What is Sermorelin?
- After age 30, human growth hormone (HGH) levels decline by up to 15%¹ per decade, impacting everything from metabolism and muscle tone to recovery and sleep quality²
- Unlike other synthetic options that override your system, Sermorelin works with your body, stimulating natural HGH production from the brain to potentially support lean muscle mass, energy, and metabolism²
- Lean muscle is a critical benchmark of longevity. Restoring natural HGH production with Sermorelin may help restore and preserve lean muscle mass as we age, which may help encourage a multitude of health benefits
SERMORELIN BENEFITS
Future-proof your health
- May improve metabolism and overall body composition by increasing lean muscle²
- Shown to support deeper, more restorative sleep²
- May support energy levels and reduce fatigue²
- May improve exercise performance and workout recovery²
- May improve cognitive function and focus²
- Well-tolerated³ with a strong safety profile and minimal side effects⁴
- Tested for purity by US-licensed pharmacies
Sermorelin has not been approved by the FDA for these or any uses, but there are multiple studies that have shown these benefits.
The science of Sermorelin
Clinically studied and naturally acting: Originally developed to treat growth hormone deficiencies in children, Sermorelin is an analog of growth hormone-releasing hormone (GHRH)¹. Unlike direct HGH therapy, Sermorelin signals the pituitary gland to release human growth hormone (HGH)¹ in a pulsed, physiological rhythm⁵, supporting a more balanced approach to hormone therapy.
Why HGH levels matter: Research suggests Sermorelin may help naturally restore essential hormones, supporting your body’s ability to build muscle², restore energy², and improve overall quality of life³, among other diverse potential benefits².
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- 100% online medical assessment
- Includes personalized dosing and follow-up care
- Free shipping and ongoing support
- Flexible care that evolves with your needs
- Compounded at a US-licensed pharmacy
- Pause or cancel anytime
- Get started for less than $8/day
CODE SER149: $149 for first month and FREE medical evaluation ($199/month after)
You will be automatically billed & sent refills based on your plan
Pause or cancel at any time.
The FDA has not approved or reviewed Sermorelin for safety, efficacy, quality, or for any use, including the AgelessRx compounded product.
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See below for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Pause or cancel at any time. Actual product packaging may appear differently than shown.
FAQs
How do you take Sermorelin?
Sermorelin is taken as a subcutaneous injection into a fatty layer of tissue such as your thigh or abdomen. If you’re approved for a Sermorelin prescription, your prescriber will provide a tailored titration schedule and dosing instructions. Your shipment will also come with enough needles and syringes to complete your monthly titration schedule.
Is Sermorelin safe?
Sermorelin is generally well tolerated with a minimal risk of side effects. In fact, Sermorelin is often considered safer than other HGH therapies because it works with the body’s natural systems to produce HGH, as opposed to direct HGH replacement. However, there are risks with any treatment. Please see important safety information for Sermorelin and consult your prescriber about the potential risks and benefits.
Is Sermorelin a steroid?
No, Sermorelin has a different mechanism of action than steroids.
Sermorelin is a peptide that mimics growth hormone-releasing hormone (GHRH), stimulating the pituitary gland in the brain to release more of the body’s natural human growth hormone (HGH).
Steroids mimic hormones directly, acting as a replacement without stimulating the body to release its own hormones. This increases the risk of hormone imbalance, mood disorders, liver damage, and other related side effects.
Why should I take Sermorelin at night?
Sermorelin stimulates the pituitary gland, which primarily releases human growth hormone (HGH) naturally during sleep. Taking Sermorelin at night helps maximize the body’s natural HGH production. Sermorelin may also encourage healthier sleep, and should be taken on an empty stomach, making nighttime dosing the most effective strategy.
Can I eat anything before taking Sermorelin?
Sermorelin should be taken on an empty stomach at night to improve absorption and reduce side effects. For the best results, take Sermorelin at least 2 hours after your last meal.
See all FAQsImportant safety information and common side effects
Side effects
The most common side effects of Sermorelin include:
- Pain, redness, or irritation at the injection site
- Face or neck flushing
- Headache
- Nausea
Side effects are usually mild and often go away on their own within a week or two.
For a full list of side effects, please review Healthline’s Sermorelin resources.
Potential drug interactions
Sermorelin has no known major drug interactions, but may have the following interactions with certain drugs:
- Glucocorticoids (prednisone)
May blunt growth hormone (GH) release - Oral estrogens
May increase IGF-1 resistance - Insulin or sulfonylureas
May alter glycemic control - Somatostatin analogs
May antagonize Sermorelin’s effects - Dopamine antagonists
May disrupt human growth hormone (HGH) regulation - GABAergic meds
May reduce pulsatility of HGH release - Beta blockers (clonidine)
May decrease the effectiveness of Sermorelin - Other secretagogues/peptides
May result in unsafe levels of HGH
Other important safety information
Sermorelin is only for patients who are at least 30 years old. Patients under 30 should explore other longevity solutions.
Your prescriber may ask you for additional information if you have one of the following conditions:
- Hypothyroidism
Untreated hypothyroidism can impair a patient’s growth hormone (GH) response. Patients with hypothyroidism may be asked to show that their condition is treated and managed - Hyperglycemia or diabetes
Taking Sermorelin with untreated hyperglycemia or diabetes may further impair glycemic control. Patients with hyperglycemia or diabetes may be asked to show that their condition is treated and managed
Sermorelin should not be used by anyone with moderate to severe liver dysfunction or kidney disease.
Do not use Sermorelin if you have an active cancer, or if you have had cancer within the last two years.
Do not use Sermorelin if you are pregnant, breastfeeding, or planning to become pregnant or breastfeed. If you become pregnant while taking Sermorelin, consult your prescriber before continuing with your next dose.
Though rare, allergic reactions to Sermorelin are still possible. If you notice any shortness of breath or swelling around your face, tongue, or throat after using Sermorelin, stop use and contact emergency services right away. Mild allergic reactions around the injection site are normal and not cause for emergency.
As with any prescription medication, the dose prescribed is for you and you alone. Do not, under any circumstances, allow anyone else to use your Sermorelin.
Our idea of bedtime reading? Clinical trials.
We vet everything on PubMed so you don’t have to. Here’s what the science says.
| 1. This review study analyzes available clinical data on the role of growth hormone in aging and various therapies that may address age-related growth hormone deficiency, including Sermorelin. | Endotext, 2019 |
| 2. A review study exploring evidence of the various potential benefits and side effects of Sermorelin. | Dialogues Clin Neurosci, 2001 |
| 3. This single-blind, randomized, placebo-controlled trial uses Nle²⁷-GRF(1-29), a modified version of Sermorelin that may have increased stability and potency, in 19 men and women aged 55-71 to show improved quality of life. | JCEM, 1997 |
| 4. This review study examines the available evidence of how various growth hormone therapies, including Sermorelin, affect men with hypogonadism. | TAU, 2020 |
| 5. An editorial review proposing Sermorelin as a superior choice of growth hormone therapy, due in part to its ability to stimulate episodic and intermittent growth hormone release. | Clin Int Aging, 2006 |