Ozempic®, FDA approved to treat type 2 diabetes, contains the active ingredient semaglutide, a GLP-1 receptor agonist that has also been shown to reduce cardiometabolic risk factors and keep you fuller, longer.

The information presented here is only applicable for non-diabetics who have been prescribed Ozempic® after their AgelessRx prescriber deemed it appropriate.

Quick Tips

Here are some simple steps to help you get the most from each dose:

• Refrigerate your pens upon arrival
• Use with a reduced-calorie meal plan & exercise
• Take Ozempic® on the same day each week
• Can be taken with or without food
• Rotate injection sites every week
• Always dispose used pens in a sharps container

Getting Started

When you first receive your Ozempic® pens, follow proper storage guidelines to maintain the quality of the solution.

You will have to prime your pen when you first use it.

For each successive use, follow the instructions for properly administering Ozempic®.

Always set the dose according to your doctor-guided titration schedule.

Storage

To maintain the utmost quality, it is best to refrigerate your pens between 36°F and 46°F before using. Once they have been used, you may safely store your Ozempic® pens at room temperature (between 46°F and 86°F) for up to 56 days. If your pen has been stored below 36°F or above 86°F for an extended time, the pen and/or the solution may become ineffective. Always keep the pen cap on when not in use.

Ozempic® will arrive with a temperature tag to indicate whether it was exposed to brief (2 hours), moderate (12 hours), or prolonged (48 hours) temperatures during transit. If the temperature tag indicates prolonged exposure, please contact us immediately.

You may safely travel with your Ozempic® pens so long as the above conditions are met while traveling. Be sure to travel with a refrigerated case if necessary, and to bring your own sharps disposal container if you will not have access to one.

How to Prime Your Pen

Whether you are taking your first dose of Ozempic® or you’ve just started using a new Ozempic® pen, you will have to prime your pen before use to ensure that the solution will be properly administered.

To prime your pen, follow these instructions:

• Apply a new needle to your pen
• Turn the dose selector to the flow check symbol
• Hold the plunger until it reads 0 again
• The 0 must line up with the dose pointer
• A drop of Ozempic® should appear at the needle tip

If no drop appears, repeat the above steps up to 6 times. If there is still no drop at the needle tip after 6 attempts, try changing the needle. If, after changing the needle, there is still no drop, stop use and contact AgelessRx to secure a replacement pen right away. Do not use your Ozempic® pen if priming fails.

How to Properly Administer Ozempic®

After you’ve successfully primed your Ozempic® pen and completed the initial use, follow these steps with each successive use:

• Apply a new needle to your pen
• Select the correct dosage on your pen
• Insert the needle into a fatty layer of skin
• Press & hold down the button at the end of the pen
• Wait for the dose counter on the pen to reach 0
• Count slowly to 6 before releasing the button & removing the needle

To avoid irritation, we recommend switching injection sites each week. You can take Ozempic® with or without food, and at any time of day, but it’s best to be as consistent as possible so you can get the best outcomes.

Ozempic® Titration Schedule

Ozempic® is always prescribed with a doctor-guided titration schedule to gradually introduce the medication to your body. This way, you have the best opportunity to experience the greatest benefits possible.

Ozempic® follows a standardized 4-month titration protocol. Unless you are specifically prescribed otherwise, your Ozempic® titration schedule will proceed as follows:

Month 1	0.25mg, once weekly
Month 2	0.50mg, once weekly
Month 3	1mg, once weekly
Month 4 & Onward	2mg, once weekly

Common Side Effects

The most commonly reported side effects for Ozempic® are nausea, vomiting, diarrhea, stomach pain, and constipation. These normally go away on their own within a few days, or up to 2-3 weeks.

To help prevent side effects from occurring or persisting, AgelessRx recommends the following:

• Eat slower & at more regular intervals throughout the day
• Try to take Ozempic® at about the same time of day each week
• Drink only water or clear, unsweetened beverages
• Avoid fried, greasy foods in favor of healthier, low-fat options

This is only a summary of potential side effects and how to address them. For more information, please see Ozempic® Prescribing Information.

Serious Side Effects

During clinical trials, Ozempic® use was associated with the following rare but serious effects:

• Thyroid C-cell Tumors
• Diabetic Retinopathy
• Hypoglycemia
• Kidney problems
• Gallbladder problems

For a full list of potential warning signs for these conditions, please see Ozempic® Prescribing Information.

Important Safety Information

Ozempic® should not be used by anyone who has a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome 2 (MEN2).

Do not use Ozempic® if you are pregnant, breastfeeding, or planning to become pregnant or breastfeed. If you become pregnant while taking Ozempic®, consult your prescriber before continuing with your next dose.

Though rare, allergic reactions to semaglutide are still possible. If you notice any shortness of breath or swelling around your face, tongue, or throat after using Ozempic®, stop use and contact emergency services right away. Mild allergic reactions around the injection site are normal and not cause for emergency.

As with any prescription medication, the dose prescribed is for you and you alone. Do not, under any circumstances, allow anyone else to use your Ozempic® pen.