Background & History

  • DMAE stands for dimethyaminoethanol (deanol for short)
  • Naturally produced in the body & found in fatty fish like salmon, sardines, & anchovies
  • A peptide that’s proven to smooth and even plump & shape skin
  • ​Scientifically proven to have acute skin-firming and tightening effects
  • Well-tolerated treatment (i.e. little to no side effects) for aging skin
  • The first & only Rx-compounded DMAE gel (ARx exclusive)
  • Contains 3% Rx-strength DMAE

Longevity Benefits

  • Increases neck firmness & tightens nasolabial folds (smile lines)
  • Smoothes crow’s feet and forehead lines
  • Diminishes dark under-eye circles
  • Improves & plumps lip shape
  • Intensive hydration properties & builds back the skin’s barrier (epidermis)
DMAE Longevity Benefits

Research & Studies

Improves Facial Muscle Tone

In a 2005 clinical study, DMAE showed potential as an ingredient that penetrates under the skin and actually improves underlying facial muscle tone as well as has an anti-inflammatory effect on skin.

Addresses Multiple Aging Skin Concerns

A randomized clinical study touted DMAE results for multiple aging skin concerns, stating: “DMAE facial gel applied daily for 16 weeks was shown to be safe and efficacious in the mitigation of forehead lines and periorbital fine wrinkles, and in improving lip shape and fullness and the overall appearance of aging skin. Beneficial trends were noted in the appearance of coarse wrinkles, under-eye dark circles, nasolabial folds, sagging neck skin, and neck firmness.”

Builds Back Skin’s Natural Barrier

A 2014 study recognized DMAE “as an exciting new skincare supplement today for its acute effects of anti-aging, anti-wrinkle and skin firmness.” The study also concluded DMAE had increased dermal thickness and increased collagen stores, stating: “Those treated with 0.1% DMAE or 0.2% DMAE showed epidermal and dermal thickness and density of collagen fiber that was significantly elevated over those of aging control groups after just 42 days. In addition, those using 0.2% DMAE showed significantly increased epidermal thickness and density of collagen fiber when compared to the aging control.”

How It Works

Do you notice your skin is dryer than it was when you were younger? This is because we lose more and more moisture and collagen as we age. Along with many other factors (lack of sleep, pollution, stress) this leads to duller, wrinkled and sagging skin. DMAE, a peptide that’s naturally found in our bodies as well as in oily fish, is literally what the doctor ordered for this skin problem. It’s routinely prescribed by dermatologists and doctors who love it for its science-backed effects on tired, dehydrated skin.

DMAE Skin Layers

Why? The skin is super receptive to DMAE therefore allowing it to build on our skin’s moisture reserves, hydrate instantly and plump and smooth where nature’s left off. A form of Vitamin B choline, DMAE acts in a similar way to the fatty Omegas we all love. Collagen (the yummy stuff that makes up healthy skin) gets an engine rev by way of DMAE too.

DMAE adds moisture back to aged, parched skin thereby building back the powerful moisture barrier we’ve lost to age. In the process, it also prevents new and future skin damage. Over short and longer periods, the epidermis layer of our skin appears and is thickened and renewed.

Science + Expertise = Real Results

Science + Expertise = Real Results

AgelessRx blends pharmaceutical-grade DMAE in a unique and effective formula with alpha lipoic acid and Hyaluronic acid. Alpha lipoic is a co-enzyme and powerhouse antioxidant that fights off skin-damaging free radicals while Hyaluronic acid pumps mega-moisturize back into the epidermis. Together, these three key ingredients make up the proprietary blend. Face and neck texture look and feel restored while being protected against future aging and stress.

Important Safety Information
& Side Effects

As with any prescription product, there may be side effects. Generally, the vast majority of side effects will subside after the gradual use of the product over 3-4 weeks. If serious burning or irritation occurs, discontinue use and consult a doctor.

Most Common DMAE Side Effects

As with any prescription product, there may be side effects. Generally, the vast majority of side effects will subside after the gradual use of the product over 3-4 weeks. If serious burning or irritation occurs, discontinue use and consult a doctor.

  • Itching
  • Burning
  • Redness
  • Peeling

Less common and more rare side effects may include muscle twitching, insomnia, sneezing/coughing/wheezing, severe eye irritation, or convulsion.

Your skin may be more sensitive to sunlight and weather extremes, such as cold and wind, while using this product. To reduce sensitivity and chance of skin irritation, AgelessRx recommends using a daily moisturizer with SPF 30 (or higher).

For a complete list of possible side effects, click here.

Possible Drug Interactions

Before starting any new prescription, be sure to tell your doctor or healthcare provider about all the medications you take, including prescription and over-the-counter medications, vitamins, and herbal supplements.

You should not use topical DMAE if you take any of the following medications: acetylcholinesterase inhibitors (i.e. Aricept, Cognex, Reminyl), anticholinergic medications (used for Parkinson’s Disease, COPD, and overactive bladder), cholinergic medications (used for Alzheimer’s and glaucoma), anticoagulants (i.e. blood thinners).

Additionally, using DMAE concurrently with topical drying agents, such as salicylic acid and benzoyl peroxide, can increase drying effects. Do not apply these agents to the same areas as your topical DMAE.

Other Important Safety Information

Do not use DMAE if you are pregnant or breastfeeding (including trying to get pregnant or are unsure whether they are pregnant). Additionally, people with an allergy to fish or fish products, DMAE, or any of its ingredients, should not take DMAE.

Note: All information included on this page is a summary. It may not cover all possible information. If you have questions about this medication, talk to a doctor, pharmacist, or health care provider.

Explore DMAE

  • The first and only topical DMAE prescription available
  • Exclusive DMAE, hyaluronic & alpha lipoic acid blend
  • Tightens & firms crepey neck, crow’s feet & forehead lines
  • Diminishes dark under-eye circles
  • Improves lip shape and fullness
Learn More

Starting at $60/mo