2 Weeks
Sermorelin begins supporting the brain’s GH regulation system and boosting systemic GH levels.2
Energy & Fatigue
Sermorelin Injection Rx
Supports energy, lean muscle mass, and strength by encouraging the body to replenish its own growth hormone gradually—without the risks of synethetic HGH.
Starting at
$99
/ first mo
- Monthly and 3-mo plans
- 3-mo plan billed $397 for first shipment
- US-licensed pharmacies
- Pause or cancel anytime
90% saw noticeable results by their 2nd check-in
Shown to support deeper, more restorative sleep⁵
Supports lean muscle and strength²
HSA / FSA
Ongoing, expert support
Free, discreet shipping
100% online
Frequently asked questions
How do you take Sermorelin Injection?
Sermorelin is taken as a subcutaneous injection into a fatty layer of tissue such as your thigh or abdomen. If you’re approved for a Sermorelin prescription, your provider will provide a tailored titration schedule and dosing instructions.
Is Sermorelin Injection safe?
Sermorelin is generally well tolerated with a minimal risk of side effects. Sermorelin is often considered safer than other HGH therapies because it works with the body’s natural systems to produce HGH, as opposed to direct HGH replacement. However, there are risks with any treatment. Please see important safety information for Sermorelin and consult your provider about the potential risks and benefits.
Is Sermorelin a steroid?
No, Sermorelin has a different mechanism of action than steroids.
Sermorelin is a peptide that mimics growth hormone-releasing hormone (GHRH), stimulating the pituitary gland in the brain to release more of the body’s natural human growth hormone (HGH).
Steroids mimic hormones directly, acting as a replacement without stimulating the body to release its own hormones. This increases the risk of hormone imbalance, mood disorders, liver damage, and other related side effects.
Usage instructions
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Sermorelin Injections are self-injected 1-3 times per week, with or without food, according to your provider-guided titration schedule. If prescribed, a US-licensed provider will provide a tailored dosage schedule and specific treatment instructions with your care plan.
Important safety information and common side effects
Side effects
The most common side effects of Sermorelin include:
- Pain, redness, or irritation at the injection site
- Face or neck flushing
- Headache
- Nausea
Side effects are usually mild and often go away on their own within a week or two.
For a full list of side effects, please review Healthline’s Sermorelin resources.
Potential drug interactions
Sermorelin has no known major drug interactions, but may have the following interactions with certain drugs:
- Glucocorticoids (prednisone)
May blunt growth hormone (GH) release - Oral estrogens
May increase IGF-1 resistance - Insulin or sulfonylureas
May alter glycemic control - Somatostatin analogs
May antagonize Sermorelin’s effects - Dopamine antagonists
May disrupt human growth hormone (HGH) regulation - GABAergic meds
May reduce pulsatility of HGH release - Beta blockers (Metoprolol or Propranolol)
- Other secretagogues/peptides
May result in unsafe levels of HGH
Other important safety information
Sermorelin is only for users who are at least 30 years old. Customers under 30 should explore other longevity solutions.
Your provider may ask you for additional information if you have one of the following conditions:
- Hypothyroidism
Untreated hypothyroidism can impair a user’s growth hormone (GH) response. Users with hypothyroidism may be asked to show that their condition is treated and managed - Hyperglycemia or diabetes
Taking Sermorelin with untreated hyperglycemia or diabetes may further impair glycemic control. Users with hyperglycemia or diabetes may be asked to show that their condition is treated and managed
Sermorelin should not be used by anyone with moderate to severe liver dysfunction or kidney disease.
Do not use Sermorelin if you have an active cancer, or if you have had cancer within the last two years.
Do not use Sermorelin if you are pregnant, breastfeeding, or planning to become pregnant or breastfeed. If you become pregnant while taking Sermorelin, consult your provider before continuing with your next dose.
Though rare, allergic reactions to Sermorelin are still possible. If you notice any shortness of breath or swelling around your face, tongue, or throat after using Sermorelin, stop use and contact emergency services right away. Mild allergic reactions around the injection site are normal and not cause for emergency.
As with any prescription medication, the dose prescribed is for you and you alone. Do not, under any circumstances, allow anyone else to use your Sermorelin.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality.
What is Sermorelin?
(ser-mor-luhn)After age 30, human growth hormone (HGH) levels decline by up to 15%1 per decade, impacting everything from metabolism and muscle tone to recovery and sleep quality.2
Unlike other synthetic options that override the system, Sermorelin works with the body, stimulating natural HGH production from the brain to potentially support lean muscle mass, energy, and metabolism.2
Unlike other synthetic options that override the system, Sermorelin works with the body, stimulating natural HGH production from the brain to potentially support lean muscle mass, energy, and metabolism.2
Growth hormone levels drop up to 45% between age 30 and 60.8
45%
How Sermorelin works
2 Months
As tissue regeneration and recovery improves, users may notice improved energy, strength, and endurance.2 3
3 Months
Sleep may become deeper and more restorative with easier weight loss and muscle gain.1 2 5
6 Months
As body composition shifts, users may notice benefits in metabolic health, mood, and overall quality of life.2
1 Year and Beyond
Studies suggest continued GH support may help build cellular resilience for long-term protection of muscle, bone, and brain health.6
2 Weeks
Sermorelin begins supporting the brain’s GH regulation system and boosting systemic GH levels.2
2 Months
As tissue regeneration and recovery improves, users may notice improved energy, strength, and endurance.2 3
3 Months
Sleep may become deeper and more restorative with easier weight loss and muscle gain.1 2 5
6 Months
As body composition shifts, users may notice benefits in metabolic health, mood, and overall quality of life.2
1 Year and Beyond
Studies suggest continued GH support may help build cellular resilience for long-term protection of muscle, bone, and brain health.6
Results you can feel
- 0
- reported better muscle building
- 0
- reported noticeable benefits by second check-in
- 0
- reported better moods
- 0
- felt more energized
Actual results may vary. Data was self-reported by 392 surveyed customers who checked in with their provider between second and third check-in; dates 8/05/2025 – 1/22/26. All respondents are AgelessRx Sermorelin Injection customers who were approved for a prescription after completing an assessment with a medical provider.
Clinically studied
The science of Sermorelin
Sermorelin is an analog of growth hormone-releasing hormone (GHRH). Unlike direct HGH therapy, Sermorelin signals the pituitary gland to release human growth hormone (HGH) in a pulsed, physiological rhythm, supporting a more balanced approach to hormone therapy.1 7
Research suggests Sermorelin may help naturally restore essential hormones, supporting the ability to build muscle, restore energy, and improve overall quality of life.2 3
Research suggests Sermorelin may help naturally restore essential hormones, supporting the ability to build muscle, restore energy, and improve overall quality of life.2 3
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Expert care that starts with you
Our in-house care team with 199+ years of combined expertise meets you where you are, and gets you to where you want to be.
$99/first month
Applies to 3-month plan billed in full ($149/mo after)
What’s included
-
Personalized, clinician-guided plan
-
Monthly and 3-month plans
-
Dispensed by US-licensed compounding pharmacy
-
Unlimited protocol adjustments and messaging
-
Ongoing support and check-ins
-
Pause or cancel anytime
-
Backed by our in-house Stanford PhD-led team
How it works
Choosing how you age starts here
1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
2
Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy partner, rigorously inspected for quality, and shipped discreetly to your door.
3
100% online
Receive continuous support
Start with one goal, then keep building over time. With our in-house care team, unlimited provider messaging, easy refills, unlimited dosage adjustments, and 40+ science-backed plans, your care evolves with you.
Get Started
Disclaimer
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. See above for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
More options
Energy, personalized.
Sermorelin Nasal Spray
New
A targeted nasal spray that may support natural growth hormone signaling in the brain, helping promote deeper sleep, clearer thinking, and balanced recovery without injections.
Starting at $149/ mo
NAD+ Injection
Boost energy, improve focus, and support cellular health with one of the most effective methods of restoring depleted NAD+ levels for a fraction of the cost of IV infusions.
Starting at $79/ mo
NAD+ Nasal Spray
Support mental clarity, focus, and cognitive energy with an easy, injection-free way to boost NAD+, designed to support brain pathways and sharper thinking on the go.
Starting at $125/ mo
B12 Injection
Boost energy, improve focus, and fight fatigue with one of the most efficient ways to restore B12 levels that naturally decline with age, delivering more reliable results than supplements.
Starting at $65/mo
Low Dose Naltrexone
Unlike other treatments, works with the immune system to support a healthier inflammatory response, potentially helping with pain, energy, brain fog, and overall quality of life.
Starting at $25/ mo
Frequently asked questions
Sermorelin is generally well-tolerated with a minimal risk of side effects. The most common side effects include:
- Pain, redness, or irritation at the injection site
- Face or neck flushing
- Headache
- Nausea
Most side effects are mild and fade away on their own within a week or two.
Individual results vary, and benefits are not guaranteed. Some people may begin noticing initial changes within 4–6 weeks of starting Sermorelin, while more pronounced changes may emerge between 3–6 months of consistent use.
Results vary based on individual factors including age, baseline HGH levels, lifestyle habits, sleep quality, and adherence to dosing schedule. Because Sermorelin works by potentially supporting the body’s natural HGH production rather than replacing HGH directly, results may develop gradually and in a more physiologically natural rhythm. Your provider will monitor your progress and may adjust your dosing over time.
Sermorelin stimulates the pituitary gland, which primarily releases human growth hormone (HGH) naturally during sleep. Taking Sermorelin at night helps maximize the body’s natural HGH production. Sermorelin may also encourage healthier sleep, and should be taken on an empty stomach, making nighttime dosing the most effective strategy.
Some medications may ship with cold packs routinely or seasonally. This depends on each individual pharmacy’s packaging protocols and the stability of the medication during transit. Many medications can remain stable at room temperature for a defined shipping window, even if they are stored refrigerated after arrival.
If your medication arrives warm or without ice packs, it does not necessarily mean it is unsafe or ineffective. However, if the package is damaged or you have concerns about the condition of your medication, please contact our team for assistance.
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Peer-reviewed peptide papers.
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