What is GHK-Cu?
- GHK-Cu is a naturally occurring peptide that may support how the body repairs and regenerates tissue
- Levels naturally decline with age, affecting skin quality, healing, and overall recovery
- When delivered by injection, GHK-Cu is studied for its ability to work beyond the surface
- Unlike topical treatments, it works within the body to potentially support skin and tissue
- May support processes involved in collagen production, tissue repair, and inflammation
- Compounded by US-licensed pharmacies
GHK-CU INJECTION BENEFITS
Repair, recovery, and regenerative signaling
- The body’s ability to repair and regenerate naturally declines over time
- This can show up as slower recovery, reduced tissue quality, and less efficient healing
- Supporting these processes may help maintain consistent recovery and tissue function
- GHK-Cu is studied for its role in supporting tissue repair, remodeling, and inflammation
- May work throughout the body to support coordinated repair, rather than one area
GHK-Cu has not been approved by the FDA for these uses.
The Science of GHK-Cu
Clinically studied and naturally occurring: GHK-Cu is a peptide found in the body that plays a role in tissue repair and regeneration, with levels that naturally decline with age. Research suggests it may help support signaling pathways involved in collagen production, tissue remodeling, and inflammatory balance.
Supports repair at a systems level: When delivered by injection, GHK-Cu is studied for its ability to work throughout the body rather than just one area. This may support more coordinated repair processes across multiple tissue types, helping maintain recovery and overall tissue function.
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Treatments are clinically vetted and clinician-reviewed
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- 100% online medical assessment
- Free shipping and ongoing support
- Unlimited provider messaging
- Subcutaneous injection, taken as prescribed
- Compounded by US-licensed pharmacy
- Pause or cancel anytime
Code x: $x for first month and FREE medical evaluation ($x/month after)
You will be automatically billed & sent refills based on your plan
You can pause or cancel at any time before your next shipment
The FDA has not approved or reviewed GHK-Cu for safety, efficacy, quality, or for any use, including the AgelessRx compounded product.
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See below for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
FAQs
What is GHK-Cu Injection?
GHK-Cu (Copper Tripeptide-1) is a naturally occurring peptide found in the body that supports skin repair and renewal processes, including collagen production and overall skin quality.4 Levels of GHK-Cu naturally decline with age.1 While GHK-Cu is not FDA-approved to treat medical conditions, it is commonly used in cosmetic dermatology for skin appearance and rejuvenation.2
How does GHK-Cu Injection work?
GHK-Cu Injection works locally within the skin layers (epidermis and dermis).1 Research suggests it may help support collagen and elastin production, promote tissue repair and remodeling, help regulate inflammatory signaling in the skin, support skin barrier integrity, and provide antioxidant activity within the skin.5 7 This treatment is intended for external skin use only.
What benefits can I expect from GHK-Cu Injection?
Individual results vary, and benefits are not guaranteed. With consistent use, some users may notice benefits such as improved skin firmness and elasticity, reduction in the appearance of fine lines, improved skin texture and tone, support for recovery from environmental stressors, and enhanced overall skin appearance.3
See all FAQsImportant safety information and common side effects
Side effects
The most common side effects of GHK-Cu Injection include:
- Mild redness
- Temporary tingling or warmth
- Dryness
- Mild irritation or sensitivity
These side effects are typically mild and often go away on their own within a week or two.
For a full list of side effects, please review Healthline’s Copper Peptide resources.
Potential drug interactions
GHK-Cu Injection has no known major drug interactions due to systemic absorption. However, certain skincare products may increase irritation when used together:
- Retinoids (Tretinoin, Adapalene)
May increase skin sensitivity. - Exfoliating acids (AHA/BHA products)
May cause irritation when layered together. - Benzoyl peroxide
May increase dryness or irritation.
Other important safety information
GHK-Cu Injection is intended for external use only. Do not use GHK-Cu Injection if you are allergic to copper peptides or any peptide components, or if you have an active skin infection, active inflammatory dermatologic condition, or open wounds.
Avoid contact with eyes and mucous membranes. If accidental contact occurs, rinse thoroughly with water.
Do not use GHK-Cu Injection if you have an active cancer, or if you have had cancer within the last two years.
Do not use GHK-Cu Injection if you have significant heart dysfunction (ejection fraction <50% or NYHA Class 3 or greater).
Do not use GHK-Cu Injection if you are pregnant, breastfeeding, or planning to become pregnant or breastfeed. If you become pregnant during treatment, discontinue immediately and consult your OB.
Though rare, allergic reactions to GHK-Cu Injection are still possible. If you notice any shortness of breath or swelling around your face, tongue, or throat after using GHK-Cu Injection, stop use and contact emergency services right away.
As with any prescription medication, the dose prescribed is for you and you alone. Do not, under any circumstances, allow anyone else to use your GHK-Cu Injection.
Show me the science.
All our claims are backed by science, and we’ve got the receipts.
| 1. A review highlighting GHK-Cu decline with age and the the broad biological actions of GHK-Cu in stimulating multiple protective effects to support overall skin health and regeneration. | Int J Mol Sci, 2018 |
| 2. A review of peptides for skin health, including GHK-Cu, demonstrating its ability to improve firmness, elasticity, and skin resilience in clinical studies. | Biomolecules. 2025 |
| 3. A review of GHK-Cu highlighting its role as a natural peptide supporting skin regeneration, wound healing, skin firmness, and elasticity. | Bio Res Int, 2015 |
| 4. A review highlighting GHK-Cu as effective and safe for reducing wrinkles through stimulating collagen and elastin production. | Journ Func Foods, 2021 |
| 5. A review summarizing the efficacy of GHK-Cu for protecting from environmental factors that accelerate skin aging. | Cosmetics, 2017 |
| 6. A comprehensive review demonstrating peptides, including GHK-Cu, improves skin barrier integrity and resilience. | Int Journ Cosm Sci, 2009 |
| 7. A review of GHK-Cu highlighting its role in enhancing wound healing, collagen production, and tissue regeneration, while demonstrating antioxidant, anti-inflammatory, and gene-regulating effects that support skin health and cellular repair. | Cosmetics, 2015 |
