INVOKANA® BENEFITS

Healthy blood sugar, healthy lifespan

By removing excess blood sugar through urine, Invokana® may mimic caloric restriction without limiting caloric intake, offering several longevity benefits:

Shown to extend lifespan in mice by mimicking caloric restriction¹
May reduce inflammation² and oxidative stress³ associated with age-related disease
By removing excess glucose, may improve cardiovascular⁴ and kidney health⁵ and lower the risk of dementia⁶ and Parkinson’s⁷
May eliminate senescent “zombie” cells, a leading driver of biological aging⁸
May encourage moderate weight loss of 2-4%⁹ total body weight by excreting an extra 360kcal per day¹⁰

*See cited studies below. SGLT2 Inhibitors have not been FDA approved for these uses, but there are multiple studies that have shown these benefits.

How does Invokana® work?

Removes up to 50-80g of glucose daily¹¹
That’s equivalent to 2 or more cans of soda per day removed through urine.
Originally developed to treat type 2 diabetes
Invokana® is an SGLT2 Inhibitor that works by limiting glucose reabsorption in the kidneys.
Creates a steady caloric deficit
Through glucose excretion, patients taking Invokana® may burn up to an extra 360kcal per day.¹⁰
Activates nutrient-sensing longevity pathways
By mimicking caloric restriction, Invokana® may activate mTOR, AMPK, and SIRT1.¹²
Broad longevity benefits
Modulating these longevity pathways may offer broad longevity potential, such as reduced risk of heart disease, improved kidney and liver health, better cognitive function, and moderate weight loss.¹³

What to expect

1 Day

With the first dose, SGLT2 Inhibitors may help flush up to 80g of excess sugar¹¹ a day, potentially reducing toxic glucose buildup¹⁴ and kickstarting a metabolic reset.

1 Month

Over several weeks, blood pressure and blood sugar may begin to stabilize¹³, often leading to clearer thinking⁶ and better energy.¹⁵

3 Months

With consistent use, SGLT2 Inhibitors may mimic steady calorie restriction, activating longevity pathways¹² that may clear senescent cells⁸ and reduce inflammation.²

6 Months

By 6 months, Invokana® may encourage moderate weight loss of 2-4%⁹ body weight, potentially improving VO2 max¹⁶ with measurable reductions in diabetes and heart disease risk.⁴

1 Year+

The true benefits of SGLT2 Inhibitors emerge, potentially offering increased protection against heart disease⁴, kidney disease⁵, dementia⁶, and overall mortality.¹⁷

“The human data of SGLT2 Inhibitors is remarkable…

The impact on kidney failure, all-cause mortality, and heart failure is pretty impressive.”

– Dr. Peter Attia, The Peter Attia Drive Podcast

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$449 / month

100% online medical assessment
Includes personalized dosing and follow-up care
Free shipping and ongoing support
Taken once daily in the morning
Pause or cancel anytime

Code INVO399: $399 for first month & FREE medical evaluation ($449/month after)

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You will be automatically billed & sent refills based on your plan

You can pause or cancel at any time before your next shipment

Not available in AL, AR, & VA.

FAQs

What’s the difference between Invokana® and Brenzavvy®?

Both Invokana® and Brenzavvy® are SGLT2 Inhibitors that work the same way. The only difference is that Invokana® has an extended range of FDA-approved uses: while Brenzavvy® is FDA approved for type 2 diabetes, Invokana® is approved for type 2 diabetes and to reduce the risk of heart and kidney disease.

Invokana® has also been patented since 2013, with a wealth of scientific studies to support its extended uses. Though Brenzavvy® is a relatively new SGLT2 (FDA approved in 2023), it still shares the same mechanism of action and may show similar longevity benefits as research continues.

Why does Invokana® cost more than Brenzavvy®?

While Brenzavvy® has only been FDA approved since 2023, Invokana® has been patented since 2013, with a wealth of scientific studies to support its extended uses, which may explain its higher price.

AgelessRx provides Invokana® and Brenzavvy® at a competitive price according to what our pharmacy partners can source from the manufacturer. The prices listed on AgelessRx.com are out-of-pocket costs and are not affected by insurance: AgelessRx does accept insurance for Invokana® or Brenzavvy® and does not treat or manage type 2 diabetes or any other FDA-approved condition for SGLT2 Inhibitors.

How do you take SGLT2 Inhibitors?

Invokana® (Canagliflozin) and Brenzavvy® (Bexagliflozin) are both oral medications, taken by mouth once per day. Simply swallow each dose with a glass of water.

Both should be taken in the morning, before the first meal of the day. Please note that some patients may have to split their Invokana® tablets to take their prescribed dose.

Why should I take SGLT2 Inhibitors in the morning?

Taking SGLT2 Inhibitors in the morning is a dual strategy for decreasing the chances of excessive nighttime urination and to avoid potential glucose spikes from your meal.

SGLT2 Inhibitors may increase urination, which can interrupt sleep if the medication is still active during bedtime. These medications can also delay glucose absorption, which can reduce glucose spikes from your first meal.

What if I miss a dose of SGLT2 Inhibitors?

SGLT2 Inhibitors are taken daily in the morning, before the first meal of the day. If it’s still morning and you haven’t had your first meal of the day, you can take the medication as normal. If morning has passed or you’ve already had breakfast, skip the dose you missed and take your dose the next morning.

See all FAQs

Important safety information and common side effects

Most common side effects

The most common side effects of SGLT2 Inhibitors include increased urination, dehydration, hypotension (low blood pressure), dizziness, urinary tract infections (UTIs), and genital mycotic infections (yeast infections). Increased urination is a normal side effect of SGLT2 Inhibitors and not cause for concern.

UTIs and yeast infections are among the most frequently reported side effects of SGLT2 Inhibitors. To reduce the risk of these and other side effects, drink plenty of water throughout the day (around 0.5 to 1 gallon) and follow proper genital hygiene practices. If you experience a UTI or yeast infection, you must seek treatment with your primary healthcare provider or a local urgent care clinic.

If you notice side effects other than increased urination, it’s okay to stop taking the medication until side effects clear—usually after a few days and up to a few weeks. Always let your prescriber know if you stop your medication so they can adjust your upcoming refills if necessary.

Serious side effects include euglycemic diabetic ketoacidosis (eDKA), Fournier’s gangrene, and acute kidney injury. These side effects typically occur in patients with diabetes or compromised kidney function. Please tell your prescriber if you or anyone in your family has diabetes or compromised kidney function, or any other medical condition. AgelessRx does not manage or treat diabetes.

The above is not an exhaustive list. Please review Cleveland Clinic’s resources for Invokana® (Canagliflozin).

Potential drug interactions

Please inform your AgelessRx prescriber of all medications you are taking, including supplements and over-the-counter medications.

Invokana® (Canagliflozin) should not be used by anyone taking insulin, sulfonylureas (Amaryl, Glucatrol, Micronase, etc.), or digoxin (Digox, Lanoxin).

Those taking colchicine (Mitigare, Colcrys) must stop taking the medication at least 72 hours before starting Invokana®.

Other important safety information

Invokana® should not be taken by anyone with the following conditions:

Type 1 diabetes
History of diabetic ketoacidosis
Severe peripheral vascular disease
History of amputation
History of pancreatic impairment
Active cancer
Pregnant or breastfeeding

Your prescriber may ask you for additional information if you have one of the following conditions:

Types 2 diabetes
Renal impairment
High AST/ALT ratio
Abnormally high or low blood pressure
Low-carbohydrate or ketogenic diet

Though rare, allergic reactions to Invokana® (Canagliflozin) are still possible. If you notice any shortness of breath or swelling around your face, tongue, or throat after using Invokana®, stop use and contact emergency services right away.

As with any medication, the dose prescribed is for you and you alone. Do not, under any circumstances, allow anyone else to use your Invokana® prescription.

Note: This product alone is not intended to diagnose, treat, cure, or prevent any disease. Please consult a medical professional to determine whether or not Invokana® is right for you.

Gatekeeping is so traditional healthcare

We read the clinical trials so you don’t have to. Here’s all the science behind our claims.

1. This study tested whether Canagliflozin (Invokana®) can extend life in mice, as part of the Interventions Testing Program, concluding that male mice had improved lifespan	JCI Insight, 2020
2. A review study monitoring the impact of Canagliflozin (Invokana®) on diabetic kidney disease based on the biodata of 296 participants, with observed reductions in inflammatory markers such as IL-6.	Diabetologia, 2019
3. This study investigates the therapeutic potential of Canagliflozin (Invokana®) on diabetic mice and how it can mitigate inducers of diabetes, like oxidative stress.	Front Endocrinol (Lausanne), 2022
4. A review study exploring the effects of Canagliflozin (Invokana®) on cardiovascular risk factors in patients with type 2 diabetes.	Int J Clin Pract, 2017
5. The CREDENCE trial, funded by Janssen Research and Development, tracks renal (kidney) outcomes on patients with type 2 diabetes taking Canagliflozin (Invokana®).	NEJM, 2019
6. This study followed patients who were at risk of dementia to determine if those taking SGLT2 Inhibitors developed dementia at a lower rate than those taking a DPP-4 inhibitor.	BMJ, Aug 2024
7. The first large-scale trial directly comparing whether SGLT2 Inhibitors or Metformin offer greater neuroprotection against Parkinson’s disease.	J Parkinson Dis, 2025
8. A clinical study using animal models to determine whether SGLT2 Inhibitors eliminate senescent cells.	Nature Aging, 2024
9. A combined weight loss study of 334 overweight or obese participants taking Canagliflozin (Invokana®), phentermine, both medications, or placebo, with patients in the Canagliflozin group losing an average of 3.6% of total body weight after 26 weeks.	Diabetes Care, May 2017
10. A double-blind, placebo-controlled trial measuring the impact of empagliflozin, an SGLT2 Inhibitor, on dietary energy restriction in 68 adults with type 2 diabetes.	Diabetes Obes Metab, 2022
11. A review study exploring the total renal glucose reabsorption of SGLT2 Inhibitors in humans.	Diabetes, Aug 2012
12. This review study explores the available peer-reviewed evidence for the ability of SGLT2 Inhibitors to target aging pathways.	Int J Mol Sci, 2022
13. General prescriber information for SGLT2 Inhibitors.	National Library of Medicine
14. A mouse study attempting to map the metabolic response of organs to the SGLT2 Inhibitor, dapagliflozin; among the results are a noted reduction in hyperglycemia and glucotoxicity.	JCI Insight, 2023
15. This review study explores the mechanisms behind SGLT2 benefits including cardiac energy metabolism.	JACC Basic Transl Sci, 2020
16. A comparative study comparing Canagliflozin (Invokana®) and sitagliptin, concluding that Canagliflozin improved lean peak VO2, noting no significant differences between the two drugs.	Diabetes Metab Res Rev, 2020
17. A randomized control trial designed to explore the comparative effectiveness of cardiovascular outcomes for SGLT2 Inhibitors versus other glucose-lowering drugs, with 300,000+ participants using Canagliflozin (Invokana®), dapagliflozin, or empagliflozin.	Circulation, Jul 2017

Invokana®