Here’s what we’ll cover in this blog post:
- What is Metformin?
- What Metformin does
- The science behind Metformin
- How you can get started today
If you’ve ever searched for medications to manage blood sugar, chances are you’ve come across Metformin. It’s one of the most prescribed medications for type 2 diabetes worldwide—and for good reason.
But there’s more to this little white pill than meets the eye, and not enough resources on its true potential. Why are longevity enthusiasts celebrating Metformin? What does it do, how does it work, and what can it do beyond blood sugar?
Understanding what Metformin does can help you see why it’s become a cornerstone not just in diabetes care, but also in longevity and metabolic health. Here’s a peek into the true benefits of Metformin.
What Is Metformin?
Metformin is one of the most prescribed medications in the world for lowering glucose levels, totaling more than 83 million prescriptions in the United States alone.
FDA approved for the treatment of type 2 diabetes, Metformin has been a staple in the medical world for decades. With over 60 years of clinical support and an outstanding safety record., it has been on the World Health organization’s List of Essential Medicines since 2011, solidifying its place as one of the safest and most effective medications available.
Recently, several prominent clinicians and scientists suggested it’s can be used as more than just a diabetes control drug. In fact, Metformin may have a significant impact on longevity, positively impact several hallmarks of aging, and even extend healthspan.
But first, let’s take a look at what Metformin does so we can better understand its potential longevity benefits.
What Metformin Does
Metformin works by lowering blood glucose in 2 main ways:
- Reduces glucose released from the liver
The liver naturally produces glucose, even when we’re not eating, releasing glucose into our bloodstream in response to hormones like glucagon, which signals to our liver to raise blood sugar. Metformin slows liver glucose production, which manages blood sugar levels. - Helps cells absorb glucose more efficiently
If too much excess glucose is in our bloodstream, our cells become less sensitive to glucose. When this happens, our cells don’t work to absorb it as quickly. This is called insulin resistance. By managing the amount of glucose released from the liver, Metformin helps our cells become more insulin sensitive, improving how effectively our body responds to insulin.
Together, these actions are what contributed to Metformin’s role as a first-line diabetes medication. But by these same actions, Metformin also has a wealth of other potential benefits that may help us live longer and healthier.
What Metformin Does for Longevity
The benefits of lowered blood sugar and insulin sensitivity extend far beyond diabetes care and risk management.
Lower blood sugar can also help:
- Reduce the risk of age-related diseases
- Improve cardiovascular health
- Boost metabolic health
- Decrease the risk of cognitive decline
- Lessen cortisol (stress) levels
- Stifle inflammation
- Encourage weight loss
These benefits go even further than blood sugar control alone, all contributing to a longer, healthier life.
And the best thing about it? These benefits aren’t limited to diabetics alone. Even healthy people can take Metformin and potentially extend their lifespan and healthspan.
That’s why this medication is the subject of one of the largest anti-aging clinical trials ever: the Targeting Aging with Metformin (TAME) trial. In fact, many of the most compelling studies on Metformin use healthy participants. The science reveals that its use isn’t limited to diabetics.
The Science of Metformin
Though Metformin science and research is still ongoing, the science behind it is substantial and promising. A growing number of peer-reviewed studies suggest that Metformin can do more than manage blood sugar.
Here’s a closer look at some of the most compelling research:
- Lowered cancer risk
A 2016 study of 1,300 cancer patients in the Netherlands concluded that “Metformin use was associated with lower cancer mortality compared to non-users.” - Reduced risk of cognitive impairment
A 5-year study of nearly 70,000 healthy participants over the age of 65 concluded diabetes is associated with an increased risk of dementia, but this risk becomes weaker in those taking Metformin. - Improved fertility
A 1999 study of 43 Ohio women with PCOS concluded that 91% of the participants resumed normal menstrual cycles after using Metformin, indicating that it potentially assisted in restoring the fertility cycle.
In addition to the TAME trial, ongoing studies include those from the Interventions Testing Program (ITP), the gold standard of testing medications for longevity potential.
This program has launched several studies into Metformin, with the goal of evaluating whether it can increase human lifespan, and though initial results are inconclusive, Metformin remains one of the most frequently tested drugs, getting us one step closer to understanding its true potential.
Why Metformin Matters
Metformin stands on the precipice of a paradigm shift in traditional medicine. With further studies and the expected results from the TAME trial, Metformin could change how healthcare professionals approach medicine, leading to a system where doctors treat diseases before symptoms emerge, rather than spot-treating symptoms as they arise.
If doctors shift to a truly preventative approach like this, they could potentially prevent before they arise, which could see the average lifespan of Americans dramatically increase.
At the end of the day, scientists are still trying to better understand how Metformin works. That’s why studies like the TAME trial are still well underway. As research continues, we may discover more about how this time-tested medication can potentially help us live longer.
But you don’t have to wait for studies to finish to experience Metformin for yourself.
With AgelessRx, you can request a prescription 100% online with a licensed medical provider. If approved, your treatment will be delivered directly to your doorstep, with ongoing medical monitoring provided by our experts in the comfort and safety of your home.
Whether you’re interested in blood sugar control, weight loss, or healthy aging, our online platform makes it easy to take control of your health and optimize your health for yours to come. The science is evolving, but your journey can start now. Get started with a free intake today to see if Metformin is right for you.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.