NAD+SCIENCE & RESEARCH
Background & History
- Discovered by Nobel Prize-winning British biochemists in 1906
- The availability of NAD+ has shown to promote DNA health and repair
- NAD+ is required to deactivate genes that accelerate aging
- Unfortunately, scientific studies show that NAD+ levels decline significantly with age
- Historically the most effective way to boost NAD+ was through expensive infusions; pills have been shown to be less effective
- AgelessRx offers new methods of delivery (e.g. patch, nasal spray, injection, and cream) that are effective, less expensive and more convenient than other treatments
- Promotes cellular energy production
- Supports DNA health and repair
- Required to “turn off” genes that accelerate degenerative aging processes
Research & Studies
Harvard Medical School Study Shows NAD+ Boosting in Mice Decreased Aging
“They focused on an intriguing compound with anti-aging properties called NAD+…It’s been known that younger mice had more of it than older mice and back in 2013, the researchers found that when they boosted the NAD+ levels in older mice, they looked, biologically, like much younger animals.” – TIME
When NAD+ levels rise, Sirtuins are activated. Sirtuins are enzymes that influence aging and longevity. They regulate a variety of metabolic processes, including the release of insulin, stress response, and modulation of lifespan.
The David Sinclair lab at Harvard Medical school has done extensive research into the benefits of NAD+ on aging and age related-diseases. Read the Studies
When damaged, DNA activates an enzyme known as PARP-1 that carries out DNA repair within cells. NAD+ is required for PARP-1 to be activated.
PARP-1 activity correlates with maximum lifespan in mammals. The higher the PARP-1 activity, the longer the lifespan. Read Full Study
Cells from centenarians (people who are at least 100 years old) show significantly higher PARP-1 activity levels than those of average 70 year olds.
A Study done by the Developmental Biology department at the Washington University of School of Medicine found that the dysfunction of NAD+ biosynthesis plays a critical role in the pathophysiologies of multiple diseases, including age-associated metabolic disorders, neurodegenerative diseases, and mental disorders.
Age related diseases that show a strong correlation with decreases of NAD+ include:
- Non-alcoholic fatty liver disease
- Alzheimer’s disease
- Retinal degeneration
How It Works
NAD+ Works on a Cellular Level in Relation to Aging
Nicotinamide adenine dinucleotide (NAD+) is an important cofactor in all living cells, involved in fundamental biological processes including metabolism, cell signaling, gene expression, DNA repair, and more.
Systemic NAD+ decline is one of the fundamental molecular events that negatively impacts the process of aging, potentially limiting lifespan.
- NAD+ is required for energy production through metabolism, and helps turn nutrients into energy – without NAD+, we cannot make energy.
- NAD+ is required for energy production in every tissue, including the brain, immune cells, muscles, and more.
- It is a required “helper” molecule for proteins that regulate other cellular functions.
- Availability of NAD+ in the body promotes DNA repair, while NAD+ decline is associated with accumulation of DNA damage.
- NAD+ levels decrease across multiple types of tissues with age, a factor associated with many hallmarks of aging.
Important Safety Information
Since extra niacinamide needs to be methylated in order to be excreted, there is a theoretical need for extra methyl donors when using NAD+. We recommend using trimethylglycine (TMG also known as betaine), 500 to 1000mg, either daily, or at least on the days when the NAD+ patch is used. TMG is easily obtainable on Amazon or any other vitamin retailer.
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