Here’s what we’ll cover in this blog post:
- What is Brenzavvy®?
- How does Brenzavvy® work?
- The longevity benefits of Brenzavvy®
If you’ve been looking for therapies that support healthy aging, you may have come across SGLT2 Inhibitors like Brenzavvy®. But what is Brenzavvy®, and why are longevity researchers and patients alike praising its potential?
Though FDA approved to treat diabetes, scientists are realizing that Brenzavvy® may do more than simply lower blood sugar. In fact, SGLT2 medications like Brenzavvy® are gaining popularity for their potential to slow the aging process and reduce the risk of age-related disease.
Here, we’ll discuss what Brenzavvy® is, how it works, and why it’s gaining attention in longevity science.
What Is Brenzavvy®?
Brenzavvy®, or Bexagliflozin, belongs to a class of medications called SGLT2 Inhibitors. First FDA approved in 2023, Brenzavvy® is a new kid in this class, sharing the space with other SGLT2 options like Invokana® (Canagliflozin), which has been FDA approved since 2013.
Short for sodium-glucose co-transporter 2, SGLT2 is a protein that reabsorbs glucose back into the bloodstream. SGLT2 Inhibitors like Brenzavvy® block the SGLT2 protein, allowing that excess protein to be flushed out in urine.
How Does Brenzavvy® Work?
Not all SGLT2 Inhibitors work exactly the same way, but they all share the same primary mechanism of action: flushing excess glucose in urine.
Normally, the kidneys filter glucose from the bloodstream into urine before reabsorbing it back into the body. Once reabsorbed, it’s used primarily to fuel cells. But excess glucose that isn’t used for fuel is left in the bloodstream, increasing insulin resistance and the risk of prediabetes.
Where SGLT2 acts like a straw to bring glucose back into the body, SGLT2 Inhibitors block that straw. This leaves up to 50-80g of excess sugar in urine, where it’s then flushed from the body.
The main result is lower, stable blood sugar levels. But healthy glucose levels also reduce the metabolic strain on the body. In turn, this may slow hallmarks of aging and reduce the risk of age-related disease.
The Longevity Potential of Brenzavvy®
Research into SGLT2 Inhibitors shows they may help protect the body from the long-term wear and tear of excess glucose. In this way, they may potentially support broader aspects of longevity and healthy aging:
- Lifespan
Though focused studies on Brenzavvy® are still ongoing, animal studies on SGLT2 Inhibitors have shown a 14% increase in lifespan. - Inflammation and oxidative stress
SGLT2 Inhibitors allow cells to use energy more efficiently, which may activate anti-inflammatory pathways and improve mitochondrial function, potentially decreasing oxidative stress and inflammation. - Cardiovascular and kidney health
Leaving excess glucose in urine reduces the afterload on the heart and kidneys, which may encourage less strain on these systems. - Alzheimer’s and Parkinson’s risk
Stable blood sugar could also improve blood flow to the brain, reducing risk factors of cognitive decline like hyperglycemia, insulin resistance, and amyloid plaque. - Moderate weight loss
Flushing excess glucose maintains a steady caloric deficit of up to an extra 360kcal per day, which may encourage moderate weight loss of up to 2-4% of total body weight. - Senescent cell removal
Senescent “zombie” cells are a leading driver of aging, caused by damaged cells that stop dividing, but won’t die. By activating anti-inflammatory pathways, SGLT2 Inhibitors like Brenzavvy® may help the body clear senescent cells.
Many of these pathways are tied to caloric restriction. In fact, SGLT2 Inhibitors mimic a state of caloric restriction by stabilizing glucose. Caloric restriction remains one of the best lifestyle factors tied to longevity, which may explain why SGLT2 Inhibitors are also associated with up to a 51% reduced risk of all-cause mortality.
Beyond Blood Sugar: Brenzavvy® for Longevity
As the research shows, Brenzavvy® has clear potential that goes far beyond diabetes care. By reducing metabolic strain, improving heart and kidney function, and even mimicking the effects of caloric restriction, Brenzavvy® may help protect against some of the most common drivers of aging.
If you’re curious about how Brenzavvy® could fit into your longevity toolkit, AgelessRx makes it simple to get started. So why wait? You can get started with a free medical intake in less than 5 minutes. If approved, you can start Brenzavvy® in less than 2 weeks. With ongoing medical support from licensed experts, you’ll never have to wonder what’s next in your longevity journey. When you’re ready, get started with Brenzavvy® to see if it’s right for you.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.