Other treatments to consider
Metformin is a widely used first-line treatment. But for certain health goals, GLP-1s may be considered next.-
GLP-1s
Starting at $199- Dosing frequency
- Weekly
- Format
- Injection
GLP-1 injections may support greater weight loss for some patients² -
Zepbound® Consultation
Starting at $50- Dosing frequency
- Weekly
- Format
- Injection
Contains the active ingredient Tirzepatide and is FDA-approved for weight management -
Ozempic®
$1,350/mo- Dosing frequency
- Weekly
- Format
- Injection
FDA-approved GLP-1 medication shown to regulate appetite and caloric intake¹ -
Wegovy®
$1,695/mo- Dosing frequency
- Weekly
- Format
- Injection
FDA-approved GLP-1 medications shown to support weight loss²
¹https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.12932 ²https://www.wegovy.com/about-wegovy/managing-weight-with-wegovy.html
METFORMIN BENEFITS
Take charge of your health
- May activate longevity pathways¹ for a longer, healthier life
- May enhance mitochondrial health and nutrient sensing¹
- May decrease cell senescence and inflammation¹
- May lower the risk of diabetes, kidney disease, and certain cancers²
- May reduce the risk of cognitive impairment and dementia³
- May improve metabolic health¹
- May help you lose 5-7% body weight⁴
- Tested for purity by US-licensed pharmacies
Metformin has not been approved by the FDA for these uses, but there are multiple studies that have shown these benefits.
METFORMIN
Background and history
- Derived from natural compounds in the French lilac plant⁵
- Used successfully for 60+ years with an outstanding safety record⁵
- Listed on the World Health Organization’s List of Essential Medicines, a catalog of the most effective, safe, and cost-effective therapies⁶
- Read more on our Metformin Blog
Science-backed treatment, real results
82% of patients felt improvement by their second check-in
74% saw improvement in blood sugar levels
75% felt better appetite control
70% noticed reduced cravings
*Actual results may vary. Data was self-reported by 1,412 surveyed customers who checked in with their provider on their second check-in between 4/1/23 and 4/1/24. All respondents are AgelessRx Metformin customers who were approved for a prescription after completing an assessment with a medical provider.
The science of Metformin
Widely Prescribed: Metformin is one of the most widely prescribed medications worldwide—the side effects of Metformin are often mild, and its safety profile is widely established⁵. FDA approved to treat diabetes since 1994⁵, Metformin works by reducing how much glucose is released from the liver and improving glucose absorption in cells⁷.
Multifaceted Benefits: In clinical studies¹, Metformin showed a range of potential benefits, including reduced inflammation, improved insulin sensitivity, weight loss, and lowered risk for heart attack and stroke, among other age-related diseases.
Real results from people like you
I can absolutely swear by Metformin, no doubt about it … the hunger control and stable energy throughout the day is unquestionable.
I have been taking Metformin for about 1 month now…I have maintained my weight and my anxiety has improved so much…I have noticed my rosacea is at bay and my skin is just glowing! Best thing I ever did.
I’m 57 and feel like I’ve watched my carbs my whole life. The weight was not budging until after I started Metformin.
*The testimonials on this page are from real AgelessRx customers sourced from Trustpilot.com. Individual results may vary. Testimonials are not a guarantee of future results.
How it works
Simple online assessments
Answer a few questions about your health history to be reviewed by a US-licensed medical provider
Free shipping
If approved, your prescription will be fulfilled by one of our US-licensed, 503A certified pharmacy partners and rigorously inspected for quality before arriving at your doorstep in 5 days or less.*
Continuous support
Enjoy ongoing access to providers, easy refills, and direct updates from your prescriber, ensuring support throughout your journey.
*Shipping times do not include pharmacy processing or doctor approval; your AgelessRx provider will take 1-2 days to review your request and send to our partner pharmacy, who will take an additional 2-3 days to process. Shipping times may be affected by regional variability. Temperature-sensitive medications are subject to state and federal requirements and may take longer to ship.
Ready to get started?
Start your free online visit now.
- 3-month supply per shipment
-
1,000mg/day or as prescribed
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Extended-release (ER) version
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Lab tested for purity (read more)
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Free shipping
CODE MET20: $20 off first quarter & FREE medical evaluation
A medical professional may recommend a different dose during medical intake process
You can request daily dose adjustments between refills
You will be automatically billed & sent refills based on your plan
You can pause or cancel at any time before your next shipment
* Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See below for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
101 video
FAQs
How often do I take Metformin?
Metformin is taken once daily with a meal. You can take your dose at any time of day or night, but for the best results, take your dose around the same time each day, and with your largest meal of the day.
Is this safe to take with other prescription medications?
Generally, yes. Metformin is one of the safest prescriptions and commonly prescribed, however, a doctor will review your health history and current medications to see if it is appropriate.
What do I do if I lose my pills?
Contact AgelessRx to order an interim shipment or move up your next refill date.
See all FAQsImportant safety information and common side effects
Metformin is generally a safe and well-tolerated medication. In 1997, Metformin was included in the World Health Organization’s List of Essential Medicines, a catalogue of the safest and most effective medications available.
You must stop taking Metformin at least a week before any surgical procedure or medical diagnostic requiring contrast, such as a CT scan. If you are unsure if you should stop Metformin for any surgery or medical procedure, please ask the doctor ordering the test or procedure.
Most common Metformin side effects
Gastrointestinal (GI) side effects are common when first starting Metformin, but often go away on their own within a few weeks. Side effects may return when increasing your dose.
Our patients report* the following as the most common side effects of Metformin:
- Diarrhea (20%)
- Upset stomach (16%)
- Nausea (11%)
- Fatigue (8%)
- GI cramping (7%)
Most people start with a small dose and slowly increase to their prescribed dose to avoid stomach discomfort. AgelessRx also prescribes the extended-release (ER) version to reduce stomach discomfort.
To help prevent side effects from occurring or persisting, try the following strategies:
- Eat slower and at more regular intervals throughout the day
- Try to take your medication at around the same time each day
- Avoid excessive alcohol intake
- Drink water before taking your dose
- Avoid fried, greasy foods in favor of healthier, low-fat options
- Take ginger or peppermint oil supplements to help relieve nausea
Read our blog for more information on how to minimize Metformin side effects.
Metformin has been associated with vitamin B12 deficiency in clinical studies. This risk may be higher in those prescribed higher doses of Metformin. Our prescribers often recommend taking B12 injections or B12 supplements to minimize the risk of deficiency. If you notice symptoms of B12 deficiency, contact your prescriber or your general healthcare provider.
For a full list of possible side effects, please review the Mayo Clinic’s Metformin resources.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
*Actual results may vary. Data was self-reported by 12,100 surveyed customers who checked in with their provider between 1/1/23 and 9/22/25, after 30 days of starting Metformin. All respondents are AgelessRx Metformin customers who were approved for a prescription and recommended a dose of 1,000mg/day after completing an assessment with a medical provider. Data does not account for patients who may experience multiple side effects.
Gatekeeping is so traditional healthcare
We read the clinical trials so you don’t have to. Here’s all the science behind our claims.
| 1. This review study evaluates modern clinical data on Metformin to assess how it affects mitochondrial health, metabolic health, cell senescence, inflammation, and other longevity pathways or hallmarks of aging. | Molecules, 2025 |
| 2. This review study explores the clinical applications of Metformin for various age-related diseases, including diabetes, kidney disease, and cancer. | Theranostics, 2022 |
| 3. A meta-analysis of 14 Metformin studies investigates the effects of Metformin of cognitive impairment, dementia, and Alzheimer’s disease. | JAD, 2018 |
| 4. This clinical trial tests the weight loss benefits of Metformin. Of the 154 participants, 47.4% showed at least 5% weight loss and 16.2% showed 10% weight loss or more, with an average weight loss of 6.5%. | Exp Clin Endocrinol Diabetes, 2013 |
| 5. A retrospective review study of the clinical history of Metformin. | ATM, 2014 |
| 6. The World Health Organization’s List of Essential Medicines | WHO, 2019 |
| 7. This editorial study presents arguments for using Metformin as a first line defense for type 2 diabetes, with review of its essential mechanisms of action. | Pharma (Basel), 2021 |