2 Weeks
NAD+ begins supporting skin repair. Some may notice signs of smoother, more hydrated skin.1 3
Aging Skin
NAD+ Support
NAD+ Face Cream Rx
Supports smoother, brighter, firmer-looking skin with a clinician-guided formula that delivers pure NAD+ to address visible signs of aging.
One of the only Rx skin creams formulated with pure NAD+
Supports skin repair against UV, oxidative stress, and inflammation¹ ⁴
Prescription-grade skincare built around the biology of aging skin⁵
HSA / FSA eligible
Ongoing, expert support
Free, discreet shipping
100% online
Frequently asked questions
What is NAD+ Face Cream?
NAD+ Face Cream is a topical skincare formulation containing nicotinamide adenine dinucleotide (NAD+), a coenzyme found in every cell in the body that plays a central role in cellular energy metabolism and DNA repair.8 As NAD+ levels naturally decline with age, skin cells may become less efficient at supporting cellular repair and renewal.6 NAD+ Face Cream delivers the coenzyme directly to the skin, where it may help support the cellular processes that contribute to healthy-looking skin over time.1 4
How does topical NAD+ Face Cream benefit skin health?
NAD+ is a coenzyme that plays a central role in cellular energy metabolism and DNA repair.3 As NAD+ levels naturally decline with age, the skin’s ability to support cellular repair and maintain healthy function may decrease over time.6 Topical NAD+ Face Cream delivers NAD+ directly to the skin, where it may help support cellular energy production, skin barrier function, and overall skin health.1 3 4 Individual experiences vary and depend on factors including skin type, age, and consistency of use.
What are the ingredients in NAD+ Face Cream?
Our NAD+ Face Cream contains NAD+ powder, sodium hydroxide (10% solution), propylene glycol, and HRT Botanical Base. 100% vegan, cruelty free.
Usage instructions
View all FAQs
Splash water on your face to moisten your skin, then apply an even layer once before bed. Allow the cream enough time to absorb and dry before adding any other cosmetic creams or products. If prescribed, a US-licensed provider will provide a tailored dosage schedule and specific treatment instructions with your care plan.
Important safety information and common side effects
Side effects
The most commonly reported side effect of NAD+ Face Cream is irritation where the cream is applied. If this occurs, consider using only once daily.
If irritation continues to occur, apply an over-the-counter itch cream, preferably with hydrocortisone.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality.
How NAD+ supports healthy skin
(nicotinamide adenine dinucleotide)NAD+ powers the cellular energy and repair processes skin depends on to renew itself.2 But levels decline starting in your 20s, leaving skin vulnerable to visible aging.6
Most skincare relies on precursors like niacinamide that the body must convert to NAD+ — with no guarantee of how much is produced. This formula delivers NAD+ directly. No conversion required.
Skin NAD+ levels may decline by up to 60% between ages 30–60
60%
How NAD+ Face Cream works
30 Days
As skin NAD+ levels are replenished, skin may begin to appear brighter, with more consistent glow.4 7
3 Months
Improvements in fine lines, wrinkles, and tone may become more noticeable with continued use.3
6 Months
Sustained NAD+ support may restore skin’s natural repair processes, strengthening resilience and improving tone, texture, and firmness.1 3 4
1 Year and Beyond
With continued use, skin may maintain stronger repair capacity, helping results last longer and reducing the need for constant skincare fixes.5 6
2 Weeks
NAD+ begins supporting skin repair. Some may notice signs of smoother, more hydrated skin.1 3
30 Days
As skin NAD+ levels are replenished, skin may begin to appear brighter, with more consistent glow.4 7
3 Months
Improvements in fine lines, wrinkles, and tone may become more noticeable with continued use.3
6 Months
Sustained NAD+ support may restore skin’s natural repair processes, strengthening resilience and improving tone, texture, and firmness.1 3 4
1 Year and Beyond
With continued use, skin may maintain stronger repair capacity, helping results last longer and reducing the need for constant skincare fixes.5 6
Results you can feel
- 0
- saw noticeable benefits
- 0
- reported less fine lines
- 0
- noticed firmer skin
- 0
- reported brighter skin
Actual results may vary. Data was self reported by 103 surveyed customers who checked in with their provider between their first and fourth check-in between 2/9/25 and 2/9/26. All respondents are AgelessRx NAD+ Cream customers who were approved for a prescription after completing an assessment with a medical provider.
Clinical skincare backed by science
Our Stanford PhD-led Research Team studies the biological drivers of aging to find treatments that go deeper than surface skincare. Every formula is compounded to clinical-grade standards by LegitScript-certified pharmacy partners.
Built on one of the largest real-world NAD+ datasets in longevity care
Studied by our Stanford PhD–led Research Team in the $101M XPRIZE Healthspan competition
Reviewed by US-licensed providers
Clinically studied
The science of NAD+
NAD+ is a critical molecule that supports essential cellular processes involved in healthy-looking skin, including energy production, DNA repair, inflammation balance, and daily skin repair rhythms. As we age, skin NAD+ levels decline, which may impact how skin cells respond to UV stress, repair damage, and maintain a healthy barrier.1 2 5
Low NAD+ levels are linked to photoaging and inflammatory skin conditions like psoriasis.
Topical NAD+ is designed to support skin repair pathways, helping to maintain healthy skin tone, texture, and barrier function.1 2 3 4
How it works
Choosing how you age starts here
1
Clinician-led
Connect with a clinician
Connect with a US-licensed medical provider to ensure your treatment is right for you. 100% online. No in-person visit required.
2
Fast, discreet shipping
Get your discreet shipment
Once approved, your prescription is fulfilled by a U.S.-licensed, certified pharmacy partner and rigorously inspected for quality in 5 days or less.
3
100% online
Receive continuous support
Easy refills and direct updates from your provider are just the start. Connect with our team to get personalized support, anytime.
Disclaimer
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. See above for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
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Frequently asked questions
Individual experiences vary. Some people may begin noticing initial changes within days, while others may find that effects become more noticeable over several weeks of consistent application. Results depend on individual factors including skin type, age, baseline skin condition, and consistency of use. For best results, apply once before bed to moistened skin as directed.
Yes, NAD+ Face Cream may be applied around the eye area. Take care to avoid direct contact with the eyes themselves. If irritation occurs, discontinue use around the eye area and consult your provider.
Refrigeration helps preserve the potency of the NAD+ in the cream, particularly during warmer months or in warm climates. Keeping the cream at a lower temperature prior to application may also help support skin comfort upon use.
Splash water on your face to moisten your skin, then apply an even layer once before bed. Allow the cream enough time to absorb and dry before adding any other cosmetic creams or products.
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