30 Days
Autophagy–the body’s version of trash removal–gets more support, potentially helping cells clear damaged material and recover more efficiently.8
Longevity Support
Rapamycin Rx
One of longevity’s most talked-about therapies, it has extended lifespan across every model organism studied by lowering mTOR, and helping cells clear damage, repair, and stay functional longer.
Starting at
$65
/ mo
- Baseline and ongoing blood work included
- Compounded and generic options
- US-licensed pharmacies
- Pause or cancel anytime
Our users were 9 biological years younger on average in 1 year
Extended lifespan across every model organism studied⁴
Guided by the Stanford PhD-led Research Team behind PEARL
HSA / FSA
Ongoing, expert support
Free, discreet shipping
100% online
Frequently asked questions
What is the PEARL Trial on Rapamycin?
PEARL stands for Participatory Evaluation of Aging with Rapamycin for Longevity. Researchers from our Stanford PhD-led Research Team designed and led the 48-week randomized, double-blind, placebo-controlled trial to study the effects of low-dose weekly Rapamycin in healthy adults ages 50 to 85.5
A total of 114 participants completed the study while our Research Team tracked safety, blood markers, body composition, and quality of life. The trial’s primary measure–visceral fat–didn’t show a significant change, but meaningful secondary findings did: women taking 10mg of compounded Rapamycin saw significant improvements in muscle mass and pain, and participants taking 5mg weekly reported improvements in general health and emotional well-being. The results were published in the peer-reviewed journal Aging in 2025.6
Why is Rapamycin being studied for longevity?
Rapamycin temporarily reduces activity in mTOR, a nutrient-sensing pathway that tells cells when to grow and when to repair. Giving that signal a break may create more time for autophagy, the process cells use to break down and recycle damaged material.2 3 Rapamycin has extended lifespan across every model organism it’s been tested in including yeast, worms, mice, and primates, making it one of the most consistently replicated longevity compounds in geroscience, and a genuinely promising candidate for extending human healthspan.6
What is the difference between Generic and Compounded Rapamycin?
A Generic Rapamycin prescription contains Sirolimus tablets that are commercially available, while Compounded Rapamycin prescriptions contain Sirolimus capsules that are compounded and mixed by a US-licensed, certified compounding pharmacy following rigorous quality controls. Compounded Rapamycin may be less potent than Generic Rapamycin, which could lead to reduced side effects as well as reduced absorption or bioavailability.7 For this reason, Compounded Rapamycin is typically prescribed at higher doses than Generic Rapamycin.
Usage instructions
View all FAQs
Rapamycin is taken once weekly according to your provider-guided titration schedule. If prescribed, a US-licensed medical provider will provide a tailored dosage schedule and specific treatment instructions with your care plan.
Important safety information and common side effects
Rapamycin is generally a well-tolerated medication and most often exhibits minor side effects, including mouth ulcers (stomatitis), nausea, and/or diarrhea.
Most side effects are mild and go away on their own within a week or two. If you notice a persistent infection, such as a mouth ulcer that won’t go away as quickly as normal, please consult your healthcare provider.
Please review the Mayo Clinic’s full list of possible side effects before getting started with a free visit.
As a substrate for p-glycoprotein and cytochrome P-450 3A4, Rapamycin may have certain interactions with other drugs or supplements that act on these proteins. These include cyclosporine, rifampin, ketoconazole, cidofovir, ritonavir, mifepristone, posaconazole, fluconazole, and grapefruit juice.
Before taking Rapamycin, be sure to review the full list of potential drug interactions and talk to your healthcare provider about any medications you are currently taking.
Do not take Rapamycin if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed.
Stop taking Rapamycin at least one month before surgery. Do not start taking Rapamycin again until your surgeon tells you it is safe to restart.
Do not take Rapamycin if you have a chronic infection (such as HIV/AIDS, Lyme disease, etc.), have any primary or secondary immune dysfunction or deficiency, and/or any allergy to Rapamycin or any of its ingredients.
While rare, it is possible that some who take Rapamycin may potentially become more susceptible to skin and/or lung infections. However, this is still being investigated and is not a proven risk associated with Rapamycin when taken at the frequency and doses prescribed at AgelessRx. If, at any time, you feel you are developing a troubling skin or lung infection, seek care at a local urgent care center, contact your PCP, or use an acute-care telemedicine service as soon as possible. Be sure to report the details to our medical team when you are able.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality.
What is Rapamycin?
(rap-uh-my-sin)Your cells are constantly deciding whether to grow or repair, and mTOR helps control that switch. With age, mTOR can stay in growth mode longer than needed, leaving less time for cellular cleanup.1 Low-dose weekly Rapamycin may briefly turn that signal down, giving cells more time to clear damaged material and repair.3
Our researchers led PEARL, the largest published randomized, placebo-controlled study of low-doses of Rapamycin for healthy aging, that showed promising improvements in muscle mass, pain, and overall health.5
Average biological age reduction after 1 year
9.43 years
Actual results may vary. Data was self-reported by 300 surveyed Rapamycin customers who checked in with their provider on between 11/1/24-10/1/25. All respondents are AgelessRx Rapamycin customers who were approved for a prescription after completing an assessment with a medical provider.
How Rapamycin works
4 Months
Immune resilience may build, with potential for fewer sick days and less inflammation-driven discomfort.9
6 Months
As inflammation eases and repair supports heart and muscle function, stamina may last longer.1 0
9 Months
Deeper cellular cleanup of senescent cells may reduce levels of pro-inflammatory factors that drive chronic inflammation, fatigue, and age-related disease.1 1
1 Year and Beyond
In our PEARL trial, we found measurable improvements in age-related decline with ongoing use, including improved lean muscle mass and reduced pain in women, and better emotional well-being and general health.5
30 Days
Autophagy–the body’s version of trash removal–gets more support, potentially helping cells clear damaged material and recover more efficiently.8
4 Months
Immune resilience may build, with potential for fewer sick days and less inflammation-driven discomfort.9
6 Months
As inflammation eases and repair supports heart and muscle function, stamina may last longer.1 0
9 Months
Deeper cellular cleanup of senescent cells may reduce levels of pro-inflammatory factors that drive chronic inflammation, fatigue, and age-related disease.1 1
1 Year and Beyond
In our PEARL trial, we found measurable improvements in age-related decline with ongoing use, including improved lean muscle mass and reduced pain in women, and better emotional well-being and general health.5
What the PEARL Trial found
- 0
- adults tracked across safety and healthspan measures⁵
- 0
- weeks well-tolerated with safety similar to placebo⁵
- 0
- improvement in pain in women⁵
- 0
- improvement in muscle mass in women⁵
Actual results may vary. Data was reported by 114 patients from the Rapamycin PEARL Trial; dates January 2020 – December 2023. Results published April 2025.
The team behind Rapamycin’s biggest healthy aging trial
The study everyone cites? We ran it. Our Stanford PhD-led team of researchers designed and led PEARL, the largest published randomized trial of Rapamycin for healthy aging.5 Those findings are built into your care, informing how your dose, formulation, labs, and responses are managed.
Peer-reviewed PEARL findings behind your protocol
199+ combined clinical and 65+ combined research years of expertise behind your protocol
Dose and formulation guided by Rapamycin blood-level research
Clinically studied
The science of Rapamycin
mTOR is one of the body’s central nutrient-sensing pathways. When nutrients are plentiful, it signals cells to grow, build proteins, and reproduce.1 Those processes are essential, but cells also need time away from growth to clear damaged material and restore internal balance.3
Rapamycin has extended lifespan across every model organism it’s been tested in–from yeast to mice to primates–one of the most consistently replicated findings in the biology of aging.6 Used intermittently, researchers believe this creates a recurring window for autophagy and cellular recycling without continuously suppressing a pathway the body also needs for normal growth and repair, showing promise for brain health, heart function, oral health, and broader inflammation markers.1 3
Expert guided care
Care that starts with you
Your longevity journey is personal. Our clinicians meet you where you are and help guide you to where you want to be.
$65/month
Billed monthly | Shipped monthly
What’s included
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Baseline + ongoing lab work
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Personalized, clinician-guided plan
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Dispensed by US-licensed compounding pharmacy
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Unlimited protocol adjustments and messaging
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Ongoing support and check-ins
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Pause or cancel anytime
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Backed by our in-house Stanford PhD-led team
How it works
Choosing how you age starts here
1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
2
Fast, discreet shipping
Get your discreet shipment
If approved, your care team will ask you to complete blood work at a local lab, then your treatment is compounded by a US-licensed, LegitScript-certified pharmacy partner and rigorously inspected for quality.
3
100% online
Receive continuous support
Start with one goal, then keep building over time. With our in-house care team, unlimited provider messaging, easy refills, unlimited dosage adjustments, and 40+ science-backed plans, your care evolves with you.
Get Started
Disclaimer
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. See above for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
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Frequently asked questions
No. Sirolimus is FDA approved for specific medical uses, including preventing organ rejection after kidney transplantation and treating lymphangioleiomyomatosis.¹² It is not FDA approved to slow aging, extend lifespan, or improve healthspan. However, there are various studies, including the PEARL Trial, that have shown Rapamycin’s potential for longevity usages. Rapamycin may be prescribed off-label for longevity when a licensed provider determines it may be appropriate.⁵
In animal models, robustly–it’s extended lifespan in every species tested, from yeast to primates, making it one of the most replicated findings in aging biology. In humans, that’s not yet proven.⁴ ⁶ Our own PEARL trial, the largest published human trial of its kind, found real, significant improvements in specific measures like muscle mass and pain in women, as well as general health and well-being, at lower doses over 48 weeks.⁵
Transplant protocols generally use continuous immunosuppressive exposure. Longevity protocols study lower, intermittent dosing intended to reduce mTOR activity temporarily and allow recovery between doses.¹²
The PEARL trial evaluated once-weekly compounded Rapamycin for 48 weeks.⁵ Its findings should not be generalized to every dose or schedule.
Individual response varies meaningfully, and formulation matters: our own research found compounded and commercial versions differ in how much reaches your bloodstream. Your dose and formulation are set and adjusted based on your labs, response, and our own trial data, not a fixed schedule.⁷
AgelessRx currently evaluates adults aged 40 and older who are clinically stable, willing to complete required blood work, and able to participate in continued monitoring.
Age alone does not determine eligibility. Your health history, medications, immune function, laboratory results, and goals are also considered.
Is Rapamycin safe? What are the side effects? In our PEARL trial, adverse events were similar across Rapamycin and placebo groups over 48 weeks, with mild gastrointestinal symptoms and mouth sores affecting roughly 1 in 5 participants being the most common issues.⁵
Outside the trial, possible side effects can include mouth sores, nausea, diarrhea, headache, changes in cholesterol, increased infection susceptibility, and delayed wound healing. Individual risk depends on dose, health history, and other medications, which is why ongoing labs and provider monitoring are part of the plan, not optional add-ons.
Toto, I’ve got a feeling we’re not in unsourced territory anymore.
We vet everything on PubMed so you don’t have to. Here’s what the science says.