FDA approved to treat organ rejection in transplant patients and other serious conditions, Rapamycin (also known as Sirolimus) has been celebrated recently for its incredible potential to slow age-related decline and enhance healthy longevity: it is the first drug proven to help mammals live longer, and has since been shown to extend the healthy lifespan of every organism tested so far.

Before you get started, read more about important usage information for Rapamycin.

Quick tips

Here are some simple steps to help you get the most from each dose:

• Slowly titrate up to your prescribed dose
• Try taking around the same time each day
• You can take Rapamycin with or without food
• Keep up with your required blood tests and check-ins
• Avoid grapefruit juice

These tips ensure that your body can absorb the most therapeutic amounts of Rapamycin and adjust to the medication over time, so you can enjoy the most optimal benefits while minimizing side effects.

Be sure to read our blog for more helpful tips on taking Rapamycin.

Getting started

When you first receive your Rapamycin prescription, follow proper storage guidelines to maintain the quality of the medication.

Before you begin, review the titration instructions provided by your prescriber.

Next, understand the benefits of Rapamycin and know what to expect throughout your journey.

Finally, learn the best strategies for reducing side effects in your first weeks.

Storage

When your prescription arrives, check that the contents are properly sealed and undamaged. Be sure to keep your medication in its original container to maintain the utmost quality.

Store at room temperature (between 68°F and 77°F) and away from direct light, like in your pantry. Avoid storing Rapamycin in areas with excessive heat or humidity, like your laundry room, garage, or utility closet. Always store Rapamycin where your children and pets can’t reach it.

Please be sure not to combine or mix tablets from multiple Rx bottles. Your Rapamycin dose will increase each month for the first 3 months, but your tablets may appear identical in size, shape, and appearance, regardless of dose. Always keep your Rapamycin refills in their original Rx bottle to ensure that you always take your prescribed dose.

Titration instructions

Week	Dose	Frequency
Weeks 1-4	2mg	Once weekly
Weeks 5-8	4mg	Once weekly
Weeks 9+	6mg	Once weekly

Your titration plan is determined by your AgelessRx prescriber based on your unique medical history. You will only take one dose of Rapamycin each week. You will always take Rapamycin once per week, but how much Rapamycin you take per week will increase over the first 3 months.

Your prescribed Rapamycin dose may differ from the standard titration plan listed above, so always follow the titration instructions listed on your Rx bottle or in your AgelessRx portal.

If you miss a dose, try to take it as soon as possible unless you are more than 3 days late on your dose, in which case you can either skip this dose, or take Rapamycin immediately and make that day your new scheduled dosing day. Do not double up on doses to compensate for a missed dose; never take more than one dose at a time.

If you feel you’re not meeting your health goals on your prescribed dose, contact your prescriber to see if changing your target dose is right for you.

Rapamycin benefits

Rapamycin works primarily to inhibit mTOR signaling. mTOR, or the mammalian target of Rapamycin, is a central regulator of many important functions within the human body, including metabolism, cellular homeostasis, nutrient sensing, immune health, and autophagy, or the recycling of damaged cellular components.

By inhibiting mTOR, Rapamycin has demonstrated the following potential benefits:

• Enhanced immune health & functioning
• Reduced chronic inflammation
• Reduced senescent cell burden
• Improved cardiovascular functioning
• Improved body composition
• Improved bone health
• Improved muscle function & health
• Enhanced overall quality of life & healthspan
• Renewed oral microbiome

The longer you take Rapamycin, the better the potential benefits. To experience the most optimal benefits of Rapamycin, it should be taken over an extended period of several months to years.

Blood tests, electronic quality-of-life check-ins, and mobility tests are among the most reliable ways to measure the benefits of Rapamycin, as many benefits occur on a cellular level and may be difficult to appreciate. Electronic check-ins help show your progress on benefits that are more difficult to measure, like increased energy and improved mobility.

As part of your Rapamycin prescription, you will undergo regular blood tests and electronic check-ins every 6 months after your baseline test. These are a requirement of your prescription that must be maintained to ensure your ongoing eligibility and keep your prescription active.

Side effects

These are the most commonly reported side effects of Rapamycin:

• Mouth ulcers (stomatitis)
• Nausea
• Diarrhea

Most side effects are mild and go away on their own within a week or two as your body adjusts to the medication. If you find that any side effects persist for longer than this or get worse over time, stop taking Rapamycin and contact your prescriber as soon as possible.

Please review the Mayo Clinic’s full list of possible Rapamycin side effects.

Important safety information

Avoid drinking grapefruit juice while taking Rapamycin. Rapamycin is a substrate for p-glycoprotein and cytochrome P-450 3A4. Grapefruit juice is known to alter how these proteins interact with Rapamycin, which may prevent Rapamycin from metabolizing within the body, potentially resulting in higher levels of Rapamycin in the bloodstream. Other drugs that are known to have similar reactions with Rapamycin include cyclosporine, rifampin, ketoconazole, cidofovir, ritonavir, mifepristone, posaconazole, and fluconazole.

Before taking Rapamycin, be sure to talk to your healthcare provider about any medications you are currently taking and review the full list of potential drug interactions for Rapamycin.
Do not take Rapamycin if you are pregnant or breastfeeding or planning to become pregnant or breastfeed during your prescription.

Do not take Rapamycin if you are scheduled to undergo major surgery, chemotherapy, or immunosuppressant therapy for a transplant within the next 6 months.

Do not take Rapamycin if you have a chronic infection (such as HIV/AIDS, Lyme disease, or latent tuberculosis), any primary or secondary immune dysfunction or efficiency, or if you have an allergy to Rapamycin or any of its ingredients.

While rare, it is possible for some who take Rapamycin to potentially become more susceptible to skin and/or lung infections. However, this is still being investigated and is not a proven risk associated with Rapamycin when taken at the frequency and doses prescribed at AgelessRx. If, at any time, you feel you are developing a troubling skin or lung infection, seek care at a local urgent care center, contact your PCP, or use an acute-care telemedicine service as soon as possible. Be sure to report the details to our medical team as soon as you can.