WHAT IS
LOW DOSE NALTREXONE?
Background & History
Low Dose Naltrexone, commonly referred to as LDN, is as its name would suggest: a low dose of naltrexone. Naltrexone (at higher dosages) has been FDA approved for over 30 years. It is FDA approved for two conditions:
- It is FDA-approved to assist with substance dependence at a standard dose of 50-150mg
- It is FDA-approved for weight loss in combination with Bupropion, at a dose of 32mg
What clinicians have more recently discovered is that at much lower doses (1/10th), LDN has completely different effects. Low Dose Naltrexone was shown to have remarkable benefits in the clinical setting as well as in clinical trials. So much so, that:
- It has documentaries filmed about its beneficial effects.
- It has non-profits dedicated to educating clinicians and consumers about its benefits
- It has numerous clinical trials completed demonstrating evidence of efficacy
- It has a large community of people sharing their stories in numerous online forums (for example Low dose Naltrexone (LDN) for chronic illness & infections group has 40k members)
LDN has an outstanding safety record (even at the approved large doses, let alone at 1/10th of the dose).
What symptoms is LDN most likely to help with?
LDN is known to help with variety of chronic inflammation related / auto-immune conditions, such as:
- Fibromyalgia
- Rheumatoid arthritis
- Thyroid Dysregulation
- Anxiety
- Multiple Sclerosis
- Crohn’s and Ulcerative Colitis
Why does LDN have potential benefits for a variety of symptoms?
There are several theories for why LDN is effective:
- LDN lowers chronic inflammation
- LDN stimulates the body to naturally produce more endogenous opioids, which has variety of positive benefits (including beneficial effect on the immune system)
- LDN increases production of endorphins 2x
Li Z, You Y, Griffin N, Feng J, Shan F. Low-dose naltrexone (LDN): A promising treatment in immune-related diseases and cancer therapy. Int Immunopharmacol. 2018;61:178-184. doi:10.1016/j.intimp.2018.05.020
LDN and Longevity
Based on the mechanisms of action and previous research, we hypothesize that Low Dose Naltrexone lowers chronic inflammation and modulates the immune system, which may prevent the onset of various chronic conditions and may delay the development of age-related health issues. Given that LDN may promote immune cell proliferation, wound healing, and reduce inflammation, it’s highly likely that LDN will be shown to have longevity benefits. Click here to learn more about Longevity and LDN and Longevity.
Our Commitment to Continuous Research
Research is core to our mission at AgelessRx, and we spend considerable efforts advancing science in a transparent manner. We are working on two IRB-approved clinical trials that include LDN:
- Long COVID Trial
- Observational Trial
How do I request an LDN prescription?
With AgelessRx, we provide access to a licensed medical professional, a prescription, and delivery of the medication to your home. You can get started with a medical evaluation and request in less than 10 minutes.
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