Day 1
Intranasal delivery allows a direct line to the brain where Sermorelin may begin signaling the pituitary gland to release natural growth hormone.3
New
Energy & Fatigue
Sermorelin Nasal Spray Rx
A targeted nasal spray that may support natural growth hormone signaling in the brain, helping promote deeper sleep, clearer thinking, and balanced recovery without injections.
Starting at
$149
/ mo
- $50 off first month
- $199/mo ongoing
- Compounded by a US-licensed pharmacy
- Pause or cancel anytime
Supports deeper and REM sleep⁴
Helps promote focus, memory, and mental clarity⁵
Works with your natural growth hormone rhythm⁶
HSA / FSA
Ongoing, expert support
Free, discreet shipping
100% online
Frequently asked questions
What is Sermorelin Nasal Spray?
Sermorelin is a peptide medication that mimics growth hormone-releasing hormone (GHRH). This triggers the pituitary gland in the brain to naturally produce human growth hormone (HGH). Sermorelin Nasal Spray doesn’t simply replace HGH like other therapies. Instead, Sermorelin may help the body make more HGH naturally, reducing some of the risks associated with synthetic HGH therapy or other hormone-replacement therapies.6
Is Sermorelin Nasal Spray safe?
Sermorelin is generally well tolerated with a minimal risk of side effects.9 Sermorelin is often considered safer than other HGH therapies because it works with the body’s natural systems to produce HGH, as opposed to direct HGH replacement.6 However, there are risks with any treatment. Please see below for important safety information for Sermorelin and consult your provider about the potential risks and benefits.
How is Sermorelin Nasal Spray different from Sermorelin Injection?
Same peptide, meaningfully different evidence and delivery profile. Injectable Sermorelin is absorbed efficiently and has a longer track record in clinical literature.4 Nasal delivery may offer a more direct route to the brain, bypassing general circulation, to engage growth hormone receptors in the brain for improved sleep, mental clarity, and cognitive recovery.1 2 7
Usage instructions
View all FAQs
Sermorelin Nasal Spray is typically administered five nights per week. If prescribed, a US-licensed medical provider will provide tailored dosing instructions with your care plan.
Important safety information and common side effects
The most common side effects of Sermorelin Nasal Spray include post-nasal drip to throat, burning during administration, congestion, face and/or neck flushing, headache, and/or nausea.
Side effects are usually mild and often go away on their own within a week or two. For a full list of side effects, please review Healthline’s Sermorelin resources.
Sermorelin Nasal Spray has no known major drug interactions, but may have the following interactions with certain drugs:
- Glucocorticoids (prednisone)
May blunt growth hormone (GH) release - Oral estrogens
May increase IGF-1 resistance - Insulin or sulfonylureas
May alter glycemic control - Somatostatin analogs
May antagonize Sermorelin’s effects - Dopamine antagonists
May disrupt human growth hormone (HGH) regulation - GABAergic meds
May reduce pulsatility of HGH release - Beta blockers (Metoprolol or Propranolol)
- Other secretagogues/peptides
May result in unsafe levels of HGH
Sermorelin Nasal Spray is only for those who are at least 30 years old. Those under 30 should explore other longevity solutions.
Your provider may ask you for additional information if you have one of the following conditions:
- Hypothyroidism
Untreated hypothyroidism can impair a patient’s growth hormone (GH) response. Patients with hypothyroidism may be asked to show that their condition is treated and managed - Hyperglycemia or diabetes
Taking Sermorelin with untreated hyperglycemia or diabetes may further impair glycemic control. Patients with hyperglycemia or diabetes may be asked to show that their condition is treated and managed
Sermorelin Nasal Spray should not be used by anyone with moderate to severe liver dysfunction or kidney disease. Do not use Sermorelin Nasal Spray if you have an active cancer, or if you have had cancer within the last two years. Do not use Sermorelin Nasal Spray if you are pregnant, breastfeeding, or planning to become pregnant or breastfeed. If you become pregnant while taking Sermorelin, discontinue immediately and consult your OB.
Though rare, allergic reactions to Sermorelin Nasal Spray are still possible. If you notice any shortness of breath or swelling around your face, tongue, or throat after using Sermorelin Nasal Spray, stop use and contact emergency services right away.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality.
What is Sermorelin Nasal Spray?
(ser-morh-luhn)As natural human growth signaling changes with age, sleep, recovery, cognitive function, and body composition change with it.2
Rather than supplying synthetic HGH directly, Sermorelin signals the pituitary gland to release the body’s own growth hormone in a more natural, pulsed rhythm with potential benefits for sleep, recovery, and cognition.1 2 5 6
Natural growth hormone production may decline up to 15% per decade after age 30.1
15%
How Sermorelin Nasal Spray works
30 Days
By supporting natural GH pulses, with continuous use Sermorelin may support deeper, more restorative sleep cycles.4
3 Months
More consistent sleep and recovery support may contribute to clearer thinking, steadier energy, and improved focus.4 5
6 Months
Continued support for natural, circadian pulses of GH rhythms may help promote cognition, physical recovery, and overall quality of life.5 6 8
1 Year and Beyond
Maintaining healthier growth hormone signaling may support the muscle, brain, sleep, and metabolic systems that change with age.2
Day 1
Intranasal delivery allows a direct line to the brain where Sermorelin may begin signaling the pituitary gland to release natural growth hormone.3
30 Days
By supporting natural GH pulses, with continuous use Sermorelin may support deeper, more restorative sleep cycles.4
3 Months
More consistent sleep and recovery support may contribute to clearer thinking, steadier energy, and improved focus.4 5
6 Months
Continued support for natural, circadian pulses of GH rhythms may help promote cognition, physical recovery, and overall quality of life.5 6 8
1 Year and Beyond
Maintaining healthier growth hormone signaling may support the muscle, brain, sleep, and metabolic systems that change with age.2
Results you can feel
- 0
- reported improvements in mental health
- 0
- noticed better energy
- 0
- saw improvements in sleep
Actual results may vary. Data was self-reported by 147 surveyed customers who checked in with their provider on their second and third check-in between 10/1/25-8/2/26. All respondents are AgelessRx Sermorelin Nasal Spray customers who were approved for a prescription after completing an assessment with a medical provider.
We’re global leaders in longevity research
Sermorelin is not simply another sleep aid. Our clinical and research teams look at the growth hormone signaling involved in sleep, cognition, recovery, and healthy aging—then build personalized protocols around how your body responds.
In-house care team with 199+ years of combined clinical experience
Studied by our Stanford PhD-led Research Team in the $101M XPRIZE Healthspan competition
Prescription-grade ingredients compounded by LegitScript-certified pharmacies
Clinically studied
The science of Sermorelin
Sermorelin is an analog of growth-hormone-releasing hormone (GHRH).1 Unlike direct HGH therapy, Sermorelin signals the pituitary gland to release human growth hormone (HGH) in a pulsed, physiological rhythm, supporting a more balanced approach to hormone therapy.1 6
Research suggests Sermorelin may help naturally restore growth hormone signaling, supporting your body’s ability to build muscle, restore energy, and improve overall quality of life, among other diverse potential benefits.8
Clinician-guided care
Personalized care that starts with you
Our in-house clinicians look beyond how many hours you sleep to support the natural growth hormone signaling behind deeper rest, clearer thinking, and balanced recovery.
$149/first month
Applies to first month ($199/mo after)
What’s included
-
Personalized, clinician-guided plan
-
Flexible monthly plans
-
Dispensed by US-licensed compounding pharmacy
-
Unlimited protocol adjustments and messaging
-
Ongoing support and check-ins
-
Pause or cancel anytime
-
Backed by our in-house Stanford PhD-led team
How it works
Choosing how you age starts here
1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
2
Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy partner, rigorously inspected for quality, and shipped discreetly to your door.
3
100% online
Receive continuous support
Start with one goal, then keep building over time. With our in-house care team, unlimited provider messaging, easy refills, unlimited dosage adjustments, and 40+ science-backed plans, your care evolves with you.
Get Started
Disclaimer
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. See above for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
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Frequently asked questions
No, Sermorelin Nasal Spray has a different mechanism of action than steroids.
Sermorelin is a peptide that mimics growth hormone-releasing hormone (GHRH), stimulating the pituitary gland in the brain to release more of the body’s natural human growth hormone (HGH).
Steroids are cholesterol-derived compounds that generally mimic hormones directly, acting as a replacement without stimulating the body to release its own hormones. This increases the risk of hormone imbalance, resistance, mood disorders, liver damage, and other related side effects.6
Sermorelin Nasal Spray stimulates the pituitary gland, which naturally produces the largest growth hormone peak during sleep.11 Taking Sermorelin Nasal Spray at night helps maximize the body’s natural HGH production. Sermorelin Nasal Spray may also encourage healthier sleep, and should be administered on an empty stomach, making nighttime dosing the most effective strategy.
Sermorelin Nasal Spray should be taken on an empty stomach at night to improve absorption and reduce side effects. For the best results, administer Sermorelin Nasal Spray at least 2 hours after your last meal.
Sermorelin Nasal Spray is for people who want to explore GH support without an injection, specifically for sleep and cognitive benefits, and who are comfortable trying a promising but less-established route based on sound mechanistic reasoning and published literature suggesting enhanced growth hormone signaling.2 10 If you want the most established, best-evidenced version of this therapy, Sermorelin Injections have a deeper track record in clinical research.
Show me the
science.
We vet everything on PubMed so you don’t have to. Here’s what the science says.