LDN Registry

The effects of Low Dose Naltrexone (LDN) on diseases of aging
Join The Registry

Are you currently taking LDN? If yes, participate in our LDN Registry to help us collect valuable information on the benefits you’re experiencing! This trial aims to provide prescribers and the entire longevity community with better-informed usage insight on LDN as a longevity therapy.

What is the LDN Registry?

  • A registry is a centralized database of patients, either taking a common drug or having a specific diagnosis, that can be used to increase knowledge about the drug or diagnosis.
  • For our trial, the LDN Registry, we welcome submissions from any individuals taking LDN. The information collected will be used to better assess the health benefits of long-term LDN usage.
  • Participants will complete a total of four surveys: Consent, Medical History, Retrospective Quality of Life, and Quality of Life. Combined, the surveys should only take about 20 minutes to complete. All information collected from these surveys will move us towards our objectives, outlined below.

How it Works

Join the

LDN Registry

Complete Total of

4 Surveys

Contribute to

Longevity Science

Trial Objectives

  • Assess the health benefits of long-term LDN use
  • Assess the effects of LDN on altering the clinical signs of aging as well as the physiological endpoints associated with declining health and aging
  • Create a database of LDN users and controls for future health-related correlative studies
  • Help determine dosing schedules for LDN
  • Examine potential cost savings of LDN
Join the Registry

About LDN

Low Dose Naltrexone (LDN) is an oral medication that has been shown to reduce chronic pain, inflammation, fatigue, autoimmunity, and obesity. The dosing for the FDA-approved use of Naltrexone is generally above 50mg per day and is typically prescribed to help patients with addiction. However, naltrexone is a drug that exerts different pharmacodynamic effects in lower quantities than it does at higher doses.

Its low dose effects were first used for the treatment of AIDS, for which doses of 1.5-3mg resulted in immune-modulating effects in the 1980s and 1990s. In recent years, clinicians have been prescribing it off-label at low doses (10mg/day or less), to help with various conditions such as multiple sclerosis (MS), Crohn’s disease, fibromyalgia and even anxiety.

Study Protocol