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Our science

Tretinoin

The prescription retinoid dermatologists have trusted for decades, studied to smooth fine lines and support the collagen that keeps skin firm.

Good to know

Tretinoin is a prescription form of vitamin A that may speed skin‑cell renewal and signal the skin to make more collagen.7

Decades of studies make it one of the most evidence‑backed ingredients in skin aging.3

What Tretinoin may support

Tretinoin works by speeding up skin-cell turnover and changing how skin builds collagen, which is why the strongest evidence is around photoaging, texture, and fine lines.
May smooth the look of fine lines and wrinkles.1
Supports the skin’s own collagen production.2
Studied to improve sun‑related skin aging.5
Available as a clinician-guided Tretinoin plan with ongoing support and dosage adjustments.

How Tretinoin works

Think of retinol as a message your skin has to translate before it can act on it. Tretinoin skips the translation, activating retinoic‑acid receptors that may help speed cell renewal and support collagen.7
Explore Tretinoin

Tretinoin is up to 20x more potent than over-the-counter retinols3

20x stronger
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality.

Tretinoin benefits

What Tretinoin may support for skin and healthy aging, with the evidence behind each.

Fine lines & wrinkles

May smooth the look of fine lines and wrinkles. Human studies.1

Collagen

Supports collagen formation in photodamaged skin. Human studies.2

Texture & tone

May even tone and improve sun‑related skin aging. Human studies.5

Cell renewal

Speeds skin‑cell turnover via retinoic‑acid receptors. Animal studies.7

Vitamin A & aging

Vitamin A supports skin as it naturally ages. Human studies.6

Stronger than retinol

More potent than OTC retinol, and available by prescription only. Human studies.3

Decades of evidence

Among the most‑studied skin-aging ingredients. Review.4

What to know before starting

We believe in full transparency. Here’s what to expect with Tretinoin and what the science doesn’t cover.

Compounded Rx blend

Our Tretinoin blend is compounded and not FDA‑approved for skin aging.

Expect an adjustment

Skin often purges or flakes early before it settles.

Not for pregnancy

Tretinoin isn’t for use during pregnancy or breastfeeding.

A cute bottle is not a clinical standard

Our in-house Research Team studies how Tretinoin fits real longevity skincare.
We pair Tretinoin with hyaluronic and ascorbic acid in one, clinically-backed blend.
Our Research Team tracks the retinoid science and formulates for skin aging.
Read our Research
Science-backed

Choose the experts in Tretinoin

Get a flexible plan with clinician‑guided care, regular check-ins, unlimited provider messaging, and adjustments along the way.
Trustpilot

Tretinoin educational content medically reviewed by our experts

Dr. Jenell Decker, MD

Medical Director

Trusted expert in preventative care, integrative medicine, and longevity driven clinical practice.
Marshall University Joan C. Edwards School of Medicine
East Carolina University
Concord University

Don’t know where to start?

Take our quick assessment to get personalized recommendations based on your goals and where you are in your longevity journey.

Frequently asked questions

01 Is Tretinoin FDA‑approved?

Tretinoin, the active retinoid, is FDA‑approved to treat fine facial wrinkles and acne. AgelessRx’s compounded blend, which pairs it with hyaluronic and ascorbic acid, is prescribed by a provider and isn’t FDA‑approved as a compounded product.

02 How is Tretinoin different from OTC retinol?

Retinol is a weaker vitamin A derivative your skin has to convert before it works. Tretinoin is the active retinoid itself, so it’s more potent and available by prescription only.

03 What should I expect when starting Tretinoin?

Many people see flaking, dryness, or a purge in the first few weeks as skin adjusts. Easing in and moisturizing helps, and a provider guides your routine.

04 How long until I see results with Tretinoin?

Skin renewal is gradual. Most people track fine lines, texture, and tone over a few months, and results build with consistent use and vary from person to person.

05 Do I need sun protection with Tretinoin?

Yes. Tretinoin can make skin more sensitive to the sun, so daily SPF is important while you use it.

06 Who should not use Tretinoin?

It isn’t for use during pregnancy or breastfeeding, or on broken or sunburned skin. A provider reviews your health history before prescribing.

Our idea of a bedtime story?
PubMed.

We vet everything on PubMed so you don’t have to. Here’s what the science says.
1
A double-blind, vehicle-controlled trial found topical Tretinoin improved the look of photoaged skin.
JAMA, 1988
2
A study found Tretinoin restored collagen formation in sun-damaged human skin.
NEJM, 1993
3
A clinical review summarizes Tretinoin’s efficacy and safety for skin aging across decades of studies.
Clin Interv Aging, 2006
5
A long-term study found Tretinoin’s benefits on photodamaged skin held with continued use.
J Dermatol Sci, 1996
6
A study found vitamin A (retinol) improved the appearance of naturally aged skin.
Arch Dermatol, 2007
7
A review explains how topical retinoids work through retinoic‑acid receptors to renew skin.
Cutis, 2005