Day 1
Drowsiness and a calming effect may begin after the first dose, helping some people settle into sleep easier without the GABA-driven grogginess of OTC sleep medications.1 3
Sleep
Trazodone Rx
Reclaim restful nights by supporting the brain pathways involved in sleep, which may help the body fall asleep faster, stay asleep longer, and wake up feeling more restored.
84% saw improvements in sleep quality by 1st check-in¹⁰
Supports deeper slow-wave sleep for overnight repair³
Non-habit forming sleep aid that may support natural sleep cycles¹
HSA / FSA
Ongoing, expert support
Free, discreet shipping
100% online
Frequently asked questions
How does Trazodone work for sleep?
At the low doses used for sleep, Trazodone works differently than most sleep medications. Rather than acting on the GABA pathway the way benzodiazepines and “Z-drug” hypnotics do, Trazodone may block specific serotonin (5-HT2A), histamine, and adrenaline receptors involved in wakefulness and arousal. Turning down those signals—rather than switching your brain “off”—is why it’s been associated with deeper, more natural-feeling sleep.4
Is Trazodone habit-forming?
No, and this is one of the more meaningful differences between Trazodone and classic sleep medications. Because it doesn’t act on the GABA receptor pathway that benzodiazepines and Z-drugs use, Trazodone isn’t associated with the same tolerance, physical dependence, or withdrawal-seizure risk.1 Stopping abruptly after prolonged use can still cause mild discontinuation symptoms like rebound insomnia or irritability, which is why your provider will typically recommend tapering rather than stopping cold turkey—but this is a different and substantially milder profile than the dependency concerns tied to classic sedative-hypnotics.
Does Trazodone improve deep sleep?
Controlled sleep studies have found Trazodone may measurably increase slow-wave sleep, the deepest, most physically restorative stage of the sleep cycle, without significantly suppressing REM sleep the way some other sleep medications do.1 3 That distinction of more time in deep sleep, not just more time asleep, is the core of why Trazodone has been studied for sleep quality.
Usage instructions
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Trazodone is taken nightly shortly after a meal or light snack according to your provider-guided titration schedule. If prescribed, a US-licensed medical provider will provide a tailored dosage schedule and specific treatment instructions with your care plan.
Important safety information and common side effects
Trazodone has the following common side effects: constipation, diarrhea, nausea, xerostomia (dry mouth), back aches, headaches, confusion, dizziness, insomnia, somnolence (drowsiness), blurred vision, nervousness, fatigue, vivid dreams, or nightmares. These side effects often lessen and resolve within the first few weeks of use, as the body adjusts to the medication. Side effects are dose dependent and may reoccur as you increase your dosage according to your doctor-prescribed titration plan. Our providers will not go over 100mg in any titration schedule.
People taking Trazodone should avoid driving or other activities requiring mental acuity or coordination until they are sure side effects such as confusion, dizziness, or drowsiness will not affect them.
Trazodone may cause the following rare but serious side effects: cardiac dysrhythmia, hypotension (low blood pressure), prolonged QT interval, torsades de pointes, hypersensitivity reaction, priapism (prolonged erection), or seizure. If you have a personal or family history of any of these, your AgelessRx provider may recommend an alternative solution.
Trazodone has a black box warning for suicidal thoughts or ideation. This risk increases in children or young adults and is higher within the first few months of treatment. AgelessRx does not prescribe Trazodone to anyone under the age of 25, but all users should watch for new or sudden changes in mood, behaviors, thoughts, or feelings. If you experience thoughts of suicide or worsening depression, stop using Trazodone immediately and contact your doctor or a qualified mental health professional. For mental health emergencies, dial or text 988 to speak with a trained health counselor 24/7.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Trazodone may affect the way some medicines work, and some medicines may affect the way Trazodone works. Tell your healthcare provider if you are taking any medications to treat depression or insomnia, including Prozac (fluoxetine) or Ambien (zolpidem).
Do not take Trazodone if you are currently prescribed a monoamine oxidase inhibitor (MAOI) or within 14 days of discontinuing an MAOI. MAOIs include saquinavir/ritonavir, colchicine, isocarboxazid, linezolid, methylene blue injection, phenelzine, pimozide, safinamide, saquinavir, selegiline transdermal, thioridazine, and tranylcypromine. Do not take Trazodone if you are allergic to Trazodone or any of its ingredients.
Some people may be advised to discontinue Trazodone at least 24 hours before surgery or diagnostic procedures, depending on the particular procedure. If you’re not sure whether you need to stop Trazodone for a particular procedure, speak with the doctor who ordered the procedure. Do not resume taking Trazodone until your doctor advises you that it is safe.
Do not take Trazodone if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed while taking Trazodone.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality.
What is Trazodone?
(TRAZ-oh-done)When sleep is off, the body has less opportunity to turn that effort into results.5 Sleep is when the brain consolidates memory, hormones recalibrate, immune defenses reset, and growth hormone supports tissue and cellular repair.6
At lower doses, Trazodone may act on serotonin, histamine, and noradrenaline pathways involved in sleep, helping potentially fall asleep easier and getting more deep, slow-wave sleep tied to physical restoration.1 4
Saw improvements in sleep quality by day 30
84%
Actual results may vary. Data was self-reported by 1,873 surveyed customers who checked in with their provider on their first check-in between 4/11/22-2/5/26. All respondents are AgelessRx Trazodone customers who were approved for a prescription after completing an assessment with a medical provider.
How Trazodone works
1 Week
Some may notice more relaxation, falling asleep faster, and fewer nighttime wakings as the body adjusts.1 3
3 Months
With consistent sleep and better sleep architecture, some may notice improved stress management and memory.2
6 Months
Some people report an increased proportion of deep, slow-wave sleep—the stage most closely tied to physical repair—with less daytime fog.3 4
1 Year and Beyond
Consistent, restorative sleep is one of the more well-supported everyday habits linked to long-term health. Studies have shown it can extend healthspan by up to 15%.7 8
Day 1
Drowsiness and a calming effect may begin after the first dose, helping some people settle into sleep easier without the GABA-driven grogginess of OTC sleep medications.1 3
1 Week
Some may notice more relaxation, falling asleep faster, and fewer nighttime wakings as the body adjusts.1 3
3 Months
With consistent sleep and better sleep architecture, some may notice improved stress management and memory.2
6 Months
Some people report an increased proportion of deep, slow-wave sleep—the stage most closely tied to physical repair—with less daytime fog.3 4
1 Year and Beyond
Consistent, restorative sleep is one of the more well-supported everyday habits linked to long-term health. Studies have shown it can extend healthspan by up to 15%.7 8
Results you can feel
- 0
- noticed benefits in first 30 days
- 0
- noticed improved sleep quality in first 30 days
Actual results may vary. Data was self-reported by 1,873 surveyed customers who checked in with their provider on their first check-in between 4/11/22-2/5/26. All respondents are AgelessRx Trazodone customers who were approved for a prescription after completing an assessment with a medical provider.
We’re advancing the science of sleep
Most sleep care stops at helping you get through the night. Our team of researchers are studying what better sleep may mean in a longevity view with Trazodone as part of our active observational Sleep for Longevity trial.
Stanford PhD-led Research Team behind 11+ longevity trials and 9 peer-reviewed publications
Fully in-house medical team with 199+ years of combined clinical experience
Real-world health outcomes used to continually inform our protocols
Clinically studied
The science of Trazodone
Trazodone may block the 5-HT2A serotonin receptor, along with histamine H1 and alpha-1 adrenergic receptors, to potentially turn down the signals that promote wakefulness and arousal.4
Sleep studies have found Trazodone measurably increases slow-wave sleep, by roughly 50 minutes in one placebo-controlled study, without significantly suppressing REM.1 3
By improving deep sleep, Trazodone may support memory, next-day cognitive function, and recovery.2 Because it doesn’t act on the GABA receptor pathway, it also isn’t associated with the physical dependence or withdrawal risk seen with benzodiazepines.1 4
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Sleep care that starts with you
We see sleep as real, measurable, and treatable. So you can get care that gets you back to where you deserve to be.
$33/mo
Applies to 3-month plan (Billed $99 every 3 months)
What’s included
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Get $20 off first shipment of 3-month plan
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Flexible monthly and 3-month plans
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Personalized, clinician-guided plan
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Dispensed by US-licensed compounding pharmacy
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Unlimited protocol adjustments and messaging
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Pause or cancel anytime
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Backed by our in-house Stanford PhD-led team
How it works
Choosing how you age starts here
1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
2
Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy partner, rigorously inspected for quality, and shipped discreetly to your door.
3
100% online
Receive continuous support
Start with one goal, then keep building over time. With our in-house care team, unlimited provider messaging, easy refills, unlimited dosage adjustments, and 40+ science-backed plans, your care evolves with you.
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Disclaimer
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See above for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
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Frequently asked questions
No. Trazodone is FDA approved for major depressive disorder. Its use for sleep is off-label, meaning a licensed provider may prescribe it when they determine it is medically appropriate.
No. Trazodone doesn’t act on the GABA receptor pathway that drives dependence and tolerance with benzodiazepines and Z-drug sleep medications, and it isn’t a federally controlled substance.4 Stopping suddenly after prolonged use may still cause mild discontinuation symptoms, which is why your provider may recommend gradually reducing your dose rather than stopping abruptly.
You may experience initial daytime drowsiness once you first start taking Trazodone, which is why you should avoid driving until you understand how Trazodone will affect you. Drowsiness may come back briefly if you increase your dose, so plan ahead.
The good news is that Trazodone side effects are dose-dependent.1 That means side effects like grogginess can be an indication that your current dose is too much for you. If you find that your grogginess doesn’t get better after a week or two, you may still be able to cut down your dose to improve groginess. Always talk with your provider before adjusting your dose.
Most prescription and OTC sleep aids work by activating the GABA pathway to sedate you. Trazodone works by potentially blocking receptors that promote wakefulness and arousal, which can be associated with increased slow-wave (deep) sleep rather than simple sedation, and doesn’t carry the same tolerance or dependence risk as GABA-acting hypnotics. It’s a different mechanism aimed at a different goal: sleep quality, not just sleep quantity.1 4
I’ll sleep when I’m done
peer reviewing.
We vet everything on PubMed so you don’t have to. Here’s what the science says.