Oral Semaglutide Drops contain only 2 main ingredients: Semaglutide and SubMagna SL HMW, a state-of-the-art suspension base that allows this medication to be safely and reliably absorbed through the lining of the mouth.

The information presented here is only applicable for non-diabetics who have been prescribed Oral Semaglutide Drops after their AgelessRx prescriber deemed it appropriate.

Quick tips

Here are some simple steps to help you get the most from each dose:

• Try taking your dose 30 minutes before your first meal of the day
• For the best results, take on an empty stomach
• Drink water before taking your dose
• Let the medication sit under your tongue for as long as possible before swallowing
• Do not eat anything for at least 30 minutes after taking your dose

Follow these tips to ensure that Oral Semaglutide Drops are properly absorbed, so you can experience the best possible benefits while minimizing side effects.

Getting started

When you first receive your Oral Semaglutide Drops, ensure proper storage guidelines to maintain the quality of the solution.

Follow the instructions for properly drawing and administering Oral Semaglutide Drops.

Always dose according to your doctor-guided titration schedule.

Storage

Your Oral Semaglutide Drops solution is room temperature stable. To maintain the utmost quality, store your vial(s) between 68°F and 77°F, and away from heat sources and direct sunlight. Keep out of reach of children and pets.

Upon receiving your Oral Semaglutide Drops, check the temperature of the bottle with the back of your hand. If it feels hot to the touch, please contact us immediately.

You may safely travel with Oral Semaglutide Drops, so long as the above conditions are met. Though Oral Semaglutide Drops are stable at room temperature, you should still take care to store your prescription as you would any other medication.

Drawing and administering Oral Semaglutide Drops

How to draw your solution

Before you draw your Oral Semaglutide Drops solution, unscrew the lid of the prescription bottle and attach the seal adapter to the top of the bottle. Confirm the adapter is in place before moving on. Be sure to reseal the cap, shake the bottle well, and check that the oral syringe is clean and dry before proceeding.

Next, insert the tip of the syringe into the top of the bottle. When it’s securely in place, flip the vial and syringe over, and hold together tightly at your eye level.
Then, slowly pull the plunger back to draw up your dose. Don’t stop until the black line on the plunger stops at the exact measurement for your dose. If there are bubbles in the oral syringe, you can gently flick the side of the syringe to release the air bubbles.

When you’ve drawn your dose, flip the bottle upright and carefully remove the syringe without touching the plunger.

How to measure units on your syringe

Each large line on your oral syringe represents increments of 0.1ml. Each small line indicates an increment of 0.01ml.

Before getting started, check to see how many milliliters (ml) are in your dose. If your dose calls for 0.2ml, simply pull back on the plunger until the black line stops at the “0.2ml” line. The level of solution in the syringe should also match this amount.

If your weekly dose is not clearly labeled on the syringe, pay close attention to the markers between the large lines when drawing up your dose. There may be even smaller measurement lines on the syringe that are more difficult to see. Count these carefully as you draw up your dose to ensure the most accurate measurement.

How to administer your solution

Oral Semaglutide Drops are delivered sublingually, or underneath the tongue.

To administer your solution, touch the tip of your tongue to the roof of your mouth, then carefully hold the tip of the oral syringe under your tongue at a downward angle. It’s okay to let the tip of the oral syringe touch your tongue.

Slowly press all the way down on the plunger until all the solution is administered, then hold the tip of the syringe under your tongue for an additional 5-10 seconds to catch any excess solution.

Avoid swallowing for as long as possible to ensure the solution is properly absorbed—at least 90 seconds. The solution will usually dissolve and disperse on its own. Do not eat anything or drink anything for at least 30 minutes after taking your dose.

Oral Semaglutide Drops titration schedule

Oral Semaglutide Drops is always prescribed with a doctor-guided titration schedule to gradually introduce the medication to your body. This way, you have the best opportunity to experience the greatest benefits possible while reducing side effects.

Your titration plan is determined by your AgelessRx prescriber based on your unique medical history. Unless you are specifically prescribed otherwise, your Oral Semaglutide Drops titration schedule will proceed as follows:

Week	Dose	Solution Strength	Frequency
Week 1-4	0.1ml	20mg/ml	Once daily
Week 5-8	0.2ml	20mg/ml	Once daily
Week 9-12	0.4ml	20mg/ml	Once daily
Week 13+	0.5ml	20mg/ml	Once daily

You will take your prescribed dose once daily. For the best results, try to take your dose around the same time each day. 

Always follow the titration schedule provided by your AgelessRx prescriber, even if it differs from the standard titration protocol above.

If you forget your titration schedule, you can always check your prescription vial or your AgelessRx portal.

If you miss a dose of Oral Semaglutide Drops, you can skip that dose and take it the next day. Never take more than your prescribed dose. If more than 2 weeks have passed since your last dose, please contact your prescriber for further guidance: you may be asked to restart your titration.

If you feel you are not meeting your health goals on your prescribed dose, contact your prescriber to see if changing your target dose is right for you.

Common side effects

Oral Semaglutide Drops has not been evaluated by the FDA, but contains Semaglutide as the primary active ingredient. Semaglutide-based medications reviewed by the FDA have the following side effects: nausea, diarrhea, vomiting, constipation, abdominal (stomach) pain, headache, fatigue, dyspepsia (indigestion), dizziness, abdominal distension, eructation (belching), hypoglycemia (low blood sugar) in patients with type 2 diabetes, flatulence (gas buildup), gastroenteritis (an intestinal infection) and gastroesophageal reflux disease (a type of digestive disorder).

Common side effects normally go away on their own within a few days or up to 2-3 weeks. If you find that any side effects persist for longer than this or get worse over time, stop taking Oral Semaglutide Drops and contact your prescriber as soon as possible.

To help prevent side effects from occurring or persisting, try the following:

• Eat slower and at more regular intervals throughout the day
• Try to take Oral Semaglutide Drops at around the same time each day
• Drink water before taking your dose
• Avoid fried, greasy foods in favor of healthier, low-fat options

Dehydration may also be an indirect side effect of Oral Semaglutide Drops for those experiencing vomiting and diarrhea. If you do experience these side effects, make sure that you are drinking plenty of water and fluids with electrolytes to avoid dehydration.

For some patients, taking probiotics may help reduce gastrointestinal side effects, but results may vary. Ginger and peppermint oil may also help to reduce gastrointestinal side effects.

This is only a summary of potential side effects and how to address them. For more information, please reference the Mayo Clinic’s Semaglutide resources, or ask your prescriber.

Fatigue & muscle loss

A common side effect of any weight loss strategy is fatigue and muscle loss, which may occur as a result of less food intake. As a result, the body has less energy from food (fatigue) and begins pulling energy from reserves stored in fat and muscle (muscle loss).

If you do experience fatigue, rest assured that it should go away on its own as your body adjusts to the medication and changes in your diet.

Maintaining muscle mass with Semaglutide requires a careful balance of diet, exercise, and protein intake. Try to eat a moderate amount of protein every day without over-consuming, and exercise at least 3-5 times per week, or 150 minutes per week.

Serious side effects

Semaglutide has been associated with the following rare but serious side effects.

• Thyroid C-cell tumors
• Diabetic retinopathy
• Hypoglycemia
• Kidney problems
• Gallbladder problems
• Pancreatitis
• Worsening of mood

Your AgelessRx prescriber will weigh these potential risks against your unique medical history when considering a prescription. If you have been approved for an Oral Semaglutide Drops prescription, your prescriber has determined that it is unlikely that you are at risk for these serious side effects.

For a full list of potential warning signs for these conditions, please see the Mayo Clinic’s Semaglutide resources.

Important safety information

Oral Semaglutide Drops should not be used by anyone who has a personal or family history of medullary thyroid carcinoma (MTC), multiple endocrine neoplasia syndrome 2 (MEN2), or pancreatitis.

The FDA is currently evaluating whether GLP-1 medications may increase the risk of suicidal thoughts or actions. Though the FDA has found no evidence supporting this risk, patients with a history of suicidal thoughts should not take Oral Semaglutide Drops.

Do not use Oral Semaglutide Drops if you are pregnant or breastfeeding, or planning to become pregnant or breastfeed.

SubMagna SL HMW is an anhydrous base developed by a professional compounding group, PCCA. SubMagna contains polyethylene glycol (PEG) ingredients such as PEG-32 stearate, and traces of coconut oil and monkfruit extract. Please read the full list of SubMagna SL HMW ingredients before getting started. If you are allergic or sensitive to PEG products, coconut, or monkfruit, please inform your AgelessRx prescriber or consider other treatment alternatives.

Though rare, allergic reactions to Semaglutide are possible. If you notice any shortness of breath or swelling around your face, tongue, or throat after using Oral Semaglutide Drops, stop use immediately and contact emergency services right away.

As with any prescription medicine, the dose prescribed is for you and you alone. Do not, under any circumstances, allow anyone else to use your Oral Semaglutide Drops.