Day 1
With the first dose, SGLT2 Inhibitors may help flush up to 80g of excess sugar a day, potentially reducing toxic glucose buildup and kickstarting a metabolic reset.4
Glucose
Longevity
Brenzavvy® Rx
One of longevity's most promising classes of treatments, this daily pill helps remove 50–80g of glucose per day while mimicking metabolic signals associated with caloric restriction.
Starting at
$99
/ mo
- Billed $99 for first order
- $125/month ongoing
- US-licensed pharmacies
- Pause or cancel anytime
Supports steady caloric deficit of up to 360 calories per day⁴
SGLT2 Inhibitors studied across lifespan, heart, kidney, brain, and cellular health⁵ ⁶ ⁷
May activate AMPK, SIRT1, and mTOR longevity pathways¹
HSA / FSA
Ongoing, expert support
Free, discreet shipping
100% online
Frequently asked questions
How does Brenzavvy® work?
Brenzavvy® (Bexagliflozin) is an SGLT2 Inhibitor, meaning it blocks a specific transporter in the kidneys that would otherwise pull glucose back into the bloodstream.3 With that transporter blocked, more glucose passes out through urine instead of staying in circulation, which is how it supports lower blood sugar and why it’s FDA-approved for adults with type 2 diabetes.2
How do I take Brenzavvy®?
Brenzavvy® is a once-daily tablet, taken in the morning with or without food, according to your provider’s guidance. It’s not automatically the right fit for everyone, kidney function plays a role in whether it’s appropriate, so your provider reviews your labs before prescribing.
What are the side effects of Brenzavvy®, and who shouldn't take it?
The most common side effects are genital yeast infections, urinary tract infections, and increased urination, since the medication’s mechanism means more sugar, and more fluid, passing through the urinary tract than usual.2 Less common but more serious risks include dehydration, low blood sugar (especially when combined with insulin or certain other diabetes medications), and rare but serious complications like ketoacidosis. It’s not recommended for anyone with significantly reduced kidney function, and your provider screens for these risk factors before prescribing. See the full safety information below for the complete list.
Usage instructions
View all FAQs
Brenzavvy® is taken once-daily in the morning, with or without food, according to your provider-guided schedule. If prescribed, a US-licensed medical provider will provide specific treatment instructions with your care plan.
Important safety information and common side effects
The most common side effects of SGLT2 Inhibitors include increased urination, dehydration, hypotension (low blood pressure), dizziness, urinary tract infections (UTIs), and genital mycotic infections (yeast infections). Increased urination is a normal side effect of SGLT2 Inhibitors and not cause for concern.
UTIs and yeast infections are among the most frequently reported side effects of SGLT2 Inhibitors. To reduce the risk of these and other side effects, drink plenty of water throughout the day (around 0.5 to 1 gallon) and follow proper genital hygiene practices. If you experience a UTI or yeast infection, you must seek treatment with your primary healthcare provider or a local urgent care clinic.
If you notice side effects other than increased urination, it’s okay to stop taking the medication until side effects clear—usually after a few days and up to a few weeks. Always let your provider know if you stop your medication so they can adjust your upcoming refills if necessary.
Serious side effects include euglycemic diabetic ketoacidosis (eDKA), Fournier’s gangrene, and acute kidney injury. These side effects typically occur in patients with diabetes or compromised kidney function. Please tell your provider if you or anyone in your family has diabetes or compromised kidney function, or any other medical condition. AgelessRx does not manage or treat diabetes.
The above is not an exhaustive list. Please review Mayo Clinic’s resources for Brenzavvy® (Bexagliflozin).
Brenzavvy® (Bexagliflozin) should not be used by anyone taking insulin, sulfonylureas (Amaryl, Glucatrol, Micronase, etc.), or digoxin (Digox, Lanoxin).
Brenzavvy® should not be taken by anyone with the following conditions:
- Type 1 diabetes
- History of diabetic ketoacidosis
- Severe peripheral vascular disease
- History of amputation
- History of pancreatic impairment
- Active cancer
- Pregnant or breastfeeding
Your provider may ask you for additional information if you have one of the following conditions:
- Types 2 diabetes
- Renal impairment
- High AST/ALT ratio
- Abnormally high or low blood pressure
- Low-carbohydrate or ketogenic diet
Though rare, allergic reactions to Brenzavvy® (Bexagliflozin) are still possible. If you notice any shortness of breath or swelling around your face, tongue, or throat after using Brenzavvy®, stop use and contact emergency services right away.
As with any medication, the dose prescribed is for you and you alone. Do not, under any circumstances, allow anyone else to use your Brenzavvy® prescription.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate.
What is Brenzavvy®?
(bren-ZA-vee)A once-daily SGLT2 Inhibitor that may help the body release 50–80g of glucose through urine each day—about the same amount of sugar found in two cans of soda.3 4
By mimicking the metabolic effects of caloric restriction, Brenzavvy® may influence nutrient-sensing pathways that support broader healthy-aging outcomes across heart, kidney, liver, cognitive, and metabolic health.1
Removes up to 50-80g of glucose daily—the equivalent of two cans of soda.
80g
How Brenzavvy® works
30 Days
Over several weeks, blood pressure and blood sugar may begin to stabilize, often leading to clearer thinking and better energy.1 3
3 Months
With consistent use, SGLT2 Inhibitors may mimic steady calorie restriction, activating longevity pathways that may clear senescent cells and reduce inflammation.1 10
6 Months
May encourage moderate weight loss of 2-4% body weight, potentially improving VO2 max with measurable reductions in diabetes and heart disease risk.2 6 11
1 Year and Beyond
The true benefits of SGLT2 Inhibitors emerge, potentially offering increased protection against heart disease, kidney disease, dementia, and overall mortality.1
Day 1
With the first dose, SGLT2 Inhibitors may help flush up to 80g of excess sugar a day, potentially reducing toxic glucose buildup and kickstarting a metabolic reset.4
30 Days
Over several weeks, blood pressure and blood sugar may begin to stabilize, often leading to clearer thinking and better energy.1 3
3 Months
With consistent use, SGLT2 Inhibitors may mimic steady calorie restriction, activating longevity pathways that may clear senescent cells and reduce inflammation.1 10
6 Months
May encourage moderate weight loss of 2-4% body weight, potentially improving VO2 max with measurable reductions in diabetes and heart disease risk.2 6 11
1 Year and Beyond
The true benefits of SGLT2 Inhibitors emerge, potentially offering increased protection against heart disease, kidney disease, dementia, and overall mortality.1
We’re advancing SGLT2 longevity research
Brenzavvy® sits at the intersection of established medicine and emerging longevity research. Our in-house expert team brings both together to understand the science and determine how SGLT2 inhibitors may fit into a broader longevity plan.
In-house care team with 199+ years of combined clinical experience
Stanford PhD-led Research Team focused specifically on longevity
Peer-reviewed research and 100,000+ data points informing our approach
Why longevity researchers are excited about Brenzavvy®
Lifespan potential
The newest SGLT2 Inhibitor, a longevity drug class that extended median lifespan by 14% in male mice.5
Heart & kidney health
The SGLT2 class has demonstrated heart and kidney benefits in specific populations.6 8
Brain-health potential
Emerging research links SGLT2 Inhibitors with lower dementia and Parkinson’s risk.7 9
Clears “zombie” cells
Preclinical research suggests SGLT2 Inhibitors may help clear senescent “zombie” cells.10
Less cellular wear
May reduce inflammation and oxidative stress associated with aging.1
Lifespan potential
The newest SGLT2 Inhibitor, a longevity drug class that extended median lifespan by 14% in male mice.5
Heart & kidney health
The SGLT2 class has demonstrated heart and kidney benefits in specific populations.6 8
Brain-health potential
Emerging research links SGLT2 Inhibitors with lower dementia and Parkinson’s risk.7 9
Clears “zombie” cells
Preclinical research suggests SGLT2 Inhibitors may help clear senescent “zombie” cells.10
Less cellular wear
May reduce inflammation and oxidative stress associated with aging.1
Clinically studied
The science of Brenzavvy®
SGLT2 Inhibitors started as blood sugar treatments. Today, researchers rank them among the leading longevity medicine candidates in geroscience because they may recreate some of the metabolic effects of caloric restriction while influencing nutrient sensing, inflammation, oxidative stress, mitochondrial function, autophagy, and cellular aging.1 12
SGLT2 Inhibitors have shown to extend lifespan in male mice, while research across the class has found meaningful heart and kidney benefits in certain human populations and explored potential effects on brain health and senescent “zombie” cells.1 5 7 10
Clinician-guided
Personalized care that starts with you
Your metabolism shapes how you feel today—and how you age tomorrow. We make it easier to support it with expert-guided, science-backed care.
$99/first month
Applies to first month ($125/mo after)
What’s included
-
Personalized, clinician-guided plan
-
Flexible monthly plans
-
Dispensed by US-licensed pharmacy
-
Unlimited protocol adjustments and messaging
-
Ongoing support and check-ins
-
Pause or cancel anytime
-
Backed by our in-house Stanford PhD-led team
How it works
Choosing how you age starts here
1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
2
Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is fulfilled by a US-licensed, LegitScript-certified pharmacy partner, rigorously inspected for quality, and shipped discreetly to your door.
3
100% online
Receive continuous support
Start with one goal, then keep building over time. With our in-house care team, unlimited provider messaging, easy refills, unlimited dosage adjustments, and 40+ science-backed plans, your care evolves with you.
Get Started
Disclaimer
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See above for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
More options
Metabolic health, personalized.
Metformin
A once-daily pill that may help the body use sugar more efficiently, support appetite control, and build a stronger metabolic foundation for long-term health.
Starting at $25/ mo
Invokana®
The SGLT2 Inhibitor behind some of longevity’s biggest headlines. This daily pill may help remove 50–80g of glucose, with extremely promising outcomes across lifespan, organ health, and cellular aging.
Starting at $399/ mo
Microdosing Tirzepatide
New
A low-dose GLP-1 approach designed to work in sync with the body, which may help minimize side effects, quiet cravings, and support moderate weight loss.
Starting at $159/ mo
Injectable GLP-1 Treatments
A clinician-guided GLP-1 treatment plan designed to support appetite regulation, metabolic health, and long-term care beyond the scale.
Starting at $139/mo
Rapamycin
One of longevity’s most talked-about therapies, it has extended lifespan across every model organism studied by lowering mTOR, and helping cells clear damage, repair, and stay functional longer.
Starting at $65/ mo
Low Dose Naltrexone
Unlike other treatments, works with the immune system to support a healthier inflammatory response, potentially helping with pain, energy, brain fog, and overall quality of life.
Starting at $25/ mo
Frequently asked questions
Both Invokana® and Brenzavvy® are SGLT2 Inhibitors that work the same way. The primary difference is that Invokana® has an extended range of FDA-approved uses: while Brenzavvy® is the newest SGLT2 Inhibitor that is FDA approved for type 2 diabetes, Invokana® is approved for type 2 diabetes and to reduce the risk of heart and kidney disease.13
Invokana® has also been patented since 2013, with a wealth of scientific studies to support its extended uses. Though Brenzavvy® is a relatively new SGLT2 Inhibitor (FDA approved in 2023), it still shares the same mechanism of action and may show similar longevity benefits as research continues.
While Brenzavvy® has only been FDA approved since 2023, Invokana® has been patented since 2013, with a wealth of scientific studies to support its extended uses, which may explain its higher price.
AgelessRx provides Invokana® and Brenzavvy® at a competitive price according to what our pharmacy partners can source from the manufacturer. AgelessRx does not accept insurance for Invokana® or Brenzavvy® and does not treat or manage type 2 diabetes or any other FDA-approved condition for SGLT2 Inhibitors.
Invokana® (Canagliflozin) and Brenzavvy® (Bexagliflozin) are both oral medications, taken by mouth once per day. Simply swallow each dose with a glass of water. Both should be taken in the morning, before the first meal of the day.
Since Brenzavvy® works on blood sugar and glucose excretion, results may mostly show up in lab work before they show up in how you feel day to day. Blood sugar improvements are often seen within the first few weeks of consistent use, while any changes in weight tend to build more gradually over months, in line with how the calorie deficit adds up over time. Your provider can adjust your plan based on how you respond.
Say hello to my
little citation.
We vet everything on PubMed so you don’t have to. Here’s what the science says.