- Try to take your medication at around the same time each day
- Avoid excessive alcohol intake
- Drink water before taking your dose
- Avoid fried, greasy foods in favor of healthier, low-fat options
- Take ginger or peppermint oil supplements to help relieve nausea
Read our blog for more information on how to minimize Metformin side effects.
Metformin has been associated with vitamin B12 deficiency in clinical studies. This risk may be higher in those prescribed higher doses of Metformin. Our providers often recommend taking B12 Injections or B12 supplements to minimize the risk of deficiency. If you notice symptoms of B12 deficiency, contact your prescriber or your general healthcare provider.
For a full list of possible side effects, please review the Mayo Clinic’s Metformin resources.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
*Actual results may vary. Data was self-reported by 12,100 surveyed customers who checked in with their provider between 1/1/23 and 9/22/25, after 30 days of starting Metformin. All respondents are AgelessRx Metformin customers who were approved for a prescription and recommended a dose of 1,000mg/day after completing an assessment with a medical provider. Data does not account for patients who may experience multiple side effects.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality.
What is Metformin?
(met-for-muhn)When sugar is not being managed efficiently, it touches everything: cravings, hunger, weight, energy, and daily life.
Metformin may help by working like a metabolic traffic controller, helping the liver release less sugar, influence gut signals tied to fullness, and support AMPK, the cellular switch that helps the body decide whether to store fuel or use it.5 6
When sugar is handled better, the whole system can feel less chaotic with fewer spikes, steadier signals, and a stronger foundation for weight, energy, and aging.
Metformin may help by working like a metabolic traffic controller, helping the liver release less sugar, influence gut signals tied to fullness, and support AMPK, the cellular switch that helps the body decide whether to store fuel or use it.5 6
When sugar is handled better, the whole system can feel less chaotic with fewer spikes, steadier signals, and a stronger foundation for weight, energy, and aging.
Metformin may help with more than metabolism.
How Metformin works
30 Days
Blood sugar responses may begin to feel steadier, with fewer energy dips and less desire to snack between meals.2 1 2
3 Months
Insulin sensitivity may improve, helping the body manage sugar with less effort. Weight support may become more noticeable.2 5
6 Months
Metabolic signals may continue to shift, supporting healthier inflammation patterns, steadier energy, and clearer focus.1 1 3
1 Year and Beyond
Long-term use may support the metabolic and cellular pathways that researchers study, which are connected to cardiovascular health, cognitive aging, cancer biology, and healthspan.1 1 0
Day 1
Within hours, Metformin begins working in the liver and gut, where it may help reduce how much extra sugar enters the bloodstream.5
30 Days
Blood sugar responses may begin to feel steadier, with fewer energy dips and less desire to snack between meals.2 1 2
3 Months
Insulin sensitivity may improve, helping the body manage sugar with less effort. Weight support may become more noticeable.2 5
6 Months
Metabolic signals may continue to shift, supporting healthier inflammation patterns, steadier energy, and clearer focus.1 1 3
1 Year and Beyond
Long-term use may support the metabolic and cellular pathways that researchers study, which are connected to cardiovascular health, cognitive aging, cancer biology, and healthspan.1 1 0
Results you can feel
- 0
- felt benefits by first check-in
- 0
- reported better blood sugar levels
- 0
- noticed improved appetite control
- 0
- noticed less cravings
Actual results may vary. Data was self-reported by 4,803 surveyed customers who checked in with their provider between their first and fourth check-in between 4/7/22-10/1/25. All respondents are AgelessRx Metformin customers who were approved for a prescription after completing an assessment with a medical provider.
Leading Metformin into longevity care
Backed by a Stanford PhD-led Research Team and more than 100,000 real-world customer journeys, we’ve spent years refining how Metformin is prescribed, dosed, and supported for people thinking beyond blood sugar.
Gentle ramp-up dosing designed for easier adjustment
Metformin included in our XPRIZE Healthspan longevity clinical trial
Protocols refined across 100K+ real-world customer journeys
Clinically studied
The science of Metformin
Metformin is one of the most widely prescribed medications worldwide. The side effects of Metformin are often mild, and its safety profile is widely established. FDA-approved to treat diabetes since 1994, Metformin supports healthy blood sugar by reducing how much glucose is released from the liver and improving glucose absorption in organs throughout the body.3
In clinical studies, Metformin showed a range of potential benefits, including reduced inflammation, improved insulin sensitivity, weight loss, and lowered risk of heart attack and dementia, among other age-related diseases.1 2
In clinical studies, Metformin showed a range of potential benefits, including reduced inflammation, improved insulin sensitivity, weight loss, and lowered risk of heart attack and dementia, among other age-related diseases.1 2
How it works
Choosing how you age starts here
1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
2
Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy partner, rigorously inspected for quality, and shipped discreetly to your door.
3
100% online
Receive continuous support
Start with one goal, then keep building over time. With our in-house care team, unlimited provider messaging, easy refills, unlimited dosage adjustments, and 40+ science-backed plans, your care evolves with you.
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Disclaimer
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. See above for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
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Frequently asked questions
Metformin is not a weight loss medication, but research suggests it may help support weight management in some individuals, particularly those with insulin resistance or metabolic dysfunction. Metformin may help support insulin sensitivity and healthy glucose metabolism, which may play a role in appetite regulation and fat storage.
It is generally not recommended for individuals with significant kidney impairment, liver dysfunction, a history of lactic acidosis, or those who consume alcohol heavily. Metformin is also not prescribed for individuals with an HbA1c above 7.5, as this may indicate a level of blood sugar dysregulation that requires more comprehensive medical management.
Individual experiences vary. Some may begin noticing initial changes such as more stable energy levels and reduced appetite within the first few weeks of consistent use. Changes in blood sugar levels may become more noticeable over 2–3 months, particularly when monitored with tools like a Continuous Glucose Monitor.
Some people notice changes in appetite or energy within the first few weeks; others feel less directly since much of what Metformin supports happens at the cellular level. Blood sugar and metabolic markers, biological age testing, and routine labs are the more reliable way to track progress over time. Your AgelessRx provider will monitor your results and may adjust your protocol as needed.
Many of our users use Metformin as part of a broader longevity protocol alongside other treatments, such as NAD+, Rapamycin, Microdosing GLP-1, and Vitamin B12. Your care team will continue to monitor your progress and adjust your protocol over time.
Some research suggests Metformin may blunt certain exercise adaptations, particularly muscle gains from strength training, in some individuals. This effect isn’t universal and appears dose- and person-dependent. If you strength train regularly, mention this to your provider. Your dose and protocol can be adjusted based on your goals and how your body responds.
As you wish
(peer reviewed).
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