Brenzavvy® is an SGLT2 Inhibitor that may not only support healthy blood sugar levels, but also heart health, kidney health, and anti-inflammatory pathways—three drivers of age-related disease. 

Before you get started, read more about important usage information for Brenzavvy®.

Quick tips

Here are some simple steps to help you get the most from each dose

• Store your prescription at room temperature
• Take Brenzavvy® in the morning
• Take before your first meal of the day
• Drink plenty of water throughout the day
• Use with a reduced-calorie diet and regular exercise

Following these tips may help you experience the best possible benefits while minimizing the risk of side effects.

Getting started

When you first receive Brenzavvy®, ensure proper storage guidelines to maintain the quality of the solution. 

Before you begin, review the titration instructions provided by your prescriber.

Learn the best strategies for reducing side effects in your first weeks.

Storage

When your prescription arrives, check that the contents are properly sealed and undamaged. Be sure to keep your medication in its original container to maintain the utmost quality.

Store at room temperature (between 68°F and 77°F) and away from direct light, like in your pantry. Avoid storing Brenzavvy® in areas with excessive heat or humidity, like your laundry room or utility closet. Always keep Brenzavvy® where your children or pets can’t reach it.

Titration instructions

Your Brenzavvy® titration follows a simple, once-daily dosing schedule:

Week	Dose	Frequency
Weeks 1+	20mg (1 tablet)	Once each morning

Your prescribed dose may be different from what’s above. Your prescriber will clearly inform you if they recommend unique dosing instructions for you. Always follow your prescriber’s instructions. You can check the side of your prescription bottle or your AgelessRx portal to confirm your prescribed dose.

If you miss a dose you can take it if it’s still morning. If morning has passed, skip the dose you missed and take your dose the next morning.

If you feel you’re not meeting your health goals on your prescribed dose, contact your prescriber to see if changing your target dose is right for you.

Side effects

The most common side effects of SGLT2 Inhibitors include increased urination, dehydration, hypotension (low blood pressure), dizziness, urinary tract infections (UTIs), and genital mycotic infections (yeast infections). Increased urination is a normal side effect of SGLT2 Inhibitors and not cause for concern. 

UTIs and yeast infections are among the most frequently reported side effects of SGLT2 Inhibitors. To reduce the risk of these and other side effects, drink plenty of water throughout the day (around 0.5-1 gallon) and follow proper genital hygiene practices. If you experience a UTI or yeast infection, you must seek treatment with your primary healthcare provider or a local urgent care clinic.

If you notice side effects other than increased urination, it’s okay to stop taking the medication until side effects clear—usually after a few days and up to a few weeks. Always let your prescriber know if you stop your medication so they can adjust your upcoming refills if necessary.

Serious side effects include euglycemic diabetic ketoacidosis (eDKA), Fournier’s gangrene, and acute kidney injury. These side effects typically occur in patients with diabetes or compromised kidney function. Please tell your prescriber if you or anyone in your family has diabetes or compromised kidney function, or any other medical condition. AgelessRx does not manage or treat diabetes.

The above is not an exhaustive list. Please review Mayo Clinic’s resources for Brenzavvy® (Bexagliflozin).

Important safety information

Brenzavvy® should not be taken by anyone with the following conditions:

• Type 1 diabetes
• History of diabetic ketoacidosis
• Severe peripheral vascular disease
• History of amputation
• History of pancreatic impairment
• Active cancer
• Pregnant or breastfeeding

Your prescriber may ask you for additional information if you have one of the following conditions:

• Types 2 diabetes
• Renal impairment
• High AST/ALT ratio
• Abnormally high or low blood pressure
• Low-carbohydrate or ketogenic diet

Please inform your AgelessRx prescriber of all medications you are taking, including supplements and over-the-counter medications. 

Brenzavvy® (Bexagliflozin) should not be used by anyone taking insulin, sulfonylureas (Amaryl, Glucotrol, Micronase, etc.), or digoxin (Digox, Lanoxin). 

Those taking colchicine (Mitigare, Colcrys) must stop taking this medication at least 72 hours before starting Brenzavvy®. 

Though rare, allergic reactions to Brenzavvy® (Bexagliflozin) are still possible. If you notice any shortness of breath or swelling around your face, tongue, or throat after using Brenzavvy®, stop use and contact emergency services right away. 

As with any medication, the dose prescribed is for you and you alone. Do not, under any circumstances, allow anyone else to use your Brenzavvy® prescription.