Day 1
With the first dose, SGLT2 Inhibitors may help flush up to 80g of excess sugar a day, potentially reducing toxic glucose buildup and kickstarting a metabolic reset.2
Glucose Management
Invokana® Rx
The SGLT2 Inhibitor behind some of longevity’s biggest headlines. This daily pill may help remove 50–80g of glucose, with extremely promising outcomes across lifespan, organ health, and cellular aging.
Starting at
$399
/ mo
- $50 off first month
- $449/mo ongoing
- US-licensed pharmacies
- Pause or cancel anytime
Shown to extend median lifespan by 14% in male mice¹
Most extensive human outcomes of any treatment with preclinical signs of lifespan extension² ⁴
Established cardiovascular, metabolic, and kidney outcomes⁵ ⁶ ⁷
HSA / FSA
Ongoing, expert support
Free, discreet shipping
100% online
Frequently asked questions
How does Invokana® work?
Invokana® (Canagliflozin) is an SGLT2 Inhibitor, meaning it blocks a transporter in the kidneys that would otherwise reabsorb glucose back into the bloodstream.2 With that transporter blocked, more glucose may leave the body through urine instead of staying in circulation, which is how it may support lower blood sugar and mimic the longevity benefits of calorie restriction. It’s currently FDA-approved for adults with type 2 diabetes, with additional approved indications to reduce cardiovascular and kidney risk in specific populations.8
How do I take Invokana®?
Invokana® is a once-daily tablet, typically started at 100mg and taken before your first meal of the day. Depending on how you respond and tolerate it, your provider may increase your dose over time.
Does Invokana® have proven heart or kidney benefits beyond blood sugar control?
Yes—and this is where Invokana® has real human data. The CANVAS program found Canagliflozin reduced major adverse cardiovascular events by 14% and heart failure hospitalizations by 33% versus placebo in people with type 2 diabetes and elevated cardiovascular risk.9
The CREDENCE trial, focused specifically on people with type 2 diabetes and chronic kidney disease, found a 30% reduction in the combined risk of kidney failure, doubling of creatinine, or cardiovascular death.6 This tier of evidence—large randomized trials with hard clinical outcomes—is the strongest ground in the entire longevity conversation around this drug class.4
Usage instructions
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Invokana® is taken once-daily in the morning, with or without food, according to your provider-guided schedule. If prescribed, a US-licensed medical provider will provide specific treatment instructions with your care plan.
Important safety information and common side effects
The most common side effects of SGLT2 Inhibitors include increased urination, dehydration, hypotension (low blood pressure), dizziness, urinary tract infections (UTIs), and genital mycotic infections (yeast infections). Increased urination is a normal side effect of SGLT2 Inhibitors and not cause for concern.
UTIs and yeast infections are among the most frequently reported side effects of SGLT2 Inhibitors. To reduce the risk of these and other side effects, drink plenty of water throughout the day (around 0.5 to 1 gallon) and follow proper genital hygiene practices. If you experience a UTI or yeast infection, you must seek treatment with your primary healthcare provider or a local urgent care clinic.
If you notice side effects other than increased urination, it’s okay to stop taking the medication until side effects clear—usually after a few days and up to a few weeks. Always let your provider know if you stop your medication so they can adjust your upcoming refills if necessary.
Serious side effects include euglycemic diabetic ketoacidosis (eDKA), Fournier’s gangrene, and acute kidney injury. These side effects typically occur in patients with diabetes or compromised kidney function. Please tell your provider if you or anyone in your family has diabetes or compromised kidney function, or any other medical condition. AgelessRx does not manage or treat diabetes.
The above is not an exhaustive list. Please review Cleveland Clinic’s resources for Invokana® (Canagliflozin).
Invokana® (Canagliflozin) should not be used by anyone taking insulin, sulfonylureas (Amaryl, Glucatrol, Micronase, etc.), or digoxin (Digox, Lanoxin).
Those taking colchicine (Mitigare, Colcrys) must stop taking the medication at least 72 hours before starting Invokana®.
Invokana® should not be taken by anyone with the following conditions:
- Type 1 diabetes
- History of diabetic ketoacidosis
- Severe peripheral vascular disease
- History of amputation
- History of pancreatic impairment
- Active cancer
- Pregnant or breastfeeding
Your provider may ask you for additional information if you have one of the following conditions:
- Types 2 diabetes
- Renal impairment
- High AST/ALT ratio
- Abnormally high or low blood pressure
- Low-carbohydrate or ketogenic diet
Though rare, allergic reactions to Invokana® (Canagliflozin) are still possible. If you notice any shortness of breath or swelling around your face, tongue, or throat after using Invokana®, stop use and contact emergency services right away.
As with any medication, the dose prescribed is for you and you alone. Do not, under any circumstances, allow anyone else to use your Invokana® prescription.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate.
What is Invokana®?
(in-vo-kahn-uh)Invokana® helps release 50–80g of glucose through urine daily, mimicking aspects of caloric restriction—one of the most studied longevity interventions in biology.2 3
It is also the molecule that extended median lifespan by 14% in male mice and has been studied for heart and kidney outcomes, inflammation, and senescent “zombie” cell clearance.1 3 4
Removes up to 50-80g of glucose daily—the equivalent of two cans of soda.
80g
How Invokana® works
30 Days
Over several weeks, blood pressure and blood sugar may begin to stabilize, often leading to clearer thinking and better energy.2 3
3 Months
With consistent use, SGLT2 Inhibitors may mimic steady calorie restriction, activating longevity pathways that may clear senescent cells and reduce inflammation.3 5 12
6 Months
By 6 months, Invokana® may encourage moderate weight loss of 2-4% body weight, potentially improving VO2 max with measurable reductions in diabetes and heart disease risk.7 13 14
1 Year and Beyond
The true benefits of SGLT2 Inhibitors emerge, potentially offering increased protection against heart disease, kidney disease, dementia, and overall mortality.4
Day 1
With the first dose, SGLT2 Inhibitors may help flush up to 80g of excess sugar a day, potentially reducing toxic glucose buildup and kickstarting a metabolic reset.2
30 Days
Over several weeks, blood pressure and blood sugar may begin to stabilize, often leading to clearer thinking and better energy.2 3
3 Months
With consistent use, SGLT2 Inhibitors may mimic steady calorie restriction, activating longevity pathways that may clear senescent cells and reduce inflammation.3 5 12
6 Months
By 6 months, Invokana® may encourage moderate weight loss of 2-4% body weight, potentially improving VO2 max with measurable reductions in diabetes and heart disease risk.7 13 14
1 Year and Beyond
The true benefits of SGLT2 Inhibitors emerge, potentially offering increased protection against heart disease, kidney disease, dementia, and overall mortality.4
We’re advancing SGLT2 longevity research
Invokana® is where our clinical care and research leadership meet. Our team did not simply review the Canagliflozin research—we completed a pilot study in healthy adults to explore its safety, glucose effects, and potential role in longevity care.
In-house care team with 199+ years of combined clinical experience
Stanford PhD-led Research Team focused specifically on longevity
Peer-reviewed studies and 100,000+ data points informing our approach
Why longevity researchers are excited about Invokana®
Lifespan evidence
Canagliflozin itself extended median lifespan by 14% in male mice in the longevity gold standard NIH Interventions Testing Program.1
Heart & kidney health
Invokana® has some of the strongest human outcomes data in its class, with FDA-approved risk-reduction indications for cardiovascular and kidney disease in specific populations.4 9
Less cellular wear
Research suggests Canagliflozin may influence inflammation and oxidative stress associated with aging.3
Clears “zombie” cells
Preclinical research found Canagliflozin may help the immune system clear senescent cells by as much as 40-50% in mouse models.5
Brain-health potential
Emerging class-wide research is exploring associations with dementia and Parkinson’s disease risk.10 11
Lifespan evidence
Canagliflozin itself extended median lifespan by 14% in male mice in the longevity gold standard NIH Interventions Testing Program.1
Heart & kidney health
Invokana® has some of the strongest human outcomes data in its class, with FDA-approved risk-reduction indications for cardiovascular and kidney disease in specific populations.4 9
Less cellular wear
Research suggests Canagliflozin may influence inflammation and oxidative stress associated with aging.3
Clears “zombie” cells
Preclinical research found Canagliflozin may help the immune system clear senescent cells by as much as 40-50% in mouse models.5
Brain-health potential
Emerging class-wide research is exploring associations with dementia and Parkinson’s disease risk.10 11
Clinically studied
The science of Invokana®
Much of the longevity excitement surrounding SGLT2 Inhibitors centers on Canagliflozin. It extended lifespan in male mice, has been explored for senescent-cell clearance, and has established human heart and kidney evidence in specific clinical populations.1 5 6 7
The evidence sits at three levels:
- Proven: CANVAS and CREDENCE trials showed real cardiovascular and kidney risk reduction in type 2 diabetes6 9
- Measured: Reliable glucose excretion, modest weight loss, and blood pressure reduction in humans2 3 13
- Preclinical: 14% lifespan extension in male mice, AMPK activation, and senescent-cell clearance1 3
Clinician-guided
Personalized care that starts with you
Your metabolism shapes how you feel today—and how you age tomorrow. We make it easier to support it with expert-guided, science-backed care.
$399/first month
Applies to first month ($449/mo after)
What’s included
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Personalized, clinician-guided plan
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Flexible monthly plans
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Dispensed by US-licensed pharmacy
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Unlimited protocol adjustments and messaging
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Ongoing support and check-ins
-
Pause or cancel anytime
-
Backed by our in-house Stanford PhD-led team
How it works
Choosing how you age starts here
1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
2
Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is fulfilled by a US-licensed, LegitScript-certified pharmacy partner, rigorously inspected for quality, and shipped discreetly to your door.
3
100% online
Receive continuous support
Start with one goal, then keep building over time. With our in-house care team, unlimited provider messaging, easy refills, unlimited dosage adjustments, and 40+ science-backed plans, your care evolves with you.
Get Started
Disclaimer
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See above for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
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Frequently asked questions
Both Invokana® and Brenzavvy® are SGLT2 Inhibitors that work the same way. The primary difference is that Invokana® has an extended range of FDA-approved uses: while Brenzavvy® is FDA approved for type 2 diabetes, Invokana® is approved for type 2 diabetes and to reduce the risk of heart and kidney disease.8
Invokana® has also been patented since 2013, with a wealth of scientific studies to support its extended uses. Though Brenzavvy® is a relatively new SGLT2 (FDA approved in 2023), it still shares the same mechanism of action and may show similar longevity benefits as research continues.
While Brenzavvy® has only been FDA approved since 2023, Invokana® has been patented since 2013, with a wealth of scientific studies to support its extended uses, which may explain its higher price.
AgelessRx provides Invokana® and Brenzavvy® at a competitive price according to what our pharmacy partners can source from the manufacturer. AgelessRx does not accept insurance for Invokana® or Brenzavvy® and does not treat or manage type 2 diabetes or any other FDA-approved condition for SGLT2 Inhibitors.
The most common side effects are genital yeast infections and urinary tract infections, reported somewhat more frequently with Invokana® than with some other SGLT2 Inhibitors, along with increased urination. Invokana® isn’t recommended for anyone with a history of foot ulcers, poor circulation, or prior amputation, and your provider screens for these factors before prescribing. See the full safety information above for the complete list.
Taking SGLT2 Inhibitors in the morning is a dual strategy for decreasing the chances of excessive nighttime urination and to avoid potential glucose spikes from your first meal.
SGLT2 Inhibitors may increase urination, which can interrupt sleep if the medication is still active during bedtime. These medications can also delay glucose absorption, which can reduce glucose spikes from your first meal.
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